Retinopathy associated with interferon: Case report

Yıl 2017, Cilt: 16 Sayı: 2, 78 - 81, 29.08.2017

Müberra Akdoğan , Meral Akdoğan Kayhan Ahmet O. Gürakar Yasemin Üstündağ

https://doi.org/10.17941/agd.338682

Öz

nterferon therapy has been known to produce various
responses, such as creating an antiviral effect, inhibiting cell proliferation,
and modulating immunity. It has been used to treat various systemic disorders,
including neoplastic disease and chronic hepatitis. The agent is also known to
inhibit vascular endothelial cells and angiogenesis. Various adverse effects of
interferon therapy have been reported. Interferon is also known to cause ocular
toxicity such as retinopathy and subconjunctival hemorrhages. Thirty patients
with chronic hepatitis C between 21 and 52 years of age (female 16, male 14;
mean age 40.6) were treated with interferon 2 alpha and ribavirin. Seventeen
patients experienced different side effects, and one patient developed ocular
toxicity. We dropped out because of ocular side effects but ocular finding were
lasted.

Anahtar Kelimeler

Interferon, hepatitis C, retinopathy

İnterferon kullanımı ile ilişkili retinopati: Olgu sunumu

Öz

İnterferon tedavisi antiviral etkisi yanında,
hücre proliferasyonunu baskılamak, immün sistemi düzenlemek gibi değişik
nedenlerle kulanılmaktadır. BU ilaçların neoplastik hastalıklar, kronik viral
hepatit tedavisi yanında vasküler endotelyal hücre proliferasyonu ve
anjiogenezi baskılama gibi etkileri de vardır. İnterferon tedavisinin değişik
yan etkileri bulunmaktadır. Retinopati, konjunktiva altı kanamaları gibi oküler
toksisiteleri de bilinir. Biz burada; kronik hepatit C tanısı alan ve
interferon +ribavirin tedavisi sonrası retinopati gelişen bir vakayı sunacağız.
Hastanın oküler yan etkilerden dolayı interfeon tedavisinin kesilmesine rağmen
oküler bulgular uzun süre sebat etmiştir.

Anahtar Kelimeler

İnterferon, hepatit C

Kaynakça

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