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Canine Distemper Virüs Enfeksiyonu Bulunan Köpeklerde Oksidatif Stres ve Antioksidan Aktivitelerin Belirlenmesi

Year 2022, Volume: 33 Issue: 3, 67 - 70, 29.11.2022

Durmuş Hatipoğlu , Irmak Dik , Erdem Gülersoy

https://doi.org/10.36483/vanvetj.1136569

Abstract

Supraphysiological reactive oxygen species (ROS) has been linked to a variety of diseases, including cancer, inflammation, and neurodegeneration. One of the diseases pathophysiologically associated with ROS accumulation is canine distemper (CD). The purpose of this study was to compare lipid peroxidation and antioxidant biomarkers in dogs infected with canine distemper virus (CDV) to healthy dogs. The animals in this study consisted of a total of 20 dogs, 10 CDV-positive dogs (Trial group) aged 0–12 months of different breeds and sexes, and 10 healthy dogs (Control group) aged 0–12 months of different breeds and sexes. Thiobarbituric acid reactive substances (TBARS), glutathione (GSH) and superoxide dismutase (SOD) were evaluated with commercially available enzyme-linked immunosorbent assay kits using serum samples. While the activities of GSH and SOD were statistically lower in CDV positive animals compared to healthy animals (p<0.05), the level of TBARS was significantly higher (p<0.05). In conclusion, current study findings that CDV increases lipid peroxidation activity in serum while decreasing antioxidant enzyme levels may be useful for future research.

