Testis İnişinin Moleküler Mekanizması

Yıl 2021, Cilt: 30 Sayı: 1, 22 - 30, 31.03.2021

Gülfidan Coşkun

https://doi.org/10.17827/aktd.699932

Cited By: 1

Öz

Erkeklerde spermatogenezin normal şekilde gerçekleşebilmesi için testislerin karın boşluğu dışında, vücuttan 2-3°C düşük sıcaklıkta skrotum adı verilen kese içerisine inmeleri gerekmektedir. Testis iniş mekanizması türler arasında farklılık göstermekle birlikte, testislerin intrabdominal seviyeden skrotuma inmeleri hormonal ve mekanik etkilere bağlı olarak transabdominal ve inguinoskrotal evreler sonunda gerçekleşmektedir. Kranial süspansör ligament dejenerasyonu ve gubernakular şişme reaksiyonu ile karakterize olan transabdominal evre Leydig hücrelerinden salınan INSL3 (İnsülin benzeri faktör-3) kontrolündedir. Testislerin inguinal kanaldan geçerek skrotuma indiği son evre olan inguinoskrotal evre ise androjen bağımlıdır. Testislerin iniş süreci INSL3 ve androjenler dışında, Sertoli hücrelerinden salınan MIS (Mülleryan inhibe edici madde), genitofemoral sinir uçlarından salınan CGRP (Kalsitonin gen-bağımlı peptid), peritoneal bir divertikül olan vaginal prosses, meme hattı altındaki MFP (Meme yağ yastıkçığı) ile Hox genlerinin rol oynadığı kompleks bir süreçtir. Testis iniş mekanizmasında meydana gelen herhangi bir aksaklık durumunda, infertilite ve testiküler kanser nedenleri arasında sayılan anorşi, refraktil testis, kriptorşidizm ve ektopik testis görülebilmektedir.

Anahtar Kelimeler

Testis inişi, Transabdominal evre, İnguinoskrotal evre, INSL3, Androjen

Kaynakça

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