Association of Heat Shock Proteins with Cancer

Year 2023, Volume: 1 Issue: 1, 60 - 66, 13.10.2023

Harika Topal Önal

Abstract

Aim: Heat shock proteins (HSPs) are proteins that assist cells in activating defense mechanisms against various stress factors. This review discusses the relationship between heat shock proteins and cancer. By shedding light on the potential effects of heat shock proteins in the context of cancer biology, it provides an important perspective for future treatment strategies and approaches to combat cancer.

Materials and Methods: This compilation is based on a review of recent studies investigating the effects of heat shock proteins on cancer formation and treatment processes.

Results: Recent research indicates that these proteins can be found at higher levels in cancer cells than in normal cells and may potentially play a role in cancer development, progression, and the acquisition of resistance to treatment. Furthermore, it is suggested that HSPs may help tumors evade the immune system by preventing the recognition of cancer cells. Additionally, heat shock proteins are proposed to be effective in the development of resistance to cancer therapies.
Conclusion: Future studies in this field may enable the development of more effective strategies for combating cancer.

Keywords

heat shock proteins, cancer, apoptosis, cancer cell resistance

Isı Şoku Proteinlerinin Kanser ile ilişkisi

Abstract

mekanizmalarını aktive etmelerine yardımcı olan proteinlerdir. Bu derleme, ısı şok proteinlerinin kanserle ilişkisini ele almaktadır. Isı şok proteinlerinin kanser biyolojisi içindeki potansiyel etkilerini aydınlatarak, gelecekteki tedavi stratejileri ve kanserle mücadele yaklaşımları için önemli bir perspektif sunmaktadır.
Materyal-Metot: Isı şok proteinlerinin kanser oluşumunda ve tedavi sürecindeki etkilerini araştıran güncel çalışmaların derlenmesi ile oluşmuştur.
Bulgular Son yapılan araştırmalar, bu proteinlerin kanser hücrelerinde normalden daha yüksek düzeylerde bulunabileceğini ve kanserin gelişiminde, yayılmasında ve tedaviye direnç kazanmasında potansiyel rol oynayabileceğini göstermektedir. HSP' lerin ayrıca, kanser hücrelerinin bağışıklık sistemince fark edilmesini engelleyerek tümörlerin bağışıklık savunma mekanizmalarından kaçmasına yardımcı olabileceği düşünülmektedir. Bunun yanı sıra, ısı şok proteinlerinin kanser tedavilerine karşı direnç gelişiminde etkili olabileceği de öne sürülmektedir.
Sonuç: Bu alanda yapılacak olan ilerideki çalışmalar, kanserle mücadelede daha etkili stratejilerin geliştirilmesine olanak tanıyabilir.

Keywords

Isı şok proteinleri, kanser, apoptoz, kanser hücre direnci

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