Keywords

Antioksidanlar canine distemper virüsü Lipid peroxidation

References

  • Avci O, Yavru S, Dik I (2014). Determination of lipid peroxidation biomarkers in Vero cell line inoculated with Bovine Ephemeral Fever Virus. EJVS, 30 (4), 217-221.
  • Beck MA (2000). Nutritionally induced oxidative stress: effect on viral disease. Am J Clin Nutr, 71 (6), 1676-1681.
  • Bedard K, Krause KH (2007). The NOX family of ROS-generating NADPH oxidases: physiology and pathophysiology. Physiol Rev, 87 (1), 245-313.
  • Beineke A, Puff C, Seehusen F, Baumgärtner W (2009). Pathogenesis and immunopathology of systemic and nervous canine distemper.Vet Immunol Immunopathol, 127 (1), 1-18.
  • Burton GJ, Jauniaux E (2011). Oxidative stress. Best Pract Res Clin Obstet, 25 (3), 287-299.
  • Camini FC, Da Silva Caetano CC, Almeida LT, De Brito Magalhães CL (2017). Implications of oxidative stress on viral pathogenesis. Arch Virol, 162 (4), 907-917.
  • Candellone A, Girolami F, Badino P, Jarriyawattanachaikul W, Odore R (2022). Changes in the Oxidative Stress Status of Dogs Affected by Acute Enteropathies. Vet Sci, 9 (6), 276.
  • Choi J, Ou JH (2006). Mechanisms of liver injury. III. Oxidative stress in the pathogenesis of hepatitis C virus. Am J Physiol Gastrointest Liver Physiol, 290 (5), G847-851.
  • Değirmençay Ş, Çamkerten G, Çamkerten İ, Aktaş MS (2021). An investigation of thiol/disulfide homeostasis and ischemia-modified albumin levels to assess the oxidative stress in dogs with canine distemper. Vet Arh, 91 (1), 39-49.
  • Dik B, Avci O, Dik I (2019). In Vitro Antıvıral and Antioxidant Actıvıtıes of Silymarin and Panax Ginseng on Vero Cells Infected with Bovine Ephemeral Fever Virus and Blue Tongue Virus. Acta Pol Pharm, 76 (2), 291-297.
  • Finaud J, Lac G, Filaire E (2006). Oxidative Stress. Sports Med, 36 (4), 327-358.
  • Gutteridge JMC, Halliwell B (1990). The measurement and mechanism of lipid peroxidation in biological systems. Trends Biochem Sci, 15 (4), 129-135.
  • Ha HL, Shin HJ, Feitelson MA, Yu DY (2010). Oxidative stress and antioxidants in hepatic pathogenesis. World J Gastroenterol, 16 (48), 6035-6043.
  • Halder S, Kar R, Galav V et al. (2016). Cadmium exposure during lactation causes learning and memory-impairment in F1 generation mice: amelioration by quercetin. Drug Chem Toxicol, 39 (3), 272-278.
  • Hatipoglu D, Keskin E (2022). The effect of curcumin on some cytokines, antioxidants and liver function tests in rats induced by Aflatoxin B1. Heliyon, 8 (7), e09890.
  • Jones DP (2006). Redefining oxidative stress. Antioxid Redox Signal, 8 (9-10), 1865-1879.
  • Kapun AP, Salobir J, Levart A, Kotnik T, Svete AN (2012). Oxidative stress markers in canine atopic dermatitis. Res Vet Sci, 92 (3), 469-470.
  • Karadeniz A, Hanedan B, Cemek M, Borku M (2008). Relationship between canine distemper and oxidative stress in dogs. Revue Med Vet, 159 (1), 462-467.
  • Lu SC (2009). Regulation of glutathione synthesis. Molecular Aspects of Medicine, 30 (1), 42-59.
  • Mahajan S, Dey S, Kumar A, Panigrahi P (2018). Nitrosative stress indices in dogs with neurological form of canine distemper. Iran J Vet Res, 19 (1), 229-232.
  • Maher P, Schubert D (2000). Signaling by reactive oxygen species in the nervous system. Cell Mol Life Sci, 57 (8), 1287-1305.
  • Mariutti LRB (2022). Lipid Peroxidation (TBARS) in Biological Samples. Basic Protocols in Foods and Nutrition, New York, NY: Springer US, 107-113.
  • Panda D, Patra RC, Nandi S, Swarup D (2009). Oxidative stress indices in gastroenteritis in dogs with canine parvoviral infection. Res Vet Sci, 86 (1), 36-42.
  • Paracha UZ, Fatima K, Alqahtani M et al. (2013). Oxidative stress and hepatitis C virus. Virol J, 10 (1), 251.
  • Peterhans E (1997). Oxidants and antioxidants in viral diseases: disease mechanisms and metabolic regulation. J Nutr, 127 (5), 962s-965s.
  • Pugliese M, Biondi V, Merola G, Landi A, Passantino A (2022). Oxidative Stress Evaluation in Dogs Affected with Canine Monocytic Ehrlichiosis. Antioxidants, 11 (2), 328.
  • Radi R (2018). Oxygen radicals, nitric oxide, and peroxynitrite: Redox pathways in molecular medicine. PNAS, 115 (23), 5839-5848.
  • Reshi ML, Su Y-C, Hong J-R (2014). RNA Viruses: ROS-Mediated Cell Death. Int J Cell Biol, 2014 (1) 467452-467452.
  • Schwarz KB (1996). Oxidative stress during viral infection: a review. Free Radic Biol Med, 21 (5), 641-649.
  • Sies H, Jones DP (2020). Reactive oxygen species (ROS) as pleiotropic physiological signalling agents. Nat Rev Mol Cell Biol, 21 (7), 363-383.
  • Stuart JA, Fonseca J, Moradi F et al. (2018). How Supraphysiological Oxygen Levels in Standard Cell Culture Affect Oxygen-Consuming Reactions. Oxid Med Cell Longev, 2018 (1), 8238459.
  • Valyi-Nagy T, Dermody TS (2005). Role of oxidative damage in the pathogenesis of viral infections of the nervous system. Histol Histopathol, 20 (3), 957-967.
  • Vandevelde M, Zurbriggen A (2005). Demyelination in canine distemper virus infection: a review. Acta Neuropathol, 109 (1), 56-68.
  • Viscone ÉA, Oliveira LA, Pereira AaBG et al. (2022). 4-hydroxy-2-nonenal as a marker of the oxidative stress in brains of dogs with canine distemper. Braz J Vet Res Anim Sci, 59 (1), e188941-e188941.
  • Wang P, Gong Q, Hu J, Li X, Zhang X (2021). Reactive Oxygen Species (ROS)-Responsive Prodrugs, Probes, and Theranostic Prodrugs: Applications in the ROS-Related Diseases. J Med Chem, 64 (1), 298-325.
  • Wang Y, Branicky R, Noë A, Hekimi S (2018). Superoxide dismutases: Dual roles in controlling ROS damage and regulating ROS signaling. J Cell Bio, 217 (6), 1915-1928.
  • Yazıcı C, Keçeci T, Hatipoğlu D (2021). The effect of coenzyme Q10 on blood plasma nitric oxide and total antioxidant capacity levels in hypothyroidism-induced rats. JIVS, 5 (1), 19-26.

