Schiff base derivatives with morpholine and antioxidant activity

Year 2019, Volume: 1 Issue: 1, - , 11.12.2019

Dilek Ünlüer , Ersan Bektaş Yasemin Ünver

Abstract

New Schiff base derivatives with morpholines, 4-bromo-2-(((4-morpholinophenyl)imino)methyl)phenol
(I) and 4-bromo-2-(((2-morpholinoethyl) imino) methyl)phenol (II)   were synthezised. The compounds I-
II were characterized by spectral methods IR, and NMR spectroscopic techniques. Antioxidant activities of compounds I and
II were determined by the
ferric reducing ability of plasma (FRAP) assay method which is based on the reduction of Fe3+
-TPTZ complex to the Fe2+ -TPTZ complex in the presence of antioxidants. Compound
I has relatively high ferric reducing power ability (i.e., antioxidant
activity) than compound II. The
ability of compound I and II to reduce iron (III) to iron (II) ions were calculated as 929 and
11 µM FeSO₄.7H₂O equivalent/g sample, respectively.To summarize, the above-mentioned results indicate
that compound II has inefficient antioxidant
activity and Compound I has
effective antioxidant activity.

Keywords

Schiff base, Morpholine, Antioxidant Activity

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