Does the use of corticosteroid nasal spray play a role in the development of central serous chorioretinopathy?

Yıl 2017, Cilt: 22 Sayı: 3, 163 - 168, 25.09.2017

Ahmet Elbay , Alper Yenigün Hakan Özdemir Ömer Faruk Çalım , Cansu Ekinci Rukiye Çetinkaya

https://doi.org/10.21673/anadoluklin.337345

Öz

Aim:
The aim of the present study is to investigate the effect of corticosteroid-containing
nasal spray on development of central serous chorioretinopathy (CSC)
development and thickness of choroid and Retinal pigment epithelium-Bruch
membrane complex (RPE-BM).

Materials and Methods: Twenty-nine patients (18 female, 11 male) receiving
nasal mometasone spray were included in the study. Systolic blood pressure
(SBP), diastolic blood pressure (DBP), visual acuity, intraocular pressure and
choroidal and RPE-BM thicknesses
were measured before and one week and one month after drug administration.
Optical coherence tomography sections were examined in terms of CSCdevelopment.
Measurements were made from the right eye.

Results: Central serous chorioretinopathy was not detected in any of the patients.
Mean choroidal thickness measurements did not show any statistically
significant changes between baseline values ​​and follow-up measurements: On
the temporal side 292.48±73.02 μm before the treatment, 296.83±79.09 μm at the
first week, 295.41±74.13 μm at the first month (p = 0.405); at the subfovea
360.62±92.44 μm at baseline, 364.04±93.65 μm at the first week, and
365.66±95.86 μm at the first month (p = 0.208) under the fovea; on the nasal
side, 282.86±96.11 μm at the beginning, 285.28±93.25 μm at the first week and
284.28±98.14 μm at the first month (p = 0.819). RPE-BM was measured as 21.65±2.86 μm at the beginning,
21.24±2.61 μm at the first week and 21.58±2.09 μm at the first month.
Differences were not statistically significant (p = 0.450). There was no
significant difference in intraocular pressure (p = 0.450), SBP (p = 0.257) and
DBP (p = 0.249) measurements.

Discussion and Conclusion: Further studies are needed to determine the incidence
of corticosteroid-induced SSR and cause-effect relationship between CSC
development and choroid or RPE-BM thickness.

Anahtar Kelimeler

Central serous chorioretinopathy, choroidal thickness, retinal pigment epithelium-Bruch membrane complex, corticosteroid, nasal spray

Kortikosteroid içerikli burun spreyi kullanımının santral seröz koryoretinopati gelişiminde rolü var mı?

Öz

Amaç:
Bu çalışmanın amacı kortikosteroid içerikli burun spreyi kullanımının santral
seröz koryoretinopati (SSR) gelişimine ve koroid ve retina pigment epiteli -
Bruch membran kompleksi (RPE-BM) 
kalınlığı üzerine etkisini araştırmaktır.

Gereç ve Yöntemler:
Çalışmaya mometazon içerikli burun spreyi tedavisi başlanan 29 hasta (18 kadın,
11 erkek)  dahil edildi. Hastaların ilaç
kullanımından önce ve ilaç kullanmaya başladıktan bir hafta ve bir ay sonra
sistolik kan basıncı (SKB), diastolik kan basıncı (DKB), görme keskinliği, göz
içi basıncı ile koroid ve RPE-BM kalınlıkları ölçüldü. Optik koherens tomografi
kesitleri SSR gelişimi açısından incelendi. Ölçümler sağ gözden yapıldı.

Bulgular:
Tedavi sonrası hiçbir hastada SSR saptanmadı. Ortalama koroid kalınlığı ölçümlerinde başlangıç
değerlerle kontrol muayenelerindeki ölçümler arasında istatistiksel  olarak anlamlı değişiklikler saptanmadı:  Temporal tarafta başlangıçta 292,48±73,02 µm,  1. haftada 296,83±79,09 µm, 1. ayda
295,41±74,13 µm (p = 0,405); fovea altında başlangıçta 360,62±92,44 µm,  1. haftada 364,04±93,65 µm, 1. ayda
365,66±95,86 µm (p = 0,208); nasal tarafta başlangıçta 282,86±96,11 µm, 1.
haftada 285,28±93,25 µm, 1. ayda 284,28±98,14 µm (p = 0,819), RPE-BM başlangıçta
21,65±2,86 µm iken 1. haftada 21,24±2,61 µm, 1. ayda ise 21,58±2,09 µm olarak
ölçüldü. Farklılıklar istatistiksel olarak anlamlı değildi (p = 0,450). Göz içi
basıncı (p = 0,450), SKB (p = 0,257) ve DKB (p = 0,249)  ölçümlerinde de anlamlı fark saptanmadı.

Tartışma ve Sonuç: Kortikosteroid kaynaklı SSR
insidansını incelemek için ve SSR gelişimi ile koroid ya da RPE-BM kalınlığı
arasında bir ilişki olup olmadığını kesin olarak belirlemek için daha ileri
çalışmalara ihtiyaç vardır.

Anahtar Kelimeler

Santral seröz koryoretinopati, koroid kalınlığı, retina pigment epiteli – Bruch membran kompleksi, kortikosteroid, nasal sprey

Kaynakça

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