Platelet Kaynaklı Büyüme Faktörünün Yapısı, Fonksiyonları ve Gelişim Üzerine Etkileri

Yıl 2009, Cilt: 4 Sayı: 3, 209 - 214, 08.03.2010

Buket Aydemir Ebru Sarı

Öz

Memelilerde kan pulcukları (platelet) ve kanatlılarda trombositler pıhtı oluşumunda görev
alan kan hücreleridir. İlk olarak plateletlerden eksprese edildiği için platelet kaynaklı büyüme
faktörü olarak adlandırılan PDGF, büyüme faktörleri ailesinin bir üyesidir. PDGF, prenatal ve
postnatal dönemde; hücresel proliferasyon, kemotaksis, dokuların şekillenmesi ve yara iyileşmesi
gibi birçok görev üstlenmektedir. Dolayısıyla, bu derlemenin amacı, PDGF’nin yapısal özellikleri,
fonksiyonları ve gelişim üzerine etkilerinin değerlendirilmesidir

Anahtar Kelimeler

Platelet kaynaklı büyüme faktörü, Platelet, Gelişim

Kaynakça

• Ataliotis P., Symes K., Chou MM., Ho L., Mercola M., 1995. PDGF Signalling is Required for Gastrulation of Xenopus Leavis. Dev., 121, 3099-110.
• Betsholtz C., Karlsson L., Lindahl P., 2001. Developmental Roles of Platelet- Derived Growth Factors. Cell. Dev. Bio., 23, 494-507.
• Brennan, J., Tilmann, C., Capel, B., 2003. PDGFR-α Organization and Fetal Leydig Cell Development in the XY Gonad. Gen. Dev., 17, 800-810. Testis Cord
• Bonthron DT., Morton CC., Orkin S.H., Collins T., 1988. Platelet-Derived Growth Factor A chain: Gene Structure, Chromosomal Location and Basis for Alternative mRNA Splicing. Proc. Natl. Acad. Sci., 85, 1492-6.
• Bork P., 1991. Complemet Components Cır/Cls, Bone Morphogenic Protein I and Xenopus leavis Developmentally Regulated Common Repeats. FEBS Lett., 282, 9- 12.
• Boström H., Willetts K., Pekny M., Leveen P.. Lindahl P., Hedstrand H., Pekna M., Helltröm M., Gebre-Medhin S., Schalling M., Nilsson M., Kurland S., İornell J., Heath JK., Betsholtz C., 1996. PDGF-A Signalling is a Critical Event in Lung Alveolar Myofibroblast Development and Alveogenesis. Cell. Pres., 85, 863-73.
• Bowen-Pope DF., Malpass TW., Foster DM., Ross R., 1984. Platelet-Derived Growth Factor in Vivo: Levels Activity and Rate of Clearance. Blood. 64, 458-69.
• Collins T., Pober JS., Gimbrone MA., Hammacher Westermark B., Heldin CH., 1987. Cultured Platelet-Derived Growth Factor A Chain. Am. J. Pathol., 126, 7-12. C., Human Cells Express
• Dalla-Favera R., Gallo RC., Giallongo A., Croce CM., 1982. Chromosomal Localization of the Human Homolog (c-sis) of the Simian Sarcoma Virus. Onc. Gen. Sci., 218, 686-8.
• Deuel TF., 1987. Polypeptide Growth Factors: Roles in Normal and Abnormal Cell Growth. Ann. Rev. Cel. Bio., 3, 443-492.
• Fredriksson L., Li H., Eriksson U., 2004. The PDGF Family: Four Gene Products Form Five Dimeric Isoforms. Box. 240:197-204.
• Heldin CH., Westermark B., 1999. Mechanism of Action and in Vivo Role of Platelet-Derived Growth Factor. Phs. Rew., 79, 1283-1316.
• Hellstrom M., Kahen M., Lindahl P., Abramsson A., Betshoholtz C., 1999. Role of PDGF-B and PDGFR-β in Recruitment of Vascular Smooth Muscle Cell and Pericytes During Embriyonic Blood Vessel Formation in the Mouse. Dev., 126, 304.
