Septisemi Şüpheli Yenidoğan Buzağılarda Hücrelerarası Adhezyon Molekül-1 (ICAM-1), Tümör nekroz faktörü α (TNF-α), İnterlökinler (IL-6, IL-8) ve C-reaktif protein (CRP) Seviyelerinin Değerlendirilmesi

Year 2019, Volume: 30 Issue: 3, 167 - 173, 22.11.2019

Yakup Akgül Ömer Akgül Süleyman Kozat , Cumali Özkan , Abdullah Kaya Nedim Yılmaz

https://doi.org/10.36483/vanvetj.577392

Cited By: 3

Abstract

Bu
çalışmada; septisemi şüpheli yenidoğan buzağılarda hücreler arası molekül-1
(ICAM-1), Tümör nekroz faktörü α (TNF-α), İnterlökin-6 (IL-6), İnterlökin-8
(IL-8) ve C-reaktif protein (CRP) düzeyleri değerlendirildi. Bu çalışmanın materyalini
aynı cins ve kiloya sahip ve yaşları 1-10 gün arasında değişen 20 septisemik
buzağı ile 10 sağlıklı buzağı olmak üzere toplam 30 buzağı oluşturdu. İstatistiksel
analizde, septisemili buzağıların lökosit (WBC), Eritrosit (RBC), hematokrit
(Hct) hemoglobin (Hb) ve ortalama korpüsküler hemoglobin konsantrasyonu (MCHC) değerleri
kontrol grubunun aynı parametrelerine göre yüksek tespit edilirken (P <0.05),
septisemili yenidoğan buzağıların PLT değerleri kontrol grubunun PLT
değerlerine göre düşük (P <0.05) saptandı. Septisemik buzağılarda ICAM-1,
TNF-α, IL-6, IL-8 ve CRP değerleri kontrol grubunun aynı değerlerine göre
anlamlı düzeyde  tespit edildi
(P<0.05).

Sonuç
olarak, TNF-α, IL-6, IL-8 ve özellikle ICAM-1 konsantrasyonlarının
analizlerinin septisemili vakalarda hastalığın şiddetini ve prognozunu
değerlendirmede yararlı parametreler olabileceği, bununla birlikte bu
parametrelerin  tedavi etkinliğinin takibinde
göz önünde bulundurulması gereken parametreler olacağı kanısına varıldı.

Keywords

Buzağı, Septisemi, Akut Faz Proteini, Sitokin, ICAM

Supporting Institution

Bilimsel Araştırma Proje Başkanlığı

Project Number

2015-VF-B302.

Evaluation of intercellular adhesion molecule-1 (ICAM-1), Tumor necrosis factor α (TNF-α), Interleukins (IL-6, IL-8) and C-reactive protein (CRP) levels in neonatal calves with presumed septicemia

Abstract

In this study; intercellular molecule-1 (ICAM-1), Tumor necrosis factor
α (TNF-α), Interleukin-6 (IL-6), Interleukin-8 (IL-8) and C-reactive protein
(CRP) levels were evaluated in neonatal calves with presumed septicemia. The
material of this study consisted of a total of 30 calves. Study group consisted
of 20 septicemic calves and 10 clinically healthy calves and with same breed
and weight and their ages were between 1 and 10 days. The statistical analysis
indicated that leukocyte (WBC), red blood cell (RBC), hematocrit (Hct)
hemoglobin (Hb) and mean corpuscular haemoglobin concentration (MCHC) values in
neonatal calves with presumed septicemia were higher than those of the control
group (P<0.05), whereas PLT values of neonatal calves with septicemia were
lower than those of the control group (P<0.05). The levels of ICAM-1, TNF-α,
IL-6, IL-8 and CRP values in septicemic calves were higher than those of the
control group (P<0.05). As a result, it was concluded that analyzes of
TNF-α, IL-6, IL-8 and particularly ICAM-1 concentrations may be considered in
evaluating the severity and prognosis of patients with septicemia, as well as monitoring
the efficacy of the treatment of the disease.

Keywords

Calf, Septicemia, Acute Phase Proteins, Cytokines, ICAM

Project Number

2015-VF-B302.

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