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Comparison of hemodialysis and online hemodiafiltration in removal of uremic toxins

Year 2014, Volume: 45 Issue: 4, 178 - 185, 27.09.2014

Abstract

Hemodialysis (HD) treatment in recent years has extended the life span of patients with end stage renal disease. Standard or conventional HD is far from fully compensating normal renal functions. Inadequately cleaned uremic toxins lead to cardiovascular morbidity and mortality. In this review, different dialysis techniques improving the quality of life of patients and reducing morbidity and mortality will be discussed on the basis of various studies and scientific innovations.

Key words: hemodialysis, renal dialysis, hemodiafiltration

References

  • Himmelfarb J, Ikizler TA. Hemodialysis.. N Engl J Med 2010 Nov;363(19):1833-1845. Available from: http://www.nlm.nih.gov/medlineplus/dialysis.html PubMed PMID: 21047227. doi: 10.1056/NEJMra0902710.
  • Song MK, Gilet CA, Lin FC, et al. Characterizing daily life experience of patients on maintenance dialysis. Nephrol Dial Transplant 2011;26(11):3671-7. Available from: http://ndt.oxfordjournals.org/cgi/pmidlookup?view=long&pmid=21382996 PubMed PMID: 21382996. doi: 10.1093/ndt/gfr071.
  • Rayner HC, Pisoni RL, Bommer J, Canaud B, Hecking E, Locatelli F, et al. Mortality and hospitalization in haemodialysis patients in five European countries: results from the Dialysis Outcomes and Practice Patterns Study (DOPPS).. Nephrol Dial Transplant 2004 Jan;19(1):108-120. Available from: http://ndt.oxfordjournals.org/cgi/pmidlookup?view=long&pmid=14671046 PubMed PMID: 14671046.
  • De Jager DJ, Grooteendorst DC, Jager KJ et al. Cardiovascular and noncardiovascular mortality among patients starting dialysis. JAMA 2009; 302:1782–1789
  • Brunelli SM, Chertow GM, Ankers ED, Lowrie EG, Thadhani R. Shorter dialysis times are associated with hinher mortality among incident hemodialysis patients. Kidney Int 2010;77:630-6.
  • Glorieux G, Vanholder R. New uraemic toxins-which solutes should be removed? Contrib Nephrol 2011; 168:117–128
  • Kerr PB, Argilés A, Flavier JL et al. Comparison of haemodialysis and haemodiafiltration: a long-term longitudinal study. Kidney Int 1992; 41:1035-1040
  • Leypoldt JK. Solute fluxes in different treatment modalities. Nephrol Dial Transplant 2000; 15(Suppl 1): 3–9
  • Vilar E, Fry AC, Wellsted D et al. Long-term outcomes in online haemodiafiltration and high-flux haemodialysis: a comparative analysis. Clin J Am Soc Nephrol 2009; 4: 1944–1953
  • Block GA, Hulbert-Shearon TE, Levin NW, Port FK. Association of serum phosphorus and calcium x phosphate product with mortality risk in chronic hemodialysis patients: A national study. Am J Kidney Dis 1988;31:607-17.
  • WizemannV, Wabel P, Chamney P, et al. The mortality risk of overhydration in hemodialysis patients. Nephrol Dial Transplant 2009; 24:1574-9.
  • Saran R, Bragg-Gresham JL, Levin NW, et al. Longer treatment time and slower ultrafiltration in hemodialysis: Associations with reduced mortality in DOPPS. Kidney Int 2006; 69:1222-8.
  • Woods JD, Port FK, Orzol S, et al. Clinical and biochemical correlates of starting “daily” hemodialysis. Kidney Int 1999; 55:2467-76.
  • Rocco MV, Lockridge RS Jr, Beck GJ, et al. The effects of frequent Hemodialysis Network Nocturnal Trial. Kidney Int 2011; 80:1080-91.
  • De Francisco AL, Pinera C. Challenges and future of renal replacement therapy. Hemodialysis Int 2006; 10:S19-23.
  • Denhaerynck K, Manhaeve D, Dobbels F, Garzoni, Nolte C, De Geest S. Prevalence and consequences of nonadherence to hemodialysis regiments. Am J Crit Care 2007; 16:222-35.
  • Kjellstrand CM, Evans RL, Petersen JR, von Hartitizsch B, Buselmeier TJ. The “unphysiology” of dialysis: Amajor cause of dialysis side effects? Hemodialysis Int 2004;8:24-9.
  • Dhondt A, Vanholder R, VanBiesen W, Lameire N. The removal of uremic toxins. Kidney Int 2000; 58:S47-59.
  • Collins AJ, Ma JZ Umen A, Keshaviah P: Urea Indexand other predictors of hemodialysis patient survival. Am J Kidney Dis 1994; 23:272-82.