• Hetan L., Kazlauskas A., 2008. Focus on molecules: Platelet-Derived Growth Factor C. Geog. Nature, 86, 711-712.
• Hoch RV., Soriano P., 2003. Roles of PDGF in Animal Development. Dev., 130, 4769-4784.
• Horiuchi H., Inoue T., Furusawa S., Matsuda H., 2001a. Cloning and Characterization Platelet-Derived Growth Factor B- Chain cDNA. Bio. Sci., 26, 739-8528.
• Horiuchi H., Inoue T., Furusawa S., Matsuda H., 2001b. Characterization and Expresson of Three Forms of cDNA Encoding Chicken Platelet- Derived Growth Factor-A Chain. Bio. Sci., 272, 739-8528.
• Johnsson A., Heldin CH., Wsteson A., Westermark B., Deuel TF., Huang J. S., Seeburg PH., Gray A., Ullrich A., Scrace G., 1984. The c-sis Gene Encodes a Precursor of the B Chain of Platelet-Derived Growth Factor. Emb., 3, 921-8.
• Karlsson L., Lindahl P., Health JK., Betsholtz Gastrointestinal PDGF-a and PDGFR-alpha Deficient Mice Implicates a Novel Mecenchymal Structure with Putative Instructive Propertiesin Villus Morphogenesis. Dev., 127, 3457-66. Abnormal in
• Östman A., Rall L., Hammacher A., Wormstead MA., Valenzuela D., Betsholtz C., Westermark B., Heldin CH., 1988. Synthesis and Assembly of a Functionally Active Recombinant Platelet-Derived Growth Factor AB Heterodimer. J. Biol. Chem., 263, 16202-16208.
• Orr-Urtreger A., Lonai P., 1992. Platelet- Derived Growth Factor-A and Its Receptor are Expressed in Seperate but Adjacent Cell Layers of the Mouse Embryo. Dev., 115, 1045-58.
• Rorsman F., Bywater M., Knott TJ., Scott J., Betsholtz C., 1988. Structural Characterization of Human Platalet- Derived Growth Factor A-Chain cDNA and Gene Alternative Exon Usage Two Different Precursor Protein. Mol. Cel. Bio., 8, 571-577.
• Sağlam M., Aştı NR., Özer A., 2001. Genel histoloji. 6. Baskı, Yorum mat., s: 231-232. Ankara.
• Shinbrot E., Peters KG., Williams LT., 1994. Expression of the Platelet- Derived Growth Factor B Receptor During Organogenesis and Tissue Differentiation in the Mouse Embryo. Dev. Dyn., 199, 169-75.
• Shure, D., Senior RM., Griffin GL., Deuel TF., 1994. PDGF-AA Homodimers are Potent Fibroblasts and Neutrophils, and for Monocytes Lymphocytes or Cytokines. Biochem. Biophys. Res., 186, 1510-4. for Activated Bye
• Uutela M., Lauren J., Bergsten E., Li X., Horelli-Kuitunen N., Ericsson U., 2001. Chromosomal Location, Exon Structure and Vascular Expression Patterns of the Human PDGF-C and PDGF-D Genes. Circula., 103, 2242-7.
• Uutela M., 2004. PDGF-D, A Novel Member of the Platelet-Derived Growth Factor Family. Mol. Can. Bio., 272, 5723-5741.
• Vermylen J., Verstraetr M., Fuster V., 1986. Roles of Platelet Activation and Fibrin Formation in Thrombogenesis. JACC., 8, 2B-9B.
• Yarden Y., Escobedo JA., Kuang WJ., Yang-feng TL., Daniel TO., Tremble PM., Chen EY., Ando ME., Harkins RN., Francke U., 1986. Structure of the Receptor for Platelet-Derived Growth Factor Helps Define a Family of Closely Related Growth Factor Receptor. Nature, 323, 226-32.