COVID-19’UN SİNDİRİM SİSTEMİ ÜZERİNE ETKİLERİ

Yıl 2020, Cilt: 53 Sayı: Ek Sayı 1, 1 - 6, 30.06.2020

Rasim Hamutoğlu , Serpil Ünver Saraydın

https://doi.org/10.20492/aeahtd.753781

Cited By: 1

Öz

Yeni koronavirüs hastalığı şu anda büyük bir pandemiye neden olmaktadır. Aralık 2019'da Yeni koronavirüs-19’un patlak vermesinden bu yana, virüs bulaşmış hastalarda sıklıkla çeşitli sindirim semptomları bildirilmiştir. Hastalar tipik olarak ateş ve solunum yolu hastalığı ile başvururken, bazı hastalar ishal, kusma ve karın ağrısı gibi sindirim semptomlarını da bildirmektedir. Hastalığın şiddeti arttıkça, sindirim semptomları da belirgin hale gelmektedir. Sindirim semptomları olan hastaların ortalama karaciğer enzim düzeyleri, düşük monosit sayısı ile daha uzun protrombin zamanının olduğu ve sindirim semptomları olmayanlara göre daha fazla antimikrobiyal tedavi gördükleri çeşitli çalışmalarda gösterilmiştir. Klinisyenler, ishal gibi sindirim semptomlarının yaygın olarak Yeni koronavirüs-19 'un özellikleri arasında olduğunu ve sindirim semptomları ile başvuran risk altındaki hastalarda şüphe endeksinin daha erken yükseltilmesi gerektiğini fark etmelidir.

