Maligniteye Eşlik Eden Bir Santral Sinir Sistemi Aktinomikozu

Yıl 2022, Cilt: 11 Sayı: 1, 107 - 111, 29.04.2022

Safiye Bilge Güçlü Kayta , Sevil Alkan , Anıl Akça , Taylan Önder , Alper Şener

Öz

Actinomyces, ağız içi florada bulunan ve nadiren granülomatoz süpüratif infeksiyona yol açan gram pozitif, anaerob bir basildir. Servikofasiyal infeksiyon genellikle kötü ağız hijyeni veya immunsupresif hastalığı bulunan kişilerde, etkenin daha derine ulaşmasına olanak sağlayan durumlarda ortaya çıkar. Actinomyces türlerinin santral sinir sistemi tutulumu oldukça nadir görülür. Radyolojik ve klinik olarak santral sinir sistemi maligniteleriyle karışabileceği gibi, olgumuzda olduğu gibi bunlarla birlikte de görülebilir. Bu tür vakalarda hastaların mutlaka klinik, görüntüleme bulguları ve mikrobiyolojik ve patolojik incelemelerle birlikte değerlendirilmesi gerekir. Bu olgu sunumunda, merkezi sinir sistemi malignitesine eşlik eden bir Actynomices spp.’e bağlı beyin absesi olgusu sunulmak istenmiştir.

Anahtar Kelimeler

Aktinomikoz, santral sinir sistemi, malignite, beyin, abse

A Central Nervous System Actinomycosis Accompanying Malignancy

Öz

Actinomyces is a gram-positive anaerobic bacillus found in the intraoral flora and rarely causes granulomatous suppurative infection. Cervicofacial infection usually occurs in people with poor oral hygiene or immunosuppressive disease, in situations that allow the agent to reach deeper. Central nervous system involvement of Actinomyces species is extremely rare. It can be confused with central nervous system malignancies radiologically and clinically. In such cases, patients must be evaluated together with clinical, imaging findings, and microbiological and pathological examinations. In this case report, we aimed to present a case of brain abscess due to Actynomices spp. which accompanying with central nervous system malignancy.

Anahtar Kelimeler

Actinomycosis, central nervous system, malignancy, brain, abcess

Kaynakça

• 1. Saleem MA, Ul Abideen Z, Kiani IS, Yousaf A, Rasheed A, Shabbir RW. Sporadic actinomycosis of the hip complicated by Central Nervous System infection. J Pak Med Assoc 2017;67(4):637-40.
• 2. LoCicero J, Jason PS, Richard SL. Surgery for Other Pulmonary Fungal Infections, Actinomyces, and Nocardia. Thorac Surg Clin 2012; 22: 363-74.
• 3. Imamura K, Kamitani H, Nakayasu H, Asai Y, Nakashima K. Purulent meningitis caused by Actinomyces successfully treated with rifampicin: a case report. Intern Med 2011;50(10):1121-5. doi: 10.2169/internalmedicine.50.4841.
• 4. Van Dellen JR. Actinomycosis: an ancient disease difficult to diagnose. World Neurosurg 2010;74(2–3):263–4.
• 5. Wong VK, Turmezei TD, Weston VC. Actinomycosis. BMJ 2011;11:343.
• 6. Valour F, Sénéchal A, Dupieux C, Karsenty J, Lustig S, Breton P, et al. Actinomyocis .etiology, clinical features, diagnosis, treatment and management. Infect Drug Resist 2014;7: 183-97.
• 7. Gajdács M, Urbán E, Terhes G. Microbiological and Clinical Aspects of Cervicofacial Actinomyces Infections: An Overview. Dent J (Basel) 2019;7(3):85. doi: 10.3390/dj7030085.
• 8. Boyanova L, Kolarov R, Mateva L, Markovska R, Mitov I. Actinomycosis: a frequently forgotten disease. Future Microbiol 2015;10(4):613-28. doi: 10.2217/fmb.14.130
• 9. https://www.uptodate.com/contents/treatment-of actinomycosis (Erişim tarihi: 18 Aralık 2020)
• 10. Ponfick E. Die Actinomykose des Menschen, eine neue Infections krankheit anf vergleichend-pathologischer nnd experimenteller Grundlage geschildert. Berlin: A Hirschwald. 1882. p. 132
• 11. Friedman ED, Levy HH. Actinomycotic infection of the central nervous system. Report of a case and review of the literature. Int Clin 1937;2:36-6.
• 12. Budenz CL, Tajudeen BA, Roehm PC. Actinomycosis of the temporal bone and brain: case report and review of the literature. Ann Otol Rhinol Laryngol 2010;119(5):313-8. doi: 10.1177/000348941011900507.
• 13. Akyol D, Işıkgöz Taşbakan M, Taşbakan MS, Pullukçu H, Ceylan N, Yamazhan T. Zor Tanı Kolay Tedavi: Aktinomikoz. Flora 2016;21(4):169-75.
• 14. Böhm I, Willinek W, Schild HH. Magnetic resonance imaging meets immunology: an unusual combination of diagnostic tools leads to the diagnosis actinomycosis. Am J Gastroenterol 2006;101(10):2439-40. doi: 10.1111/j.1572-0241.2006.00742_7.x.