  • Eknoyan G, Beck GJ, Cheung AK, et al. Effect of dialysis dose and membrane flux in maintenance hemodialysis. N Engl J Med 2002; 347:2010-9.
  • Locatelli F, Buoncristiani U, Canaud B, Köhler H, Petitclerc T, Zucchelli P. Dialysis dose and frequency. Nephrol Dial Transplant 2005; 20:285-96.
  • Komenda P, Gavaghan MB, Garfield SS, Poret AW, Sood MM. An economic model for incenter, home, and more frequent home hemodialysis. Kidney Int 2012;81:307-13.
  • Van Laecke S, De Wild K, Vanholder R. Online hemodiafiltration. Artif Organs 2006;30:579-85.
  • Locatelli F, Martin-Malo A, Hannedouvhe T, et al. Effect of membrane permeability on survival of hemodialysis patients. J Am Soc Nephrol 2009;20:645-54.
  • Blankestjin PJ, Ledebo I, Canud B. Hemdiafiltration: Clinical evidence and remaining questions. Kidney Int 2010; 77:581-7.
  • Tessitore N, Lapolla A, Arico NC, et al. Effect of protein leaking BK-F PMMA-based hemodialysis on plazma pentosidine levels. J Nephrol 2004;17:707-14.
  • Lameire N, Van Biesen W, Vanholder R. Did 20 years of technological innovations in hemodialysis contribute to better outcomes? Clin J Am Nephrol 2009;4:S30-40.
  • Meert N, Eloot S, Waterloos MA, et al. Effective removal of protein-bound uremic solutes by different convective strategies: A prospective trial. Nephrol Dialysis Transplant 2009;24:562-70.
  • Jirka T, Cesare S, Di Benedetto A, et al. Mortality risk for patients receiving hemodiafiltration versus hemodialysis. Kidney Int 2006; 70:1524-5.
  • Penne EL, Blankestijin PJ, Bots ML, et al. Effect of increased convective clearance by online hemodiafiltration on all cause and cardiovascular mortality in chronic hemodialysis patients the Dutch CONnvectiveTRAnsport Study (CONTRAST): Rationale and design of a randomized controlled trial (ISRCTN38365124). Curr Control Trials Cardiovasc Med 2005;6:8.
  • Penne EL, van der Weerd NC, van den Dorpel MA, et al. Short-term effects of online hemodiafiltration on phosphate control: A result from the randomized controlled convective transport study (CONTRAST). Am J Kidney Dis 2009;55:77-87.
  • Maduell F, del Pozo C, Garcia H, et al Change from conventional hemodiafitration to online hemodiafiltration. Nephrol Dial Transplant 1999; 14:1202-7.
  • Badiou S, Morena M, Bargnoux AS, et al. Does hemodiafiltration improve the removal of homocysteine? Hemodialysis Int 20111;15:515-21.
  • Ok E, Asci G, Ok ES, et al. Comparison of post-dilution online hemodiafiltration and hemodialysis(Turkish HDF Study). Nephrol Dial Transplant Plus 2011;4:Suppl 2.
  • Pedrini LA, De Cristofaro V, Comelli M, et all. Long-term effects of high-efficiency on-line haemodiafiltration on uraemic toxicity. A multicenter prospective randomized study. Nephrol Dial Transplant 2011;26:2617-24.
  • Altieri P, Sorba G, Bolasco P, et al. On-line hemofiltration in chronic renal failure: Advantages and limits. Saudi J Kidney Dis Transpl 2001;12:387-97.
  • Locatelli F, Martin-Malo A, Hannedouche T, et al. Effect of membrane permeability on survival of hemodialysis patients. J Am Soc Nephrol 2009; 20:645-54.
  • Locatelli F, Altier, P, Andrulli S, et al. Hemofiltrastion and hemodiafiltration reduce intradialytic hypotension in ESRD. J Am Soc Nephrol 2010;21:1798-807.
  • Silberberg JS, Barre PE, Prichard SS, Sniderman AD. Impact of left ventricular hypertrophy on survival in end-stage renal disease. Kidney Int 1989;36:286-90.
  • Maduell F, Arias M, Duran CE, et al. Nocturnal, every-other-day, online haemodiafiltration: an effecrtive therapeutic alternative. Nephrol Dial Transplant 2012;27:1619-31.
  • Foley RN, Gilbertson DT, Murray T, Collins AJ. Long İnterdialytic interval and mortality among patients receiving hemodialysis. N Engl J Med 2011;365:1099-107.
  • Meert N, Eloot S, Waterloos MA, et al. Effective removal convective strategies: A prospective trial. Nephrol Dialysis Transplant 2009;24:562-70.
  • Karkar A. Modalities of Hemodialysis: Quality Improvement. Saudi J Kidney Dis Transpl 2012; 23(6):1145-1161.

