Metallothionein Proteins in Aquacultural Products

Yıl 2018, Cilt: 15 Sayı: 2, 107 - 112, 31.12.2018

Semra Küçük

https://doi.org/10.25308/aduziraat.427601

Öz

Nowadays, water and environment have been polluted in a fast manner by domestic, agricultural and industrial activities. As a matter of fact that water, soil and atmosphere are polluted, aquacultural products in the nature or cultivated habitat are contaminated by heavy metals. Therefore, there is a protective protein called metallothionein in aquacultural products to protect them from heavy metal toxicity. Metallothionein is well used as heavy metals indicators in aquatic organisms such as brown trout, white shrimp, freshwater mussel and crab., Descirption of the metallothionein and its features, and the studies evaluating the metallothionein as heavy metals indicators in aquatic organisms is presented in this review.

Anahtar Kelimeler

metallothionein, indicator, heavy metal, aquacultural products

Su Ürünlerinde Metallotionein Proteinleri

Öz

Günümüzde su ve çevre evsel, tarımsal
ve endüstriyel faaliyetler ile hızlı bir şekilde kirlenmektedir. Bu kirliliğin içinde ağır metal kirliliği oldukça
önemli bir yer tutmaktadır. Suyun, toprağın ve atmosferin ağır metallerle
kirlenmesi sonucu, doğal ortamlarında yaşayan veya yetiştiriciliği yapılan su
ürünleri ağır metallerle kontamine olmaktadır. Bu nedenle, su ürünleri, ağır
metal zehirlenmesine karşı kendini korumak için metallotionein olarak
isimlendirilen korucu bir protein oluşturmaktadırlar. Metallotioneinler su
ürünlerinden kahverengi alabalıklarda, tatlısu midyelerinde, yengeçlerinde ve
beyaz karideslerde başarılı şekilde kirlilik indikatörü olarak
kullanılmaktadır. Metallotionein tanımına ve özelliklerine ve ayrıca sucul
canlılarda ağır metal indikatörü olarak metallotioneinlerin kullanıldığı araştırmalara
bu derlemede yer verilmiştir.

