Deneysel Diyabet Modelinde Solanum nigrum Ekstraktının Antioksidan ve Antihiperlipidemik Etkisi

Year 2023, Volume: 34 Issue: 3, 184 - 188, 27.11.2023

Ahmet Cihat Öner , Fatmagül Yur , Mohammed Nooraddin Fethullah

https://doi.org/10.36483/vanvetj.1233043

Abstract

Diabetes mellitus (DM), kronik, metabolik, bulaşıcı olmayan bir hastalıktır, dünya çapında beşinci ölüm nedeni olarak kabul edilir ve dünya çapında epidemik oranlara ulaşmıştır. Çalışmamızda kontrol grubu (K), diyabet grubu (D), Solanum nigrum özü (SN) ve diyabet + Solanum nigrum özü (D+SN) verilen gruplar kullanılarak Solanum nigrum ekstraktının diyabetik etkilerini araştırmayı amaçladık. Sonuçlarımız, Solanum nigrum ekstraktının glukoz seviyeleri üzerinde biyolojik etkinliği gözlenirken, serum glukoz seviyesinde (D) (663±21.8 mg/dL) C'ye (131±9.8 mg/dL) kıyasla anlamlı artış kaydedildi. Ancak C grubu (131±9.8 mg/dl) ve SN grubu (196.14±12.1 mg/dL) arasında glukoz düzeyi açısından anlamlı fark yoktu. Ayrıca D + SN grubunun glukoz düzeyi (484.8±40.0 mg/dL), C (131±9.8 mg/dl), D (663±21.8 mg/dl) ve SN gruplarına (196.14±12.1 mg/dL) göre anlamlı olarak yüksekti). D grubunda (1,85±0,15,7) toplam antioksidan durum (TAS) düzeyi, C grubu (1.28±0.17) ile karşılaştırıldığında anlamlıydı. D grubu ile D+SN grubu arasında anlamlı farklar gözlendi (154±007). Ancak TAS düzeyleri hem SN (1.27±0.10) hem de D+SN (1.54±0.07) gruplarında kontrole göre anlamlı farklılık göstermedi. D grubunda (6.30±1.41) toplam oksidan durum (TOS) düzeyi, kontrol C (3.87±0.34), SN (4.87±0,80) grubu ve D+SN (4.14±0.34) gruplarına göre anlamlı farklılık gösterdi. Aksine, tüm C, SN, D+SN grupları arasında anlamlı bir fark yoktu. Sonuç olarak Solanum nigrum bitki ekstraktının diyabet üzerinde etkili olduğunu ancak glikoz seviyesini normal seviyelere indiremediğini, farklı dozlarda ve farklı ekstraksiyon yöntemleri ile etkilerinin ileriki çalışmalarda araştırılması gerektiğini söyleyebiliriz.

Keywords

Hipolipidemik ajan, Oksidatif stres, Streptozosin

Supporting Institution

Van YYÜ BAP

Project Number

TYL-2016-5135

Thanks

Bu çalışma TYL-2016-5135 proje kodu ile VAN YYÜ BAP birimi tarafından desteklenmiştir.

Antioxidant and Antihyperlipidemic Effect of Solanum Nigrum Extract in Experimental Diabetes Model

Abstract

Diabetes mellitus (DM) is a chronic metabolic non-commu¬nicable disease; it is globally considered the fifth cause of death and it has attained worldwide epidemic pro¬portions. In our study, we aimed to investigate the diabetic effects of Solanum nigrum extract using the control group (C), diabetes group (D), groups given the Solanum nigrum extract (SN) and diabetes group + Solanum nigrum extract (D+SN). Our results observed the biological effectiveness of Solanum nigrum extract on glucose levels, significant increase serum glucose level group (D) (663±21.8 mg/dL) in comparison with C (131±9.8 mg/dL) were recorded. However, there were no significant difference in glucose level between C group (131±9.8 mg/dl) and SN group (196.14±12.1 mg/dL). Moreover, glucose level of D+SN group (484.8±40.0 mg/dL) was significantly higher than C (131±9.8 mg/dl), D (663±21.8 mg/dl) and SN groups (196.14±12.1 mg/dL). Total antioxidant status (TAS) level in D group (1.85±0.15.7) was significant when compared C group (1.28±0.17). Significant differences were observed between D group and D+SN group (1.54±0.07). However, TAS levels showed no significant difference in both SN (1.27±0.10) and D+SN (1.54±0.07) groups in comparison to the control group. Total oxidant status (TOS) level in D group (6.30±1.41) was given significant differences in comparison with control C (3.87±0.34), SN (4.87±0.80) group and D+SN (4.14±0.34) groups. In contrary, there were no significant differences between all of C, SN, D+SN groups. As a result, we can say that the Solanum nigrum plant extract is effective on diabetes, but it cannot lower the glucose level to normal levels, it needs to be investigated in future studies and its effects at different doses by different extraction methods.

Keywords

Hypolipidemica agent, Streptozocin, Oxidative stress

Project Number

TYL-2016-5135

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