TARAXACUM OFFICINALE; TRADITIONAL AND EXPERIMENTAL BIOLOGICAL ACTIVITIES

Year 2025, Volume: 6 Issue: 1, 37 - 60, 13.01.2025

Mehmet Erdem , Mehmet Özaslan

https://doi.org/10.55549/zbs.1564629

Abstract

It is observed that Taraxacum officinale has been traditionally used for the treatment of various diseases for many years, and its use has also been identified clinically in disorders such as dyspepsia, liver, gallbladder, and urinary tract diseases.It is a plant with many bioactivities, especially strong anti-inflammatory, antioxidant, and hepatoprotective properties. When considering its side effects and toxicity, it is seen that there are no serious side effects or toxicity. In light of this information, it is evaluated that if brought into herbal medicine format due to its strong antioxidant, anti-inflammatory, anticancer, and hepatoprotective effects, it could be effective in the treatment of commonly seen diseases such as cancer, liver, and gallbladder diseases. According to the results of bioactivity studies conducted on the plant, Taraxacum officinale has been reported analgesic, antiallergic, antidepressant, anti-inflammatory, anti-hyperglycemic, anticarcinogenic, antimicrobial, antimutagenic, antioxidant, antispermic, antithrombotic, diuretic, hypolipidemic, immunological, choloretic, and prebiotic effects. Additionally, that it has hepatoprotective, nephroprotective, and neuroprotective properties. The acute toxicity of Taraxacum officinale seems to be low; when 95% ethanol extract of the whole plant was administered intraperitoneally in rats, the lethal dose was found to be 28.8 mg/kg. When 50% ethanol extract of the whole plant was administered intraperitoneally to rats, the maximum tolerable dose was found to be 500.0 mg/kg. No adverse or complex toxic effects have been reported for Taraxacum officinale. This literature review was prepared with the studies of articles on the Google Scholar and PubMed platforms. This review confirms the importance of phytotherapy studies for pharmacological purposes, aiming at therapeutic improvement.

Keywords

Taraxacum officinale, antioxidant, anti-inflammatory, anticancer, in vivo, in vitro.

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