Cancer and Phytotherapy

Yıl 2024, , 580 - 586, 19.09.2024

Ezgi Yaraşır , İrem Bulut

https://doi.org/10.53394/akd.1243419

Öz

The incidence of cancer is increasing in the world and in Turkey, but the survival rate of patients is prolonged due to early diagnosis and treatment opportunities. Cancer patients resort to traditional and complementary medicine (GETAT) methods as well as conventional medicine in treatment. In the literature, it has been seen that cancer patients commonly use phytotherapy among GETAT methods. In this review, 16 of the phytotherapy methods (nettle, pomegranate, green tea, thyme, garlic, flaxseed, sage, linden, grape seed, turmeric, black mulberry, ginger, chamomile, black cumin, ginseng, echinacea) used by cancer patients were examined. Considering the prevalence of phytotherapy use among cancer patients and the potential interactions of phytotherapy with drugs used in conventional treatment, it can be recommended that healthcare professionals be aware of this issue and inform cancer patients about the potential benefits and harms of phytotherapy.

Anahtar Kelimeler

Cancer, Traditional and Complementary Medicine, Phytotherapy.

Kanser ve Fitoterapi

Öz

Dünyada ve Türkiye'de kanser görülme sıklığı artmaktadır fakat erken teşhis ve tedavi olanakları nedeniyle hastaların hayatta kalma oranı uzamaktadır. Kanser hastaları tedavide, konvansiyonel tıbbın yanı sıra geleneksel ve tamamlayıcı tıp (GETAT) yöntemlerine de başvurmaktadır. Literatürde kanser hastalarının GETAT yöntemleri içerisinde fitoterapiyi yaygın kullandıkları görülmüştür. Bu derlemede kanser hastalarının kullandıkları fitoterapi yöntemlerinden 16’sı (ısırgan otu, nar, yeşil çay, kekik, sarımsak, keten tohumu, adaçayı, ıhlamur, üzüm çekirdeği, zerdeçal, karadut, zencefil, papatya, çörek otu, ginseng, ekinezya) incelenmiştir. Kanser hastaları arasında fitoterapi kullanımının yaygınlığı ve fitoterapinin konvansiyonel tedavide kullanılan ilaçlarla potansiyel etkileşimleri göz önüne alındığında, sağlık profesyonellerinin bu konunun farkında olmaları ve kanser hastalarının fitoterapinin potansiyel fayda ve zararları hakkında bilgilendirilmesi önerilebilinir.

Anahtar Kelimeler

Kanser, Geleneksel ve Tamamlayıcı Tıp, Fitoterapi.

