Review
BibTex RIS Cite

A LITTLE KNOWN BEE PRODUCT WITH THE POTENTIAL TO BECOME A FUNCTIONAL FOOD AND NUTRITIONAL SUPPLEMENT: APILARNIL

Year 2024, Volume: 24 Issue: 2, 403 - 416
https://doi.org/10.31467/uluaricilik.1523198

Abstract

Beekeeping plays a crucial role in supporting agricultural sustainability and the economy through pollination and the production of honey and other bee products. Among these products is apilarnil, a less known substance derived from drone larvae that provides health benefits. Apilarnil is rich in essential nutrients and has been reported to have favorable effects on the reproductive system, autonomic nervous system and cardiovascular health. In addition to its natural medicinal properties, its nutritional and pharmaceutical potential is increasingly recognized, leading to the commercial production of apilarnil. This bee product is very important for health as it contains amino acids, fatty acids, vitamins, minerals, hormones and antioxidants. Apilarnil is recognized as a complete food and is included in various food products. Research emphasizes the androgenic, estrogenic, antioxidant and immune system boosting effects of apilarnil. Animal studies indicate its potential to improve reproductive health, reduce stress and promote growth and development. It also shows promise in protecting against oxidative stress and improving general health. In this review, information on apilarnil and its uses is compiled.

Ethical Statement

The authors declare that they have no conflicts of interest. RIT and TA contributed equally to writing of the review article.

Supporting Institution

Mugla Sitki Kocman University, Scientific Research Projects Unit (Contract # 22/134/06/1/5)

Project Number

Mugla Sitki Kocman University, Scientific Research Projects Unit (Contract # 22/134/06/1/5)

Thanks

This study received financial supported from Mugla Sitki Kocman University, Scientific Research Projects Unit (Contract # 22/134/06/1/5).

