The role of molecular imaging in orthopedic infections

Yıl 2020, Cilt: 29 Sayı: 3, 209 - 217, 30.09.2020

Ebru Salmanoğlu

Öz

Inflammation
is the response of immune system cells to tissue damage. Infection is caused by
the presence of microorganisms. Acute and chronic osteomyelitis,
spondylodiscitis and orthopedic implant infections are a heterogeneous group of
infectious diseases. Common feature of these diseases is diagnosis and treatment
of them is made by clinicians, radiologists and nuclear medicine physicians.
Early diagnosis and localization of the infection is important to perform
appropriate and early treatment. Pathological processes in ttissue after
infection is shown with radiological methods. However nuclear medicine methods
have great importance for the determination of the infection focus in cases
with the infection is at the cellular level. Radiopharmaceuticals such as Gallium-67
citrate, Technetium-99m (Tc-99m) nanocolloid and Tc-99m diphosphonate
derivatives  are commonly used for  infection imaging. This article aims to underline
importance of molecular imaging methods for diagnosis of orthopedics infections
and guidance for clinicians in clinical practice.

Anahtar Kelimeler

Infection, Nuclear Medicine, Molecular Imaging

Proje Numarası

Yok

Ortopedik enfeksiyonlarda moleküler görüntülemenin rolü

Öz

İnflamasyon, immun sistem hücrelerinin doku hasarına karşı
yanıtıdır. Enfeksiyon, mikroorganizmaların varlığı ile meydana gelir. Akut ve
kronik osteomiyelit, spondilodiskit ve ortopedik implant enfeksiyonları
enfeksiyöz hastalıkların heterojen grubudur. Bu hastalıkların ortak yönü
klinisyen, radyolog ve nükleer tıp hekimleri tarafından  tanı ve tedavisinin  yapılmasıdır. Enfeksiyonun erken tanısı ve
lokalizasyonu,  tedavinin uygun ve erken
zamanda  yapılabilmesi için önem
taşımaktadır. Enfeksiyon sonrası dokuda oluşan patoloji radyolojik yöntemlerle
gösterilmektedir. Fakat enfeksiyonun hücresel düzeyde olduğu durumlarda
enfeksiyon odağının belirlenmesi açısından nükleer tıp yöntemlerinin önemi
büyüktür. Galyum-67 sitrat, Teknesyum-99m (Tc-99m)  nanokolloid ve Tc-99m difosfonat türevleri gibi
radyofarmasötikler enfeksiyon görüntülemede sık kullanılmaktadır. Bu makalede ortopedik
enfeksiyonların tanısında moleküler görüntüleme yöntemlerinin öneminin
vurgulanması ve klinik pratikte klinisyenlere yol gösterici olması amaçlanmıştır.

Anahtar Kelimeler

Enfeksiyon, Nükleer Tıp, Moleküler Görüntüleme

Destekleyen Kurum

Yok

Proje Numarası

Yok

Teşekkür

Yok

Kaynakça

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