Determination of Oxidative Stress and Antioxidant Activities in Dogs Infected with Canine Distemper Virus

Year 2022, Volume: 33 Issue: 3, 67 - 70, 29.11.2022

Durmuş Hatipoğlu , Irmak Dik , Erdem Gülersoy

https://doi.org/10.36483/vanvetj.1136569

Abstract

Supraphysiological reactive oxygen species (ROS) has been linked to a variety of diseases, including cancer, inflammation, and neurodegeneration. One of the diseases pathophysiologically associated with ROS accumulation is canine distemper (CD). The purpose of this study was to compare lipid peroxidation and antioxidant biomarkers in dogs infected with canine distemper virus (CDV) to healthy dogs. The animals in this study consisted of a total of 20 dogs, 10 CDV-positive dogs (Trial group) aged 0–12 months of different breeds and sexes, and 10 healthy dogs (Control group) aged 0–12 months of different breeds and sexes. Thiobarbituric acid reactive substances (TBARS), glutathione (GSH) and superoxide dismutase (SOD) were evaluated with commercially available enzyme-linked immunosorbent assay kits using serum samples. While the activities of GSH and SOD were statistically lower in CDV positive animals compared to healthy animals (p<0.05), the level of TBARS was significantly higher (p<0.05). In conclusion, current study findings that CDV increases lipid peroxidation activity in serum while decreasing antioxidant enzyme levels may be useful for future research.