References

  • Abd El-Wahed AA, Khalifa SAM, Aldahmash B, Zhang H, Du M, Zhao C et al. Exploring the Chemical Constituents and Nutritive Potential of Bee Drone (Apilarnil): Emphasis on Antioxidant Properties Chem. Biod. 2024;21: e202400085, doi.org/10.1002/cbdv.202400085.
  • Akcicek E, Yucel B. Apiterapi’de Apilarnil. Arı Ürünleri ve Sağlık (Apiterapi). Sidas Yayınevi, İzmir, 2015 p. 183-190.
  • Altan O, Yucel B, Acikgoz Z, Seremet C, Kosoglu M, Turgan N et al. Apilarnil reduces fear and advances sexual development in male broilers but has no effect on growth Br. Poultry Sci. 2013;54(3): 355-361, http://dx.doi.org/10.1080/00071668.2013.791382.
  • Balkanska R, Karadjova I, Ignatova M. Comparative analyses of chemical composition of royal jelly and drone brood Bulgarian Chem. Comm. 2014;46(2):412-416.
  • Barnutiu LI, Marghitas L, Dezmirean D, Bobis O, Mihai C, Pavel C. Physicochemical composition of Apilarnil (bee drone larvae) Lucrări Ştiinţifice-Seria Zootehnie 2013;59:199-202.
  • Baskaran S, Finelli R, Agarwal A, Henkel R. Reactive oxygen species in male reproduction: A boon or a bane? Andrologia 2021;53: e13577, https://doi.org/10.1111/and.13577.
  • Bieljajew WA., Safonowskaja JW. Adaptogenic relationship training based on drone brood Beekeeping 2009; 6:51–52.
  • Bogdanov S. The royal jelly book, chapter 1. Royal jelly and bee brood: harvest, composition, quality Bee Prod. Sci. 2012; www.bee-hexagon.net.
  • Bogdanov S. Bee product science: royal jelly, bee brood: composition, health, medicine: a review. 2017; www.bee-hexagon.net/fles/fle/flE/Health/RJBookReview. pdfMay2017
  • Bolatovna KS, Omirzak T, Akhanov UK, Rustenov A, Eleuqalieva N. Improving reproductive qualities of pigs using the drone brood homogenate Biol. Med. 2015;7(2):BM-091.
  • Borkovcova M, Mlcek J, Adamkova A, Adamek M, Bednarova M, Musilova Z, Sevcikova V. Use of foods based on bee drone brood: Their sensory and microbiological evaluation and mineral composition Sustainability 2022;14 (5): 2814, https://doi.org/10.3390/su14052814.
  • Cosmia M, Gallenti G, Marangon F, Troiano S. Reprint of “Attitudes towards honey among Italian consumers: A choice experiment approach” Appetite 2016;106:110-116, https://doi.org/10.1016/j.appet.2016.08.005.
  • Doganyigit Z, Silici S, Kaymak E, Okan A, Pandir D. LPS’nin böbrek DNA’sı üzerine akut toksik etkisi ve apilarnilin koruyucu rolü Eurasian J. Biol. Chem. Sci. 2019a;2:111-114.
  • Doganyigit Z, Silici S, Kaymak E, Okan A, Akın A T, Pandır D. Apilarnilin'in erkek sıçanlarda lipopolisakkarite (LPS) bağlı testis toksisitesine karşı koruyucu rolünün belirlenmesi determination of the protective role of apilarnil against testicular toxicity due to lipopolysaccharide (LPS) in male rats Bozok Tip Derg. 2019b; 9(2):146-154.
  • Doganyigit Z, Okan A, Kaymak E, Pandir D, Silici S. Investigation of protective effects of apilarnil against lipopolysaccharide induced liver injury in rats via TLR 4/ HMGB-1/ NF-κB pathway Biomed. Pharm. 2020a;125:109967, https://doi.org/10.1016/j.biopha.2020.109967.
  • Doganyigit Z, Kaymak E, Okan A, Pandir D, Silici S. Investigation of protective effects of apilarnil against lipopolysaccharide induced lung injury in rats Mellifera 2020b;20:3-15.
  • Doganyigit Z, Koklu B, Uner A, Okan A, Kaymak E, Silici S. The Effect of apilarnil on the autophagia against lipolysaccarite-based sepsis in liver New Trends in Med. Sci., 2020c;1: 84-89.
  • Dzugan M, Sidor E, Milek M, Tomczyk M. The possibility of using bee drone brood to design novel dietary supplements for apitherapy Appl. Sci. 2023;13:4687, https://doi.org/10.3390/app13084687.
  • Efanova N, Osintseva LA, Osina LM, Batalova SV, Mikhailova DS. Correction of endocrine and metabolic status of dogs with the help of drone homogenate Innovat. Food Safety 2019;2(24):64-68, https://doi.org/10.31677/2311-0651-2019-24-2-64-68.
  • Elashal MH, Abd El-Wahed AA, Mohamed MA, Hamad R, Abd Eldaim MA, Khalifa SAM et al. Apilarnil ameliorates Bisphenol A-induced testicular toxicity in adult male rats via improving antioxidant potency and PCNA expression Reprod. Toxic. 2024; 125:108570, https://doi.org/10.1016/j.reprotox.2024.108570.
  • Erdem B, Arslan OC, Mulayim MS. Testosterone enhancer containing lipid extract of Apilarnil Turk PatentAppl. 2017; TR 2016014275 A1 20170821.
  • Erdem B, Ozkok A. Can food supplement produced from apilarnil be an alternative to testosterone replacement therapy? Hacettepe J. Biol. Chem. 2017;45(4):635–638, DOI: 10.15671/HJBC.2018.207.
  • Erdem S, Inci H. Apilarnilin yağ asidi özelliklerinin belirlenmesi (Determination of fatty acid properties of apilarnil) Türk Tarım Doğa Bil. Derg. 2022;9(4):900-6, https://doi.org/10.30910/turkjans.1111152.
  • Finke MD. Nutrient composition of bee brood and its potential as human food Ecol. Food Nutri. 2005;44(4):257-270, DOI:10.1080/03670240500187278.
  • Food and Agriculture Organization (FAO). Production, Crops Primary. Available from: https://www.fao.org/faostat/en/#data/QCL Accesses:May, 2024.
  • Ghosh S, Herren P, Meyer-Rochow VB, Jung C. Nutritional composition of honeybee drones of two subspecies relative to their pupal developmental stages Insects 2021;12(8):759, DOI:10.3390/insects12080759.
  • Ghosh S, Sohn HY, Pyo SJ, Jensen AB, Meyer-Rochow VB, Jung C. Nutritional composition of Apis mellifera drones from korea and denmark as a potential sustainable alternative food source: comparison between developmental stages Foods 2020;9:389, DOI:10.3390/foods9040389.
  • Hamamci M, Doganyigit Z, Silici S, Okan A, Kaymak E, Yilmaz S, Inan LE. Apilarnil: a novel neuroprotective candidate Acta Neurologica Taiwanica 2020;29(2):33-45.