Üremik toksiklerin temizlenmesinde diyaliz ve online hemodiafiltrasyonun karşılaştırılması

Year 2014, Volume: 45 Issue: 4, 178 - 185, 27.09.2014

Abstract

Hemodiyaliz (HD) tedavisi son yıllarda son dönem böbrek yetmezlikli hastaların yaşam süresini uzatmıştır.  Standart veya geleneksel HD normal böbrek fonksiyonlarını tam olarak karşılayamamaktadır. Üremik toksinlerin tam olarak temizlenmemesi nedeniyle kardiovasküler mortaliteye ve morbititeye yol açmaktadır. Bu derlemede değişik çalışmalar ve yenilikler temelinde hastaların yaşam kalitesini yükseltecek ve mortalite ve morbititeyi azaltacak değişik diyaliz tekniklerinden söz edilecektir.

Anahtar kelimeler: hemodiyaliz, böbrek diyalizi, hemodiyafiltrasyon

References

  • Himmelfarb J, Ikizler TA. Hemodialysis.. N Engl J Med 2010 Nov;363(19):1833-1845. Available from: http://www.nlm.nih.gov/medlineplus/dialysis.html PubMed PMID: 21047227. doi: 10.1056/NEJMra0902710.
  • Song MK, Gilet CA, Lin FC, et al. Characterizing daily life experience of patients on maintenance dialysis. Nephrol Dial Transplant 2011;26(11):3671-7. Available from: http://ndt.oxfordjournals.org/cgi/pmidlookup?view=long&pmid=21382996 PubMed PMID: 21382996. doi: 10.1093/ndt/gfr071.
  • Rayner HC, Pisoni RL, Bommer J, Canaud B, Hecking E, Locatelli F, et al. Mortality and hospitalization in haemodialysis patients in five European countries: results from the Dialysis Outcomes and Practice Patterns Study (DOPPS).. Nephrol Dial Transplant 2004 Jan;19(1):108-120. Available from: http://ndt.oxfordjournals.org/cgi/pmidlookup?view=long&pmid=14671046 PubMed PMID: 14671046.
  • De Jager DJ, Grooteendorst DC, Jager KJ et al. Cardiovascular and noncardiovascular mortality among patients starting dialysis. JAMA 2009; 302:1782–1789
  • Brunelli SM, Chertow GM, Ankers ED, Lowrie EG, Thadhani R. Shorter dialysis times are associated with hinher mortality among incident hemodialysis patients. Kidney Int 2010;77:630-6.
  • Glorieux G, Vanholder R. New uraemic toxins-which solutes should be removed? Contrib Nephrol 2011; 168:117–128
  • Kerr PB, Argilés A, Flavier JL et al. Comparison of haemodialysis and haemodiafiltration: a long-term longitudinal study. Kidney Int 1992; 41:1035-1040
  • Leypoldt JK. Solute fluxes in different treatment modalities. Nephrol Dial Transplant 2000; 15(Suppl 1): 3–9
  • Vilar E, Fry AC, Wellsted D et al. Long-term outcomes in online haemodiafiltration and high-flux haemodialysis: a comparative analysis. Clin J Am Soc Nephrol 2009; 4: 1944–1953
  • Block GA, Hulbert-Shearon TE, Levin NW, Port FK. Association of serum phosphorus and calcium x phosphate product with mortality risk in chronic hemodialysis patients: A national study. Am J Kidney Dis 1988;31:607-17.
  • WizemannV, Wabel P, Chamney P, et al. The mortality risk of overhydration in hemodialysis patients. Nephrol Dial Transplant 2009; 24:1574-9.
  • Saran R, Bragg-Gresham JL, Levin NW, et al. Longer treatment time and slower ultrafiltration in hemodialysis: Associations with reduced mortality in DOPPS. Kidney Int 2006; 69:1222-8.
  • Woods JD, Port FK, Orzol S, et al. Clinical and biochemical correlates of starting “daily” hemodialysis. Kidney Int 1999; 55:2467-76.
  • Rocco MV, Lockridge RS Jr, Beck GJ, et al. The effects of frequent Hemodialysis Network Nocturnal Trial. Kidney Int 2011; 80:1080-91.
  • De Francisco AL, Pinera C. Challenges and future of renal replacement therapy. Hemodialysis Int 2006; 10:S19-23.
  • Denhaerynck K, Manhaeve D, Dobbels F, Garzoni, Nolte C, De Geest S. Prevalence and consequences of nonadherence to hemodialysis regiments. Am J Crit Care 2007; 16:222-35.
  • Kjellstrand CM, Evans RL, Petersen JR, von Hartitizsch B, Buselmeier TJ. The “unphysiology” of dialysis: Amajor cause of dialysis side effects? Hemodialysis Int 2004;8:24-9.
  • Dhondt A, Vanholder R, VanBiesen W, Lameire N. The removal of uremic toxins. Kidney Int 2000; 58:S47-59.
  • Collins AJ, Ma JZ Umen A, Keshaviah P: Urea Indexand other predictors of hemodialysis patient survival. Am J Kidney Dis 1994; 23:272-82.
