Extracellular Matrix Structure and Tasks

Year 2018, Volume: 23 Issue: 1, 295 - 310, 24.04.2018

İbrahim Üçgül , Sultan Aras , Ufuk Elibüyük

https://doi.org/10.17482/uumfd.327376

Abstract

The extracellular matrix (ECM) is a complex
structure located between and supporting cells within mammalian tissues. The
ECM is secreted by cells in contact or contact. Extracellular matrix (ECM) is
traditionally classified as glycosphingolipids and fibrous proteins. In
glycosphingolipids, they are divided into two groups: non-sulfated proteins
(hyaluronic acid) and sulfated proteins (chondroitin sulfate, keratin sulphate
I and II, heparin, heparan sulfate and dermatan sulphate). Fibrous proteins are
classified as structural proteins (collagen, elastin) and adhesion proteins
(fibronectin, laminin, tenascin, vitronectin, integrin).This work deals with the
structure of the extracellular matrix molecule affecting cell growth and
differentiation, affecting cell growth and differentiation, water and minerals
affecting the growth factor, and the proteins involved in this structure.

Keywords

ECM, Glycosaminoglycans (GAGs), Fibrous proteins, Proteoglycans

EKSTRASELÜLER MATRİS YAPISI VE GÖREVLERİ

Abstract

Ekstrasellüler
matriks (ECM), memeli dokuları içindeki hücrelerin arasında bulunan ve onları
destekleyen bir kompleks yapıdır. ECM içinde bulunduğu veya temas halindeki
hücreler tarafından salgılanmaktadır. Ekstrasellüler matriks (ECM), geleneksel
olarak glikoaminglikanlar ve fibröz proteinler olarak sınıflandırılırlar.
Glikoaminglikanlarda kendi içlerinde sülfatlanmamış proteinler (Hyalüronik
asit) ve sülfatlanmış proteinler (kondroitin sülfat, keratan sülfat I ve II,
heparin, heparan sülfat ve dermatan sülfat) olmak üzere ikiye ayrılır. Fibröz
proteinler ise yapısal proteinler (kollajen, elastin) ve yapıştırıcı (adhezyon)
proteinler (Fibronektin, laminin, tenaskin, vitronektin, integrin) olarak
sınıflandırılır. Yapılan
bu çalışma ile hücrelerin yapısı ve hareketini etkileyen, hücre gelişme ve
farklılaşmasını etkileyen, su ve mineral tutan, büyüme faktörünü etkileyen ekstrasellüler
matris molekülünün yapısı ve bu yapıda bulunan proteinlerin görevlerinden
bahsedilmiştir.

Keywords

ECM, Glikoaminglikanlar (GAGs), Fibröz proteinler, Proteoglikanlar

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