Comparison of Bipolar Disorder Patients with Healthy Controls in terms of Inflammatory Biomarkers

Yıl 2019, Cilt: 5 Sayı: 1, 1352 - 1360, 15.04.2019

Murat Eren Özen , Mehmet Hamdi Örüm , Mehmet Bertan Yılmaz , Aysun Kalenderoğlu

https://doi.org/10.30569/adiyamansaglik.481915

Cited By: 3

Öz

Aim:
Inflammatory
changes occur in various episodes of Bipolar Disorder (BD) Type 1. These
changes can be considered as peripheral symptoms of the disorder. In this study,
we aimed to compare the BD patients in the manic, depressive and euthymic
period with respect to healthy control group and inflammatory biomarkers.

Method:
Interleukins
(IL) and tumor necrosis factor (TNF) values were measured and compared in 78
healthy controls and 108 patients with BD.

Results:
In the
subgroup of mania, the rate of psychiatric hospitalization was higher compared
to the subgroups of depression or subgroup (p=0.041). When the blood values of
peripheral biomarkers (IL-2, IL-4, IL-8, IL-10 and TNFα) were compared, there
was no statistically significant difference between the three subgroups of BD
(mania, depression and euthymic) and healthy control group (p>0.05).

Conclusions:
There was
no significant difference between the control group and the BD subgroups in
terms of IL and TNF levels. Further studies are needed to clarify the issue.

Anahtar Kelimeler

Interleukin, tumor necrosis factor, bipolar disorder, inflammation

İnflamatuar Biyobelirteçler Açısından Bipolar Bozukluk Tip 1 Tanılı Hastaların Sağlıklı Kontrollerle Karşılaştırılması

Öz

Amaç:
Bipolar
Bozukluk (BB) Tip 1’in çeşitli epizotlarında inflamatuar değişiklikler ortaya
çıkar. Bu değişiklikler bozukluğun periferik belirtileri olarak
değerlendirilebilir. Biz bu çalışmada, manik, depresif ve ötimik dönemdeki BB
hastalarını kendi aralarında ve sağlıklı kontrol grubu ile inflamatuar
biyobelirteçler açısından karşılaştırmayı amaçladık.

Yöntem:
İnterlökinler
(IL) ve tümör nekrozis faktör (TNF) değerleri 78 sağlıklı kontrol ve 108 BB
tanılı hastada ölçüldü ve karşılaştırıldı.

Bulgular:
Mani alt grubunda, depresyon veya ötimi alt gruplarına
göre daha fazla psikiyatrik yatış oranı görülmüştür (p=0.041). Periferik biyobelirteçlerin
(IL-2, IL-4, IL-8, IL-10 ve TNFα) kan değerlerini karşılaştırıldığında BB
(mani, depresyon ve ötimi)’nin 3 alt grubu ve kontrol grubu arasında
istatistiksel olarak anlamlı fark bulunmadı (p>0.05).

Sonuçlar:
IL ve TNF
seviyeleri açısında BB ve kontrol grubu arasında ve BB alt grupları arasında
farklılık yoktu. Örneklem sayısının artırıldığı çalışmalara ihtiyaç
duyulmaktadır.

Anahtar Kelimeler

İnterlökin, tümör nekrozis faktör, bipolar bozukluk, inflamasyon

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