Herbal Treatment in Menopause

Yıl 2015, Cilt: 24 Sayı: 4, 520 - 530, 15.09.2015

Çiğdem Gün , Nurdan Demirci

https://doi.org/10.17827/aktd.52798

Cited By: 5

Öz

The digest has been prepared to review available clinical evidence on herbs used in treatment of menopause symptoms. Effectives of Humulus lupulus, Vitex agnus-castus, Dioskorea vilosa, Linum usitatissimum, Pinus pinaster, Turpgillere ait sebzeler, Cimicifuga racemosa L., Angelica sinensis, Oenothera biennis L., Hypericum perforatum L., Panax ginseng, Ginkgo biloba, Glycine soja, Trifolium pratense and Piper methysticum herbs were assessed for treatment of menopausal symptoms, in the studies. It was concluded that herbs used as alternative supplementary treatment for menopause symptoms have a limited effect, thus herb studies to contribute to available literature which constitute evidence are needed in order to assess effectiveness of herbal treatments for menopausal symptoms.

Anahtar Kelimeler

Menopause, herbal treatment

Menopozda Bitkisel Tedavi Kullanımı

Öz

Derleme menopoz belirtilerinin tedavisinde kullanılan bitkilere ilişkin mevcut klinik kanıtları gözden geçirmek amacıyla hazırlanmıştır. Menopozal belirtilerin tedavisi için çalışmalarda Humulus lupulus, Vitex agnus-castus, Dioskorea vilosa, Linum usitatissimum, Pinus pinaster, Turpgillere ait sebzeler, Cimicifuga racemosa L., Angelica sinensis, Oenothera biennis L., Hypericum perforatum L., Panax ginseng, Ginkgo biloba, Glycine soja, Trifolium pratense ve Piper methysticum bitkilerinin etkinlikleri değerlendirilmiştir. Sonuç olarak menopoz belirtilerindetamamlayıcı alternatif tedavi olarak kullanılan bitkilerin sınırlı bir yere sahip olduğu, bundan dolayı menopozal belirtilerde bitkisel tedavilerin etkinliğini değerlendirmek için mevcut literatüre katkıda bulunacak kanıt düzeyi yüksek çalışmalara ihtiyaç duyulduğu söylenebilir

