Islak Kupa Tedavisinin Oksidatif Stres İndeksi ve Total Anti Oksidan Kapasite Düzeylerine Etkisinin Araştırılması: Pilot Bir Çalışma

Yıl 2021, Cilt: 5 Sayı: 2, 134 - 139, 25.08.2021

Hasan Esat Yücel , Kenan Güçlü , Cahit Uçar , Selcen Duran , Naime Meriç

https://doi.org/10.46332/aemj.836358

Öz

Amaç: Islak kupa tedavisi bilinen en eski tedavi yöntemlerinden biridir. Son zamanlarda oksidanları uzaklaştırarak, oksidatif stresi azalttığına dair bazı çalışmalar yapılmıştır. Ancak bu çalışmalar sınırlı sayıdadır. Amacımız ıslak kupa tedavisinin oksidan ve anti-oksidan sistem üzerindeki etkinliğini araştırmaktır.

Araçlar ve Yöntem: Çalışmamıza 26 hasta dahil edildi. Islak kupa tedavisinde hemen önce venöz kan örneklemesi yapıldı. Kupa tedavisiyle birlikte kupaya dolan kandan, işlemden hemen sonra ve 14. günde yine venöz kandan örneklemeleri yapıldı. Tüm örnek-lerden total oksidan düzey, total anti-oksidan düzey ve oksidatif stress indeksi düzeyleri çalışılarak karşılaştırılması yapıldı.

Bulgular: Kupa kanındaki total oksidan düzey, total anti-oksidan düzey ve oksidatif stres indeksi seviyeleri, tüm venöz kan parametrelerinden yüksek bulundu. Uygulama sonrası, total oksidan ve total anti-oksidan düzeylerde belirgin bir değişiklik olmazken, oksidatif stres indeksi önemli bir şekilde azalmıştır.

Sonuç: Islak kupa tedavisi, oksidatif doku hasarının en önemli göstergesi olan oksidatif stres indexini azaltır. Bu nedenle oksidatif doku hasarıyla ilişkili hastalıkların tedavisinde yer alabilir.

Anahtar Kelimeler

ıslak kupa tedavisi, oksidatif stres indeksi, total oksidan düzey, total anti-oksidan düzey

Proje Numarası

TIP.A4.19.012(D16)

Study on the Effect of Wet Cupping Therapy on Oxidative Stres Index and Total Antioxidant Capacity Levels: A Pilot Study

Öz

Purpose: Wet cupping treatment is one of the oldest known methods of treatment.Recently, some studies have shown that wet cupping therapy removes oxidants and reduces oxidative stres.However, these studies are limited.The aim of this study is to investigate the effectiveness of wet cupping treatment on oxidant-anti oxidant system.

Materials And Methods: Our study consisted of 26 patients. Right before the wet cupping treatment, venous blood samples were collected. During the procedure, samples were collected from the cup blood. Right after the wet cupping treatment venous blood samples were collected again. On the 14th day, the participants were called and venous blood samples were collected. In all of these samples, total oxidant level (TOS), oxidative stress index (OSI) and total antioxidant level (TAS) levels were studied and compared.

Results: Total anti-oxidant level, total oxidant level and oxidative stress index levels in cup blood were higher than all venous blood samples.
While there was no significant change in TAS and TOS levels after the application, oxidative stress index levels decreased significantly.

Conclusions: Wet cupping therapy reduced the oxidative stress index.

Key Words:Wet Cupping Treatment, Oxidative Stress Index Total Oxidant Level and Total Anti-Oxidant Level

Anahtar Kelimeler

oxidative stress ındex, wet cupping treatment, total oxidant level, total anti-oxidant level

Proje Numarası

TIP.A4.19.012(D16)