  • Hroshovyi T, Dobrynchuk M, Pavliuk B, Chubka M. Drone brood—As a raw material for the manufacture of medicines and dietary supplements Sci. Europe 2021;63:36-39.
  • Hryniewicka M, Karpinska A, Kijewska M, Turkowicz MJ, Karpinska J. LC/MS/MS analysis of α‐tocopherol and coenzyme Q10 content in lyophilized royal jelly, beebread and drone homogenate J. Mass Spectro. 2016;51(11):1023-1029, DOI:10.1002/jms.3821.
  • Ilieşiu NV. Apilarnil, Editura Apimondia, Bucuresti 1991.
  • Inandiklioglu N, Doganyigit Z, Okan A, Kaymak E, Silici S. Nephroprotective effect of apilarnil in lipopolysaccharide-induced sepsis through TLR4/NF-κB signaling pathway Life Sci. 2021;284:119875, DOI:10.1016/j.lfs.2021.119875.
  • Inci H, Izol E, Yilmaz MA, Ilkaya M, Bingol Z, Gulcin I. Comprehensive Phytochemical Content by LC/MS/MS and Anticholinergic, Antiglaucoma, Antiepilepsy, and Antioxidant Activity of Apilarnil (Drone Larvae) Chem. Biodiv. 2023;20:e202300654, doi.org/10.1002/cbdv.202300654. IPBES (2016). The assessment report of the Intergovernmental Science-Policy Platform on Biodiversity and Ecosystem Services on pollinators, pollination and food production. S.G. Potts, V. L. Imperatriz-Fonseca, and H. T. Ngo (eds). Secretariat of the Intergovernmental Science-Policy Platform on Biodiversity and Ecosystem Services, Bonn, Germany. 552 pages. https://doi.org/10.5281/zenodo.3402856.
  • IPIFF (International Platform of Insects for Food and Feed). Guide on food hygiene practices for European Union (EU) producers of insects as food and feed. 2022;https://ipiff.org/wp-content/uploads/2019/12/IPIFF-Guide-on-Good-Hygiene-Practices.pdf (last accessed on 24.08. 2023).
  • Isidorov VA, Bakier S, Stocki M. GC-MS investigation of the chemical composition of honeybee drone and queen larvae homogenate. J. Apicultural Sci. 2016;60(1):111-120, DOI:10.1515/jas-2016-0011
  • Jensen AB, Evans J, Joans-Levi A, Benjamin O, Matrinez I, Dahle B, Roos N, Lecocq A, Foley K. Standard methods for Apis mellifera brood as human food. J. Apicult. Res. 2019; 58:1-28, http://dx.doi.org/10.1080/00218839.2016.1226606.
  • Kekecoglu M, Keskin M, Birinci C, Birinci E, Kolayli S. Effects of honeybee race and season on propolis composition J. Agricult. Sci. 2021;27(3):292-297, DOI: 10.15832/ankutbd.619996.
  • Kistanova E, Zdoroveva E, Nevitov M, Nosov A, Vysokikh M, Sukhanova I, Boryaev G. Drone brood fed supplement impacts on the folliculogenesis in growing gilts Veterinarski Arhiv. 2020;90(6):583-592, DOI:10.24099/vet.arhiv.0886.
  • Kogalniceanu S, Lancrajan I, Ardelean G. Changes of the glucidic metabolism determined by the physical effort of the treatment with the Aslavital and Apilarnil Arad Med. J. 2010;3:33-41.
  • Kosum N, Taskin T, Kandemir C, Yucel B, Ekren Asici GS, Kiral F. Effects of Apilarnil on growth, body measurement and testes characteristics for Saanen male kids. Agrifood Conference, 26-28 September, İzmir. 2018; P 40-47.
  • Kosum N, Yucel B, Kandemir C, Taskin T, Duru M.E, Kuçukaydın S, Cornea‐Cipcigan M. Chemical composition and androgenic effect of bee drone larvae (Apilarnil) for goat male kids. Chem. Biodiv. 2022;19(8):e202200548, https://doi.org/10.1002/cbdv.202200548.
  • Kuzmenko LM, Polishchuk AA, Usenko SO, Shostya AM, Bulavenko RV. Prooxidant-antioxidant homeostasis in the tissues of the uterus of pig, depending on the periods of the reproductive cycle World Med. Biol. 2018;64(2): 198-203, DOI:10.26724/2079-8334-2018-2-64-198-203.
  • Lazaryan DS. Comparative amino acid analysis of bee brood Pharma. Chem. J. 2002;36(12):680-682. Lecocq A, Foley K, Jensen AB. Drone brood production in Danish apiaries and its potential for human consumption. J. Apicult. Res. 2018;57(3):331-336, https://doi.org/10.1080/00218839.2018.1454376.
  • Lipinski MJ, Froenicke L, Baysac KC, Billings NC, Leutenegger CM, Levy AM, Lyons LA. The ascent of cat breeds: genetic evaluations of breeds and worldwide random-bred populations Genomics, 2008;91(1):12-21, DOI: 10.1016/j.ygeno.2007.10.009.
  • Marangoz M, Dolu ZT. Tüketicilerin arı ürünlerine ilişkin bilgi ve güven düzeyleri ile satın alma davranışlarının araştırılması U. Ari. Derg. 2019;19(2):110-125.
  • Margaoan R, Marghitas LA, Dezmirean DS, Bobis O, Bonta V, Catana C et al. Comparative study on quality parameters of royal jelly, apilarnil and queen bee larvae triturate. Bull. U. Agricult. Sci. Vet. Med. Cluj-Napoca-Anim. Sci. Biotech. 2017;74(1): 51-58, https://doi.org/10.15835/buasvmcn-asb:12622.
  • Meda A, Lamien CE, Millogo C, Romito M, Nacoulma OG. Therapeutic uses of honey and honeybee larvae in central Burkina Faso J. Ethanopharm. 2004;(95): 103-107, doi:10.1016/j.jep.2004.06.016.
  • Mishyna M, Martinez JJI, Chen J, Benjamin O. Extraction, characterization and functional properties of soluble proteins from edible grasshopper (Schistocerca gregaria) and honeybee (Apis mellifera) Food Res. Intern. 2019;6:697-706, https://doi.org/10.1016/j.foodres.2018.08.098.
  • Mitrofanov DV, Budnikova NV. Influence of technology on the quality indicators of the composition of drone brood and royal jelly. International Conference on Agricultural Science and Engineering, 2021;845:1-6, doi:10.1088/1755-1315/845/1/012060.
  • Moraru D, Alexa E, Cocan I, Obistioiu D, Radulov I, Simiz E et al. Chemical characterization and antioxidant activity of apilarnil, royal jelly, and propolis collected in Banat region, Romania Appl. Sci. 2024;14;1242, https://doi.org/10.3390/app14031242
  • Okan A, Kaymak E, Uner AK, Silici S, Doganyigit Z. Apilarnil protects the LPS induced endotoxemic heart. Turk. Bull. Hyg. Exp. Biol. 2022;79(4):720-729.