Anahtar Kelimeler

metallotionein, indikatör, ağır metal, su ürünleri

Kaynakça

• Acker LA, Mcmahan JR, Gawel JE (2005) The effect of heavy metal pollution in aquatic environmentals on metallothionein production in Mytillus sp. Proceedings of the 2005 Puget Sound Georgia Basin Research.
• Bais UE, Lokhande MV (2012) Effect of cadmium chloride on histopathological changes in the freshwater fish Ophiocephalus striatus (Channa). International Journal of Zoological Research 8: 23-32.
• Bayhan T, Ünübol Aypak S (2016) Büyük Menderes Deltasından avlanan kefal ve levreklerde Cu, Zn ve Cd düzeylerinin belirlenmesi ve metalotiyonin ile ilişkisinin araştırılması. Gıda 41(5):359-365.
• Begum A, Mustafa AI Amin MN, Chowdhury TR, Quraihi SB, Banu N (2013) Levels of heavy metals in tissues of shingi fish (Heteropneustes fossilis) from Buriganga River, Bangladesh. Environmental Monitoring Assessment 185:5461-5469.
• Capdevila M, Atrian S (2011) Metallothionein protein evolution: a miniassay. Journal of Biological Inorganic Chemistry 16(7):977-989.
• Cobbett C, Goldsbrough P (2002) Phytochelatins and metallothioneins: Roles in heavy metal detoxification and homeostasis. Annual Review Plant Biology 53:159-182.
• Coyle P, Philcox JC, Carey LC, Rofe AM (2002) Metallothionein the multipurpose protein. Cellular Molecular Life Sciences 59:627-647.
• Çalta M, Canpolat Ö, Nacar A (2000) Elazığ Keban Baraj Göl’nde yakalanan Capoeta trutta (HECKEL, 1843)’da bazı ağır metal düzeylerinin belirlenmesi, Doğu Anandolu Bölgesi IV. Su Ürünleri Sempozyumu, 28-30 Haziran 2000, Erzurum.
• Dąbrowska G (2012) Plant metallothioneins: Putative functions identified by promoter analysis in silico. Acta Biologica Cracoviensia Series Botanica 54:109-120.
• de Miranda JR, Thomas MA, Thurman DA, Tomsett AB (1990) Metallothionein genes from the flowering plant Mimulus guttatus. Fresenius Environmental Bulletin 260(2):277-280.
• Figueiredo-Fernandes A, Ferreira-Cardoso JV, Garcia-Santos S, Monteiro SM, Carrola J, Matos P, Fernandes AF (2007) Histopathological changes in liver and gill epithelium of Nile tilapia, tilapia, Oreochromis niloticus, exposed to waterborne copper. Pesquisa Veterinaria Brassileira 27(3):103-109.
• Ghasemian S, Karimzadeh K., Zahmatkesh A. 2016. Metallothionein levels and heavy metals in Caspian Sea gammarid, Pontogammarus maeticus (Crustacea, Amphipoda, Pontogammaridae). Bioflux 9(1):1-7.
• Hamer DH (1986) Metallotionein. Annual Review Biochemistry 55:913-951.
• Hassinen V, Tervahauta A, Schat H, Kärenlampi S (2011) Plant metallothioneins-metal chelators with ROS scavenging activity? Plant Biology 13:225-232.
• Higashimoto M, Isoyama N, Ishibashi S, Inoue M, Takiguchi M, Suzuki S, Ohnishi Y Sato, M (2009) Tissue-dependent preventive effect of metallothionein against DNA damage in dyslipidemic mice under repeated stresses of fasting or restraint. Life Sciences 84:569-575.
• Kägi JH, Vallee BL (1960) Metallothionein: A cadmium-and zinc-containing protein from equine renal cortex. Journal Biological Chemistry 235:3460-3465.
• Kalay M, Canlı M (2000). Elimination of Essential (Cu, Zn) and non-essential (Cd, Pb) metals from tissues of a freshwater fish Tilapia zilli. Turkish Journal of Zoology 24: 429-436.
• Kojima Y, Berger C, Vallee BL, Kägi J (1976) Amino-acid sequence of equine renal metallothionein-1B. Proceeding of the National Academy, Sci. USA 73:3413-3417.
• Kovarova J, Kizek R, Adam V, Harustiakova D, Celechovska O, Svobodova Z (2009) Effect of cadmium chloride on metallothionein levels in carp. Sensors 9:4789-4803.
• Küçük S (2018) Balıklarda Ağır Metal Birikimlerinin İncelenmesi, Uluslararası Su ve Çevre Kongresi. Sözlü Bildiri, 22-24. Mart. 2018. Bursa-Türkiye.
