Opiyat Kullanım Bozukluğu Hastalarında İnflamasyon: Nötrofil/Lenfosit, Monosit/Lenfosit, Trombosit/Lenfosit, Monosit/Lenfosit Oranları ve Ortalama Trombosit Hacmi

Yıl 2023, Cilt: 24 Sayı: 1, 83 - 92, 31.03.2023

Müberra Kulu , Filiz Özsoy , Bahadır Demir

https://doi.org/10.51982/bagimli.1120280

Cited By: 2

Öz

Amaç: Bu çalışmada; Opiyat Kullanım Bozukluğu (OpKB) tanılı hastaların nötrofil/lenfosit (NLO), platelet/lenfosit (PLO), monosit/lenfosit (PLO) oranı gibi periferik inflamasyon belirteçlerini kontroller ile karşılaştırarak retrospektif incelemeyi amaçladık.
Yöntem: Çalışmaya; 201 kişi (101 kişi OpKB ve 100 kontrol) alındı. Tüm katılımcıların yaş, cinsiyet gibi demografik verilerini içeren demografik veri formu oluşturuldu. Sonrasında tam kan sayımı ile değerlendirilen laboratuvar parametreleri incelendi.
Bulgular: Tüm katılımcılar erkek ve yaş ortalaması 30,68±10,60 idi. Hasta grubunun hemoglobin değeri 14,78±1,29, hematokrit değeri 44,02±3,70 olarak hesap edildi. Yine hastalarda eritrosit 5,00±0,39 ve RDW-SD 43,90±4,26 ile sağlıklı kontrollerden yüksekti. NLO, MLO ve PLO değerleri hasta grubunda sağlıklı kontrollere göre düşük olarak hesap edildi.
Sonuç: OpKB hastalarında bazı inflamatuvar parametrelerinde değişiklikler olduğu gösterilmiştir. İnflamatuvar parametrelerindeki bu değişikliklere bağlı oluşabilecek komplikasyonlar; hem tedavi planı hem hastanın semptomlarının değerlendirilmesinde dikkate alınmalıdır.

Anahtar Kelimeler

Opiyat kullanım bozukluğu, inflamasyon, nötrofil/lenfosit oranı, trombosit/lenfosit oranı, monosit/lenfosit oranı., Opiate use disorder, inflammation, neutrophil/lymphocyte ratio

Destekleyen Kurum

Yoktur

Proje Numarası

-

Inflammation in Patients with Opiate Use Disorder: Neutrophil/Lymphocyte, Platelet/Lymphocyte, Monocyte/Lymphocyte Ratios and Mean Platelet Volume

Öz

Objective: The aim of this study was to retropeectivelyt analyse the inflammation markers such as neutrophil/lymphocyte ratio (NLR), platelet/lymphocyte ratio (PLO), and monocyte-lymphocyte ratio (PLO), of the patients with opiate use disorder (OUD) by comparing them with healthy controls.
Method: 201 people (101 people OUD, 100 control) were included in the study. A demographic data form containing demographic data such as age and gender of all participants was created. Afterwards, laboratory parameters evaluated by complete blood count were examined.
Results: All participants were male and mean age 30.68±10.60. Hemoglobin values 14.78±1.29, hematocrit values 44.02±3.70 for patients group. Erythrocyte 5.00±0.39 and RDW-SD values 43.90±4.26; These values were higher in patients than in healthy controls. NLR, MLR and PLR values were lower in the patient group compared to the controls.
Conclusion: There are changes in some inflammatory parameters in OUD patients. Complications that may occur due to these changes in inflammatory parameters; should be considered in both the treatment plan and the evaluation of the patient's symptoms.

