BIOLOGICAL IMPORTANCE OF VITAMIN D AND RELATIONSHIP BETWEEN DENTISTRY

Yıl 2015, Cilt: 25 Sayı: 1, 128 - 134, 21.05.2015

Saim Yanık , Aydın Keskinrüzgar Mutan Aras Sedat Çetiner

https://doi.org/10.17567/dfd.72382

Öz

Vitamin D has an important effect on calcium and phosphorus homeostasis and it is indispensible for bone formation. Moreover vitamin D regulates alot of genes involved in cell differentiation and cell proliferation through nuclear vitamin D receptor of its active form, 1,25-dihydroksyvitamin D3. Besides its important effects, vitamin D contributes to the prevention of various cancers such as colon cancer, prostate cancer, and breast cancer, autoimmune diseases such as multiple sclerosis and diabetes, allergic diseases, cardiovascular and infectious diseases. In many studies, vitamin D insufficiency that is proved to be related with bisphosphonate related osteonecrosis of jaw and periodontal diseases. In this review the metabolism of vitamin D, its function, the effects of vitamin D on systems, and relationship between dentistry is going to be mentioned

Anahtar Kelimeler

1α, 25(OH)2D, bisphosphonate, Vitamin D, osteonecrosis

VİTAMİN D’NİN BİYOLOJİK ÖNEMİ VE DİŞ HEKİMLİĞİ İLE OLAN İLİŞKİSİ

Öz

ÖZET

Vitamin D, kalsiyum ve fosfor hemostazı üzerinde önemli bir etkiye sahiptir ve kemik gelişimi için de vazgeçilmezdir. Ayrıca aktif form olan 1,25-dihidroksivitamin D3’ün nükleer vitamin D reseptörü aracılığı ile hücre diferansiyasyonu ve proliferasyonu ile ilgili birçok geni regüle etmektedir. Vitamin D’nin bu önemli etkilerinin yanında kolon kanseri, prostat kanseri, akciğer kanseri gibi birçok kanser tipinin, multiple skleroz ve diyabet gibi otoimmun hastalıkların, allerjik, kardiyovasküler ve enfeksiyon hastalıkların önlenmesinde de önemli bir yeri vardır. Vitamin D yetersizliğinin çenelerde görülen bifosfonata bağlı osteonekroz ve periodontal hastalıklarla bağlantılı olduğu yapılan çalışmalarla kanıtlanmıştır. Bu derlemede vitamin D’nin metabolizması, fonksiyonu, sistemler üzerine olan etkileri ve diş hekimliği ile olan ilişkisinden bahsedilecektir.

Anahtar Kelimeler: 1α,25(OH)2D, bifosfonat, Vitamin D, osteonekroz

BIOLOGICAL IMPORTANCE OF VITAMIN D AND RELATIONSHIP BETWEEN DENTISTRY

ABSTRACT

Vitamin D has an important effect on calcium and phosphorus homeostasis and it is indispensible for bone formation. Moreover vitamin D regulates alot of genes involved in cell differentiation and cell proliferation through nuclear vitamin D receptor of its active form, 1,25-dihydroksyvitamin D3. Besides its important effects, vitamin D contributes to the prevention of various cancers such as colon cancer, prostate cancer, and breast cancer, autoimmune diseases such as multiple sclerosis and diabetes, allergic diseases, cardiovascular and infectious diseases. In many studies, vitamin D insufficiency that is proved to be related with bisphosphonate related osteonecrosis of jaw and periodontal diseases. In this review the metabolism of vitamin D, its function, the effects of vitamin D on systems, and relationship between dentistry is going to be mentioned.

 Keywords: 1α,25(OH)2D, bisphosphonate, Vitamin D, osteonecrosis.

