Araştırma Makalesi
BibTex RIS Kaynak Göster

Kefir ve Sağlık Açısından Önemi

Yıl 2017, Cilt: 17 Sayı: 2, 834 - 853, 31.08.2017

Öz

Fermente süt ürünleri içinde yoğurttan sonra önemli bir yer tutan ve herkes tarafından beğenilerek tüketilen diğer bir ürün kefirdir. Kefir; gerek içermiş olduğu bileşenler, gerekse fermantasyon aşamasında oluşan yeni bileşenler sayesinde insan sağlığı üzerine olumlu etkilere sahiptir. Kullanılan sütün özelliği, yapım metodu, kullanılan kefir kültürünün mikrobiyal florası, fermantasyon şartları, muhafaza şartları ve süresine bağlı olarak kefirin bileşiminde değişiklikler görülebilir. Son yıllarda yapılan çalışmalarda kefirin insan sağlığına olan faydalarının arttırılması amaçlanmıştır. Fermente süt ürünleri içerisinde önemli bir yeri olan ve aynı zamanda probiyotik özelliğiyle dikkatleri çeken kefir, başta gastrointestinal etkileri olma üzere, kroner kalp rahatsızlıkları, antimikrobiyal, antitümör, antikarsinojenik, antialerjik etkiler ve astım etkilerinin azaltılması, bağışıklık sisteminin güçlendirilmesi gibi bir dizi sağlık faydasıyla ilişkilendirilmiştir.

Kaynakça

  • Adiloğlu, A.K., Gönülateş, N., İşler, M. and Şenol, A., 2013. The effect of kefir consumption on human immune system: A cytokine study. Mikrobiyoloji Bülteni,47: 273-281.
  • Aghatabay, N.M., 2005. Keyf-i kefir.Kimya Teknolojileri, 58: 64-65.
  • Ahmed, Z., Wang, Y., Ahmad, A., Khan, S. T., Nisa, M., Ahmad, H. and Afreen, A., 2013. Kefir and health: a contemporary perspective. Critical reviews in food science and nutrition, 53(5): 422-434.
  • Alessandri, C., Sforza, S., Palazzo, F., Lambertini, S., Paolella, D. and Zennaro, C., 2012. Tolerability of a fully maturated cheese in cow’s milk allergic children: biochemical, immunochemical, and clinical aspects. PloS one, 7(7), e40945.
  • Alp, G. and Aslım, B., 2009.İnsan bağırsak sisteminde probiyotik olarak bifidobakterilerin önemi.Anadolu Üniversitesi Bilim ve Teknoloji Dergisi,10: 343-354.
  • Alpkent, Z. and Küçükçetin, A., 2000. Farklı sıcaklıklarda muhafaza edilen kefirlerin duyusal, fiziksel, kimyasal ve mikrobiyolojik özelliklerinde meydana gelen değişimler.Süt Mikrobiyolojisi ve Katkı Maddeleri, VI. Süt ve Süt Ürünleri Sempozyumu Tebliğler Kitabı, Editör: Mehmet Demirci, Tekirdağ, s. 363-373.
  • Angulo, L., Lopez, E. and Lema, C., 1993. Microflora present in kefir grains of the Galician region (north-west of Spain). Journal of Dairy Research,60: 263-267.
  • Anonim, 2009. Türk Gıda Kodeksi Fermente Süt Ürünleri Tebliği. Sayı: 27143, Tebliğ No:2009/25.
  • Anonim, 2011.Kefir. Milli Eğitim Bakanlığı, Gıda teknolojisi Programı, Süt İşleme/ Süt ve Süt Ürünleri Operatörü 541GI0031, s: 46 Ankara.
  • Arslan, S., 2015. A review: chemical, microbiological and nutritional characteristics of kefir. CyTA-Journal of Food,13: 340-345.
  • Azad, M.B., Konya, T., Maughan, H., Guttman, D.S., Field, C.J., Sears, M.R. and Kozyrskyj, A.L., 2013. Infant gut microbiota and the hygiene hypothesis of allergic disease: impact of household pets and siblings on microbiota composition and diversity. Allergy, Asthma & Clinical Immunology, 9(1), 15.
  • Bakan, K., Boz, B., Ertürk, G., Nomikos, G. and Ayca, I.B. 2016.Probiyotik süt ürünü olarak kefirin sporcu beslenmesinde kullanımı.TURAN: Stratejik Arastirmalar Merkezi, 8(30), 169.
  • Beena, A. and Prasad, V., 1997. Effect of yogurt and bifidus yogurt fortified with skim milk powder, condensed whey and lactose-hydrolysed condensed whey on serum cholesterol and triacylglycerol levels in rats. Journal of Dairy Research, 64(03), 453-457.
  • Berruga, M.I., Jaspe, A. and San Jose, C., 1997. Selection of yeast strains for lactose hydrolysis in dairy effluents. International Biodeterioration and Biodegradation,40: 119-123.
  • Beshkova, D.M., Simova, E.D., Frengova, G.I., Simov, Z.I. and Dimitrov, Z.P. 2003. Production of volatile aroma compounds by kefir starter cultures. International Dairy Journal,13: 529-535.
