Dipeptidil Peptidaz- 4 Enzimine Biyokimyasal Yaklaşım

Yıl 2019, Cilt: 28 Sayı: 1, 41 - 50, 31.03.2019

Hülya Leventerler , İbrahim Ferhat Ürünsak , Nurten Dikmen

Öz

Dipeptidil
peptidaz- 4 (DPP-4, EC 3.4. 14.5 ), 
proteaz ailesinin bir üyesidir. DPP-4 aynı zamanda adenozin deaminaz
bağlayan protein (ADBP) ya da T-hücre aktivasyon antijeni CD26 olarak da
bilinmektedir. Bir serin ekzopeptidaz olan DPP-4; bir proteinin N-terminal
dipeptitin en sonunda yer alan prolin, hidroksiprolin, dehidroprolin ya da
alanin ayrılmasını katalizlemektedir. Enzim kanda, serbest ve bağlı olmak üzere
iki formda bulunmaktadır.

DPP-4’ün  pek çok dokudaki yaygın dağılımı ve
fizyolojik olaylarda rol almasına bağlı olarak çeşitli patolojik durumlarda da
DPP-4 ekspresyonunda ya da aktivitesinde değişiklikler saptanmıştır. Bu
patolojik durumlar: diyabet, psiko-nöroendokrin bozukluklar, otoimmün ve
inflamatuar hastalıklar, enfeksiyon hastalıkları, hematolojik malignansiler,
solid tümörlerdir. Plazmada değişen CD26/DPP-4 aktivitesi ya da derişimleri
fizyolojik ve otoimmün çeşitli patolojik durumlarla ilgili bulunmuştur. Ayrıca tükürük,
serebrospinal, sinoviyal sıvılar, folikül sıvısı, semen ve idrarda da DPP-4
aktivitesi bildirilmiştir. 

Anahtar Kelimeler

Dipeptidil peptidaz-4, adenozin deaminaz bağlayan protein, CD antijeni

Kaynakça

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