Anahtar Kelimeler

Menopoz, bitkisel tedavi

Kaynakça

• World Health Organisation. Research on the Menopause: Report of a WHO Scientific Group. Geneva, World Health Organisation, 1981. 2. Kaufert P, Lock M, McKinlay S, Beyenne Y, Coope J, Davis D et al. Menopause research: the korpilampi workshop. Soc Sci Med. 1986;22:1285-9.
• Artazcoz L, Borrell C, Benach J, Cortès I, Rohlfs I. Women, family demands and health: the importance of employment status and socio-economic position. Soc Sci Med. 2004;59:263-74.
• Darsareh F, Taavoni S, Joolaee S, Haghani H. Effect of aromatherapy massage on menopausal symptoms: a randomized placebo-controlled clinical trial. Menopause. 2012;19:995-9.
• Hanna K, Day A, O’Neill S, Patterson C, Lyons-Wall P. Does scientific evidence support the use of non-prescription supplements for treatment of acute menopausal symptoms such as hot flushes? Nutr Diet. 2005;62:138-51.
• Newton KM, Buist DSM, Keenan NL, Anderson LA, LaCroix AZ. Use of alternative therapies for menopause symptoms: results of a population-based sample. Am Coll Obstet Gynecol. 2002;100:18-25.
• Upchurch DM, Chyu MA. Use of complementary and alternative medicine among American women. Womens Health Issues. 2005;15:5-13.
• Heyerick A, Vervarcke S, Depypere H, Bracke M, De Keukeleire D. A first prospective, randomized, double-blind, placebo-controlled study on the use of a standardized hop extract to alleviate menopausal discomforts. Maturitas. 2006;54:164–75.
• Erkkola R, Vervarcke S, Vansteelandt S, Rompotti P, De Keukeleire D, Heyerick A. A randomized, double-blind, placebo-controlled, cross-over pilot study on the use of a standardized hop extract to alleviate menopausal discomforts. Phytomedicine. 2010;17:389–96.
• Morali G, Polatti F, Metelitsa EN, Mascarucci P, Magnani P, Marr‘e GB. Open, non-controlled clinical studies to assess the efficacy and safety of a medical device in form of gel topically and intravaginally used in postmenopausal women with genital atrophy. Arzneimittel-Forshung Drug Res. 2006;56:230–8.
• Borrelli F, Ernst E. Alternative and complementary therapies for the menopause. Maturitas. 2010;66:333–43.
• Laakmann E, Grajecki D, Doege K, zu Eulenburg C, Buhling KJ. Efficacy of Cimicifuga racemosa, Hypericum perforatum and Agnus castus in the treatment of climacteric complaints: a systematic review. Gynecol Endocrinol. 2012;28:703–9.
• Chiang SS, Chang SP, Pan TM. Osteoprotective effect of monascus-fermented dioscorea in ovariectomized rat model of postmenopausal osteoporosis. J Agric Food Chem. 2011;59:9150–7.
• Wu WH, Liu LY, Chung CJ, Jou HJ, Wang TA. Estrogenic effect of yam ingestion in healthy postmenopausal women. J Am Coll Nutr. 2005;24:235–43.
• Pittler MH & Ernst E. Kava extract for treating anxiety. Cochrane Database Systematic Review 2003; http://www.ncbi.nlm.nih.gov/pubmed/11687196 Access date:20.07.2014.
• De Leo V, La Marca A, Lanzetta D, Palazzi S, Torricelli M, Facchini C et al. Assessment of the association of Kava-Kava extract and hormone replacement therapy in the treatment of postmenopause anxiety. Minerva Ginecol. 2000;52:263-7.
• Medicines and Healthcare Products Regulatory Agency. Traditional herbal medicine registration scheme. www.mhra.gov.uk/home/. Access date:20.07.2014.
• Grimm T, Chovanová Z, Muchová J, Sumegová K, Liptáková A, Duracková Z, Högger P. Inhibition of NF-kB activation and MMP-9 secretion by plasma of human volunteers after ingestion of maritime pine bark extract (Pycnogenol). J Inflamm. 2006;3:1
• Yang HM, Liao MF, Zhu SY, Liao MN, Rohdewald P. A randomized, double-blind, placebo- controlled trial on the effect of Pycnogenol on the climacteric syndrome in peri-menopausal women. Acta Obstet Gynecol Scand. 2007;86:978–85.
• Kohama T, Negami M. Effect of low-dose French maritime pine bark extract on climacteric syndrome in 170 perimenopausal women. J Reprod Med. 2013;58:39–46.
• Enseleit F, Sudano I, Périat D, Winnik S, Wolfrum M, Flammer AJ et al. Effects of Pycnogenol on endothelial function in patients with stable coronary artery disease: a double-blind, randomized, placebo controlled, cross-over study. Eur Heart J 2012;33:1589–97.
• Naik R, Nixon S, Lopes A, Godfrey K, Hatem MH, Monaghan JM. A randomized phase II trial of indole-3- carbinol in the treatment of vulvar intraepithelial neoplasia. Int J Gynecol Cancer.2006;16:786–90.
• Bell MC, Crowley-Nowick P, Bradlow HL, Sepkovic DW, Schmidt-Grimminger D, Howell P et al. Placebo-controlled trial of indole-3-carbinol in the treatment of CIN. Gynecol Oncol. 2000;78:123- 9.
• Moschonis G, Kanellakis S, Papaioannou N, Schaafsma A, Manios Y. Possible site-effect of an intervention combining nutrition and lifestyle counselling with consumption of fortified dairy products on bone mass: the Postmenopausal Health Study II. J Bone Miner Metab. 2011;29:501– 6.
