Şizofreni ve Adenozin Reseptörleri

Yıl 2019, Cilt: 28 Sayı: 4, 275 - 284, 31.12.2019

Kübra Akıllıoğlu , Zehra Çiçek , Meltem Dönmez

https://doi.org/10.17827/aktd.455458

Öz

Şizofreni
hastalığı toplumda yaklaşık %1 oranında görülmekle birlikte kesin tedavisi
olmayan, kronik nöropsikiyatrik bir hastalıktır. Kişinin günlük yaşamını
olumsuz etkileyen bilişsel ve duygusal işlevlerde bozulmaya neden olan
şizofreninin fizyopatolojisi henüz aydınlatılamamıştır. Adenozin, merkezi sinir
sisteminde birçok fonksiyonu etkileyen endojen bir nöromodülatör olarak rol
oynamaktadır. Son yıllarda ise merkezi sinir sisteminde nöromodülatör olarak
işlev gören adenozin ve reseptörlerinin şizofreni fizyopatolojisinde rol
oynayabileceği ileri sürülmektedir. Biz de derlememizde şizofrenide adenozin ve
reseptörlerinin nöromodülatör işlevini son literatür bilgileri ışığında
inceledik.

Anahtar Kelimeler

adenozin, NMDA, şizofreni

Kaynakça

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