  • Bourdichon, F., Casaregola, S., Farrokh, C., Frisvad, J.C., Gerds, M.L., Hammes, W.P., 2012. Food fermentations: microorganisms with technological beneficial use. Int. Journal of FoodMicrobiology,154, 87–97.
  • Bourrie, B.C., Willing, B.P. and Cotter, P.D. 2016.The microbiota and health promoting characteristics of the fermented beverage kefir.Frontiers in microbiology, 7: 647.
  • Cais-Sokolinska, D., Dankow, R. and Pikul, J., 2008.Physicochemical and sensory characteristics of sheep kefir during storage.Acta Scientiarum Polonorum, Technologia Alimentaria,7: 63-73.
  • Çakır-Topdemir, P., Meriç, Ş., Çakır, Ç. and Topdemir, T., 2010.Kefir ve özellikleri.1. Uluslararası Adryatik ’ten Kafkaslar ’a Geleneksel Gıdalar Sempozyumu, 15-17 Nisan, Tekirdağ, 305.
  • Çevikbaş, A., Yemni, E., Ezzedenn, F.W., Yardimiçi, T., Çevikbaş, U. and Stohs, S.J., 1994.Antitumoural antibacterial ve antifungal activities of kefir ve kefir grain.Phytotherapy Research,8: 78-82.
  • Czamanski, R.T., Greco, D.P. and Wiest, J.M., 2004. Evaluation of antibiotic activity in filtrates of traditional kefir.Higiene Alimentar, 18 (124): 75-77.
  • De Angelis-Pereira, M.C., Barcelos, M.F.P., Sousa, M.S.B., Pereira, J.A.R., 2013. Effects of the kefir and banana pulp and skin flours on hypercholesterolemic rats.Acta Cirurgica Brasileira, 28(7): 481-486.
  • De Moreno de LeBlanc, A. and Perdigon, G., 2010. The application of probiotic fermented milks in cancer and intestinal inflammation. Proceedings of the Nutrition Society,69: 421-428.
  • De Moreno de LeBlanc, A., Chaves, S., Carmuega, E., Weill, R., Antoine, J. and Perdigon, G., 2008.Effect of long term continuous consumption of fermented milk containingprobiotic bacteria on mucosal immunity and the activity of peritoneal macrophages.Immunobiology,213: 97-108.
  • De Moreno de LeBlanc, A., Matar, C., LeBlanc, N. and Perdigon, G., 2005.Effects of milk fermented by Lactobacillus helveticus R389 on a murine breast cancer model.Breast Cancer Res.,7: 477-486.
  • De Oliveira Leite, A.M., Miguel, M.A., Peixoto, R.S., Rosado, A.S., Silva, J.T. and Paschoalin, V.M., 2013. Microbiological, technological and therapeutic properties of kefir: a natural probiotic beverage. Brazilian Journal of Microbiology, 44(2): 341-349.
  • Dinç, A., 2008.Kefirin bazı mikrobiyolojik ve kimyasal özelliklerinin belirlenmesi. Yüksek Lisans Tezi, Ankara Üniversitesi, Sağlık Bilimleri Enstitüsü, Ankara.
  • Dousset, X. and Caillet, F., 1993. Aspects microbiologiques et biochimiques de la fermentation du kefir. Microbiologie Aliments Nutrition,11: 463-470.
  • Ender, G., Karagözlü, C., Yerlikaya, O. and Akbulut, N., 2006.Dünyada ve Türkiye'de tüketimi artan fermente süt içecekleri.Türkiye 9. Gıda Kongresi; 24-26 Mayıs 2006, Bolu s: 149-152.
  • Engel, G., Krusch, U. and Teuber, M., 1986.Microbiological composition of kefir. I. Yeasts. Milchwissenschaft,41: 418-421.
  • Ergüllü, E. and Üçüncü, M., 1983.Kefir mikroflorası üzerine bir araştırma.Gıda, 8: 310.
  • Farhad M., Kailasapathy K. and Tamang J.P., 2010. “Health aspects of fermented foods,” in Fermented Foods and Beverages of the World, eds Tamang J. P., Kailasapathy K., editors. (New York, NY: CRC Press; ), 391–414
  • Farnworth, E.R., 2005. Kefir: a complex probiotic. Food Science and Technology Bulletin: Functional Foods,2: 1-17.
  • Farnworth, E.R., 2008a. Handbook of fermented functional foods.2nd ed., Farnworth, E.R. (Eds.), CRC, p: 602.
  • Farnworth, E.R., 2008b. The Evidence to support health claims for probiotics. The Journal of Nutrition,138: 1250-1254.
  • Frengova, G.I., Simova, E. D., Beshkova, D. M. and Simov, Z.I., 2002. Exopolysaccharides produced by lactic acid bacteria of kefir grains. Zeitschrift für Naturforschung C, 57(9-10), 805-810.
  • Fujisawa, T., Adachi, S., Toba, T., Arihara, K. and Mitsuoka, T., 1988. Lactobacillus kefiranofaciens sp. nov. isolated from kefir grains. International Journal of Systematic Bacteriology,38: 12- 14.
  • Furuno, T. and Nakanishi, M., 2012. Kefiran suppresses antigen-induced mast cell activation. Biological and Pharmaceutical Bulletin, 35(2): 178-183.
