Cold Injury and Perniosis (Chilblain)

Yıl 2015, Cilt: 24 Sayı: 4, 463 - 471, 15.09.2015

Tuba Koca , Tolga Bağlan Gülbahar Saraç Aydın Arslan

https://doi.org/10.17827/aktd.79126

Öz

Perniosis (chilblain) is inflammatory cutaneous lesions located on acral surfaces (fingers, toes, nose, aurikula) which present in association with cold exposure. They can appear as an idiopathic (primary) dermatosis or with an underlying autoimmune disease (secondary). The primary or idiopathic form is not associated with an underlying disease and is clinically indistinguishable from the secondary form. The secondary form is associated with an underlying condition such as connective tissue disease, monoclonal gammopathy, cryoglobulinemia, or chronic myelomonocytic leukemia. Histopathology cannot accurately help distinguish the primary from secondary forms of chilblains. This review aims to raise the awareness ofperniosis to avoid excessive investigation and anxiety and to help patients with only appropriate simple advice and treatment.

Anahtar Kelimeler

Perniosis, chilblain, cold injury

Soğuk Hasarı ve Perniosis (Mayasıl)

Öz

Perniosis (mayasıl) soğuğa maruziyet ile ortaya çıkan, akral yüzeylerde (el ve ayak parmakları, burun, aurikula) lokalize inflamatuvar kütenöz lezyonlardır. İdiopatik (primer) dermatoz veya altta yatan bir otoimmun hastalık (sekonder) ile ortaya çıkabilir. Primer veya idiopatik form altta yatan herhangi bir hastalık ile ilişkili değil iken, klinik olarak sekonder formdan ayırımı zordur. Sekonder form konnektif doku hastalığı, monoklonal gammopati, kyroglobunemi, veya kronik myelositik lösemi gibi hastalıklar ile ilişkili olabilir. Histopatoloji, primer formu sekonder formdan tam olarak ayırımını yapamamaktadır. Bu derleme perniosis'e farkındalık oluşturularak gereksiz araştırma ve anksiyetenin önüne geçip, uygun basit öneriler ve tedaviye izin vermeyi amaçlamaktadır.

Anahtar Kelimeler

Perniosis, mayasıl, soğuk hasarı

Kaynakça

• Gordon R, Arikian AM, Pakula AS. Chilblains in Southern California: two case reports and a review of the literature. J Med Case Rep. 2014;8:381.
• Goette DK. Chilblains (perniosis). J Am Acad Dermatol. 1990;23:257-62.
• Long WB 3rd, Edlich RF, Winters KL, Britt LD. Cold injuries. J Long Term Eff Med Implants. 2005;15:67-78.
• Crowson AN, Magro CM. Idiopathic perniosis and its mimics: a clinical and histological study of 38 cases. Hum Pathol. 1997;28:478-84.
• Larkins N, Murray KJ. Major cluster of chilblain cases in a cold dry Western Australian winter. J Paediatr Child Health. 2013;49:144-7.
• Sarteel-Delvoye AM, Wiart T, Durier A. Chilblains. Rev Prat. 1998;48:1673-5.
• Price RD, Murdoch DR. Perniosis (Chilblains) of the thigh: report of five cases, including four following river crossings. High Alt Med Biol. 2001;2:535-8.
• Prakash S, Weisman MH. İdiopathic chilblains. Am J Med. 2009;122:1152-5.
• Akkurt ZM, Uçmak D, Yıldız K, Yürüker SK, Çelik HÖ. Chilbrains in Turkey: a case-control study. An Bras Dermatol. 2014;89:44-50.
• Herman EW, Kezis JS, Silvers DN. A distinctive variant of pernio: clinical and histopathologic study of nine cases. Arch Dermatol. 1981;117:26-8.
• Boada A, Bielsa I, Fernandez-Figueras MT, Ferrandiz C. Perniosis: clinical and histopathological analysis. Am J Dermatopathol. 2010;32:19-23.
• Viquier M, Pinguier L, Cavelier-Balloy B, de la Salmoniere P, Cordoliani F, Flaqeul B et al. Clinical and histopathological features and immunologic variables in patients with severe chilblains. A study of the relationship to lupus erythematosus. Medicine (Baltimore). 2001;80:180-8.
• Vayssairat M. Chilblains. J Mal Vasc. 1992;17:229-31.
• AlMahameed A, Pinto DS. Pernio (Chilblains). Curr Treat Options Cardiovasc Med. 2008,10:128- 35.
• Chambers HF. Community-associated MRSA-resistance and virulence. N Engl J Med. 2005;353:1485-7.
• Weisman K, Larson FG. Pernio of the hips in young girls wearing tight-fitting jeans with a low waistband. Acta Derm Venereol. 2006,86:558-9.
• Patra AK, Das AL, Ramadasan P. Diltiazem vs. nifedipine in chilblains: a clinical trial. Indian J Dermatol Venereal Leprol. 2003;69:209-11.
• Rustin MH, Newton JA, Dowd PM. Nifedipine: a new treatment for perniosis. Br J Dermatol. 2006;117:20-1.
• Rustin MH, Newton JA, Smith NP, Dowd PM. The treatment of chilblains with nifedipine: the results of a pilot study, a double-blind placebo-controlled randomized study and a long-term open trial. Br J Dermatol. 1989;120:267-75.
• Dowd PM, Rustin MH, Lanigan S. Nifedipine in the treatment of chilblains. Br Med J (Clinc Res Ed). 1986, 293:923-4.
• Correspondence Address / Yazışma Adresi