Effect of oleuropein on element distributions in liver of diabetic rats

Year 2018, Volume: 2 Issue: 1, 1 - 9, 28.06.2018

Funda Karabağ Çoban , Ali Osman Albayrak

Abstract

Keywords

diabetes, rat, element, , oleuropein

Effect of oleuropein on element distributions in liver of diabetic rats

Abstract

There is accumulating
evidence demonstrating that the metabolism of many trace elements is modified
in diabetes mellitus. In
addition, essential elements and minerals are key to nutrition and sound health.
Oleuropein,
a major phenolic compound in olives, is known to reduce the blood glucose
levels in alloxaninduced diabetic rats and rabbits. The purpose of this study was to
compare the levels of essential trace elements, selenium (Se), manganese (Mn), copper
(Cu), chromium (Cr) and zinc (Zn) in Strepsttozotocin (STZ)-induced diabetic rats and to evaluate the effects
of oleuropein on trace elements levels. Animals were apportioned into 4 groups
of 8 rats each. The control group was fed with standard rat provender and got
no added treatment. In the oleuropein group, 20 mg/kg dosages of oleuropein
were given to normal animals intraperitoneally (i.p) for 28 days. In the
diabetic group, STZ was injected to rats at a single dose of 50 mg/kg i.p. The
last group, 20 mg/kg dosages of oleuropein were given to diabetic animals i.p
for 28 days. In this study, trace elements levels were evaluated by using
ICP-MS and MDA, SOD CAT levels were evaluated by using spectrophotometers
methods.

Trace elements levels were
significantly (p <0,05) decreased in diabetic rats liver but oleuropein was
significantly (p<0,05) increased trace element levels in this group.

In the diabetic group, serum blood glucose levels were significantly (p <0,05)  increased and STZ
increased total oxidant status (TOS), malondialdehyde (MDA) in the liver, whereas it
decreased superoxide dismutase (SOD) and catalase (CAT) and total antioxidant
capacity (TAS) in diabetic rats liver.

As a consequence, oleuropein
treatment shows an antioxidant and in diabetes by reducing oxidative stress and
it was increased trace element levels.

Keywords

Rat, diabetes, element, oleuropein

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