• Küçük S, Midilli S, Güler M, Çoban D (2018) Kadmiyuma Maruz Bırakılmış Sarı Prenses (Labidochromis caeruleus) Balıklarında Saptanan Histolojik Değişiklikler Üzerine Bir Ön Çalışma. Ege Su Ürünleri Dergisi 35(3):261-266.
• Li Y, Kimura T, Laity JH, Andrewa GK (2006) The zinc sensing mechanism of mouse MTF-1 involves linker peptides between the zinc fingers. Molecular and Cellular Biology 26:5580-5587.
• Li Y, Yang H, Liu N, Luo J, Wang Q,Wang L (2015) Cadmium accumulation and metallothionein biosynthesis in cadmium-treated freshwater mussel Anodonta woodiana. Plos One 10(2):1-15.
• Linde AR, Sanchez-Galan S, Valles-Mota P, Garcia-Vazquez E (2001) Metallothionein as bioindicator of freshwater of metal pollution: European eel and brown trout. Ecotoxicology and Environmental Safety 49:60-63.
• Liu J-Y, Lu T, Zhao N-M (2000) Classification and nomenclature of plant metallothionein-like proteins based on their cysteine arrangement patterns. Acta Botanica Sinica 42:649-652.
• Liu XJ, Luo Z, Li CH, Xiong BX, Zhao YH, Li XD (2011) Antioxidant responses, hepatic intermediary metabolism, histology and ultrastructure in Synechogobius hasta exposed to waterborne cadmium. Ecotoxicology and Environmental Safety 74:1156-1163.
• Loebus J, Leitenmaier B, Meissner D, Braha B, Krauss GJ, Dobritzsch D, Freisinger E (2013) The major function of a metallothionein from the aquatic fungus Heliscus lugdunensis is cadmium detoxification. Journal of Inorganic Biochemistry 127:253-260.
• Lv J, Ehteshami P, Samak MJ, Tighiouart H, Jun M, Ninomiya T, Foote C, Rodgers A, Zhang H, Wang H, Strippoli GF, Perkovic V (2013) Effects of intensive blood pressure lowering on the progression of chronic kidney disease: a systematic review and meta-analysis. CMAJ 185(11):949-957.
• Ma W, Wang L, He Y, Yan Y (2008) Tissue-specific cadmium and metallothionein levels in freshwater crab Sinopotamon henanense during acute exposure to waterborne cadmium. Environmental Toxicology 23(3):393-400.
• Margoshes M, Vallee BL (1957) A cadmium protein from equine kidney cortex. Journal of the American Chemical Society 79:4813-4814.
• Mol S, Özden Ö, Oymak SA (2010) Trace metal contents in fish species from Atatürk Dam Lake (Euphrates, Turkey). Turkish Journal of Fisheries and Aquatic Sciences 10: 209-213.
• Moksnes PO, Lindahl U, Haux C (1995) Metallothionein as a bioindicator of heavy metal exposure in the tropical shrimp, Penaeus vannamei: a study of dose-dependent induction. Marine Environmental Research 39:143-146.
• Overnell J, Abdullah MI (1988) Metallothionein and metal levels in flounder Platichthys flesus from four field sites and in flounder dosed with water-borne copper. Marine Ecology Progress Series 46:71-74.
• Omer SA, Elobeid MA, Fouad D, Daghestani MH (2012) Cadmium bioaccumulation and toxicity in tilapia fish (Oreochromis niloticus). Journal of Animal and Veterinary Advances 11: 1601-1606.
• Özkan E, Taşlıpınar MY, Yeşilkaya Ş (2018) Ağır Metal Zehirlenmeleri. http://www.jcam.com.tr/files/KATD-1599.pdf. (20 Kasım, 2018).
• Öztürk M, Bat L, Öztürk M (1995) Altınkaya Barajı’nda (Samsun) yaşayan Cyprinus carpio L., 1758 türünün çeşitli organ ve dokularındaki bazı ağır metallerin birikimi. II.Ulusal Ekoloji ve Çevre Kongresi Bildirileri, 11-13 Eylül, Ankara.
• Raimundo J, Costa PM, Vale C, Costa MH, Moura I (2010) Metallothionein and trace elements in digestive gland, gills, kidney and gonads of Octopus vulgaris. Comparative Biochemistry and Physiology Part C 152:139-146.
• Ryan KR, Menold MM, Garrett S, Jensen RE (1994) SMS1,a high-copy suppressor of the yeast mas6 mutant, encodes an essential inner membrane protein required for mitochondrial protein import. Molecular Biology of the Cell 5(5):529-538.