  • Garbers, I.M., Britz, T.J. and Witthuhn, R.C., 2004. PCR-based DGGE typfication and identification of the microbial consortium present in Kefir grains. World Journal of Microbiology and Biotechnology,20: 687-693.
  • Garrote, G.L., Abraham, A.G. and Antoni, G.L., 1998. Characteristics of kefir prepared with different grain: milk ratios. Journal of Dairy Research,65: 149-154.
  • Garrote, G.L., Abraham, A.G. and De-Antoni, G.L., 2001. Chemical an microbiological characterisation of kefir grains. Journal of Dairy Research,68: 639-652.
  • Ghoneum, M. and Gimzewski, J., 2014. Apoptotic effect of a novel kefir product, PFT, on multidrug-resistant myeloid leukemia cells via a hole-piercing mechanism. International Journal of Oncology, 44(3): 830-837.
  • Golowczyc, M.A., Gugliada, M.J., Hollmann, A., Delfederico, L., Garrote, G.L. and Abraham, A.G., 2008. Characterization of homofermentative Lactobacilli isolated from kefir grains: potential use as probiotic. Journal of Dairy Research,75, 211–217. doi:10.1017/S0022029908003117
  • Grishina, A., Kulikova, I., Alieva, L., Dodson, A. and Rowland, I., Jin, J., 2011. Antigenotoxic effect of kefir and ayran supernatants on fecal water-induced DNA damage in human colon cells.Nutrition and Cancer, 63(1): 7379.
  • Gürsoy, O. and Kınık, Ö., 2006. Türkiye'de fonksiyonel süt ürünleri pazarı: Gerçekler, beklentiler, öneriler. Türkiye 9. Gıda Kongresi; 24-26 Mayıs 2006, Bolu s: 123-124.
  • Güzel-Seydim, Z.B., Seydim, A.C. and Greene, A.K., 2000a. Organic acids and volatile flavor components evolved during refrigerated storage of kefir. Journal of Dairy Science,83: 275-277.
  • Güzel-Seydim, Z.B., Seydim, A.C., Greene, A.K. and Bodine, A.B., 2000b.Determination of organic acids and volatile flavor substances in kefir during fermentation.Journal of Food Composition and Analysis,13: 35-43.
  • Güzel-Seydim, Z.B., Seydim, A.C. and Greene, A.K., 2003. Comparison of amino acid profiles of milk, yoğurt and Turkish Kefir. Milchwissenschaft, 58(3-4): 158- 160.
  • Güzel-Seydim, Z.B., Wyffels, J.T., Seydim, A.C. and Greene, A.K., 2005. Turkish kefir and kefir grains: microbial enumeration and electron microscobic observation. International Journal of Dairy Technology,58: 25-29.
  • Güzel-Seydim, Z.B, Kök-Taş, T. and Greene, A.K., 2010. Kefir and Koumiss: Microbiology and Technology. In:"Development and Manufacture of Yogurt and Other Functional Dairy Products", 143-164, ISBN 978-1-4200-8207-4.
  • Güzel-Seydim, Z.B., Kök-Tas, T., Greene, A.K. and Seydim, A.C., 2011. Review: Functional properties of kefir. Critical Reviews in Food Science and Nutrition,51: 261-268.
  • Hamet, M. F., Medrano, M., Pérez, P. F. and Abraham, A.G., 2016. Oral administration of kefiran exerts a bifidogenic effect on BALB/c mice intestinal microbiota. Beneficial microbes, 7(2), 237-246.
  • Hertzler, S.R. and Clancy, S.M., 2003. Kefir improves lactose digestion and tolerance in adults with lactose maldigestion. Journal of the American Dietetic Association, 103, 582–587. 10.1053/jada.2003.50111
  • Hill, C., Guarner, F., Reid, G., Gibson, G.R., Merenstein, D.J. and Pot, B., 2014. Expert consensus document: the international scientific association for probiotics and prebiotics consensus statement on the scope and appropriate use ofthetermprobiotic. Nature Reviews Gastroenterology & Hepatology,11, 506–514.doi: 10.1038/nrgastro.2014.66
  • Hong, W.S., Chen Y.P. and Chen, M.J., 2010.The anti-allergic effect of kefir lactobacilli.Journal of Food Science,75: 244-253.
  • Hong, W.S., Chen, H.C., Chen, Y.P. and Chen, M.J., 2009. Effects of kefir supernatant and lactic acid bacteria isolated from kefir grain on cytokine production by macrophage. International Dairy Journal,19: 244-251.
  • Huseini, H.F., Rahimzadeh, G., Fazeli, M.R., Mehrazma, M. and Salehi, M., 2012.Evaluation of wound healing activities of kefir products.Burns,38(5), 719-723.
  • Irigoyen, A., Akana, I., Castiella, M., Torre, P. and Ibanez, F.C., 2005.Microbiological, physicochemical and sensory characteristics of kefir during storage.Food Chemistry,90: 613-620.
  • Iwasawa, S., Ueda, M., Miyata, N., Hirota, T. and Ahiko, K., 1982. Identification and fermentation character of kefir yeast. Agricultural and Biological Chemistry,46: 2631-2636.