Kaynakça

• 1. Kashyap AK, Dubey SK. Molecular mechanisms in cancer development. In: Jain B, Pandey S, eds. Understanding Cancer. Academic Press 2022:79-90.
• 2. Turan GB, Yanmis S, Gunduz Oruc F. Cancer patients' use of complementary and alternative treatments. International Journal of Caring Sciences 2020; 13(2):1297-304.
• 3. International Agency for Research on Cancer. Estimated number of new cases from 2020 to 2040, Both sexes, age [0-85+] 2020. [cited 2023 Jan 26]. Available from: https://gco.iarc.fr/tomorrow/en/dataviz/isotype?types=0&sexes=0&mode=population&group_populations=1&multiple_populations=1&multiple_cancers=0&cancers=39&populations=903_904_905_908_909_935
• 4. Taefehshokr S, Parhizkar A, Hayati S, Mousapour M, Mahmoudpour A, Eleid L, Rahmanpour D, Fattahi S, Shabani H, Taefehshokr N. Cancer immunotherapy: challenges and limitations. Pathology - Research and Practice 2022; 229:153723.
• 5. Kim D, Sung SH, Shin S, Park M. The effect of cancer on traditional, complementary and alternative medicine utilization in Korea: a fixed effect analysis using Korea Health Panel data. BMC Complementary Medicine and Therapies 2022; 22(1):137.
• 6. Mao JJ, Pillai GG, Andrade CJ, Ligibel JA, Basu P, Cohen L, Khan IA, Mustian KM, Puthiyedath R, Dhiman KS, Lao L, Ghelman R, Guido PC, Lopez G, Gallgo-Perez DF, Salicruo LA. Integrative oncology: Addressing the global challenges of cancer prevention and treatment. CA Cancer J Clin 2022; 72(2):144-64.
• 7. Sağlık Bakanlığı. Geleneksel Ve Tamamlayıcı Tıp Uygulamaları Yönetmeliği. 27.10.2014 [cited 2023 Jan 26]. Available from: https://www.resmigazete.gov.tr/eskiler/2014/10/20141027-3.htm.
• 8. Heinrich M. Phytotherapy: Encyclopedia Britannica. [cited 2023 Jan 26]. Available from: https://www.britannica.com/science/phytotherapy.
• 9. Uzun MB, Aykaç G, Özçelikay G. Bitkisel ürünlerin yanlış kullanımı ve zararları. Mersin Üniversitesi Tıp Fakültesi Lokman Hekim Tıp Tarihi ve Folklorik Tıp Dergisi 2014; 4(3):1-5.
• 10. Uğurlu M, Üstü Y, Dağcıoğlu BF. Onion (bulbus allii cepae) and garlic (bulbus allii sativi) use in phytotherapy. Ankara Medical Journal 2016;16(1):0-0.
• 11. ESCOP. The Scientific Foundation for Herbal Medicinal Products. [cited 2023 Jan 26]. Available from: https://escop.com/.
• 12. Jacevičiūtė E, Minelgaitė R, Liutkauskienė S. Complementary and alternative medicine remedies in the treatment of oncological patients – possible adverse effects and interactions with drugs: a literature review. Journal of Medical Sciences 2022; 10(1):191-9.
• 13. Girard L, Vohra S. Ethics of Using Herbal Medicine as Primary or Adjunct Treatment and Issues of Drug-Herb Interaction. In: Benzie IFF, Wachtel-Galor S, eds. Herbal Medicine: Biomolecular and Clinical Aspects. Boca Raton (FL): CRC Press/Taylor & Francis Copyright © 2011 by Taylor and Francis Group, LLC.; 2011.
• 14. Daştan N. attitude analysis against traditional and complementary medicine: an application specific to Covid-19. Pakistan Journal of Medical and Health Sciences 2021; 15:3063-8.
• 15. Dhouibi R, Affes H, Ben Salem M, Hammami S, Sahnoun Z, Zeghal KM, Ksouda K. Screening of pharmacological uses of Urtica dioica and others benefits. Prog Biophys Mol Biol 2020; 150:67-77.
• 16. Fattahi S, Ghadami E, Asouri M, Motevalizadeh Ardekanid A, Akhavan-Niaki H. Urtica dioica inhibits cell growth and induces apoptosis by targeting Ornithine decarboxylase and Adenosine deaminase as key regulatory enzymes in adenosine and polyamines homeostasis in human breast cancer cell lines. Cell Mol Biol (Noisy-le-grand) 2018; 64(3):97-102.
• 17. Vučić V, Grabež M, Trchounian A, Arsić A. Composition and potential health benefits of pomegranate: A review. Curr Pharm Des 2019; 25(16):1817-27.
• 18. Baradaran Rahimi V, Ghadiri M, Ramezani M, Askari VR. Antiinflammatory and anti-cancer activities of pomegranate and its constituent, ellagic acid: Evidence from cellular, animal, and clinical studies. Phytother Res 2020; 34(4):685-720.
• 19. Abe SK, Saito E, Sawada N, Tsugane S, Ito H, Lin Y, Tamakoshi A, Sado J, Kitamura Y, Sugawara Y, Tsuji I, Nagata C, Sadakane A, Shimazu T, Mizoue T, Matsuo K, Naito M, Tanaka K, Inoue M. Green tea consumption and mortality in Japanese men and women: a pooled analysis of eight population-based cohort studies in Japan Eur J Epidemiol 2019; 34(10):917-26.
• 20. Topuz E. Kanserde Alternatif ve Tamamlayıcı Tıp (Bilimsel Yaklaşım) İstanbul: İletişim Yayınları. 2008.
• 21. Patil SM, Ramu R, Shirahatti PS, Shivamallu C, Amachawadi RG. A systematic review on ethnopharmacology, phytochemistry and pharmacological aspects of Thymus vulgaris Linn. Heliyon 2021; 7(5):e07054.
• 22. Zhou X, Qian H, Zhang D, Zeng L. Garlic intake and the risk of colorectal cancer: A meta-analysis. Medicine (Baltimore) 2020; 99(1):e18575.
• 23. Zaidi Z. Katan (Linum Usitatissimum Linn.) A Potent Unani Therapeutic Agent For Respiratory Tract Diseases. International Journal of Pharmacognosy 2021; 8(3):112-8.