• Santovito G, Boldrin F, Irato P (2015) Metal and metllothionein distribution in different tissues of the Mediterranean clam Venerupis philippinarum during copper treatment and detoxification. Comparative Biochemistry and Physiology, Part C 174-175:46-53.
• Selvanathan J, Vincent S, Nirmala A (2013) Histopathology changes in freshwater fish Clarias batrachus (Linn.) exposed to mercury and cadmium. International Journal of Life Sciences and Pharma Research 3(2): 11-21.
• Siscar R, Torreblanca A, del Ramo J, Sole M (2014) Modulation of metallothionein and metal partitioning in liver and kidney of Solea senegalensis after long-term acclimation to two environmental temperatures. Environmental Research 132:197-205.
• Ünlü E, Cengiz Eİ, Akba O, Gümgüm B (1995) Dicle Nehrindeki Capoeta trutta Heckel, 1843’da ağır metal birikimi. II.Ulusal Ekoloji ve Çevre Kongresi Bildirileri, 11-13 Eylül, Ankara.
• Trinchella F, Esposito MG, Simoniello P, Scudiero R (2013) Cadmium, lead and metallothionein content in cultivated mussels (Mytillus galloproviancialis) from the Gulf of Naples (Southern Italy). Aquaculture Research 44:1076-1084.
• Thophon S, Kruatrachue M, Upatham ES, Pokethitiyook P, Sahaphong S, Jaritkhuan S (2003) Histopathological alterations of White seabass, Lates calcarifer, in acute and subchronic cadmium exposure. Environmental Pollution 121: 307-320.
• Vasak M (2005) Advances in metallotionein structure and functions. Journal of Trace Elements in Medicine and Biology 19:13-17.
• Van Dyk JC, Pieterse GM, Van Vuren JHJ (2007) Histological changes in the liver of Oreochromis mossambicus (Cichlidae) after exposure to cadmium and zinc. Ecotoxicology and Environmental Safety 66: 432-440.
• Velcheva IG, Arnaudov AD, Georgieva ES (2010) Influence of Zinc on Gill Morphology of Gibelio Carp (Carassius gibelio). Ecologia Balkanica 2:19-23.
• Vergani L, Grattarola M, Borghi C, Dondero F, Viarengo A (2005) Fish and molluscan metallothioneins. A structural and functional comparison. The FEBS Journal 272: 6014-6023.
• Wahid M, Prasarnpun S, Yimtragool N (2017) Cadmium accumulation and metallothionein gene expresion in the liver of swamp eel (Monopterus albus) collected from the Mae Sot District, Tak Province, Thailand. Genetic and Molecular Research 16(3):1-14.
• Wu JP, Chen HC (2005) Metallothionein induction and heavy metal accumulation in white shrimp Litopenaeus vannamei exposed to cadmium and zinc. Comparative Biochemistry and Physiology Part C 140:383-394.
• Yang M, Zhang F, Wang F, Dong Z, Cao Q, Chen M (2015) Characterization of a type I metallothionein gene from the stresses-tolerant plant Ziziphus jujuba. International Journal of Molecular Sciences 16:16750-16762.
• Yıldız M, Cenkci S, Terzi H (2012) Fitoşelatinler ve metallotiyoninler: moleküler yaklaşımlar. AKÜ FEBİD 12:1-16.
• Yılmaz M, Ersan Y, Koç E, Özen H, Karaman M (2011) Toxic effects of cadmium sulphate on tissue histopathology and serum protein expression in European chub, Leuciscus cepahlus (Linnaeus, 1758). Kafkas Üniversitesi Veteriner Fakültesi Dergisi 17:131-135.
• Younis E, Abdel-Wahab A, Nasser A, Hossam E (2015) Histopathological alterations in the liver and intestine of Nile tilapia Oreochromis niloticus exposed to long-term sublethal conentrations of cadmium chloride. Chinese Journal of Oceanology and Limnology 33: 846-852.
• Yu LH, Umeda M, Liu JY, Zhao NM, Uchimiya H (1998) A novel MT gene of rice plants is strongly expressed in the node portion of the stem. Gene 206:29-35.
• Yu LH, Liu JY, Umeda M, Uchimiya H, Zhao NM (2000) Cloning and sequence characteristics of the genomic gene of a rice metallothionein. China Science Bulletin 45:153-155.