  • Olas B. Bee Products as Interesting Natural Agents for the Prevention and Treatment of Common Cardiovascular Diseases. Nutrients. 2022 May 28;14(11):2267, doi: 10.3390/nu14112267.
  • Osnicewa LA, Efanowa NW, Kabyszewa WW. Homogenate of drone in the diet of dogs Beekeeping 2009;10:50-51.
  • Ramos-Elorduy J, Costa Neto EM, Pino JM, Cuevas Correa MS, Garcia-Figueroa J, Zetina D.H. Conocimiento de la entomofauna útil en el poblado La Purísima Palmar de Bravo, Estado de Puebla, México Biotemas 2007; 20(2):121–34.
  • Sahin P. Sarı prenses balığı (Labidochromis caeruleus Fryer, 1956) anaçlarının erkek bal arısı larvası (Apilarnil) ile beslenmesinin üreme performansı ve vücut kompozisyonuna etkilerinin araştırılması. Master's thesis, Ordu University, Ordu, Türkiye. 2020.
  • Sawczuk R, Karpinska J, Filipowska D, Bajguz A, Hryniewicka M. Evaluation of total phenols content, anti-DPPH activity and the content of selected antioxidants in the honeybee drone brood homogenate Food Chem. 2022;368:130745, https://doi.org/10.1016/j.foodchem.2021.130745.
  • Sawczuk R, Karpinska J, Miltyk W. What do we need to know about drone brood homogenate and what is known J. Ethnopharm. 2019;245:111581, https://doi.org/10.1016/j.jep.2018.10.042.
  • Schiel L, Wind C, Ulmer M, Braun PG, Koethe M. Honey bee drone brood used as food Ernahrungs Umschau 2022;69(7):96-104, DOI: 10.4455./eu.2022.019.
  • Schreck CB. Stress and fish reproduction: the roles of allostasis and hormesis Gen. Comp. Endocrinol. 2010;165(3):549-556, https://doi.org/10.1016/j.ygcen.2009.07.004.
  • Seres AB., Ducza E, Bathori M, Hunyadi A, Beni Z, Dekany M, Gaspar R. Raw drone milk of honeybees elicits uterotrophic effect in rats: evidence for estrogenic activity J. Med. Food 2013;16(5):404-409, DOI: 10.1089/jmf.2012.0232.
  • Seres AB, Ducza E, Bathor M, Hunyadi A, Beni Z, Dekany M, Gaspar R. Androgenic effect of honeybee drone milk in castrated rats: Roles of methyl palmitate and methyl oleate J. Ethnopharm. 2014;153(2):446-453, DOI: 10.1016/j.jep.2014.02.050.
  • Shoinbayeva KB, Omirzak T, Bigara T, Abubakirova A., Dauylbay A. Biologically active preparation and reproductive function of stud rams Asian J. Pharm. 2017;11(3):184–191.
  • Shostya AM, Yemets YM, Kuzmenko LM, Moroz OG, Stupar II. The influence of drone larvae homogenate on prooxidant-antioxidant homeostasis in gilts in the period of puberty Bull. Poltava State Agricult. Acad. 2019;4:134-140.
  • Sidor E, Dzugan M. Drone brood homogenate as natural remedy for treating health care problem: A scientific and practical approach Molecules 2020;25(23):5699, DOI:10.3390/molecules25235699.
  • Sidor E, Milek M, Tomczyk M, Dzugan M. Antioxidant activity of frozen and freeze-dried drone brood homogenate regarding the stage of larval development Antioxidants, 2021b;10(5):639, DOI: 10.3390/antiox10050639.
  • Sidor E, Milek M, Zagula G, Bocian A, Dzugan M. Searching for differences in chemical composition and biological activity of crude drone brood and royal jelly useful for their authentication Foods 2021a;10(9): 2233, https://doi.org/10.3390/foods10092233.
  • Silici S. Chemical content and bioactive properties of drone larvae (Apilarnil) Mellifera 2019;19(2):14-22.
  • Silici S. Honeybee products and apitherapy Turk. J. Agricult.-Food Sci. Tech. 2019;7(9):1249-1262.
  • Silici S. Drone larvae homogenate (Apilarnil) as natural remedy: scientific review J. Agricult. Sci. 2023; 29(4):947-959, DOI: 10.15832/ankutbd.1293015.
  • Seremet-Tugalay C, Altan O. Anti-ageing effects of dietary bee products and calorie restriction on semen production and oxidative damage in older broiler breeder males Slovenian Vet. Res.2020;57:149–57, https://doi.org/10.26873/SVR-954-2020.
  • Topal E, Strant M, Yucel B, Kosoglu M, Margaoan R, Dayioglu M. Biochemical properties and apitherapeutic usage of queen bee and drone larvae J. Anim. Prod. 2018;59(2):77-82, DOI: 10.29185/ hayuretim.455478.
  • Ubilla A, Valdebenito I. Use of antioxidants on rainbow trout Oncorhynchus mykiss (Walbaum, 1792) sperm diluent: effects on motility and fertilizing capability Latin American J. Aquatic Res. 2011;39(2):338-343.
  • Ulmer M, Smetana S, Heinz V. Utilizing honeybee drone brood as a protein source for food products: Life cycle assessment of apiculture in Germany Resour. Conser. Recycl. 2020;154:104576, https://doi.org/10.1016/j.resconrec.2019.104576.
  • Vakina TN, Petrova EV, Trifonov VN, Fedorov EN, Fedorov AV, Andreeva ES, et al. Method for restoring male sex drive (libido). United States Patent Application Publication 2017;US 9730973 B2.
  • Vasilenko YK, Klimova OV, Lazaryan DS. Biological effect of drone brood under chronic hyperlipidemia conditions Pharm. Chem. J. 2002;36(8):434-436, https://doi.org/10.1023/A:1021214728006.
  • Vasilenko YK, Klishina II, Lazaryan DS. A comparative study of the immunotropic and hepatotropic action of beekeeping products in rats with drug-induced hepatitis Pharm. Chem. J. 2005;39(6):319-322. https://doi.org/10.1007/s11094-005-0144-6.
  • Yemets YM. Dietary effects of drone larves homogenate on the homeostatic constants and the reproductive capacity of large white gilts Translat. Res. Vet. Sci. 2020;3(2):27-39, https://doi.org/10.12775/TRVS.2020.008.
  • Yucel B, Acikgoz Z, Bayraktar H, Seremet C. The effects of Apilarnil (drone bee larvae) administration on growth performance and secondary sex characteristics of male broilers J Anim. Vet. Adv. 2011;10(17): 2263-2266, DOI: 10.3923/javaa.2011.2263.2266.
  • Yucel B, Sahin H, Yildiz O, Kolayli S. Bioactive Components and Effect Mechanism of Apilarnil J. Anim. Prod. 2019;60(2):125-130, DOI: 10.29185/hayuretim.591007.