Keywords

Antioxidants Lipid peroxidation Canine distemper virus

References

  • Avci O, Yavru S, Dik I (2014). Determination of lipid peroxidation biomarkers in Vero cell line inoculated with Bovine Ephemeral Fever Virus. EJVS, 30 (4), 217-221.
  • Beck MA (2000). Nutritionally induced oxidative stress: effect on viral disease. Am J Clin Nutr, 71 (6), 1676-1681.
  • Bedard K, Krause KH (2007). The NOX family of ROS-generating NADPH oxidases: physiology and pathophysiology. Physiol Rev, 87 (1), 245-313.
  • Beineke A, Puff C, Seehusen F, Baumgärtner W (2009). Pathogenesis and immunopathology of systemic and nervous canine distemper.Vet Immunol Immunopathol, 127 (1), 1-18.
  • Burton GJ, Jauniaux E (2011). Oxidative stress. Best Pract Res Clin Obstet, 25 (3), 287-299.
  • Camini FC, Da Silva Caetano CC, Almeida LT, De Brito Magalhães CL (2017). Implications of oxidative stress on viral pathogenesis. Arch Virol, 162 (4), 907-917.
  • Candellone A, Girolami F, Badino P, Jarriyawattanachaikul W, Odore R (2022). Changes in the Oxidative Stress Status of Dogs Affected by Acute Enteropathies. Vet Sci, 9 (6), 276.
  • Choi J, Ou JH (2006). Mechanisms of liver injury. III. Oxidative stress in the pathogenesis of hepatitis C virus. Am J Physiol Gastrointest Liver Physiol, 290 (5), G847-851.
  • Değirmençay Ş, Çamkerten G, Çamkerten İ, Aktaş MS (2021). An investigation of thiol/disulfide homeostasis and ischemia-modified albumin levels to assess the oxidative stress in dogs with canine distemper. Vet Arh, 91 (1), 39-49.
  • Dik B, Avci O, Dik I (2019). In Vitro Antıvıral and Antioxidant Actıvıtıes of Silymarin and Panax Ginseng on Vero Cells Infected with Bovine Ephemeral Fever Virus and Blue Tongue Virus. Acta Pol Pharm, 76 (2), 291-297.
  • Finaud J, Lac G, Filaire E (2006). Oxidative Stress. Sports Med, 36 (4), 327-358.
  • Gutteridge JMC, Halliwell B (1990). The measurement and mechanism of lipid peroxidation in biological systems. Trends Biochem Sci, 15 (4), 129-135.
  • Ha HL, Shin HJ, Feitelson MA, Yu DY (2010). Oxidative stress and antioxidants in hepatic pathogenesis. World J Gastroenterol, 16 (48), 6035-6043.
  • Halder S, Kar R, Galav V et al. (2016). Cadmium exposure during lactation causes learning and memory-impairment in F1 generation mice: amelioration by quercetin. Drug Chem Toxicol, 39 (3), 272-278.
  • Hatipoglu D, Keskin E (2022). The effect of curcumin on some cytokines, antioxidants and liver function tests in rats induced by Aflatoxin B1. Heliyon, 8 (7), e09890.
  • Jones DP (2006). Redefining oxidative stress. Antioxid Redox Signal, 8 (9-10), 1865-1879.
  • Kapun AP, Salobir J, Levart A, Kotnik T, Svete AN (2012). Oxidative stress markers in canine atopic dermatitis. Res Vet Sci, 92 (3), 469-470.
  • Karadeniz A, Hanedan B, Cemek M, Borku M (2008). Relationship between canine distemper and oxidative stress in dogs. Revue Med Vet, 159 (1), 462-467.
  • Lu SC (2009). Regulation of glutathione synthesis. Molecular Aspects of Medicine, 30 (1), 42-59.
  • Mahajan S, Dey S, Kumar A, Panigrahi P (2018). Nitrosative stress indices in dogs with neurological form of canine distemper. Iran J Vet Res, 19 (1), 229-232.
  • Maher P, Schubert D (2000). Signaling by reactive oxygen species in the nervous system. Cell Mol Life Sci, 57 (8), 1287-1305.
  • Mariutti LRB (2022). Lipid Peroxidation (TBARS) in Biological Samples. Basic Protocols in Foods and Nutrition, New York, NY: Springer US, 107-113.
  • Panda D, Patra RC, Nandi S, Swarup D (2009). Oxidative stress indices in gastroenteritis in dogs with canine parvoviral infection. Res Vet Sci, 86 (1), 36-42.
  • Paracha UZ, Fatima K, Alqahtani M et al. (2013). Oxidative stress and hepatitis C virus. Virol J, 10 (1), 251.
  • Peterhans E (1997). Oxidants and antioxidants in viral diseases: disease mechanisms and metabolic regulation. J Nutr, 127 (5), 962s-965s.
  • Pugliese M, Biondi V, Merola G, Landi A, Passantino A (2022). Oxidative Stress Evaluation in Dogs Affected with Canine Monocytic Ehrlichiosis. Antioxidants, 11 (2), 328.
  • Radi R (2018). Oxygen radicals, nitric oxide, and peroxynitrite: Redox pathways in molecular medicine. PNAS, 115 (23), 5839-5848.
  • Reshi ML, Su Y-C, Hong J-R (2014). RNA Viruses: ROS-Mediated Cell Death. Int J Cell Biol, 2014 (1) 467452-467452.
  • Schwarz KB (1996). Oxidative stress during viral infection: a review. Free Radic Biol Med, 21 (5), 641-649.
  • Sies H, Jones DP (2020). Reactive oxygen species (ROS) as pleiotropic physiological signalling agents. Nat Rev Mol Cell Biol, 21 (7), 363-383.
  • Stuart JA, Fonseca J, Moradi F et al. (2018). How Supraphysiological Oxygen Levels in Standard Cell Culture Affect Oxygen-Consuming Reactions. Oxid Med Cell Longev, 2018 (1), 8238459.
  • Valyi-Nagy T, Dermody TS (2005). Role of oxidative damage in the pathogenesis of viral infections of the nervous system. Histol Histopathol, 20 (3), 957-967.
  • Vandevelde M, Zurbriggen A (2005). Demyelination in canine distemper virus infection: a review. Acta Neuropathol, 109 (1), 56-68.
  • Viscone ÉA, Oliveira LA, Pereira AaBG et al. (2022). 4-hydroxy-2-nonenal as a marker of the oxidative stress in brains of dogs with canine distemper. Braz J Vet Res Anim Sci, 59 (1), e188941-e188941.
  • Wang P, Gong Q, Hu J, Li X, Zhang X (2021). Reactive Oxygen Species (ROS)-Responsive Prodrugs, Probes, and Theranostic Prodrugs: Applications in the ROS-Related Diseases. J Med Chem, 64 (1), 298-325.
  • Wang Y, Branicky R, Noë A, Hekimi S (2018). Superoxide dismutases: Dual roles in controlling ROS damage and regulating ROS signaling. J Cell Bio, 217 (6), 1915-1928.
  • Yazıcı C, Keçeci T, Hatipoğlu D (2021). The effect of coenzyme Q10 on blood plasma nitric oxide and total antioxidant capacity levels in hypothyroidism-induced rats. JIVS, 5 (1), 19-26.
There are 37 citations in total.