Anahtar Kelimeler

1α, 25(OH)2D, bifosfonat, Vitamin D, osteonekroz

Kaynakça

• Jameson JL, Weetman AP. Tiroid bezi hastalıkları. In: Braunwald E, Fauci AS, Kasper DL, Hauser SL, Longo DL, Jameson JL. Harrison İç Hastalıkları Prensipleri. 15 ed. İstanbul; Çeviri editörü: Sağlıker Y: Nobel Matbaacılık. 2004. p.2060-75.
• Atas A, Çakmak A, Soran M. D Vitamin Metabolizması ve Rikets Hastalığı. Bakırköy Tıp Derg 2008;4:1-7.
• Ersöz B, Kalsiyum ve fosfor metabolizmasını düzenleyen hormonlar. In: Onat T, Emerk K, Sözmen EY. İnsan Biyokimyası. Ankara; 2002. p.467-72.
• Jones G. Metabolism and biomarkers of vitamin D. Scand J Clin Lab Invest Suppl 2012;243:7-13.
• Bordelon P, Ghetu MV and Langan RC. Recognition and management of vitamin D deficiency. Am Fam Physician 2009;80:841-6.
• Holick MF and Chen TC. Vitamin D deficiency: a worldwide problem with health consequences. Am J Clin Nutr 2008;87:1080-6.
• Holick MF. Vitamin D: importance in the prevention of cancers, type 1 diabetes, heart disease, and osteoporosis. Am J Clin Nutr 2004;79:362-71.
• Holick MF. Sunlight and vitamin D for bone health and prevention of autoimmune diseases, cancers, and cardiovascular disease. Am J Clin Nutr 2004; 8:1678-88.
• Hokugo A, Christensen R, Chung EM, Sung EC, Felsenfeld AL, Sayre JW, Garrett N, Adams JS, Nishimura bisphosphonate- related osteonecrosis of the jaw with vitamin D deficiency in rats. J Bone Miner Res 2010;25:1337-49. prevalence of
• Brannon PM, Yetley EA, Bailey RL, Picciano MF. Overview of the conference "Vitamin D and Health in the 21st Century: an Update". Am J Clin Nutr 2008;88:483-90.
• Norman AW. From vitamin D to hormone D: fundamentals of the vitamin D endocrine system essential for good health. Am J Clin Nutr 2008;88:491-9.
• Shihadeh Y. Güneşe maruz kalma şekillerinin D vitamini üretimindeki rolü. Uzmanlık Tezi İ.Ü, İstanbul. 1998.
• Rucker RB. Handbook of vitamins. 3 ed. New York; Marcel Dekker: 2001. p.616
• Zempleni J. Handbook of vitamins. 4 ed. New York; CRC Press:2008.p.608.
• Lips P. Vitamin D physiology. Prog Biophys Mol Biol 2006;92:4-8.
• Holick MF, MacLaughlin JA, Clark MB, Holick SA, Potts JT, Anderson RR, Blank, IH, Parrish JA, Elias P. Photosymhesis of previtamin D3 in human skin and the physiologic consequences. Science 1980;210:203-5.
• Mosekilde L. Vitamin D and the elderly. Clin Endocrinol (Oxf) 2005;62:265-1.
• Holick. MF. Vitamin D Deficiency Medical Progress The New England Journal Of Medicine 2007; 357:266.
• Ozkan B. Nutritional rickets. J Clin Res Pediatr 33. Rheem DS, Baylink DJ, Olafsson S, Jackson CS, Endocrinol 2010;2:137-43.
• Holick MF. Vitamin D: extraskeletal health. Endocrinol Metab Clin North Am 2010;39:381-400.
• Liu. (University Medical Center, Groningen, Netherlands),European Society of Cardiology's Congress, Stockholm. 2010.
• Oh J, Weng S, Felton SK, Bhandare S, Riek A, Butler B, Proctor BM, Petty M, Chen Z, Schechtman KB, Bernal-Mizrachi L, Bernal-Mizrachi C. 1,25(OH)2 vitamin d inhibits foam cell formation and suppresses macrophage cholesterol uptake in 36. Garland C GF. Do sunlight and vitamin D reduce patients with type 2 diabetes mellitus. Circulation 2009;120:687-98.
• Parker J, Hashmi O, Dutton D, Mavrodaris A, Stranges S, Kandala NB, Clarke A, Franco OH. Levels of vitamin D and cardiometabolic disorders: systematic review and meta-analysis. Maturitas 38. Lefkowitz ES and Garland CF. Sunlight, vitamin D, 2010;65:225-36.
• Chiu KC, Chu A, Go VL, Saad MF. Hypovitaminosis D is associated with insülin resistance and β cell 39. Schwartz GG HB. Is vitamin D deficiency a risk dysfunction. Am J Clin Nutr 2004;79:820-5.
• Boucher BJ, Mannan N, Noonan K, Hales CN, Evans SJ. Glucose intolerance and impairment of 40. Lappe JM, Travers-Gustafson D, Davies KM, Recker insulin secretion in relation to vitamin D deficiency in east London Asians. Diabetologia 1995;38:1239- 45.
• Pittas AG, Dawson-Hughes B, Li T, Van Dam RM, 41. Khosla S and Melton LJ, 3rd. Clinical practice. Willett WC, Manson JE, Hu FB. Vitamin D and calcium intake in relation to type 2 diabetes in 42. Vaidya A, Forman JP. Vitamin D and vascular women. Diabetes Care 2006;29:650-6.
• Hypponen E, Laara E, Reunanen A, Jarvelin MR, Virtanen SM: Intake of vitamin D and risk of type 1 diabetes: a birthcohort study. Lancet 2001, 43. Lishmanov A, Dorairajan S, Pak Y, Chaudhary K, 358:1500-3.