  • Kakisu, E.J., Abraham, A.G., Perez, P.F. and De Antoni, G.L., 2007. Inhibition of Bacillus cereus in milk fermented with kefir grains. Journal of Food Protection®,70(11), 2613-2616.
  • Kakisu, E., Abraham, A.G., Farinati, C.T., Ibarra, C. and De Antoni, G.L., 2013. Lactobacillus plantarum isolated from kefir protects vero cells from cytotoxicity by type-II shiga toxin from Escherichia coli O157: H7. Journal of dairy research, 80(01), 64-71.
  • Kandler, O. and Kanuth, P., 1983. Lactobacillus kefir sp. nov., a component of the microflora of kefir.Systematic and Applied Microbiology,4: 286-294.
  • Karagözlü, C., 1990. Farklı ısıl işlem uygulanmış inek sütlerinden kefir kültürü ve kefir danesi ile üretilen kefirlerin dayanıklılığı ve nitelikleri üzerinde araştırmalar. Ege Üniversitesi Fen Bilimleri Enstitüsü, Yüksek Lisans Tezi, İzmir.
  • Khoury, N., El-Hayek, S., Tarras, O., El-Sabban, M., El-Sibai, M. and Rizk, S., 2014. Kefir exhibits anti-proliferative and pro-apoptotic effects on colon adenocarcinoma cells with no significant effects on cell migration and invasion. International Journal of Oncology,45(5): 2117-2127.
  • Kojic, M., Lozo, J., Begovic, J. and Jovcic, B., 2007. Characterisation of lactoccoci isolated from homemade kefir. Archives of Biological Sciences,59: 13-22.
  • Kök-Taş, T., 2010.Kontrollü atmosfer uygulamasının kefir danesi ve kefir üzerine etkilerinin belirlenmesi. Doktora Tezi, Süleyman Demirel Üniversitesi, Fen Bilimleri Enstitüsü, İsparta.
  • Köroğlu, Ö., Bakı,r E., Uludağ, G., Köroğlu, S. and Dayısoylu, K.S., 2015. Kefir ve sağlık.Kahramanmaraş Sütçü İmam Üniversitesi Doğa Bilimleri Dergisi, 18(1): 26-30.
  • Koroleva, N.S., 1991. Products prepared with lactic acid bacteria and yeasts. In: Robinson, R.K., editor. Therapeutic Properties of Fermented Milks: 159-179. Elsevier Sciences Publishers, London, UK.
  • Latorre-Garcia, L., Castillo-Agudo, L. and Polaina, J., 2007. Taxonomical classification of yeasts isolated from kefir based on the sequence of their ribosomal RNA genes. World Journal of Microbiology and Biotechnology,23: 785-791.
  • Lee, M.Y., Ahn, K.S., Kwon, O.K., Kim, M.J., Kim, M.K., Lee, I.Y., Oh, S.R. and Lee, H.K. 2007.Antiinflammatory and anti-allergic effects of kefir in a mouse asthma model.Immunobiology,212(8): 647- 654.
  • Leite, A., Miguel, M., Peixoto, R., Ruas-Madiedo, P., Paschoalin, V. and Mayo, B., 2015. Probiotic potential of selected lacticacid bacteria strains isolated from Brazilian kefirgrains. Journal of Dairy Science, 98, 3622–3632.doi:10.3168/jds.2014-9265
  • Leite, A.M.O., Leite, D.C.A., Del Aguila, E.M., Alvares, T.S.,Peixoto, R.S., Miguel, M.A.L., Silva, J.T. and Paschoalin, V.M.F., 2013a. Microbiological and chemical characteristics of Brazilian kefir during fermentation and storage processes.Journal of Dairy Science,96, 4149-4159.
  • Leite, A.M.O., Miguel, M.A.L., Peixoto, R.S., Rosado, A.S., Silva, J.T. and Paschoalin, V.M.F., 2013b. Microbiological, technological and therapeutic properties of kefir: a natural probiotic beverage. Brazilian Journal of Microbiology, 44(2), 341-349.
  • Likotrafiti, E., Valavani, P., Argiriou, A., and Rhoades, J., 2015. Invitroevaluation of potential antimicrobial synbioticsusing Lactobacilluskefiri isolated from kefir grains. International Dairy Journal,45, 23–30. doi:10.1016/j.idairyj.2015.01.013
  • Lin, C.W., Chen, H.L. and Liu, J.R., 1999. Identification and characterization of lactic acid bacteria and yeasts isolated from kefir grains in Taiwan. Australian Journal of Dairy Technology,54: 5-9.
  • Liu, J.R., Chen, M.J. and Lin, C.W., 2002a. Characterization of polysaccharide and volatile compounds produced by kefir grains grown in soymilk.Journal of Food Science,67:104-108.
  • Liu, J.R., Wang, S.Y., Lin, Y.Y. and Lin, C.W., 2002b. Antitumor activity of milk kefir and soy milk kefir in tumor-bearing mice.Nutrition and Cancer, 44(2): 183-187.
  • Liu, J.R., Wang, S.Y., Chen, M.J., Chen, H.L., Yueh, P.Y. and Lin, C.W., 2006a. Hypocholesterolaemic effects of milk-kefir and soyamilk-kefir in cholesterol-fed hamsters. British journal of nutrition, 95(05), 939-946.