Details

Primary Language English
Subjects Veterinary Surgery
Journal Section Araştırma Makaleleri
Authors

Durmuş Hatipoğlu 0000-0003-3790-7821

Irmak Dik 0000-0003-2516-9489

Erdem Gülersoy 0000-0001-8511-0150

Publication Date November 29, 2022
Submission Date June 27, 2022
Acceptance Date August 19, 2022
Published in Issue Year 2022 Volume: 33 Issue: 3

Cite

APA Hatipoğlu, D., Dik, I., & Gülersoy, E. (2022). Determination of Oxidative Stress and Antioxidant Activities in Dogs Infected with Canine Distemper Virus. Van Veterinary Journal, 33(3), 67-70. https://doi.org/10.36483/vanvetj.1136569
AMA Hatipoğlu D, Dik I, Gülersoy E. Determination of Oxidative Stress and Antioxidant Activities in Dogs Infected with Canine Distemper Virus. Van Vet J. November 2022;33(3):67-70. doi:10.36483/vanvetj.1136569
Chicago Hatipoğlu, Durmuş, Irmak Dik, and Erdem Gülersoy. “Determination of Oxidative Stress and Antioxidant Activities in Dogs Infected With Canine Distemper Virus”. Van Veterinary Journal 33, no. 3 (November 2022): 67-70. https://doi.org/10.36483/vanvetj.1136569.
EndNote Hatipoğlu D, Dik I, Gülersoy E (November 1, 2022) Determination of Oxidative Stress and Antioxidant Activities in Dogs Infected with Canine Distemper Virus. Van Veterinary Journal 33 3 67–70.
IEEE D. Hatipoğlu, I. Dik, and E. Gülersoy, “Determination of Oxidative Stress and Antioxidant Activities in Dogs Infected with Canine Distemper Virus”, Van Vet J, vol. 33, no. 3, pp. 67–70, 2022, doi: 10.36483/vanvetj.1136569.
ISNAD Hatipoğlu, Durmuş et al. “Determination of Oxidative Stress and Antioxidant Activities in Dogs Infected With Canine Distemper Virus”. Van Veterinary Journal 33/3 (November 2022), 67-70. https://doi.org/10.36483/vanvetj.1136569.
JAMA Hatipoğlu D, Dik I, Gülersoy E. Determination of Oxidative Stress and Antioxidant Activities in Dogs Infected with Canine Distemper Virus. Van Vet J. 2022;33:67–70.
MLA Hatipoğlu, Durmuş et al. “Determination of Oxidative Stress and Antioxidant Activities in Dogs Infected With Canine Distemper Virus”. Van Veterinary Journal, vol. 33, no. 3, 2022, pp. 67-70, doi:10.36483/vanvetj.1136569.
Vancouver Hatipoğlu D, Dik I, Gülersoy E. Determination of Oxidative Stress and Antioxidant Activities in Dogs Infected with Canine Distemper Virus. Van Vet J. 2022;33(3):67-70.
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