Fonksiyonel Bir Gıda ve Besin Takviyesi Olma Potansiyeline Sahip Az Bilinen Bir Arı Ürünü: Apilarnil

Year 2024, Volume: 24 Issue: 2, 403 - 416
https://doi.org/10.31467/uluaricilik.1523198

Abstract

Arıcılık, tozlaşmanın yanında bal ve diğer arı ürünlerinin üretimi yoluyla tarımsal sürdürülebilirliğin ve ekonominin desteklenmesinde çok önemli bir rol oynamaktadır. Bu ürünler arasında, erkek arı larvalarından elde edilen ve sağlık açısından fayda sağlayan, az bilinen bir madde olan apilarnil de yer almaktadır. Apilarnil temel besinler açısından oldukça zengindir ve üreme sistemi, otonom sinir sistemi ve kardiyovasküler sağlık üzerinde olumlu etkileri olduğu bildirilmiştir. Doğal tıbbi özellikleri yanında, besleyici ve farmasötik potansiyeli giderek daha fazla kabul görmekte ve apilarnilin ticari üretimine yol açmaktadır. Bu arı ürünü amino asitler, yağ asitleri, vitaminler, mineraller, hormonlar ve antioksidanlar içerdiğinden sağlık için oldukça önemlidir. Apilarnil tam bir gıda olarak kabul edilmekte ve çeşitli gıda ürünlerine dahil edilmektedir. Araştırmalar apilarnilin androjenik, östrojenik, antioksidan ve bağışıklık sistemini güçlendirici etkilerini vurgulamaktadır. Hayvanlar üzerinde yapılan çalışmalar, üreme sağlığını iyileştirme, stresi azaltma ve büyüme ve gelişmeyi destekleme potansiyeline işaret etmektedir. Ayrıca oksidatif strese karşı koruma ve genel sağlığı iyileştirme konusunda da umut vaat etmektedir. Bu derlemede apilarnil ve kullanım alanlarına ilişkin bilgiler derlenmiştir.

Ethical Statement

The authors declare that they have no conflicts of interest. RIT and TA contributed equally to writing of the review article.

Supporting Institution

Mugla Sitki Kocman University, Scientific Research Projects Unit (Contract # 22/134/06/1/5)

Project Number

Mugla Sitki Kocman University, Scientific Research Projects Unit (Contract # 22/134/06/1/5)

Thanks

This study received financial supported from Mugla Sitki Kocman University, Scientific Research Projects Unit (Contract # 22/134/06/1/5).