  • Liu, J.R., Wang, S.Y., Chen, M.J., Yueh, P.Y. and Lin, C.W., 2006b. The anti‐allergenic properties of milk kefir and soymilk kefir and their beneficial effects on the intestinal microflora.Journal ofthe Science of Food and Agriculture, 86(15), 2527-2533.
  • Lopitz-Otsoa, F., Rementeria, A., Elguezabal, N. and Garaizar, J., 2006. Kefir: a symbiotic yeasts-bacteria community with alleged healthy capabilities. Revista Iberoamericana de Micología, 23: 67-74.
  • Maalouf, K., Baydoun, E. and Rizk, S., 2011. Kefir induces cell-cycle arrest and apoptosis in HTLV-1-negative malignant T-lymphocytes. Cancer Managemet and Research,3: 39-47.
  • Maeda, H., Zhu, X., Suzuki, S., Suzuki, K. and Kitamura, S., 2004. Structural characterization and biological activities of an exopolysaccharide kefiran produced by Lactobacillus kefiranofaciens WT-2BT.Journal of agricultural and food chemistry,52(17), 5533-5538.
  • Mainville, I., Robert, N., Lee, B.H. and Farnworth, E.R., 2006. Polyphasic characterization of the lactic acid bacteria in kefir.Systematic Applied Microbiology,29: 59-68.
  • Marquina, D., Santos, A., Corpas, I., Munoz, J., Zazo, J. and Peinado, J.M., 2002. Dietary influence of kefir on microbial activities in the mouse bowel.Letters in Applied Microbiology, 35: 136-140.
  • Marsh, A.J., O’Sullivan, O., Hill, C., Ross, R.P. and Cotter, P.D., 2013. Sequencing-based analysis of the bacterial and fungal composition of kefir grains and milks from multiple sources.PLOS ONE, 8(7), e69371.
  • Marshall, V.M., 1993. Starter cultures for milk fermentation and their characteristics. Journal of Society of Dairy Technology,46: 49-56.
  • Miao, J., Guo, H., Ou, Y., Liu, G., Fang, X. and Liao, Z., 2014. Purification andcharacterizati on of bacteriocin F1 ,an ovel bacteriocin produced by Lactobacillus paracasei sub sp. Tolerans FX-6 from Tibet an kefir, a traditional fermented milk from Tibet, China Food Control, 42, 48–53. doi: 10.1016/j.foodcont.2014.01.041
  • Micheli, L., Uccelletti, D., Palleschi, C. and Crescenzi, V., 1999.Isolation ve characterization of a ropy Lactobacillus strain producing exopolysaccharide kefiran.Applied Microbiology ve Biotechnology,53: 69-74.
  • Mobili, P., Londero, A., Maria, T.M.R., Eus'ebio, M.E.S., De Antoni, G.L., Fausto, R. and G'omez-Zavaglia, A., 2008.Characterization of S-layer proteins of Lactobacillus by FTIR spectroscopy and differential scanning calorimetry.Vibrational Spectroscopy,50: 68-77.
  • Motaghi, M., Mazaheri, M., Moazami, N., Farkhondeh, A., Fooladi, M.H. and Goltapeh, E.M., 1997. Short communication: Kefir production in Iran. World Journal of Microbiology and Biotechnology,13: 579–581.
  • Okur, Ö.D., Artan, E., Soyyiğit, H. and Seydim, Z.G., 2008. Production of yogurt with improved functional properties.Gıda,33: 57-67.
  • Ottogalli, G., Galli, A., Resmini, P. and Volonterio, G., 1973. Composizione microbiologica, chimica ed ultrastruttura dei granuli di kefir. Annuario Microbiologia,23: 109-121.
  • Parvez, S., Malik, K.A., Ah Kang, S. and Kim, H.Y., 2006. Probiotics and their fermented food products are beneficial for health. Journal of applied microbiology, 100(6), 1171-1185.
  • Pintado, M.E., Lopes Da Silva, J.A., Fernandes, P.B., Malcata, F.X. and Hogg, T.A., 1996.Microbiological and rheological studies on Portuguese kefir grains.International Journal of Food Science Technology,31: 15-26.
  • Rattray, F.P. and O’Connell, M.J., 2011. Fermented Milks Kefir. In: Fukay, J. W. (ed.), Encyclopedia of Dairy Sciences (2th ed). Academic Press , San Diego, USA, p.518-524.
  • Rea, M.C., Clayton, .,O’Connor, P.M.,Shanahan, F., Kiely, B. and Ross, R.P., 2007. Antimicrobial activity of lacticin 3,147 against clinical Clostridium difficile strains.Journal of Medical Microbiology, 56, 940–946. doi:10.1099/jmm.0.47085-0
  • Rimada, P.S. and Abraham, A.G., 2006. Kefiran improves rheological properties of glucono-δ-lactone induced skim milk gels. International Dairy Journal, 16(1), 33-39.
  • Rizk, S., Maalouf, K. and Baydoun, E., 2009.The antiproliferative effect of kefir cell-free fraction on HuT-102 malignant T lymphocytes.Clinical Lymphoma, Myeloma and Leukemia, 9(3): 198- 203.
