Kolinesteraz İnhibitörlerinin Alzheimer Hastalığı Tedavisindeki Rolü

Yıl 2024, Cilt: 2 Sayı: 1, 42 - 45, 29.02.2024

Muhammet Gürkan Kurban , Murat Şentürk

https://doi.org/10.61845/agrimedical.1375889

Öz

Alzheimer Hastalığı (AH) günümüzde demansın en sık görülen nedeni olup özellikle yaşlı popülasyonda sıklıkla görülen bir nörodejeneratif bozukluktur. Prevalansının zamanla artması nedeniyle AH Dünya Sağlık Örgütü tarafından da ciddi bir sağlık problemi olarak belirtilmiştir. Günümüzde AH etiyolojisi tam olarak aydınlatılamamışsa da oluşumunda rol oynayan etmenlerden bazıları bilinmektedir. AH tedavi stratejisinde kolinerjik hipotez önemli bir yol açmıştır. Bu hipoteze göre geliştirilen tedavi stratejisini sinaptik yarıkta azalmış asetilkolin düzeyini arttırmak için asetilkolinesteraz ve butirilkolinesteraz olmak üzere iki kolinesterazın inhibisyonu oluşturmaktadır. Rivastigmin, galantamin ve donepezil günümüzde AH tedavisinde bu amaçla kullanılmakta olan ilaçlardır. Ancak bu ilaçların tedavi süresinin sınırlı olması ve yan etki profillerinin geniş olması yeni tedavileri gerektirmektedir.

Anahtar Kelimeler

Alzheimer, Kolinesteraz, Demans, İnhinitör

Kaynakça

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