• Lee MS, Shin BC, Yang EJ, Lim HJ, Ernst E. Maca (Lepidium meyenii) for treatment of menopausal symptoms: a systematic review. Maturitas 2011;70:227–33.
• Borrelli F, Ernst E. Black cohosh (Cimicifuga racemosa) for menopausal symptoms: a systematic review of its efficacy. Pharmacol Res. 2008;58:8–14.
• Borrelli F, Ernst E. Black cohosh (Cimicifuga racemosa): a systematic review of adverse events. Am J Obstet Gynecol. 2008;199:455-66.
• Hirata JD, Swiersz LM, Zell B, Small R, Ettinger B. Does dong quai have estrogenic effects in postmenopausal women? a double-blind, placebo-controlled trial. Fertil Steril. 1997;68:981–6.
• Page R, Lawrence JD. Potentiation of warfarin by dong quai. Pharmacotherapy. 1999;19:870 –6.
• Rotem C, Kaplan B. Phyto-Female Complex for the relief of hot flushes, night sweats and quality of sleep: randomized, controlled, double-blind pilot study. Gynecol Endocrinol. 2007;23:117–22.
• Kupfersztain C, Rotem C, Fagot R, Kaplan B. The immediate effect of natural plant extract. Angelica sinensis and Matricaria chamomilla (Climex) for the treatment of hot flushes during menopause. A preliminary report. Clin Exp Obstet Gynecol. 2003;30:203–6.
• Fugate SE, Church CO. Nonestrogen treatment modalities for vasomotor symptoms associated with menopause. Ann Pharmacother. 2004;38:1482-99.
• Chenoy R, Hussain S, Tayob Y, O'Brien PM, Moss MY, Morse PF. Effect of oral gamolenic acid from evening primrose oil on menopausal flushing. BMJ. 1994;308:501-3.
• Al-Akoum M, Maunsell E, Verreault R, Provencher L, Otis H, Dodin S. Effects of Hypericum perforatum (St. John’s wort) on hot flashes and quality of life in perimenopausal women: a randomized pilot trial. Menopause. 2009;16:307–14.
• Wiklund IK, Mattsson LA, Lindgren R, Limoni C. Effects of a standardized ginseng extract on quality of life and physiological parameters in symptomatic postmenopausal women: a double- blind, placebo-controlled trial. Int J Clin Pharmacol Res. 1999;19:89–9.
• Hartley DE, Heinze L, Elsabagh S, File SE. Effects on cognition and mood in postmenopausal women of 1-week treatment with Ginkgo biloba. Pharmacol Biochem Behav. 2003;75:711–20.
• Elsabagh S, Hartley DE, File SE. Limited cognitive benefits in stage+2 postmenopausal women after 6 weeks of treatment with Ginkgo biloba. J Psychopharmacol. 2005;19:173–81.
• Elkind-Hirsch K. Effect of dietary phytoestrogens on hot flushes: can soy based proteins substitute for traditional estrogen replacement therapy? Menopause. 2001;8:154 –6.
• Knight DC, Eden JA. A review of the clinical effects of phytoestrogens. Obstet Gynecol. 1996;87:897–904.
• Setchell KDR, Adlercreutz H. Mammalian ligans and phytoestrogens: recent studies on their formation, metabolism, and biological role in health and disease. In: Role of the Gut Flora in Toxicity and Cancer (Ed I Rowland). London, Academic Press, 1988.
• Lagari VS, Levis S. Phytoestrogens for menopausal bone loss and climacteric symptoms. J Steroid Biochem Mol Biol. 2014;139:294-301.
• Bolanos-Diaz R, Zavala-Gonzales J, Mezones-Holguin E, Francia-Romero J. Soy extract versus hormone therapy for reduction of menopausal hot flushes: indirect comparison. Menopause. 2011;18: 825-29.
• North American Menopause Society. The role of soy isoflavones in menopausal health: report of the North American Menopause Society/Wulf H. Utian Translational Science Symposium in Chicago. Menopause. 2011;18:732-53.
• Burdette JE, Liu J, Lantvit D, Lim E, Booth N, Bhat KP et al. Trifolium pratense (red clover) exhibits estrogenic effects in vivo in ovariectomized Sprague-Dawley rats. J Nutr . 2002;132:27-30.
• Booth NL, Piersen CE, Banuvar S, Geller SE, Shulman LP, Farnsworth NR. Clinical studies of red clover (Trifolium pratense) dietary supplements in menopause: a literature review. Menopause. 2006;13:251-64.
• Lipovac M, Chedraui P, Gruenhut C, Gocan A, Kurz C, Neuber B et al. The effect of red clover isoflavone supplementation over vasomotor and menopausal symptoms in postmenopausal women. Gynecol Endocrinol. 2012;28:203-7.
• Coşkun T. Fonksiyonel besinlerin sağlığımız üzerine etkileri. Çocuk Sağlığı ve Hastalıkları Dergisi 2005;48:69-84.
• Colli MC, Bracht A, Soares AA, de Oliveira AL, Bôer CG, de Souza CG, Peralta RM. Evaluation of the efficacy of flaxseed meal and flaxseed extract in reducing menopausal symptoms. J Med Food. 2012;15:840–5.
• Dew TP, Williamson G. Controlled flax interventions for the improvement of menopausal symptoms and postmenopausal bone health: a systematic review. Menopause. 2013;20:1207-15.
• Correspondence Address / Yazışma Adresi