• Garland CF, Garland FC, Gorham ED, Lipkin M, Newmark H, Mohr SB, Holick MF. The role of vitamin D in cancer prevention. Am J Public Health 2006;96:252-61.
• Abe E. Differentiation of mouse myeloid leukemia cells induced by 1α,25-dihydroxyvitamin D3. Proc Natl Acad Sci 1981;78:4990–4.
• Colston K, Colston MJ, Feldman D. 1,25- Dihydroxyvitamin D3 and malignant melanoma: the presence of receptors and inhibition of cell growth in culture. Endocrinology 1981;108: 1083– 6. Walter MH. Prevention of colorectal cancer with vitamin D. Scand J Gastroenterol 2010;45:775-84.
• Schwartz GG. Vitamin D and intervention trials in prostate cancer: from theory to therapy. Ann Epidemiol 2009;19:96-102.
• Jenab M, Bueno-de-Mesquita HB, Ferrari P, van Duijnhoven FJ. Association between pre-diagnostic circulating vitamin D concentration and risk of colorectal cancer in European populations: a nested case-control study. BMJ 2010;340:5500. the likelihood of colon cancer? Int J Epidemiol 1980;9:227-31.
• Bhalla AK, Amento EP, Clemens T L, Holick, MF, Krane SM. Specific high-affinity receptors for 1,25- dihydroxyvitamin D3 in human peripheral blood mononuclear cells: presence in monocytes and induction in T lymphocytes following activation. J Clin Endocrinol Metab 1983;57:1308–10.
• Adorini L and Penna G. Control of autoimmune diseases by the vitamin D endocrine system. Nat Clin Pract Rheumatol 2008;4:404-12.
• Yang S, Smit C, DeLuca HF. 1α,25- Dihydroxyvitamin D3 and 19-nor-1α, 25- dihydroxyvitamin D2 suppress immunoglobulin production and thymic lymphocyte proliferation in vivo. Biochim Biophys Acta 1993; 1158:279–86.
• Schoindre Y, Terrier B, Kahn JE, Saadoun D, 57. Altundag O, Altundag K, Selim Silay Y, Gunduz M, Souberbielle JC, Benveniste O, Amoura Z, Piette JC, Cacoub P and Costedoat-Chalumeau N. [Vitamin D and autoimmunity. Second part: Clinical aspects]. Rev Med Interne 2012;33:87-93.
• Munger KLM, Zhang S M, O’Reilly E. Vitamin D intake and incidence of multiple sclerosis. 58. Ritchie CS, Joshipura K, Hung HC, Douglass CW. Neurology 2004; 62:60-5.
• Merlino LA CJ, Mikuls TR, Crhan JR, Criswell LA, Saag KG. Vitamin D intake is inversely associated with rhematoid arthritis: results from the Iowa Women’s Health Study. Arthritis Rheum 2004; 50: 59. Jeffcoat MK, Chesnut CH. Systemic osteoporosis 72-7.
• Hypponen E LE, Reunanen A, Jarvelin MR, Virtanen SM. Intake of vitamin D and risk of type 1 60. Jabbar S, Drury J, Fordham J, Datta HK, Francis diabetes: A birth-cohort study. Lancet 2001; 358:1500-3.
• Russell RG. Bisphosphonates: the first 40 years. Bone 2011;49:2-19.
• Koçyiğit İD, Kaman S, Atıl F, Tekin U, Tüz H.H. Bisfosfonatlara Bağlı Olarak Çene Kemiklerinde Gelişen Osteonekroz (Bon) Ve Güncel Tedavi Yöntemleri. Atatürk Üniv. Diş Hek. Fak. Derg 2013;7: 116-24.
• Rhee Y, Song K, Park S, Park HS, Lim SK, Park BW. Efficacy of a combined alendronate and calcitriol agent (Maxmarvil(R)) in Korean postmenopausal women with early breast cancer receiving aromatase inhibitor: a double-blind, randomized, placebo-controlled study. Endocr J 2013; 60:167- 72.
• Marx RE, Sawatari Y, Fortin M and Broumand V. Bisphosphonate-induced (osteonecrosis/osteopetrosis) of the jaws: risk factors, recognition, prevention, and treatment. J Oral Maxillofac Surg 2005;63:1567-75. bone
• Badros A, Goloubeva O, Terpos E, Milliron T, Baer MR and Streeten E. Prevalence and significance of vitamin D deficiency in multiple myeloma patients. Br J Haematol 2008;142:492-4.
• Nutrition as a mediator in the relation between oral
• and systemic disease: associations between
• specific measures of adult oral health and nutrition
• outcomes. Crit Rev Oral Biol Med 2002;13:291-300
• and oral bone loss: evidence shows increased risk
• factors. J Am Dent Assoc 1993;124:49-56.
• RM, Tuck SP. Plasma vitamin D and cytokines in periodontal
• osteoporosis. J Periodontal Res 2011;46:97-104. and postmenopausal
• Krall EA, Wehler C, Garcia RI, Harris SS, Dawson- Hughes B. Calcium and vitamin D supplements reduce tooth loss in the elderly. Am J Med 2001;111:452-6.
• Andresen C, Olson E, Nduaka C, Pero R, Bagi CM. Action of calciotropic hormones on bone metabolism–Role of Vitamin D3 in bone remodeling events. Am J Immunol 2006;2:40–51.
• Anand N, Chandrasekaran SC, Rajput NS. Vitamin D and periodontal health: Current concepts. J Indian Soc Periodontol 2013;17:302-8.