  • Rodrigues, K.L., Caputo, L.R., Carvalho, J.C., Evangelista, J. and Schneedorf, J.M., 2005. Antimicrobial and healing activity of kefir and kefiran extract. International Journal of Antimicrobial Agents,25, 404–408, doi:10.1016/j.ijantimicag.2004.09.020.
  • Rohm, H., Eliskases-Lechner, F. and Brauer, M., 1992. Diversity of yeasts in selected dairy products. Journal of Applied Bacteriology,72: 370-376.
  • Rosi, J. and Rossi, J., 1978. The kefir microorganisms: The lactic acid bacteria. Sciezae Tecnica Lattiero Caseariad, 29: 91-305.
  • Ryan, M.P., Rea, M.C., Hill,C. and Ross,R.P., 1996. Anapplicationin cheddar cheese manufacture for astrain of Lactococcuslactis producing a novel broad-spectrum bacteriocin, lacticin 3147.Applied and Environmental Microbiology,62, 612–619.
  • Santos, A., Mauro M.S. , Sanchez, A., Torres, J.M. and Marquina, D., 2003. The antimicrobial properties of different strains of Lactobacillus spp. isolated from kefir. Systematic and Applied Microbiology,26: 434-437.
  • Sarkar, S., 2007.Potential of kefir as a dietetic beverage - a review.British Food Journal,109: 280-290.
  • Sarkar, S., 2008. Biotechnological innovations in kefir production: a review. British Food Journal,110: 283-295.
  • Seppo, L., Kerojoki, O., Suomalainen, T. and Korpela, R., 2002. The effect of a Lactobacillus helveticus LBK-16 H fermented milk on hypertension — a pilot study on humans. Milchwissen,57, 124–127.
  • Setyowati, H. and Setyani, W., 2016. Kefir: a new role as nutraceuticals. Jurnal Kedokteran dan Kesehatan Indonesia Indonesian Journal of Medicine and Health, 7 (5). pp. 200-209. DOI : 10.20885/JKKI.Vol7.Iss5.art5
  • Sezgin, E., 2010. Fermente süt ürünleri teknolojisi. Süt Teknolojisi, (Editör: Prof. Dr. Atila Yetişemiyen), Ankara Üniversitesi Ziraat Fakültesi Süt Teknolojisi Bölümü Yayınları, Yayın No: 1560 s: 101-136, Ankara.
  • Shah, N.P., 2015.“Functional properties of fermented milks,” in Health Benefits of Fermented Foods, ed. Tamang J. P., editor. (New York, NY: CRC Press; ), 261–274.
  • Shiby, V.K. and Mishra, H.N., 2013. Fermented milks and milk products as functional foods- A review.Critical Reviews in Food Science and Nutrition,53: 482-96.
  • Simova, E., Beshkova, D., Angelov, A., Hristozova, T., Frengova, G. and Spasov, Z., 2002. Lactic acid bacteria and yeasts in kefir grains and kefir made from them. Journal of Industrial Microbiology and Biotechnology,28: 1-6.
  • Simova, E., Simov, Z., Beshkova, D., Frengova, G., Dimitrov, Z. and Spasov, Z., 2006. Amino acid profiles of lactic acid bacteria, isolated from kefir grains and kefir starter made from them. International Journal of Food Microbiology, 107: 112-123.
  • Sipola, M., Finckenberg, P., Korpela, R., Vapaatalo, H., Nurminen, M., 2002.Effect of long-term intake of milk products on blood pressure in hypertensive rats.Journal of Dairy Research,69, 103–111. 10.1017/S002202990100526X
  • Sjögren, Y. M., Jenmalm, M. C., Böttcher, M. F., Björkstén, B. and Sverremark‐Ekström, E., 2009. Altered early infant gut microbiota in children developing allergy up to 5 years of age.Clinical & Experimental Allergy, 39(4), 518-526.
  • Takizawa, S., Kojima, S., Tamura, S., Fujinaga, S., Benno, Y. and Nakase, T., 1994. Lactobacillus kefirgranum sp. nov. and Lactobacillus parakefir sp.nov., two new species from kefir grains.International Journal of Systematic Bacteriology,44: 435-439.
  • Tamang, J.P., Tamang, B., Schillinger, U., Guigas, C. and Holzapfel, W.H., 2009. Functional properties of lactic acid bacteria isolated from ethnic fermented vegetables of the Himalayas. International Journal of Food Microbiology,135, 28–33.
  • Tamang, J. P., Shin, D.-H., Jung, S.-J.and Chae, S.W., 2016a. Functional Properties of Microorganisms in Fermented Foods.Frontiers in Microbiology,7,578,http://doi.org/10.3389/fmicb.2016.00578
  • Tamang, J.P., Watanabe, K. and Holzapfel, W.H., 2016b. Review: Diversity of microorganisms in global fermented foods and beverages. Frontiers in Microbiology, 7: 377 10.3389/fmicb.2016.00377.
  • Tamime, A.Y., 2002. Fermented milks: ahistorical food with modern applications–areview The European Journal of Clinical Nutrition,56, (Suppl. 4), S2–S15, doi: 10.1038/sj.ejcn.1601657
  • Tamime. A.Y, 2006 Production of Kefir, Koumiss and Other Related Products. In: Tamime, AY (ed.), Fermented Milk Blackwell Science Ltd , Oxford, UK, p.174-216.