References

  • Abd El-Wahed AA, Khalifa SAM, Aldahmash B, Zhang H, Du M, Zhao C et al. Exploring the Chemical Constituents and Nutritive Potential of Bee Drone (Apilarnil): Emphasis on Antioxidant Properties Chem. Biod. 2024;21: e202400085, doi.org/10.1002/cbdv.202400085.
  • Akcicek E, Yucel B. Apiterapi’de Apilarnil. Arı Ürünleri ve Sağlık (Apiterapi). Sidas Yayınevi, İzmir, 2015 p. 183-190.
  • Altan O, Yucel B, Acikgoz Z, Seremet C, Kosoglu M, Turgan N et al. Apilarnil reduces fear and advances sexual development in male broilers but has no effect on growth Br. Poultry Sci. 2013;54(3): 355-361, http://dx.doi.org/10.1080/00071668.2013.791382.
  • Balkanska R, Karadjova I, Ignatova M. Comparative analyses of chemical composition of royal jelly and drone brood Bulgarian Chem. Comm. 2014;46(2):412-416.
  • Barnutiu LI, Marghitas L, Dezmirean D, Bobis O, Mihai C, Pavel C. Physicochemical composition of Apilarnil (bee drone larvae) Lucrări Ştiinţifice-Seria Zootehnie 2013;59:199-202.
  • Baskaran S, Finelli R, Agarwal A, Henkel R. Reactive oxygen species in male reproduction: A boon or a bane? Andrologia 2021;53: e13577, https://doi.org/10.1111/and.13577.
  • Bieljajew WA., Safonowskaja JW. Adaptogenic relationship training based on drone brood Beekeeping 2009; 6:51–52.
  • Bogdanov S. The royal jelly book, chapter 1. Royal jelly and bee brood: harvest, composition, quality Bee Prod. Sci. 2012; www.bee-hexagon.net.
  • Bogdanov S. Bee product science: royal jelly, bee brood: composition, health, medicine: a review. 2017; www.bee-hexagon.net/fles/fle/flE/Health/RJBookReview. pdfMay2017
  • Bolatovna KS, Omirzak T, Akhanov UK, Rustenov A, Eleuqalieva N. Improving reproductive qualities of pigs using the drone brood homogenate Biol. Med. 2015;7(2):BM-091.
  • Borkovcova M, Mlcek J, Adamkova A, Adamek M, Bednarova M, Musilova Z, Sevcikova V. Use of foods based on bee drone brood: Their sensory and microbiological evaluation and mineral composition Sustainability 2022;14 (5): 2814, https://doi.org/10.3390/su14052814.
  • Cosmia M, Gallenti G, Marangon F, Troiano S. Reprint of “Attitudes towards honey among Italian consumers: A choice experiment approach” Appetite 2016;106:110-116, https://doi.org/10.1016/j.appet.2016.08.005.
  • Doganyigit Z, Silici S, Kaymak E, Okan A, Pandir D. LPS’nin böbrek DNA’sı üzerine akut toksik etkisi ve apilarnilin koruyucu rolü Eurasian J. Biol. Chem. Sci. 2019a;2:111-114.
  • Doganyigit Z, Silici S, Kaymak E, Okan A, Akın A T, Pandır D. Apilarnilin'in erkek sıçanlarda lipopolisakkarite (LPS) bağlı testis toksisitesine karşı koruyucu rolünün belirlenmesi determination of the protective role of apilarnil against testicular toxicity due to lipopolysaccharide (LPS) in male rats Bozok Tip Derg. 2019b; 9(2):146-154.
  • Doganyigit Z, Okan A, Kaymak E, Pandir D, Silici S. Investigation of protective effects of apilarnil against lipopolysaccharide induced liver injury in rats via TLR 4/ HMGB-1/ NF-κB pathway Biomed. Pharm. 2020a;125:109967, https://doi.org/10.1016/j.biopha.2020.109967.
  • Doganyigit Z, Kaymak E, Okan A, Pandir D, Silici S. Investigation of protective effects of apilarnil against lipopolysaccharide induced lung injury in rats Mellifera 2020b;20:3-15.
  • Doganyigit Z, Koklu B, Uner A, Okan A, Kaymak E, Silici S. The Effect of apilarnil on the autophagia against lipolysaccarite-based sepsis in liver New Trends in Med. Sci., 2020c;1: 84-89.
  • Dzugan M, Sidor E, Milek M, Tomczyk M. The possibility of using bee drone brood to design novel dietary supplements for apitherapy Appl. Sci. 2023;13:4687, https://doi.org/10.3390/app13084687.
  • Efanova N, Osintseva LA, Osina LM, Batalova SV, Mikhailova DS. Correction of endocrine and metabolic status of dogs with the help of drone homogenate Innovat. Food Safety 2019;2(24):64-68, https://doi.org/10.31677/2311-0651-2019-24-2-64-68.
  • Elashal MH, Abd El-Wahed AA, Mohamed MA, Hamad R, Abd Eldaim MA, Khalifa SAM et al. Apilarnil ameliorates Bisphenol A-induced testicular toxicity in adult male rats via improving antioxidant potency and PCNA expression Reprod. Toxic. 2024; 125:108570, https://doi.org/10.1016/j.reprotox.2024.108570.
  • Erdem B, Arslan OC, Mulayim MS. Testosterone enhancer containing lipid extract of Apilarnil Turk PatentAppl. 2017; TR 2016014275 A1 20170821.
  • Erdem B, Ozkok A. Can food supplement produced from apilarnil be an alternative to testosterone replacement therapy? Hacettepe J. Biol. Chem. 2017;45(4):635–638, DOI: 10.15671/HJBC.2018.207.
  • Erdem S, Inci H. Apilarnilin yağ asidi özelliklerinin belirlenmesi (Determination of fatty acid properties of apilarnil) Türk Tarım Doğa Bil. Derg. 2022;9(4):900-6, https://doi.org/10.30910/turkjans.1111152.
  • Finke MD. Nutrient composition of bee brood and its potential as human food Ecol. Food Nutri. 2005;44(4):257-270, DOI:10.1080/03670240500187278.
  • Food and Agriculture Organization (FAO). Production, Crops Primary. Available from: https://www.fao.org/faostat/en/#data/QCL Accesses:May, 2024.
  • Ghosh S, Herren P, Meyer-Rochow VB, Jung C. Nutritional composition of honeybee drones of two subspecies relative to their pupal developmental stages Insects 2021;12(8):759, DOI:10.3390/insects12080759.
  • Ghosh S, Sohn HY, Pyo SJ, Jensen AB, Meyer-Rochow VB, Jung C. Nutritional composition of Apis mellifera drones from korea and denmark as a potential sustainable alternative food source: comparison between developmental stages Foods 2020;9:389, DOI:10.3390/foods9040389.
  • Hamamci M, Doganyigit Z, Silici S, Okan A, Kaymak E, Yilmaz S, Inan LE. Apilarnil: a novel neuroprotective candidate Acta Neurologica Taiwanica 2020;29(2):33-45.
  • Hroshovyi T, Dobrynchuk M, Pavliuk B, Chubka M. Drone brood—As a raw material for the manufacture of medicines and dietary supplements Sci. Europe 2021;63:36-39.
  • Hryniewicka M, Karpinska A, Kijewska M, Turkowicz MJ, Karpinska J. LC/MS/MS analysis of α‐tocopherol and coenzyme Q10 content in lyophilized royal jelly, beebread and drone homogenate J. Mass Spectro. 2016;51(11):1023-1029, DOI:10.1002/jms.3821.
