Evaluation of Complete Blood Count in Chronic Lymphoid Leukemia Patients

Year 2025, Volume: 6 Issue: 1, 61 - 67, 13.01.2025

Ayşe Dalyan , Sibel Bayıl Oguzkan , Mehmet Özaslan

https://doi.org/10.55549/zbs.1586463

Abstract

Chronic Lymphoid Leukemia (CLL) is characterized by the uncontrolled proliferation of lymphocytes, usually in the elderly, which can lead to various hematological abnormalities in patients. Analysis of hematological parameters is very important for the diagnosis, prognosis, and monitoring of treatment response in CLL. This study aimed to compare the complete blood count (CBC) parameters of CLL patients with a healthy control group. The study included 50 patients diagnosed with CLL and 50 healthy controls without a history of cancer. CBC parameters (WBC, RBC, HGB, HCT, MCV, MCH, MCHC, RDW, RDW-SD, PDW, PLT, MPV, PCT, NEU%, LYM%, MONO%, EOS%, BASO%, NEU#, LYM#, MONO#, EOS#, BASO#, NRBC#) of CLL patients and control group were statistically compared. According to the analysis results, no significant difference was found between MCV, RDW, RDW-SD, PDW, MPV, BASO%, NEU#, and EOS# values of the patient and control groups (p>0.05). However, WBC, RBC, HGB, HCT, LYM%, MONO%, LYM#, MONO#, BASO#, and NRBC# values of the patient group were significantly higher relative to the control group (p<0.05). MCH, MCHC, PLT, PCT, NEU%, and EOS% parameters were significantly higher in the control group relative to the patient group (p<0.05). As a result, significant differences were observed in some CBC parameters between patients and the control groups. Particularly, the significant difference observed in some parameters emphasizes that the hematological profile of CLL can be used in the diagnosis and monitoring processes. Our findings support

Keywords

CLL, Prognosis, CBC, Leukemia, Hematological parameters

Ethical Statement

Local ethics committee approval was obtained for the study with protocol number 2021/163.

Thanks

We thank Prof. Dr. Mehmet Yılmaz for his help in collecting samples from Sanko University Hospital for our study. This study was presented as an oral presentation at the X. Experimental Hematology Congress with International Participation.

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