• 24. Zeidabadi A, Yazdanpanahi Z, Dabbaghmanesh MH, Sasani MR, Emamghoreishi M, Akbarzadeh M. The effect of Salvia officinalis extract on symptoms of flushing, night sweat, sleep disorders, and score of forgetfulness in postmenopausal women. J Family Med Prim Care 2020; 9(2):1086-92.
• 25. Al-bedhawi M, Dakheel M. The effect of purified flavonoids (tannins) of tilia flower on the proliferation and the migration activity of cancer cells Plant Archives. 2021; 21:821-5.
• 26. Streyczek J, Apweiler M, Sun L, Fiebich BL. Turmeric Extract (Curcuma longa) Mediates Anti-Oxidative Effects by Reduction of Nitric Oxide, iNOS Protein-, and mRNA-Synthesis in BV2 Microglial Cells. Molecules 2022; 27(3):784.
• 27. Dawczak-Dębicka A, Kufel-Grabowska J, Bartoszkiewicz M, Perdyan A, Jassem J. Complementary and Alternative Therapies in Oncology. Int J Environ Res Public Health 2022;19(9).
• 28. Costa JC, Pereira BC, Soares EA, Gonçalves NLS, Esteves A, Rossi Junior WCR. Effects of Morus nigra L. in Bone Healing. Journal of Morphological Sciences 2019; 36(04):286-90.
• 29. Choi SJ, Kunwor SK, Im HB, Hwang JH, Choi D, Han D. Traditional and complementary medicine use among cancer patients in Nepal: a cross-sectional survey. BMC Complementary Medicine and Therapies 2022; 22(1):70.
• 30. Komakech R, Matsabisa MG, Kang Y. The wound healing potential of Aspilia africana (Pers.) C. D. Adams (Asteraceae). Evidence-Based Complementary and Alternative Medicine 2019; 7957860.
• 31. Yimer EM, Tuem KB, Karim A, Ur-Rehman N, Anwar F. Nigella sativa l. (Black Cumin): A promising natural remedy for wide range of illnesses. Evidence-Based Complementary and Alternative Medicine 2019; 1528635.
• 32. Mahmoud YK, Abdelrazek HMA. Cancer: Thymoquinone antioxidant/pro-oxidant effect as potential anticancer remedy. Biomed Pharmacother 2019; 115:108783.
• 33. Peksoy S, Demirhan İ, Kaplan S, Şahin S, Arıöz Düzgün A. Tamamlayıcı ve alternatif tedavinin jinekolojik kanserlerde kullanımı. Türkiye Sağlık Bilimleri ve Araştırmaları Dergisi 2018; 1(1):36-47.
• 34. Nugraha RV, Ridwansyah H, Ghozali M, Khairani AF, Atik N. Traditional herbal medicine candidates as complementary treatments for COVID-19: A review of their mechanisms, pros and cons. Evidence-Based Complementary and Alternative Medicine 2020; 2020:2560645.
• 35. Kremser T, Evans AJ, Moore A, Luxford K, Begbie S, Bensoussan A, Marigliani R, Zorbas H. Use of complementary therapies by Australian women with breast cancer 2008; 17 4:387-94.
• 36. Abuelgasim KA, Alsharhan Y, Alenzi T, Alhazzani A, Ali YZ, Jazieh AR. The use of complementary and alternative medicine by patients with cancer: a cross-sectional survey in Saudi Arabia. BMC Complement Altern Med 2018; 18(1):88.
• 37. Yan A, Wei XL, Zheng HY, Xie KR, Yan X, Zhao SB, Liu ZH. The potential of complementary and alternative medicine combination chemotherapy in the treatment of non-small cell lung cancer. Drug Comb Ther 2022; 4(2):8.
• 38. Eren T, İmamoğlu Gİ, Karaçin C, Zeynelgil E, Şahinli H, Cilbir E, Yazılıtaş D, İsak ÖA, Turker S, Perkin P, Sökmen FC, Altınbaş M. Investigation of clinical features and the use of complementary and alternative medicines in cancer patients, a single-center experience. Acta Oncol Tur 2019; 52(3):455-62.
• 39. Özer Z, Bahçecioğlu Turan G, Bakır E. Dahiliye polikliniğine başvuran hastaların geleneksel ve tamamlayıcı tıbba karşı tutumları ve etkileyen faktörler. Sağlık Profesyonelleri Araştırma Dergisi 2020 ;2(3):102-12.
• 40. Kasprzycka K, Kurzawa M, Kucharz M, Godawska M, Oleksa M, Stawowy M, Slupinska-Borowka K, Sznek W, Gisterek I, Boratyn-Nowicka A, Rucinska M, Osowiecka K, Nawrocki S. Complementary and alternative medicine use in hospitalized cancer patients-study from Silesia, Poland. Int J Environ Res Public Health 2022;19(3).
• 41. Özkaya H, Karakaya Y, Aslaner H, Yaman N, Gül M, Alagöz Ş, Ekinci O. Investigation of the status of using traditional and complementary medicine practices in patients hospitalized in a palliative care center. Konuralp Medical Journal 2020; 12(1):124-30.
• 42. Akyürek S, Önal C, Kurtman C. Akciğer kanserli hastalarda alternatif tıp kullanımı. Türk Hemotoloji-Onkoloji Dergisi 2005; 15(2):73-7.
• 43. Yin SY, Wei WC, Jian FY, Yang NS. Therapeutic applications of herbal medicines for cancer patients. Evidence-Based Complementary and Alternative Medicine 2013; 302426.
• 44. El Orfi N, Boutayeb S, Haddou Rahou B, Errihani H. Use of medicinal plants by cancer patients under chemotherapy in the Northwest of Morocco (Rabat Area): Cross-sectional study. Journal of Evidence-Based Integrative Medicine 2022; 27:2515690X221128036.
• 45. Correard F, Blanc-léger F, Roux C, Lobrot F, Pinguet F, Pourrat X, Pourroy B, Donamaria C, Kopferschmitt J. Complementary medicine and cancer: A French multicenter survey. Journal of Clinical Oncology 2019;37:15:e23127-e23127.
• 46. Laurent V, Saillard J, Thierry M, Lepelletier A, Fronteau C, Huon JF. Anticancer agents and phytotherapy: Interactions that are often unrecognized. Journal of Oncology Pharmacy Practice 2021; 27(2):322-8.