  • Tellez, A., Corredig, M., Brovko, L.Y. and Griffiths, M.S., 2010. Characterization of immune active peptides obtained from milk fermented by Lactobacillus helveticus.Journal of Dairy Research, 77: 129-36.
  • Teruya, K., Yamashita, M., Tominaga, R., Nagira, T., Shim, S.Y., Katakura, Y., Tokumaru S., Tokumaru, K., Barnes, D. and Shirahata, S., 2002. Fermented milk, Kefram-Kefir enhances glucose uptake into insulinresponsive muscle cells. Cytotechnology,40(1-3): 107-116.
  • Terzi, G., 2007. Kefirin bileşimi ve beslenme açısından önemi.Veteriner Hekimler Derneği Dergisi, 78: 23-30.
  • Thapa, N. and Tamang, J.P., 2015. “Functionality and therapeutic values of fermented foods,” in Health Benefits of Fermented Foods, ed. Tamang J. P., editor. (New York: CRC Press; ), 111–168.
  • Tomar, O., 2015. Farklı yağ oranlarına sahip inek ve manda sütleri kullanılarak iki ayrı üretim metoduyla üretilen kefir örneklerinin depolama süresince bazı kalite karakteristiklerinin belirlenmesi. Doktora Tezi, Afyon Kocatepe Üniversitesi Fen Bilimleri Enstitüsü Gıda Mühendisliği Anabilim Dalı, Afyonkarahisar, 176.
  • Valasaki, K., Staikou, A., Theodorou, L.G., Charamopoulou, V., Zacharaki, P. and Papamichae, E.M., 2008. Purification and kinetics of two novel thermophilic extracellular proteases from Lactobacillushelveticus, from kefir with possible biotechnological interest. Bioresource Technology, 99: 5804-5813.
  • Verna, E.C. and Lucak, S., 2010. Use of probiotics in gastrointestinal disorders: what to recommend?.Therapeutic Advances in Gastroenterology, 3, 307–319.
  • Viljoen, B.C., 2001. The interaction between yeasts ve bacteria in dairy environments.International Journal of Food Microbiology,69: 37-44.
  • Vinderola, C.G., Duarte, J., Thangavel, D., Perdigon, G., Farnworth, E. and Matar, C., 2005. Immunomodulating capacity of kefir.Journal of Dairy Research,72(02): 195-202.
  • Vinderola, G., Perdigón, G., Duarte, J., Farnworth, E. and Matar, C., 2006. Effects of the oral administration of the exopolysaccharide produced by Lactobacillus kefiranofaciens on the gut mucosal immunity. Cytokine, 36: 254-260.
  • Wagar, L.E., Champagne, C.P., Buckley, N.D., Raymond, Y. and Gren-Johnson, J.M., 2009. Immunomodulatory properties of fermented soy and dairy milks prepared with lactic acid bacteria. Journal of food scienc.,74: 423-430.
  • Walsh, A.M., Crispie, F., Kilcawley, K., O’Sullivan, O., O’Sullivan, M.G., Claesson, M. J. and Cotter, P.D., 2016.Microbial Succession and Flavor Production in the Fermented Dairy Beverage Kefir.mSystems,1(5), e00052-16.
  • Wang, S.Y., Chen, H.C., Liu, J.R., Lin, Y.C. and Chen, M.J., 2008. Identification of yeasts and evaluation of their distribution in Taiwanese kefir and Viili starters.Journal of Dairy Science,91: 3798-3805.
  • Wang, Y., Xu, N., Xi, A., Ahmed, Z., Zhang, B. and Bai, X., 2009. Effects of Lactobacillus plantarum MA2 isolated from Tibet kefir on lipid metabolism and intestinal microflora of rats fed on high-cholesterol diet. Applied Microbiology and Biotechnology,84(2), 341-347.
  • West, C.E., 2014. Gut microbiota and allergic disease: new findings. Current Opinion İn Clinical Nutrition And Metabolic Care,17, 261–266. doi: 10.1097/MCO.0000000000000044
  • Wojtowski, J., Dankow, R., Skrzypek, R. and Fahr, R.D., 2003. The fatty acid profile in kefirs from sheep, goat and cow milk.Milchwissenchaft,58: 633-636.
  • Wood, R.A., 2003.The natural history of food allergy. Pediatrics, 111, 1631–1637.
  • Wouters, J.T.M., Ayad, E.H.E., Hugenholtz, J. and Smit, G., 2002. Microbes from raw milk for fermented dairy products.International Dairy Journal, 12: 91-109.
  • Wszolek, M., Tamime, A., Muir, D. and Barclay, M., 2001. Properties of kefir made in Scotland and Poland using bovine, caprine and ovine milk with different starter cultures. LWT- Food Science and Technology. 34, 251–261. doi: 10.1006/ fstl.2001.0773
  • Yanping, W., Nv, X., Aodeng, X., Zaheer, A., Bin, Z. and Xiaojia B., 2009. Effects of Lactobacillus plantarum MA2 isolated from Tibet kefir on lipid metabolism and intestinal microflora of rats fed on high-cholesterol diet. Applied Microbiology and Biotechnology,84, 341–347. 10.1007/s00253-009-2012-x
  • Yetişemiyen, A., 1995. Süt Teknolojisi. Ankara Üniversitesi Ziraat Fakültesi Yayınları, Yayın No: 1420, Ankara, s: 220.