Kaynakça

• 1. Ullah K, Younis A, Wali M. An investigation into the effect of Cupping Therapy as a treatment for Anterior Knee Pain and its potential role in Health Promotion. Internet J. Altern Med. 2007;4(1):1‐9.
• 2. Michalsen A, Bock S, Lüdtke R, et al. Effects of Traditional Cupping Therapy in Patients With Carpal Tunnel Syndrome: A Randomized Controlled Trial. J. Pain. 2009;10(6):601‐8.
• 3. Eisenberg DM, Davis RB, Ettner SL, et al. Trends in Alternative Medicine Use in the United States, 1990‐1997: Results of a Follow‐up National Survey. JAMA 1998;280(18):1569‐1575.
• 4. Christopoulou Aletra H, Papavramidou N. Cupping: an alternative surgical procedure used by Hippocratic physicians. J Altern Complement Med. 2008;14(8):899‐902
• 5. Kim T, Kang JW, Kim KH, et al. Cupping for Treating Neck Pain in Video Display Terminal (VDT) Users: A Randomized Con-trolled Pilot Trial. J Occup. Health. 2012;54(6):416‐426.
• 6. Yoo SS, Tausk F. Cupping: East meets West. Int J Dermatol. 2004;43(9):664-665.
• 7. Ersoy S,İnci H, Sunay D, et al. Wet Cupping Therapy Improves Health Related Quality of Life: A Self‐Controlled Interventional Study. Ankara Med J. 2019;(1):270‐277.
• 8. Karabulut AR. Tıbb-ı Nebevî Ansiklopedisi 1-2, 6. baskı. Ankara: Kozan Ofset; 2006.
• 9. Zhang SJ, Liu JP, He KQ. Treatment of acute gouty arthritis by bloodletting cupping plus herbal medicine. J Tradit Chin Med. 2010;30(1):18‐20.
• 10. Ahmedi M, Siddiqui MR. The value of wet cupping as a therapy in modern medicineAn Islamic Perspective. Webmed Central Alternative Medicine. 2014;5(12):WMC004785.
• 11. Cao H, Li X, Liu J. An updated review of the efficacy of cupping therapy. PloS one 2012;7(2):e31793.
• 12. El Sayed SM, Mahmoud HS, Nabo MMH. Medical and scientific bases of Wet Cupping Therapy (Al-Hijamah): In Light of Modern Medicine and Prophetic Medicine. AlternInteg Med. 2013;2:1–16.
• 13. El Sayed SM, Al-Quliti A-S, Salah Mahmoud H,et al. Therapeutic Benefits of Al-hijamah: in Light of Modern Medicine and Prophetic Medicine. American Journal of Medical and Biological Research. 2014;2(2):46–71.
• 14. Kaki A, Sawsan R, Samiha M, et al. Wet Cupping Reduces Pain and Improves Health-related Quality of Life Among Patients with Migraine: A Prospective Observational Study. Oman Med J. 2019;34(2):105-109.
• 15. Kavadar G, Eroğlu Demir S, Aytekin E, Akbal Y. Use of traditional and complementary medicine for musculoskeletal diseases. Turk J Med Sci. 2019;49(3):809-814.
• 16. El-Shanshory M, Hablas NM, Shebl Y, et al. Al-hijamah (wet cupping therapy of prophetic medicine) significantly and safely reduces iron overload and oxidative stress in thalassemic children: a novel pilot study. J Blood Med. 2018; 9:241–251.
• 17. Tagil SM, Celik HT, Ciftci S. et al. Wet-cupping removes oxidants and decreases oxidative stress. Complement Ther Med. 2014;22(6):1032–1036.
• 18. Urso ML, Clarkson PM. Oxidative stress, exercise, and antioxidant supplementation, Toxicology. 2003;189(1-2):41-54.
• 19. Clarkson PM, Thompson HS. Antioxidants: What role do they play in physical activity and health?. Am J Clin Nutr. 2000;72(2):637-646.
• 20. Yeum KJ, Russell MR, Krinsky IN, Adlini G. Biomarkers of antioxidan capacity in hydrophilic and lipophilic compartments of human plasma. Arch. Biochem. Biophys. 2004;430(1):97-103.
• 21. Kisaoglu A, Borekci B, Yapca OE, Bilen H, Suleyman H. Tissue Damage and Oxidant/Antioxidant Balance. EAJM 2013;45(1):47-49.
• 22. Goulart M, Batoreu MC, Rodrigues AS, Laires A, Rueff J. Lipoperoxidation products and thiol antioxidants in chromium exposed workers. Mutagenesis. 2005;20(5):311-315.
• 23. Yuliani S, Mustofa, Partadiredja G.The neuroprotective effects of an ethanolic turmeric (Curcuma longa L.) extract against trimethyltin-induced oxidative stress in rats. Nutr Neurosci. 2018;7:1-8.
• 24. Dai DF, Chiao YA, Marcinek DJ, Szeto HH, Rabinovitchet PS. Mitochondrial oxidative stress in aging and healthspan. Longevity Healthspan. 2014;3(1):6.
• 25. Mei Y, Thompson MD, Cohen RA, Tong XY. Autophagy and oxidative stress in cardiovascular diseases. Biochim Biophys Acta. 2015;1852(2):243-251.
• 26. Erdamar H, Demirci H, Yaman H, et al. The effect of hypothyroidism, hyperthyroidism, and their treatment on parameters of oxidative stress and antioxidant status. Clin Chem Lab Med. 2008;46(7):1004-1010.
• 27. Weinberg F, Chandel NS. Reactive oxygen species-dependent signaling regulates cancer. Cell Mol Life Sci. 2009;66(23):3663-3673.
• 28. Kamat PK, Kalani A, Kyles P, Tyagi SC, Tyagi N. Autophagy of mitochondria: a promising therapeutic target for neurodegenera-tive disease. Cell Biochem Biophys. 2014;70(2):707-719.
• 29. Erel O. A novel automated direct measurement method for total antioxidant capacity using a new generation, more stable ABTS radical cation. Clin Biochem. 2004;37(4):277–285.
• 30. Erel O. A new automated colorimetric method for measuring total oxidant status. Clin Biochem. 2005;38(12):1103-1111.
• 31. Ersoy S, Altinoz E, Benli AR, et al. Investigation of wet cupping therapy’s effect on oxidative stress based on biochemical parameters. Eur J Integr Med. 2019;30:100946.