Aerobic-training effects on CD4 cell count and health related quality of life of people living with human immunodeficiency virus

Year 2024, , 10 - 17, 25.03.2024

Thabo Muswere , Ignatius Onyewadume

https://doi.org/10.31459/turkjkin.1375448

Abstract

This study compared the effects of 12 weeks of aerobic training against baseline data of People Living with Human Immunodeficiency Virus (PLWH) Cluster of Differentiation 4 (CD4) cell count, and Health-Related Quality of life (HRQoL) (Physical-health Component Summary (PCS) and Mental-health Component Summary (MCS)). A within-subject quasi-experimental multimethod design was used. There was purposive sampling of participants on Highly Active Antiretroviral Therapy (HAART) under Botswana Network of People Living with HIV/AIDS (BONEPWA). The 28 participants (23 females and 5 males) who met the inclusion criteria were of age 18 to 45. After 6 weeks, one female dropped out of the study. Participants were subjected to 12 weeks of aerobic training, three times a week for 60 minutes per session. The significant differences between CD4 cell count and the HRQoL variables at baseline and week 12 of the participants were compared using the paired t-test. All analysis was done using Statistical Package for the Social Sciences (SPSS) version 24.0 software. The alpha value was set at p<0.05 level of significance. The mean age and standard deviation of participants was 37.7 (± 6.84) years. Statistically significant (p< 0.05) improvements were found in MCS measures after intervention. There were no statistically significant (p>0.05) improvements in CD4 count and PCS measures after intervention. PLWH can be advised to engage in regular aerobic training 3 times a week for 60 minutes especially when on HAART. The research is relatively preliminary; therefore, there could be some replication of the study by other researchers.

Keywords

Aerobic training, CD4 cell count, highly active antiretroviral therapy (HAART), human immunodeficiency virus (HIV), health related quality of life (HRQoL)

Ethical Statement

Ethical Approval Ethical clearance was obtained from the University of Botswana Review Board, Ref: UBR/RES/IRB/SOC/GRAD/131 and the Ministry of Health of the Republic of Botswana Research Division Review Board, Ref: HPDME: 13/18/1. Permission to draw pilot study’s participants from Greater Gaborone clinics was granted by Ministry of Health Greater Gaborone District Health Management Team (Ministry of Health GGDHMT), Ref: GGDHMT 2/27 V (25) and an approval to draw participants for the major study was from Informed consent Informed consent was obtained from all individual participants included in the study BONEPWA. Data obtained from participants was kept confidential using numbers for identification.

Thanks

Acknowledgement The Department of Sports Science, the Department of Culture, Sports and Recreation, the University of Botswana Office of Research and Development, the Republic of Botswana Ministry of Health and Wellness, Botswana Network of People Living with HIV and AIDS (BONEPWA), the trainers and the volunteers, all contributed a lot to the success of this study.

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