  • Eknoyan G, Beck GJ, Cheung AK, et al. Effect of dialysis dose and membrane flux in maintenance hemodialysis. N Engl J Med 2002; 347:2010-9.
  • Locatelli F, Buoncristiani U, Canaud B, Köhler H, Petitclerc T, Zucchelli P. Dialysis dose and frequency. Nephrol Dial Transplant 2005; 20:285-96.
  • Komenda P, Gavaghan MB, Garfield SS, Poret AW, Sood MM. An economic model for incenter, home, and more frequent home hemodialysis. Kidney Int 2012;81:307-13.
  • Van Laecke S, De Wild K, Vanholder R. Online hemodiafiltration. Artif Organs 2006;30:579-85.
  • Locatelli F, Martin-Malo A, Hannedouvhe T, et al. Effect of membrane permeability on survival of hemodialysis patients. J Am Soc Nephrol 2009;20:645-54.
  • Blankestjin PJ, Ledebo I, Canud B. Hemdiafiltration: Clinical evidence and remaining questions. Kidney Int 2010; 77:581-7.
  • Tessitore N, Lapolla A, Arico NC, et al. Effect of protein leaking BK-F PMMA-based hemodialysis on plazma pentosidine levels. J Nephrol 2004;17:707-14.
  • Lameire N, Van Biesen W, Vanholder R. Did 20 years of technological innovations in hemodialysis contribute to better outcomes? Clin J Am Nephrol 2009;4:S30-40.
  • Meert N, Eloot S, Waterloos MA, et al. Effective removal of protein-bound uremic solutes by different convective strategies: A prospective trial. Nephrol Dialysis Transplant 2009;24:562-70.
  • Jirka T, Cesare S, Di Benedetto A, et al. Mortality risk for patients receiving hemodiafiltration versus hemodialysis. Kidney Int 2006; 70:1524-5.
  • Penne EL, Blankestijin PJ, Bots ML, et al. Effect of increased convective clearance by online hemodiafiltration on all cause and cardiovascular mortality in chronic hemodialysis patients the Dutch CONnvectiveTRAnsport Study (CONTRAST): Rationale and design of a randomized controlled trial (ISRCTN38365124). Curr Control Trials Cardiovasc Med 2005;6:8.
  • Penne EL, van der Weerd NC, van den Dorpel MA, et al. Short-term effects of online hemodiafiltration on phosphate control: A result from the randomized controlled convective transport study (CONTRAST). Am J Kidney Dis 2009;55:77-87.
  • Maduell F, del Pozo C, Garcia H, et al Change from conventional hemodiafitration to online hemodiafiltration. Nephrol Dial Transplant 1999; 14:1202-7.
  • Badiou S, Morena M, Bargnoux AS, et al. Does hemodiafiltration improve the removal of homocysteine? Hemodialysis Int 20111;15:515-21.
  • Ok E, Asci G, Ok ES, et al. Comparison of post-dilution online hemodiafiltration and hemodialysis(Turkish HDF Study). Nephrol Dial Transplant Plus 2011;4:Suppl 2.
  • Pedrini LA, De Cristofaro V, Comelli M, et all. Long-term effects of high-efficiency on-line haemodiafiltration on uraemic toxicity. A multicenter prospective randomized study. Nephrol Dial Transplant 2011;26:2617-24.
  • Altieri P, Sorba G, Bolasco P, et al. On-line hemofiltration in chronic renal failure: Advantages and limits. Saudi J Kidney Dis Transpl 2001;12:387-97.
  • Locatelli F, Martin-Malo A, Hannedouche T, et al. Effect of membrane permeability on survival of hemodialysis patients. J Am Soc Nephrol 2009; 20:645-54.
  • Locatelli F, Altier, P, Andrulli S, et al. Hemofiltrastion and hemodiafiltration reduce intradialytic hypotension in ESRD. J Am Soc Nephrol 2010;21:1798-807.
  • Silberberg JS, Barre PE, Prichard SS, Sniderman AD. Impact of left ventricular hypertrophy on survival in end-stage renal disease. Kidney Int 1989;36:286-90.
  • Maduell F, Arias M, Duran CE, et al. Nocturnal, every-other-day, online haemodiafiltration: an effecrtive therapeutic alternative. Nephrol Dial Transplant 2012;27:1619-31.
  • Foley RN, Gilbertson DT, Murray T, Collins AJ. Long İnterdialytic interval and mortality among patients receiving hemodialysis. N Engl J Med 2011;365:1099-107.
  • Meert N, Eloot S, Waterloos MA, et al. Effective removal convective strategies: A prospective trial. Nephrol Dialysis Transplant 2009;24:562-70.
  • Karkar A. Modalities of Hemodialysis: Quality Improvement. Saudi J Kidney Dis Transpl 2012; 23(6):1145-1161.
There are 43 citations in total.