  • Yıldırım, Z. and Yıldırım, M., 2000.Probiyotik özellik gösteren bifidobakteriler.Süt Mikrobiyolojisi ve Katkı Maddeleri, VI. Süt ve Süt Ürünleri Sempozyumu Tebliğler Kitabı, Editör: Mehmet Demirci, s. 266-271, Tekirdağ.
  • Yıldız, F., 2009. Farklı yağ oranlarının ve farklı starter kültürlerin kefirin nitelikleri üzerine etkisi, Doktora Tezi, Ankara Üniversitesi, Fen Bilimleri Enstitüsü, Ankara.
  • Yilmaz-Ersan, L., Ozcan, T., Akpinar-Bayizit, A. and Sahin, S., 2016. The Antioxidative Capacity of Kefir Produced from Goat Milk. International Journal of Chemical Engineering and Applications, 7(1), 22.
  • Yoshida, T. and Toyoshima, K., 1994. Lactic acid bacteria and yeast from kefir. Journal of Japan Society of Nutrition Food Science, 47: 55-59.
  • Yüksekdağ, Z.N., Beyatlı, Y. and Aslım, B., 2004. Determination of some characteristics coccoid forms of lactic acid bacteria isolated from Turkish kefirs with natural probiotic. Lebensmittel-Wissenschaft und -Technologie, 37: 663-667.
  • Zacconi, C., Scolari, G., Vescovo, M. and Sarra, P.G., 2003. Competitive exclusion of Campylobacter jejuni by kefir fermented milk. Annals of Microbiology,53(2): 179-188.
  • Zanirati, D.F., Abatemarco, M., deCiccoSandes, S.H., Nicoli, J.R., Nunes, ÁC.and Neumann, E., 2015. Selection of lactic acid bacteria from Brazilian kefir grains for potential use as starter or probiotic cultures. Anaerobe,32, 70–76. doi: 10.1016/j.anaerobe.2014.12.007
  • Zhou, J., Liu, X., Jiang, H. and Dong, M., 2009. Analysis of the microflora in Tibetan kefir grains using denaturing gradient gel electrophoresis. Food Microbiology, 26(8): 770-775.
Toplam 149 adet kaynakça vardır.

Ayrıntılar

Birincil Dil Türkçe
Bölüm Makaleler
Yazarlar

Oktay Tomar

Abdullah Çağlar Bu kişi benim

Gökhan Akarca Bu kişi benim

Yayımlanma Tarihi 31 Ağustos 2017
Gönderilme Tarihi 2 Mart 2017
Yayımlandığı Sayı Yıl 2017 Cilt: 17 Sayı: 2

Kaynak Göster

APA Tomar, O., Çağlar, A., & Akarca, G. (2017). Kefir ve Sağlık Açısından Önemi. Afyon Kocatepe Üniversitesi Fen Ve Mühendislik Bilimleri Dergisi, 17(2), 834-853.
AMA Tomar O, Çağlar A, Akarca G. Kefir ve Sağlık Açısından Önemi. Afyon Kocatepe Üniversitesi Fen Ve Mühendislik Bilimleri Dergisi. Ağustos 2017;17(2):834-853.
Chicago Tomar, Oktay, Abdullah Çağlar, ve Gökhan Akarca. “Kefir Ve Sağlık Açısından Önemi”. Afyon Kocatepe Üniversitesi Fen Ve Mühendislik Bilimleri Dergisi 17, sy. 2 (Ağustos 2017): 834-53.
EndNote Tomar O, Çağlar A, Akarca G (01 Ağustos 2017) Kefir ve Sağlık Açısından Önemi. Afyon Kocatepe Üniversitesi Fen Ve Mühendislik Bilimleri Dergisi 17 2 834–853.
IEEE O. Tomar, A. Çağlar, ve G. Akarca, “Kefir ve Sağlık Açısından Önemi”, Afyon Kocatepe Üniversitesi Fen Ve Mühendislik Bilimleri Dergisi, c. 17, sy. 2, ss. 834–853, 2017.
ISNAD Tomar, Oktay vd. “Kefir Ve Sağlık Açısından Önemi”. Afyon Kocatepe Üniversitesi Fen Ve Mühendislik Bilimleri Dergisi 17/2 (Ağustos 2017), 834-853.
JAMA Tomar O, Çağlar A, Akarca G. Kefir ve Sağlık Açısından Önemi. Afyon Kocatepe Üniversitesi Fen Ve Mühendislik Bilimleri Dergisi. 2017;17:834–853.
MLA Tomar, Oktay vd. “Kefir Ve Sağlık Açısından Önemi”. Afyon Kocatepe Üniversitesi Fen Ve Mühendislik Bilimleri Dergisi, c. 17, sy. 2, 2017, ss. 834-53.
Vancouver Tomar O, Çağlar A, Akarca G. Kefir ve Sağlık Açısından Önemi. Afyon Kocatepe Üniversitesi Fen Ve Mühendislik Bilimleri Dergisi. 2017;17(2):834-53.