DRESS Syndrome After Phenytoin Use: A Case Report

Yıl 2017, Cilt: 17 Sayı: 4, 308 - 313, 20.12.2017

Bora Tetik , Ali Serdar Oğuzoğlu Burcu Kayhan Tetik , Gülbahar Saraç

https://doi.org/10.17098/amj.339338

Öz

DRESS syndrome
is alife threatening, rare  hypersensitivity
reaction to drugs with an acute onset that is characterized by fever, skin
rash, visceral involvement, and hematological abnormalities. It is often seen
after the use of aromatic anticonvulsants. In this article, a forty-four year
old male patient with fever and skin rash after two weeks of phenytoin
administration is discussed. He has been treated successfully with systemic
corticosteroids and supportive therapy after the discontinuation of phenytoin
therapy. In first step health-care, the primary physician should be able to
administer his patients’ acute and chronic health problems concurrently. As in
our case, a family physician should administer his patient well in the presence
of fever with acute onset and he should question about the drugs used in the
presence of accompanying skin rash.

Anahtar Kelimeler

DRESS syndrome, phenytoin, skin rash

Fenitoin Kullanımı Sonrası Gelişen DRESS Sendromu: Olgu Sunumu

Öz

DRESS Sendromu ateş, cilt döküntüsü, iç organ tutulumu ve
hematolojik anormalliklerle karakterize akut başlangıçlı, hayatı tehdit eden,
nadir görülen, ilaca bağlı bir aşırı duyarlılık reaksiyonudur. En sık nedeni
aromatik antikonvülzan kullanma sonrası görülmektedir. Bu olguda fenitoin
kullanımı sonrasında ikinci haftada ateş yüksekliği ve cilt döküntüleri başlayan
kırk dört yaşında bir erkek hasta sunulmuştur. 
Olgu, fenitoin tedavisinin kesilmesi sonrasında sistemik kortikosteroid
ve destek tedavisi ile başarılı bir şekilde tedavi edilebilmiştir. Birinci
basamakta aile hekimi, hastalarının akut ve kronik sağlık sorunlarını aynı anda
yönetebilmelidir. Olgumuzda olduğu gibi akut başlangıçlı ateşe yaklaşımda bir
aile hekimi hastasını iyi yönetebilmeli ve beraberinde cilt döküntüleri de
gördüğünde kullandığı ilaçları da sorgulayarak DRESS Sendromunu akla
getirmelidir.

Anahtar Kelimeler

DRESS sendromu, fenitoin, cilt döküntüsü

Kaynakça

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