  • Ilieşiu NV. Apilarnil, Editura Apimondia, Bucuresti 1991.
  • Inandiklioglu N, Doganyigit Z, Okan A, Kaymak E, Silici S. Nephroprotective effect of apilarnil in lipopolysaccharide-induced sepsis through TLR4/NF-κB signaling pathway Life Sci. 2021;284:119875, DOI:10.1016/j.lfs.2021.119875.
  • Inci H, Izol E, Yilmaz MA, Ilkaya M, Bingol Z, Gulcin I. Comprehensive Phytochemical Content by LC/MS/MS and Anticholinergic, Antiglaucoma, Antiepilepsy, and Antioxidant Activity of Apilarnil (Drone Larvae) Chem. Biodiv. 2023;20:e202300654, doi.org/10.1002/cbdv.202300654. IPBES (2016). The assessment report of the Intergovernmental Science-Policy Platform on Biodiversity and Ecosystem Services on pollinators, pollination and food production. S.G. Potts, V. L. Imperatriz-Fonseca, and H. T. Ngo (eds). Secretariat of the Intergovernmental Science-Policy Platform on Biodiversity and Ecosystem Services, Bonn, Germany. 552 pages. https://doi.org/10.5281/zenodo.3402856.
  • IPIFF (International Platform of Insects for Food and Feed). Guide on food hygiene practices for European Union (EU) producers of insects as food and feed. 2022;https://ipiff.org/wp-content/uploads/2019/12/IPIFF-Guide-on-Good-Hygiene-Practices.pdf (last accessed on 24.08. 2023).
  • Isidorov VA, Bakier S, Stocki M. GC-MS investigation of the chemical composition of honeybee drone and queen larvae homogenate. J. Apicultural Sci. 2016;60(1):111-120, DOI:10.1515/jas-2016-0011
  • Jensen AB, Evans J, Joans-Levi A, Benjamin O, Matrinez I, Dahle B, Roos N, Lecocq A, Foley K. Standard methods for Apis mellifera brood as human food. J. Apicult. Res. 2019; 58:1-28, http://dx.doi.org/10.1080/00218839.2016.1226606.
  • Kekecoglu M, Keskin M, Birinci C, Birinci E, Kolayli S. Effects of honeybee race and season on propolis composition J. Agricult. Sci. 2021;27(3):292-297, DOI: 10.15832/ankutbd.619996.
  • Kistanova E, Zdoroveva E, Nevitov M, Nosov A, Vysokikh M, Sukhanova I, Boryaev G. Drone brood fed supplement impacts on the folliculogenesis in growing gilts Veterinarski Arhiv. 2020;90(6):583-592, DOI:10.24099/vet.arhiv.0886.
  • Kogalniceanu S, Lancrajan I, Ardelean G. Changes of the glucidic metabolism determined by the physical effort of the treatment with the Aslavital and Apilarnil Arad Med. J. 2010;3:33-41.
  • Kosum N, Taskin T, Kandemir C, Yucel B, Ekren Asici GS, Kiral F. Effects of Apilarnil on growth, body measurement and testes characteristics for Saanen male kids. Agrifood Conference, 26-28 September, İzmir. 2018; P 40-47.
  • Kosum N, Yucel B, Kandemir C, Taskin T, Duru M.E, Kuçukaydın S, Cornea‐Cipcigan M. Chemical composition and androgenic effect of bee drone larvae (Apilarnil) for goat male kids. Chem. Biodiv. 2022;19(8):e202200548, https://doi.org/10.1002/cbdv.202200548.
  • Kuzmenko LM, Polishchuk AA, Usenko SO, Shostya AM, Bulavenko RV. Prooxidant-antioxidant homeostasis in the tissues of the uterus of pig, depending on the periods of the reproductive cycle World Med. Biol. 2018;64(2): 198-203, DOI:10.26724/2079-8334-2018-2-64-198-203.
  • Lazaryan DS. Comparative amino acid analysis of bee brood Pharma. Chem. J. 2002;36(12):680-682. Lecocq A, Foley K, Jensen AB. Drone brood production in Danish apiaries and its potential for human consumption. J. Apicult. Res. 2018;57(3):331-336, https://doi.org/10.1080/00218839.2018.1454376.
  • Lipinski MJ, Froenicke L, Baysac KC, Billings NC, Leutenegger CM, Levy AM, Lyons LA. The ascent of cat breeds: genetic evaluations of breeds and worldwide random-bred populations Genomics, 2008;91(1):12-21, DOI: 10.1016/j.ygeno.2007.10.009.
  • Marangoz M, Dolu ZT. Tüketicilerin arı ürünlerine ilişkin bilgi ve güven düzeyleri ile satın alma davranışlarının araştırılması U. Ari. Derg. 2019;19(2):110-125.
  • Margaoan R, Marghitas LA, Dezmirean DS, Bobis O, Bonta V, Catana C et al. Comparative study on quality parameters of royal jelly, apilarnil and queen bee larvae triturate. Bull. U. Agricult. Sci. Vet. Med. Cluj-Napoca-Anim. Sci. Biotech. 2017;74(1): 51-58, https://doi.org/10.15835/buasvmcn-asb:12622.
  • Meda A, Lamien CE, Millogo C, Romito M, Nacoulma OG. Therapeutic uses of honey and honeybee larvae in central Burkina Faso J. Ethanopharm. 2004;(95): 103-107, doi:10.1016/j.jep.2004.06.016.
  • Mishyna M, Martinez JJI, Chen J, Benjamin O. Extraction, characterization and functional properties of soluble proteins from edible grasshopper (Schistocerca gregaria) and honeybee (Apis mellifera) Food Res. Intern. 2019;6:697-706, https://doi.org/10.1016/j.foodres.2018.08.098.
  • Mitrofanov DV, Budnikova NV. Influence of technology on the quality indicators of the composition of drone brood and royal jelly. International Conference on Agricultural Science and Engineering, 2021;845:1-6, doi:10.1088/1755-1315/845/1/012060.
  • Moraru D, Alexa E, Cocan I, Obistioiu D, Radulov I, Simiz E et al. Chemical characterization and antioxidant activity of apilarnil, royal jelly, and propolis collected in Banat region, Romania Appl. Sci. 2024;14;1242, https://doi.org/10.3390/app14031242
  • Okan A, Kaymak E, Uner AK, Silici S, Doganyigit Z. Apilarnil protects the LPS induced endotoxemic heart. Turk. Bull. Hyg. Exp. Biol. 2022;79(4):720-729.
  • Olas B. Bee Products as Interesting Natural Agents for the Prevention and Treatment of Common Cardiovascular Diseases. Nutrients. 2022 May 28;14(11):2267, doi: 10.3390/nu14112267.
  • Osnicewa LA, Efanowa NW, Kabyszewa WW. Homogenate of drone in the diet of dogs Beekeeping 2009;10:50-51.
  • Ramos-Elorduy J, Costa Neto EM, Pino JM, Cuevas Correa MS, Garcia-Figueroa J, Zetina D.H. Conocimiento de la entomofauna útil en el poblado La Purísima Palmar de Bravo, Estado de Puebla, México Biotemas 2007; 20(2):121–34.
  • Sahin P. Sarı prenses balığı (Labidochromis caeruleus Fryer, 1956) anaçlarının erkek bal arısı larvası (Apilarnil) ile beslenmesinin üreme performansı ve vücut kompozisyonuna etkilerinin araştırılması. Master's thesis, Ordu University, Ordu, Türkiye. 2020.
