Biochemistry of Apoptosis

Yıl 2016, Cilt: 25 Sayı: 1, 52 - 69, 31.03.2016

Kezban Kartlaşmış , Umut Kökbaş , Levent Kayrın

Öz

Apoptosis is one of the cell death types which is studied for a long times. During the last 30 years many investigation were carried out for this type cell death and the molecular mechanism of this self destruction of live cell were explained. Whether the effect is too little or high. Apoptosis is one of the most important reason for many disease such as hematologic disorder, autoimmune and neurodegenerative diseases, ischemic damages and for various types of cancers. The cell life cycle regulation of the cell is the indication of it is therapeutic potentials. For this reason the studies still hardly continue on the life cycle and signaling pathways that control the cell cycle and apoptosis. It is known that many apoptotic role is were. İnvestigated but more studies needed for their mechanistic action. The goal of this review is to provide a general overview of current knowledge on the process of apoptosis including apoptotic mechanisms, the role of apoptosis in health and disease, therapeutic opportunities to exploit apoptosis for cancer therapy and treatment samples.

Anahtar Kelimeler

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Apoptozisin Biyokimyası

Öz

Apoptozis üzerinde uzun süredir çalışılan bir hücre ölüm tipidir. Son 30 yıl boyunca bu hücre ölüm tipi oldukça geniş bir şekilde araştırılmış ve bu hücre intiharının altında yatan moleküler mekanizmalar açıklanmıştır. Apoptozisin çok az ya da çok fazla olması hematolojik bozukluklar, otoimmün hastalıklar, nörodejeneratif hastalıklar, iskemik hasar ve birçok kanser türü gibi durumları içeren önemli bir etmendir. Bu amaçla apoptoz araştırma alanı muazzam bir hızla ilerlemektedir. Anahtar apoptotik ve antiapoptotik proteinlerin birçoğu tanımlanmasına rağmen bu proteinlerin etkisinin ve etkili olmamasının moleküler mekanizmalarının araştırılmasına ihtiyaç vardır. Bu derlemenin amacı apoptotik mekanizmaları, hastalıkta ve sağlıkta apoptozisin rolü, kanser tedavisinde apoptozisten yararlanılarak oluşturulan terapötik fırsatlar ve tedavi örneklerini içeren apoptozis sürecinde güncel bilgilere genel bir bakış sağlamaktır.

Anahtar Kelimeler

Programlanmış hücre ölümü, antiapoptotik proteinler, kanser, ölüm reseptörleri

Kaynakça

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• Correspondence Address / Yazışma Adresi Kezban Kartlaşmış
• Çukurova Üniv. Tıp Fakültesi
• Tıbbi Biyokimya Anabilim Dalı. Adana, Turkey
• e-mail: [e-mail]
• Geliş tarihi/ Received: 04.06.2015
• Kabul tarihi/Accepted: 03.07.2015