Investigations on Clinic, Haematology, Biochemistry, Oxidative Stress, Acute Phase Proteins in Infectious Respiratory Disease Complex (BRDC) in Cattle

Yıl 2017, Cilt: 12 Sayı: 1, 34 - 44, 30.04.2017

Gürbüz Gökçe

https://doi.org/10.17094/ataunivbd.309771

Cited By: 4

Öz

In this study, clinical status,
treatment, acute phase proteins, oxidant and antioxidant status, changes in
serum biochemistry and hematological parameters in Bovine Respiratory Disease
Complex (BRDC) in cattle were investigated. A total of 30 cattle were used in
the study. The sick animals included in the study were divided into two groups.
Group I (n = 10) given tulathromycin + flunixin-meglumine + Vitamin E and
selenium combination. Group II (n = 10) given tulathromycin + flunixin-meglumine.
Blood samples were collected one time from the control group (n = 10), and four
times (pre-treatment and in 1, 3, 5 days of post-treatment) from the patient
groups. Serum acute phase proteins (Hp and SAA), biochemical and hematological
analyzes, total antioxidant (TAS) and total oxidant (TOS) levels were
determined from all samples. Pre-treatment (day 0) serum Fe and Ca
concentrations in both disease groups were significantly (P<0.05) lower compared to the control group. It was
observed that these parameters improved parallel to clinical improvement with
treatment. It was determined that the total leukocyte counts of the patient
groups were significantly higher than the control group before the treatment.
In both treatment groups, pre-treatment serum amyloid A and haptaglobulin
levels and TOS levels were higher than the control group (P<0.05). In conclusion, it was found
that significant increases occurred in serum Hp and SAA concentrations in acute
phase proteins and serum TOS concentrations in oxidative stress parameters in
Bovine Respiratory Disease Complex, and that there were significant hematologic
and biochemical changes in this disease.

Anahtar Kelimeler

AFP, Biochemistry, BRDC, Haematology, Oxidative stress

Sığırlarda Enfeksiyöz Solunum Sistemi Hastalıkları Kompleksinde (BRDC) Klinik, Hematoloji, Biyokimya, Oksidatif Stres, Akut Faz Proteinler Üzerinde Araştırmalar

Öz

Bu çalışmada,
sığırlarda solunum sistemi kompleksi (BRDC) hastalığında klinik, tedavi, akut
faz proteinler, oksidant ve anti oksidant durumu, serum biyokimyası ve
hematolojik parametrelerdeki değişmeler araştırıldı. Çalışmada toplam 30 sığır
kullanıldı. Çalışma kapsamına alınan hasta hayvanlar iki gruba ayrıldı. I.
Gruptaki hayvanlara (n=10), tulatromycin +Flunixin meglumin + Vitamin E ve
selenyum kombinasyonu uygulandı. II. gruptaki hayvanlara (n=10) tulatromycin+
flunixin meglumin uygulandı. Kontrol grubundan (n=10) tek sefer, hasta
gruplarda tedavi öncesi (0. gün) ve tedavi sonrası 1, 3 ve 5. günlerde kan ve
serum örnekleri alınarak biyokimyasal, hematolojik analizlerle serum akut faz
proteinleri (Hp ve SAA), Total antioksidant (TAS) ve Total oksidant düzeyleri
(TOS) ölçüldü. Hasta grupların her ikisinde de serum Fe, Ca
konsantrasyonlarının tedavi öncesinde (0. gün) kontrol grubuna göre önemli
derecede (P<0.05) düşük olduğu belirlendi. Bu parametrelerin tedaviyle
birlikte klinik iyileşmeye paralel olarak düzeldiği gözlendi. Hasta grupların
tedavi öncesinde total lökosit sayılarının kontrol grubuna göre önemli derecede
yüksek olduğu belirlendi. Her iki tedavi grubundaki hayvanlarda tedavi öncesi
serum amyloid A ve haptoglobulin düzeyleri ile TOS değerlerinin kontrol grubuna
göre yüksek olduğu belirlendi (P<0.05). Sonuç olarak, sığırlarda solunum
sistemi hastalıkları kompleksinde hematolojik ve biyokimyasal değişimlerin
olduğu ve özellikle de akut faz proteinlerinden serum Hp ve SAA ile oksidatif
stres parametrelerinden serum TOS konsantrasyonlarında önemli artışların olduğu
saptandı.

Anahtar Kelimeler

AFP, Biyokimya, BRDC, Hematoloji, Oksidatif stres

Kaynakça

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