Düşük Çözünürlüklü İlaç Etken Maddeleri ve Setrimid Temelli Yüzey Aktif Madde Miselleri Arasındaki Etkileşimlere Polaritenin Etkisi

Yıl 2025, Cilt: 25 Sayı: 2, 305 - 311, 11.04.2025

Sinem Gokturk , Onur Cirit

https://doi.org/10.35414/akufemubid.1400616

Öz

Bu çalışmanın amacı farmasötik uygulamalarda sıklıkla kullanılan üçlü katyonik yüzey aktif madde karışımı olan setrimid (dodesiltrimetil ammonyum bromür; DTAB + tetradesiltrimetil amonyum bromür; TTAB + hekzadesiltrimetil amonyum bromür; CTAB) ve bileşenlerinin suda düşük çözünürlüğe sahip olan asidik sülfametoksazol (SMZ) ve bazik trimetoprim (TMP) ilaç etken maddeleri ile arasındaki etkileşimlerin incelenmesidir. SMZ ve TMP’nin DTAB, TTAB, CTAB ve Setrimid ile etkileşimleri katyonik yüzey aktif maddelerin kritik misel derişimleri altında ve üzerindeki derişimlerinde spektrofotometrik yöntemle 298 K’de çalışıldı. Benesi-Hildebrand Denklemi kullanılarak, TMP ve SMZ’nin katyonik misellere bağlanma sabitleri hesaplandı. İlaç etken maddelerinin farklı hidrofobisiteye sahip katyonik miselere bağlanma sabitleri büyüklüğü karşılaştırıldığında CTAB > TTAB > DTAB sırasını izlediği ve en kuvvetli etkileşimin CTAB miselleri varlığında gerçekleştiği bulundu. TMP’nin, setrimid misellerine bağlanma eğilimi en yüksek ilaç etken maddesi olduğu saptandı. TMP ve SMZ'nin katyonik misellere bağlanma eğilimleri karşılaştırıldığında bağlanma sabitleri ve misellerin hidrofobisiteleri arasında doğrudan bir ilişki olduğu görüldü.

Anahtar Kelimeler

Sülfametoksazol, Trimetoprim, Katyonik yüzey aktif madde, Setrimid, Etkileşim, Bağlanma sabiti

Effect of Polarity on the Interactions Between Poorly Water-soluble Drugs and Cetrimide-Based Surfactant Micelles

Öz

This study aims to examine the interactions of cetrimide which is a ternary cationic surfactants mixture (dodecyl trimethyl ammonium bromide; DTAB + tetradecyl trimethyl ammonium bromide; TTAB + hexadecyl trimethyl ammonium bromide; CTAB) which is frequently used in pharmaceutical applications and its components with sulfamethoxazole (SMX) and basic trimethoprim (TMP) known as poorly water-soluble drugs at 298 K. The interactions of SMX and TMP with DTAB, TTAB, CTAB and Cetrimid have been studied by absorption spectra as a function of cationic surfactant concentration ranging from the premicellar to postmicellar region at 298 K. Binding constants (Kb) of SMX and TMP to cationic micelles have been calculated employing the Benesi-Hildebrand Equation. When comparing the binding tendencies of drugs having different hydrophobicities of cationic micelles the stronger interaction has been found in the presence of CTAB micelles and followed the order as CTAB>TTAB>DTAB. It has also been determined that TMP had the highest tendency to bind to cetrimide micelles compared with SMX. Comparing the binding affinities of TMP and SMX to cationic micelles indicated that there was a direct relationship between the binding constants and the hydrophobicity of the micelles.

Anahtar Kelimeler

Sulfamethoxazole, Trimethoprim, Cationic surfactant, Cetrimide, Interaction, Binding constant

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