Anahtar Kelimeler

COVID-19, Karaciğer hasarı, Pnömoni, Sindirim sistemi enfeksiyonu

Kaynakça

• Gremel G, Wanders A, Cedernaes J, et al. The human gastrointestinal tract-specific transcriptome and proteome as defined by RNA sequencing and antibody-based profiling. J Gastroenterol. 2015; 50: 46–57.
• Phelan AL, Katz R, Gostin LO. The novel coronavirus originating in Wuhan, China: Challenges for global health governance. JAMA. 2020; 323: 709–10.
• Wu Y, Ho W, Huang Y, et al. SARS-CoV-2 is an appropriate name for the new coronavirus. Lancet. 2020; 395: 949–50.
• Zhou Y, Yang Y, Huang J, Jiang S, Du L. Advances in MERS-CoV Vaccines and Therapeutics Based on the Receptor-Binding Domain. Viruses. 2019; 11(1): 60.
• Weiss SR, Leibowitz JL. Coronavirus pathogenesis. Adv Virus Res. 2011; 81: 85–164.
• De Wilde AH, Snijder EJ, Kikkert M, van Hemert MJ. Host Factors in Coronavirus Replication. In: Tripp RA, Tompkins SM; eds. In Roles of Host Gene and Non-Coding RNA Expression in Virus Infection. Switzerland: Cham;2018.p.1–42.
• Khot WY, Nadkar MY. The 2019 novel coronavirus outbreak—A global threat. J Assoc Physicians India. 2020; 68: 67–71.
• Legido-Quigley H, Asgari N, Teo YY, et al. Are high-performing health systems resilient against the COVID-19 epidemic? Lancet. 2020; 395: 848–50.
• Wang P, Anderson N, Pan Y, et al. The SARS-CoV-2 outbreak: Diagnosis, infection prevention, and public perception. Clin Chem. 2020 Mar 10;hvaa080. [Epub ahead of print].
• Cascella M, Rajnik M, Cuomo A, Dulebohn SC, Di Napoli R. Features, Evaluation and Treatment Coronavirus (COVID-19). StatPearls:Treasure Island. 2020 May: PMID: 32150360 [Epub ahead of print] Review.
• Chen N, Zhou M, Dong X, et al. Epidemiological and clinical characteristics of 99 cases of 2019 novel coronavirus pneumonia in Wuhan, China: A descriptive study. Lancet. 2020; 395: 507–13.
• Wang D, Hu B, Hu C, et al. Clinical characteristics of 138 hospitalized patients with 2019 novel coronavirus-infected pneumonia in Wuhan, China. JAMA. 2020; 323: 1061–9.
• Young BE, Ong SWX, Kalimuddin S, et al. Epidemiologic features and clinical course of patients infected with SARS-CoV-2 in Singapore. JAMA. 2020; 323(15): 1488-94.
• Lee C, Huo T, Huang Y. Gastrointestinal and liver manifestations in patients with COVID-19. J Chin Med Assoc. 2020; 83(6): 521-3.
• Gao QY, Chen YX, Fang JY. 2019 novel coronavirus infection and gastrointestinal tract. J Dig Dis. 2020; 21(3): 125-6. doi: 10.1111/1751-2980.12851. 2020. [Epub ahead of print].
• Pan L, Mu M, Yang P, et al. Clinical Characteristics of COVID-19 Patients With Digestive Symptoms in Hubei, China: A Descriptive, Cross-Sectional, Multicenter Study. Am J Gastroenterol. 2020; 115: 766–73.
• Holshue ML, DeBolt C, Lindquist S, et al. First case of 2019 novel coronavirus in the United States. N Engl J Med. 2020; 382: 929–36.
• Huang C, Wang Y, Li X, et al. Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China. Lancet. 2020; 395: 497–506.
• Xu XW, Wu XX, Jiang XG, et al. Clinical findings in a group of patients infected with the 2019 novel coronavirus (SARS CoV-2) outside of Wuhan, China: retrospective case series. BMJ. 2020; 368: m606.
• Guan WJ, Ni ZY, Hu Y, et al. Clinical characteristics of coronavirus disease 2019 in China. N Engl J Med. 2020; 382: 1708-20.
• WHO. WHO issues consensus document on the epidemiology of SARS. Wkly Epidemiol Rec. 2003; 78: 373–5.
• Song Y, Liu P, Shi XL, et al. SARS-CoV-2 induced diarrhoea as onset symptom in patient with COVID-19. Gut. 2020; 69(6): 1143-4.
• Liang W, Feng Z, Rao S, et al. Diarrhoea may be underestimated: a missing link in 2019 novel coronavirus. Gut. 2020. [Epub ahead of print] Derleme.
• Jin Y, Yang H, Ji W, et al. Virology, Epidemiology, Pathogenesis, and Control of COVID-19. Viruses. 2020; 12: 372.
• Yeo C, Kaushal S, Yeo D. Enteric involvement of coronaviruses: is faecal- oral transmission of SARS-CoV-2 possible? Lancet Gastroenterol Hepatol. 2020; 5: 335–7.
• Chen L, Luo JH, Bai Y, Wang M. COVID-19 disease with positive fecal and negative pharyngeal and sputum viral tests. Am J Gastroenterol. 2020 May 115(5): 790. doi: 10.14309/ajg.0000000000000610. [Epub ahead of print] Case report.
• Wang W, Xu Y, Gao R, et al. Detection of SARSCoV-2 in different types of clinical specimens. JAMA. 2020; 323(18): 1843-4.
• Xiao F, Tang M, Zheng X, Liu Y, Li X, Shan H. Evidence for gastrointestinal infection of SARS-CoV-2. Gastroenterology. 2020; 158(6): 1831-3.
• Lin L, Jiang X, Zhang Z, et al. Gastrointestinal symptoms of 95 cases with SARS-CoV-2 infection. Gut. 2020; 69: 997–1001.
• Hoffmann M, Kleine-Weber H, Schroeder S, et al. SARS-CoV-2 cell entry depends on ACE2 and TMPRSS2 and is blocked by a clinically proven protease inhibitor. Cell. 2020; 181(2): 271-80.
• Yan R, Zhang Y, Li Y, Xia L, Guo Y, Zhou Q. Structural basis for the recognition of the SARS-CoV-2 by full-length human ACE2. Science. 2020; 367(6845): 1444-8.
• Wan Y, Shang J, Graham R, Baric RS, Li F. Receptor recognition by the novel coronavirus from Wuhan: an analysis based on decade-long structural studies of SARS coronavirus. J Virol. 2020; 94(7): e00127–20.
• sondakika.com/haber/haber-hasarin-en-net-goruntusu-koronavirus-sindim-13188404 [homepage on the Internet]. Türkiye: Haber Yayın Tarihi: 04.05.2020.
• Mao R, Liang J, Shen J, et al. Implications of COVID-19 for patients with pre-existing digestive diseases. Lancet Gastroenterol Hepatol. 2020; 5(5): 425-7.
• Ianiro G, Mullish BH, Kelly CR, et al. Screening of faecal microbiota transplant donors during the COVID-19 outbreak: suggestions for urgent updates from an international expert panel. Lancet Gastroenterol Hepatol. 2020; 5(5): 430-2.
• Repici A, Maselli R, Colombo M, et al. Coronavirus (COVID-19) outbreak: what the department of endoscopy should know. Gastrointest Endosc. 2020; (20): 30245-5. doi: 10.1016/j.gie.2020.03.019.
• Soetikno R, Teoh AYB, Kaltenbach T, et al. Considerations in performing endoscopy during the COVID-19 pandemic. Gastrointest Endosc. 2020; 20: 34033-5. doi: 10.1016/j.gie.2020.03.3758.
• ESGE. ESGE and ESGENA Position Statement on gastrointestinal endoscopy and the COVID-19 pandemic. Endoscopy. 2020; 52(6): 483-90.
• Xu L, Liu J, Lu M, Yang D, Zheng X. Liver injury during highly pathogenic human coronavirus infections. Liver Int. 2020; 40(5): 998-1004.
• Zhang C, Shi L, Wang FS. Liver injury in COVID-19: management and challenges. Lancet Gastroenterol Hepatol. 2020; 5(5): 428-30.
• Chau TN, Lee KC, Yao H, et al. SARS associated viral hepatitis caused by a novel coronavirus: report of three cases. Hepatology. 2004; 39: 302–10.
• Xu Z, Shi L, Wang Y, et al. Pathological findings of COVID-19 associated with acute respiratory distress syndrome. Lancet Respir Med. 2020; 8(4): 420-2.
• Tang A, Tong ZD, Wang HL, et al. Detection of novel coronavirus by RTPCR in stool specimen from asymptomatic child, China. Emerg Infect Dis. 2020; 26(6): 1337-9.
• Li M, Wang B, Zhang M, et al. Symbiotic gut microbes modulate human metabolic phenotypes. Proc Natl Acad Sci USA. 2008; 105: 2117–22.
• Budden KF, Gellatly SL, Wood DL, et al. Emerging pathogenic links between microbiota and the gut-lung axis. Nat Rev Microbiol. 2017; 15: 55–63.
• He Y, WenQ, Yao F, et al. Gut-lung axis: The microbial contributions and clinical implications. Crit Rev Microbiol. 2017; 43: 81–95.