Clinicopathological evaluation of our patients with ultrasound assisted percutaneous kidney biopsy

Yıl 2022, Cilt: 4 Sayı: 3, 295 - 299, 26.07.2022

Tamer Selen , Mehmet Deniz Aylı , Gülay Ulusal Okyay , Hatice Şahin , Elif Kahraman Güner , Kadir Gökhan Atılgan , Fatma Ayerden Ebinç , Ebru Gök Oğuz , Arzu Sağlam , Onur Ergun

https://doi.org/10.38053/acmj.1106533

Öz

Aim: This study aims to determine the frequency of kidney diseases based on histological diagnosis and to evaluate the relationship between clinical and histopathological findings in patients undergoing percutaneous kidney biopsy for various indications.
Material and Method: In this cross-sectional study, demographic, anthropometric and laboratory data of the patients were obtained retrospectively from medical files and computer records. Biopsy indications and histopathological diagnoses (primary glomerular diseases, secondary glomerular diseases, tubulointerstitial diseases and other causes) of the patients were examined.
Results: Of 103 patients, 57 (55.3%) were male and 46 (44.7%) were female. The mean age of the patients was 44.67±15.29 years. The most common biopsy indication was hematuria+proteinuria+renal dysfunction (n=28, 27.2%). The most common pathology in histopathological diagnoses was primary glomerular diseases (56.3%), the most common diagnosis was IgAN (n=16, 15.5%). Tubulointerstitial diseases were seen more frequently in the 60 years and older group. (n=4, 25%). The most common cause of secondary glomerulonephritis was AA amyloidosis. The number of tubular disorders increased with advanced age.
Conclusion: In our center, renal biopsy was performed most frequently with the combination of proteinuria, hematuria, and renal dysfunction. The most common histopathological result was primary glomerulonephritis, in which IgAN took the first place.

Anahtar Kelimeler

glomerulonephritis, histopathological diagnoses, renal biopsy

Kaynakça

• Korbet SM. Percutaneous renal biopsy. Semin Nephrol 2002; 22: 254-67.
• Topham PS, Chen Y.: Renal Biopsy. In: Investigation of Renal Disease, Feehally J. Floege J. Tonelli M. Johnson RJ (eds). Comprehensive Clinical Nephrology, 6th ed. China: Elsevier; 2019: 72-9
• Stratta P, Canavese C, Marengo M, et al. Risk management of renal biopsy: 1387 cases over 30 years in a single centre. Eur J Clin Invest 2007; 37: 954-63.
• Gesualdo L, Di Palma AM, Morrone LF, Strippoli GF, Schena FP. Italian Immunopathology Group, Italian Society of Nephrology. The Italian experience of the national registry of renal biopsies. Kidney Int 2004; 66: 890-4.
• Pişkinpaşa S, Dede F, Akoğlu H, et al. Böbrek biyopsilerinin klinikopatolojik değerlendirmesi: Tek merkez deneyimi. Turk Neph Dial Transpl 2012; 21: 167-72.
• O’Shaughnessy MM, Hogan SL, Poulton CJ, et al. Temporal and demographic trends in glomerular disease epidemiology in the southeastern United States, 1986-2015. Clin J Am Soc Nephrol 2017; 12: 614-23.
• Rivera F, López-Gómez JM, Pérez-García R. Spsnish Registry of Glomerulonephritis. Frequency of renal pathology in Spain 1994-1999. Nephrol Dial Transplant 2002; 17: 1594-602.
• Rychlík I, Jancová E, Tesar V, et al. The Czech registry of renal biopsies. Occurrence of renal diseases in the years 1994-2000. Nephrol Dial Transplant 2004; 19: 3040-9.
• Schena FP. Survey of the Italian Registry of Renal Biopsies. Frequency of the renal diseases for 7 consecutive years. The Italian Group of Renal Immunopathology. Nephrol Dial Transplant 1997; 12: 418-26.
• Heaf J, Løkkegaard H, Larsen S. The epidemiology and prognosis of glomerulonephritis in Denmark 1985-1997. Nephrol Dial Transplant 1999; 14: 1889-97.
• National Nephrology, Dialysis and Transplantation Registry Report of Turkey 2020. Türk Nefroloji Derneği Yayınları Ankara 2021.
• Simon P, Ramee MP, Boulahrouz R, et al. Epidemiologic data of primary glomerular diseases in western France. Kidney Int 2004; 66: 905-8.
• Hanko JB, Mullan RN, O’Rourke DM, McNamee PT, Maxwell AP, Courtney AE. The changing pattern of adult primary glomerular disease. Nephrol Dial Transplant 2009; 24: 3050-4.
• Swaminathan S, Leung N, Lager DJ, et al. Changing incidence of glomerular disease in Olmsted County, Minnesota: a 30-year renal biopsy study. Clin J Am Soc Nephrol 2006; 1: 483-7.
• Hou JH, Zhu HX, Zhou ML, et al. Changes in the spectrum of kidney diseases: an analysis of 40,759 biopsy-proven cases from 2003 to 2014 in China. Kidney Dis 2018; 4: 10-9.
• Chang JH, Kim DK, Kim HW, et al. Changing prevalence of glomerular diseases in Korean adults: a review of 20 years of experience. Nephrol Dial Transplant 2009; 24: 2406-10.
• Ecder SA, Kılıçaslan I, Ecder T ve ark. Beşyüzonüç böbrek biyopsisinin klinikopatolojik açıdan değerlendirilmesi. J Ist Faculty Med 2005; 68: 43-5.
• Kidney Disease: Improving Global Outcomes (KDIGO) Glomerular Diseases Work Group. KDIGO 2021 clinical practice guideline for the management of glomerular diseases. Kidney Int 2021; 100: 1-276
• Aydın, E, Yılmaz Aydın, F, Yılmaz, E, Alabalık, U. Böbrek biyopsilerinin histopatolojik değerlendirilmesi: tek merkez yedi yıllık deneyim. Dicle Tıp Derg 2020; 47: 417-22
• Yılmaz T, Alp A, Akdam H. Böbrek biyopsisi yapılan olgularımızın retrospektif genel değerlendirilmesi ve histopatolojik alt gruplarının incelenmesi. Turk Neph Dial Transpl 2014; 23: 185-95.
• Salant JD, Cattran CD: Membranous Nephropathy. In: Glomeruler Disease, Feehally J. Floege J (eds.). Comprehensive Clinical Nephrology, 6th ed. China: Elsevier; 2019: 240-53
• Zhou FD, Shen HY, Chen M, et al. The renal histopathological spectrum of patients with nephrotic syndrome: an analysis of 1523 patients in a single Chinese centre. Nephrol Dial Transplant 2011; 26: 3993-7.
• Akarsu Ö, Aytuğ F, Yavuz A, et al. Hastanemiz nefroloji kliniğinde böbrek biyopsisi yapılan olguların özelliklerinin değerlendirilmesi. Turk Neph Dial Transpl 2016; 25: 245-50.
• Akın D, Sehmus Ö, Danış D: 2001-2007 döneminde nefrotik sendromlu 152 hastanın analizi. Turk Neph Dial Transpl 2008; 17: 74-6.