Details

Primary Language Turkish
Journal Section PEDIATRICS
Authors

Seçil Conkar

Sevgi Mir This is me

Publication Date September 27, 2014
Published in Issue Year 2014 Volume: 45 Issue: 4

Cite

APA Conkar, S., & Mir, S. (2014). Üremik toksiklerin temizlenmesinde diyaliz ve online hemodiafiltrasyonun karşılaştırılması. Zeynep Kamil Tıp Bülteni, 45(4), 178-185. https://doi.org/10.16948/zktb.26011
AMA Conkar S, Mir S. Üremik toksiklerin temizlenmesinde diyaliz ve online hemodiafiltrasyonun karşılaştırılması. Zeynep Kamil Tıp Bülteni. October 2014;45(4):178-185. doi:10.16948/zktb.26011
Chicago Conkar, Seçil, and Sevgi Mir. “Üremik Toksiklerin Temizlenmesinde Diyaliz Ve Online Hemodiafiltrasyonun karşılaştırılması”. Zeynep Kamil Tıp Bülteni 45, no. 4 (October 2014): 178-85. https://doi.org/10.16948/zktb.26011.
EndNote Conkar S, Mir S (October 1, 2014) Üremik toksiklerin temizlenmesinde diyaliz ve online hemodiafiltrasyonun karşılaştırılması. Zeynep Kamil Tıp Bülteni 45 4 178–185.
IEEE S. Conkar and S. Mir, “Üremik toksiklerin temizlenmesinde diyaliz ve online hemodiafiltrasyonun karşılaştırılması”, Zeynep Kamil Tıp Bülteni, vol. 45, no. 4, pp. 178–185, 2014, doi: 10.16948/zktb.26011.
ISNAD Conkar, Seçil - Mir, Sevgi. “Üremik Toksiklerin Temizlenmesinde Diyaliz Ve Online Hemodiafiltrasyonun karşılaştırılması”. Zeynep Kamil Tıp Bülteni 45/4 (October 2014), 178-185. https://doi.org/10.16948/zktb.26011.
JAMA Conkar S, Mir S. Üremik toksiklerin temizlenmesinde diyaliz ve online hemodiafiltrasyonun karşılaştırılması. Zeynep Kamil Tıp Bülteni. 2014;45:178–185.
MLA Conkar, Seçil and Sevgi Mir. “Üremik Toksiklerin Temizlenmesinde Diyaliz Ve Online Hemodiafiltrasyonun karşılaştırılması”. Zeynep Kamil Tıp Bülteni, vol. 45, no. 4, 2014, pp. 178-85, doi:10.16948/zktb.26011.
Vancouver Conkar S, Mir S. Üremik toksiklerin temizlenmesinde diyaliz ve online hemodiafiltrasyonun karşılaştırılması. Zeynep Kamil Tıp Bülteni. 2014;45(4):178-85.