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Experimental Models in Parkinson’s Disease: Advantages and Disadvantages

Yıl 2024, Cilt: 2 Sayı: 2, 80 - 87, 30.06.2024

Öznur Altunlu , Esma Topatan , Ziadoon Al-yaqoobi , Feyza Burul , Cemil Bayram , Selma Sezen , Irmak Ferah Okkay , Ufuk Okkay , Ahmet Hacımüftüoğlu

https://doi.org/10.61845/agrimedical.1471854

Öz

Parkinson’s disease is a complex neurodegenerative disease that affects millions of people worldwide. The incidence and prevalence of Parkinson’s disease, the second most common neurodegenerative disease after Alzheimer’s disease, is gradually increasing. Although it is an important public health concern, the mechanisms related to Parkinson’s disease have not been fully elucidated. One of the main approaches to research on mechanisms and treatment related to Parkinson’s disease is the use of experimental models. In vitro and in vivo models enable the investigation of disease-related molecular and cellular processes and the testing of potential treatments. A variety of experimental models are used in Parkinson’s disease research, including toxin-induced models, genetic models, and transgenic models, each with their strengths and limitations. Experimental models come to the fore in research on Parkinson’s disease, which does not yet have a radical treatment. However, it is important to recognize that no experimental model truly represents all aspects of human Parkinson’s disease. For this reason, the findings obtained from the studies need to be supported by different test systems and interpreted carefully. Experimental models are invaluable in the quest to elucidate the mechanism of Parkinson’s disease and develop effective treatments.

Anahtar Kelimeler

6-OHDA Haloperidol MPTP Paraquat Reserpine Rotenone

Kaynakça

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Parkinson Hastalığında Deneysel Modeller: Avantajlar ve Dezavantajlar

Yıl 2024, Cilt: 2 Sayı: 2, 80 - 87, 30.06.2024

Öznur Altunlu , Esma Topatan , Ziadoon Al-yaqoobi , Feyza Burul , Cemil Bayram , Selma Sezen , Irmak Ferah Okkay , Ufuk Okkay , Ahmet Hacımüftüoğlu

https://doi.org/10.61845/agrimedical.1471854

Öz

Parkinson hastalığı dünya çapında milyonlarca insanı etkileyen kompleks nörodejeneratif bir hastalıktır. Alzheimer hastalığından sonra en sık görülen ikinci nörodejeneratif hastalık olan Parkinson hastalığının insidansı ve prevalansı giderek artmaktadır. Önemli bir halk sağlığı problemi olmasına rağmen, Parkinson hastalığına ilişkin mekanizmalar tam olarak aydınlatılamamıştır. Parkinson hastalığıyla ilişkili mekanizmaların ve tedaviye yönelik araştırmaların temel yaklaşımlarından biri deneysel modellerin kullanılmasıdır. İn vitro ve in vivo modeller, hastalıkla ilişkili moleküler ve hücresel süreçlerin araştırılmasına ve potansiyel tedavilerin test edilmesine olanak sağlamaktadır. Toksin kaynaklı modeller, genetik modeller ve transgenik modeller de dahil olmak üzere, Parkinson hastalığı araştırmalarında her birinin güçlü ve sınırlayıcı yönleri bulunan çeşitli deneysel modeller kullanılmaktadır. Henüz radikal bir tedavisi bulunmayan Parkinson hastalığı araştırmalarında deneysel modeller ön plana çıkmaktadır. Ancak hiçbir deneysel modelin insandaki Parkinson hastalığının tüm yönlerini, tam anlamıyla temsil etmediğini kabul etmek önemlidir. Bu nedenle çalışmalardan elde edilen bulguların farklı test sistemleriyle desteklenmesi ve dikkatle yorumlanması gerekmektedir. Deneysel modeller, Parkinson hastalığının mekanizmasının aydınlatılması ve etkili tedaviler geliştirme arayışında paha biçilmez yöntemlerdir.

Anahtar Kelimeler

6-OHDA Haloperidol MPTP Parakuat Rezerpin Rotenon

Kaynakça

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  • 4. Armstrong MJ, Okun MS. Diagnosis and treatment of Parkinson disease: a review. JAMA. 2020;323(6):548-560.
  • 5. Hayes MT. Parkinson’s disease and Parkinsonism. Am J Med. 2019;132(7):802-807.
  • 6. Bloem BR, Okun MS, Klein C. Parkinson’s disease. Lancet. 2021;397(10291):2284-2303.
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  • 11. Jankovic J, Tan EK. Parkinson’s disease: etiopathogenesis and treatment. J Neurol Neurosurg Psychiatry. 2020;91(8):795-808.
  • 12. Reich SG, Savitt JM. Parkinson’s disease. Med Clin North Am. 2019;103(2):337-350.
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Toplam 108 adet kaynakça vardır.

Ayrıntılar

Birincil Dil İngilizce
Konular Sinirbilim (Diğer)
Bölüm Derleme Makalesi
Yazarlar

Öznur Altunlu 0000-0003-3192-3118

Esma Topatan 0009-0007-0420-216X

Ziadoon Al-yaqoobi 0000-0003-4691-728X

Feyza Burul 0009-0002-2193-1106

Cemil Bayram 0000-0001-8940-8560

Selma Sezen 0000-0001-6575-6149

Irmak Ferah Okkay 0000-0001-8836-9547

Ufuk Okkay 0000-0002-2871-0712

Ahmet Hacımüftüoğlu 0000-0002-9658-3313

Yayımlanma Tarihi 30 Haziran 2024
Gönderilme Tarihi 25 Nisan 2024
Kabul Tarihi 29 Mayıs 2024
Yayımlandığı Sayı Yıl 2024 Cilt: 2 Sayı: 2

Kaynak Göster

AMA Altunlu Ö, Topatan E, Al-yaqoobi Z, Burul F, Bayram C, Sezen S, Ferah Okkay I, Okkay U, Hacımüftüoğlu A. Experimental Models in Parkinson’s Disease: Advantages and Disadvantages. Ağrı Med J. Haziran 2024;2(2):80-87. doi:10.61845/agrimedical.1471854
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