  • Sawczuk R, Karpinska J, Filipowska D, Bajguz A, Hryniewicka M. Evaluation of total phenols content, anti-DPPH activity and the content of selected antioxidants in the honeybee drone brood homogenate Food Chem. 2022;368:130745, https://doi.org/10.1016/j.foodchem.2021.130745.
  • Sawczuk R, Karpinska J, Miltyk W. What do we need to know about drone brood homogenate and what is known J. Ethnopharm. 2019;245:111581, https://doi.org/10.1016/j.jep.2018.10.042.
  • Schiel L, Wind C, Ulmer M, Braun PG, Koethe M. Honey bee drone brood used as food Ernahrungs Umschau 2022;69(7):96-104, DOI: 10.4455./eu.2022.019.
  • Schreck CB. Stress and fish reproduction: the roles of allostasis and hormesis Gen. Comp. Endocrinol. 2010;165(3):549-556, https://doi.org/10.1016/j.ygcen.2009.07.004.
  • Seres AB., Ducza E, Bathori M, Hunyadi A, Beni Z, Dekany M, Gaspar R. Raw drone milk of honeybees elicits uterotrophic effect in rats: evidence for estrogenic activity J. Med. Food 2013;16(5):404-409, DOI: 10.1089/jmf.2012.0232.
  • Seres AB, Ducza E, Bathor M, Hunyadi A, Beni Z, Dekany M, Gaspar R. Androgenic effect of honeybee drone milk in castrated rats: Roles of methyl palmitate and methyl oleate J. Ethnopharm. 2014;153(2):446-453, DOI: 10.1016/j.jep.2014.02.050.
  • Shoinbayeva KB, Omirzak T, Bigara T, Abubakirova A., Dauylbay A. Biologically active preparation and reproductive function of stud rams Asian J. Pharm. 2017;11(3):184–191.
  • Shostya AM, Yemets YM, Kuzmenko LM, Moroz OG, Stupar II. The influence of drone larvae homogenate on prooxidant-antioxidant homeostasis in gilts in the period of puberty Bull. Poltava State Agricult. Acad. 2019;4:134-140.
  • Sidor E, Dzugan M. Drone brood homogenate as natural remedy for treating health care problem: A scientific and practical approach Molecules 2020;25(23):5699, DOI:10.3390/molecules25235699.
  • Sidor E, Milek M, Tomczyk M, Dzugan M. Antioxidant activity of frozen and freeze-dried drone brood homogenate regarding the stage of larval development Antioxidants, 2021b;10(5):639, DOI: 10.3390/antiox10050639.
  • Sidor E, Milek M, Zagula G, Bocian A, Dzugan M. Searching for differences in chemical composition and biological activity of crude drone brood and royal jelly useful for their authentication Foods 2021a;10(9): 2233, https://doi.org/10.3390/foods10092233.
  • Silici S. Chemical content and bioactive properties of drone larvae (Apilarnil) Mellifera 2019;19(2):14-22.
  • Silici S. Honeybee products and apitherapy Turk. J. Agricult.-Food Sci. Tech. 2019;7(9):1249-1262.
  • Silici S. Drone larvae homogenate (Apilarnil) as natural remedy: scientific review J. Agricult. Sci. 2023; 29(4):947-959, DOI: 10.15832/ankutbd.1293015.
  • Seremet-Tugalay C, Altan O. Anti-ageing effects of dietary bee products and calorie restriction on semen production and oxidative damage in older broiler breeder males Slovenian Vet. Res.2020;57:149–57, https://doi.org/10.26873/SVR-954-2020.
  • Topal E, Strant M, Yucel B, Kosoglu M, Margaoan R, Dayioglu M. Biochemical properties and apitherapeutic usage of queen bee and drone larvae J. Anim. Prod. 2018;59(2):77-82, DOI: 10.29185/ hayuretim.455478.
  • Ubilla A, Valdebenito I. Use of antioxidants on rainbow trout Oncorhynchus mykiss (Walbaum, 1792) sperm diluent: effects on motility and fertilizing capability Latin American J. Aquatic Res. 2011;39(2):338-343.
  • Ulmer M, Smetana S, Heinz V. Utilizing honeybee drone brood as a protein source for food products: Life cycle assessment of apiculture in Germany Resour. Conser. Recycl. 2020;154:104576, https://doi.org/10.1016/j.resconrec.2019.104576.
  • Vakina TN, Petrova EV, Trifonov VN, Fedorov EN, Fedorov AV, Andreeva ES, et al. Method for restoring male sex drive (libido). United States Patent Application Publication 2017;US 9730973 B2.
  • Vasilenko YK, Klimova OV, Lazaryan DS. Biological effect of drone brood under chronic hyperlipidemia conditions Pharm. Chem. J. 2002;36(8):434-436, https://doi.org/10.1023/A:1021214728006.
  • Vasilenko YK, Klishina II, Lazaryan DS. A comparative study of the immunotropic and hepatotropic action of beekeeping products in rats with drug-induced hepatitis Pharm. Chem. J. 2005;39(6):319-322. https://doi.org/10.1007/s11094-005-0144-6.
  • Yemets YM. Dietary effects of drone larves homogenate on the homeostatic constants and the reproductive capacity of large white gilts Translat. Res. Vet. Sci. 2020;3(2):27-39, https://doi.org/10.12775/TRVS.2020.008.
  • Yucel B, Acikgoz Z, Bayraktar H, Seremet C. The effects of Apilarnil (drone bee larvae) administration on growth performance and secondary sex characteristics of male broilers J Anim. Vet. Adv. 2011;10(17): 2263-2266, DOI: 10.3923/javaa.2011.2263.2266.
  • Yucel B, Sahin H, Yildiz O, Kolayli S. Bioactive Components and Effect Mechanism of Apilarnil J. Anim. Prod. 2019;60(2):125-130, DOI: 10.29185/hayuretim.591007.
There are 79 citations in total.

Details

Primary Language English
Subjects Zootechny (Other)
Journal Section Review
Authors

Rahşan İvgin Tunca 0000-0003-0745-6732

Tülin Arslan 0000-0001-9661-045X

Project Number Mugla Sitki Kocman University, Scientific Research Projects Unit (Contract # 22/134/06/1/5)
Early Pub Date November 12, 2024
Publication Date
Submission Date July 27, 2024
Acceptance Date September 17, 2024
Published in Issue Year 2024 Volume: 24 Issue: 2

Cite

Vancouver İvgin Tunca R, Arslan T. A LITTLE KNOWN BEE PRODUCT WITH THE POTENTIAL TO BECOME A FUNCTIONAL FOOD AND NUTRITIONAL SUPPLEMENT: APILARNIL. U. Arı. D.-U. Bee J. 2024;24(2):403-16.

Important Note: Since the author-referee information is kept confidential on both sides in our journal, both the author and the referees must upload the document to the system after removing their personal information in the review document section.

Note: Authors can also use homepage of our Journal.

https://creativecommons.org/licenses/by-nc-nd/4.0/

download
 

This work is licensed under Attribution-NonCommercial-NoDerivatives 4.0 International.