İleri Evre Küçük Hücreli Dışı Akciğer Kanserinde Palyatif Amaçlı Tek Doz 10 Gy Tedavi Şemasının Etkinliği
Öz
Amaç: Biz bu çalışmamızda, ileri evre
küçük hücreli dışı akciğer kanserli 17 hastada
tek doz 10 Gy tedavisinin palyatif etkinliğini
araştırmayı amaçladık.
Materyal Metod:Daha önce tedavi
görmemiş, genel durumu kötü, ileri evre küçük
hücreli dışı 15 hastaya kobalt teleterapi cihazı
ile tek fraksiyonda 10 Gy palyatif RT
uygulanmıştır.
Sonuçlar: Tedavi sonrası öksürük
yakınması olan 15 hastanın 8’inde komplet
(%53), 3’ünde parsiyel (%20); hemoptizisi
olan 8 hastanın tümünde komplet (%100)
cevap alındı. Göğüs ağrısı olan 11 hastanın
3’ünde parsiyel (%27) parsiyel cevap alınırken
8 hasta cevapsızdı (%72). Nefes darlığı olan 9
hastanın 5’inde parsiyel (%55) cevap
gözlenirken 4 hasta tedaviye cevap vermedi
(%45).
İleri evre, performansı kötü küçük hücreli
dışı akciğer kanserli hastalarda özellikle
hemoptizi palyasyonu için tek doz 10 Gy
radyoterapi uygulanması rasyonel olabili
Anahtar Kelimeler
Kaynakça
- Chay TK: Role of radiotherapy in advanced carcinoma of the lung. Proceedins 7th Asia-Pasific Congres on Diseases of the Chinese, Nandi PL , Lam WK (Eds) Hong Kong, Southeast Printing Co 1981, pp. 300-304
- Perez CA , Stanley K , Grandy G. et al: Impact of irradiation technique and tumor extent in tumor control and survival of patients with unresectable non-oat cell carcinoma of the lung: Report by the Radiation Therapy Oncology Group. Cancer 1989; 1091-1099
- Carroll M , Morgan SA, Yarnold. et all. Prospective evaluation of a watch policy in patients with inoperabl non–small-cell lung cancer. Eur J. Cancer Clin. Oncol, 22, 1353-1356
- Fowler JF. : Non-standard fractionation in radiotherapy. Int. J. Radiat. Oncol. Biol Phys. 1984; 10(5) : 755-759
- Moore J: Recent advances in radiobiology. In Modern Trends in Radiotherapy, vol.2, Deeley TJ. (Ed.).London, Betherworths. 1972, pp 21-25
- Overgoard M: The clinical implications of non-standard fractionation (Letter). Int J. Radiat. Oncol. Biol. Phys. 1985; 11(6): 1225-1227
- Peschel RE, Fisher JJ. : Optimization of the time–dose relationship, Sem. Oncol. 1981; 8 (1): 38-48
- Withers HR : Biologic basis for altered fractionation scheme. Cancer 1985; 55 (Suppl,9):2086-2095
- Peter Teo TH, Tai Domon Cho et al: A randomized study on palliative radiation therapy for inoperable non small cell carcinoma of lung . Int J Radiation Oncology Biol. Phys: 1987; 14: 867-870
- Lung Cancer Working Party: In operable non small cell lung cancer: A Medical Research Council randomize trial of palliative radiotherapy with two fraction or ten fraction.
- Lung Cancer Working Party, MRC randomize trial of palliative radiotherapy with two fraction or single fraction in patient with inoperable non small cell lung cancer and poor performance status. Br J. Cancer 1992; 65: 934-941
The Effectivenes of Single Fraction 10 Gy Treatment Planning in Patients with Advanced Non-Small Cell Lung Cancer
Öz
Purpose: In our study we evaluated the
effectivenes of single fraction of 10 Gy
radiotherapy on non-small cell lung cancer
patients who had symptoms such as cough,
pain, hemoptysis and dyspnea.
Material and Method: Previously
untreated fifteen patients who had advanced
non-small cell lung cancer and poor prognostic
criterions were irradiated by cobalt 60 with 10
Gy doses in single fraction
Results: We observed complete response
in 8 patients (%53) and partial response in 3
patients (%20) of total number of 15 having
cough symptom. We also had complete
response in all the patients with hemoptysis, 8
patients out of 8 (%100). Of 11 patients with
chest pain we had 3 were partially responsive
(% 55) and 4 non responsive (%45)
Delivering single dose radiotherapy can
be rational for palliation symptoms especially
hemoptysis in advanced non-small cell lung
cancer patients who have poor performance
status
Anahtar Kelimeler
Kaynakça
- Chay TK: Role of radiotherapy in advanced carcinoma of the lung. Proceedins 7th Asia-Pasific Congres on Diseases of the Chinese, Nandi PL , Lam WK (Eds) Hong Kong, Southeast Printing Co 1981, pp. 300-304
- Perez CA , Stanley K , Grandy G. et al: Impact of irradiation technique and tumor extent in tumor control and survival of patients with unresectable non-oat cell carcinoma of the lung: Report by the Radiation Therapy Oncology Group. Cancer 1989; 1091-1099
- Carroll M , Morgan SA, Yarnold. et all. Prospective evaluation of a watch policy in patients with inoperabl non–small-cell lung cancer. Eur J. Cancer Clin. Oncol, 22, 1353-1356
- Fowler JF. : Non-standard fractionation in radiotherapy. Int. J. Radiat. Oncol. Biol Phys. 1984; 10(5) : 755-759
- Moore J: Recent advances in radiobiology. In Modern Trends in Radiotherapy, vol.2, Deeley TJ. (Ed.).London, Betherworths. 1972, pp 21-25
- Overgoard M: The clinical implications of non-standard fractionation (Letter). Int J. Radiat. Oncol. Biol. Phys. 1985; 11(6): 1225-1227
- Peschel RE, Fisher JJ. : Optimization of the time–dose relationship, Sem. Oncol. 1981; 8 (1): 38-48
- Withers HR : Biologic basis for altered fractionation scheme. Cancer 1985; 55 (Suppl,9):2086-2095
- Peter Teo TH, Tai Domon Cho et al: A randomized study on palliative radiation therapy for inoperable non small cell carcinoma of lung . Int J Radiation Oncology Biol. Phys: 1987; 14: 867-870
- Lung Cancer Working Party: In operable non small cell lung cancer: A Medical Research Council randomize trial of palliative radiotherapy with two fraction or ten fraction.
- Lung Cancer Working Party, MRC randomize trial of palliative radiotherapy with two fraction or single fraction in patient with inoperable non small cell lung cancer and poor performance status. Br J. Cancer 1992; 65: 934-941
Ayrıntılar
| Birincil Dil | Türkçe |
|---|---|
| Konular | Sağlık Kurumları Yönetimi |
| Diğer ID | JA75NN48CK |
| Bölüm | Araştırma Makalesi |
| Yazarlar | |
| Yayımlanma Tarihi | 1 Mayıs 2004 |
| Gönderilme Tarihi | 1 Mayıs 2004 |
| Yayımlandığı Sayı | Yıl 2004 |