Anahtar Kelimeler

Opiate use disorder, inflammation, neutrophil/lymphocyte ratio

Proje Numarası

-

Kaynakça

• Referans 1. Tarabar AF, Nelson LS. The resurgence and abuse of heroin by children in the United States. Curr Opin Pediatr 2003;15:210–215.
• Referans 2. Bailey A, Yuferov V, Bendor J, Schlussman S, Zhou Y, Ho A, Kree JM. Immediate withdrawal from chronic “binge” cocaine administration increases mu-opioid receptor mRNA levels in rat frontal cortex. Mol Brain Res 2005;137:258–262.
• Referans 3. Rudd RA, Seth P, David F, Scholl L. Increases in drug and opioid-involved overdose deaths—United States, 2010-2015. MMWR Morb Mortal Wkly Rep. 2016;65:1445–1452.
• Referans 4. Webster LR. Risk factors for opioid-use disorder and overdose. Anesthesia Analgesia 2017; 125(5): 1741-1748.
• Referans 5. Sharma B, Bruner A, Barnett G, Fishman M. Opioid use disorders. Child and Adolescent Psychiatric Clinics 2016; 25(3): 473-487.
• Referans 6. Johnston LD, O’Malley PM, Bachman JG, Schulenberg JE. Secondary School Students. Institute for Social Research, The University of Michigan; Ann Arbor, Michigan, USA: 2011. Monitoring The Future National Survey Results On Drug Use, 1975–2010.
• Referans 7. Substance Abuse and Mental Health Services Administration. Results from the 2013 National Survey on Drug Use and Health: Summary of National Findings. Substance Abuse and Mental Health Services. Administration; Rockville, MD: 2014. NSDUH Series H-48, HHS Publication No. (SMA) 14-4863.
• Referans 8. Müller N. Inflammation in schizophrenia: pathogenetic aspects and therapeutic considerations. Schizophr Bull 2018; 44(5): 973-982.
• Referans 9. Muneer A. Bipolar disorder: role of inflammation and the development of disease biomarkers. Psychiatry Investig 2016; 13: 18-33.
• Referans 10. Michopoulos V, Powers A, Gillespie CF, Ressler KJ, Jovanovic T. Inflammation in fear- and anxiety-based disorders: PTSD, GAD, and beyond. Neuropsychopharmacol 2017; 42: 254-270.
• Referans11. Sunbul M, Gerin F, Durmus E, Kivrak T, Sari I, Tigen K, Cincin A. Neutrophil to lymphocyte and platelet to lymphocyte ratio in patients with dipper versus non-dipper hypertension. Clin Exp Hypertens 2014; 36:217-221.
• Referans 12. Orum MH, Kara MZ, Egilmez OB. Mean platelet volume and neutrophil to lymphocyte ratio as parameters to indicate the severity of suicide attempt. J Immunoassay Immunochem 2018; 39(6): 647-659.
• Referans 13. Özdin S, Sarisoy G, Böke Ö. A comparison of the neutrophil-lymphocyte, platelet-lymphocyte and monocyte-lymphocyte ratios in schizophrenia and bipolar disorder patients–a retrospective file review. Nord J Psychiatry 2017; 71(7): 509-512.
• Referans 14. Soder HE, Berumen AM, Gomez KE, Green CE, Suchting R, Wardle MC, Vincent J, Teixeria AL, Schimitz JM, Lane SD. Elevated neutrophil to lymphocyte ratio in older adults with cocaine use disorder as a marker of chronic inflammation. Clin Psychopharmacol Neurosci 2020; 18(1): 32.
• Referans 15. Demir B, Kocamer Sahin S, Ozsoy F, Altindag A, Elboga G. Neutrophil-lymphocyte ratio and platelet-lymphocyte ratio in methamphetamine use disorder. Psychiatr Clin Psychopharmacol 2021; 31: 34-39.
• Referans 16. Omar YA, Randhawa T, Attar B, Agrawal R, Wang Y, Richardo R, Majeed MB, Patel SA. Prognostic value of neutrophil-lymphocyte ratio in patients with severe alcoholic hepatitis. Cureus 2019; 11(11): e6141.
• Referans 17. Cıcek E, Demırel B, Cıcek IE, Kıraç AS, Eren I. Increased neutrophil-lymphocyte and platelet-lymphocyte ratios in male heroin addicts: a prospective controlled study. Clin Psychopharmacol Neurosci 2018; 16(2): 190.
• Referans 18. Orum MH, Kara MZ. Monocyte-to-lymphocyte ratio and platelet-to-lymphocyte ratio in opioid use disorder and marijuana use disorder. Dusunen Adam Derg 2020; 33(2): 139-145.
• Referans 19. Nakanishi N, Yoshida H, Okamoto M, Matsuo Y, Suzuki K, Tatara K. Association of Alcohol Consumption with White Blood Cell Count: A Study of Japanese Male Office Workers. J Intern Med 2003; 253 (3): 367-374.
• Referans 20. Ransing RS, Patil B, Grigo O. Mean platelet volume and platelet distribution width level in patients with panic disorder. J Neurosci Rural Pract 2017; 8(2): 174.
• Referans 21. Guzel D, YaziciAB, Yazici E, Erol A. Alterations of the hematologic cells in synthetic cannabinoid users. J Clin Lab Anal. 2017; 31(6): e22131.
• Referans 22. Castaneira G, Rojas K, Galili Y, Field Z, Perez-Perez A, Madruga M, Carlan S. Idiopathic thrombocytopenic purpura induced by synthetic cannabinoid. J Addict Med 2019; 13(3): 235-236.
• Referans 23. Brantl SA, Khandoga AL, Siess W. Mechanism of platelet activation induced by endocannabinoids in blood and plasma. Platelets 2014; 5(3): 151-161.
• Referans24. De Angelis V, Koekman AC, Weeterings C, Roest M, de Groot PG, Herczenik E, Maas C. Endocannabinoids control platelet activation and limit aggregate formation under flow. PLoS One 2014; 9(9): e108282.
• Referans 25. Liu L, Chen M, Zhao L, Zhao Q, Hu R, Zhu J, Yan R, Dai K. Ethanol induces platelet apoptosis. Alcohol Clin Exp Res 2017; 41(2): 291-298.
• Referans 26. Orum MH, Kara MZ. Platelet to lymphocyte ratio (PLR) in alcohol use disorder. J Immunoassay Immunochem 2020; 41(2): 184-194.
• Referans 27. Marazziti D, Torrigiani S, Carbone MG, Mucci F, Flamini W, Ivaldi T, Dell'Osso L. Neutrophil/lymphocyte, platelet/lymphocyte and monocyte/lymphocyte ratios in mood disorders. Curr Med Chemistry 2022; Published Online.
• Referans 28. Zhu X, Zhou J, Zhu Y, Yan F, Han X, Tan Y, Li R. Neutrophil/lymphocyte, platelet/lymphocyte and monocyte/lymphocyte ratios in schizophrenia. Australasian Psychiatry 2021; Published Online.
• Referans29. Mazza MG, Lucchi S, Rossetti A, Clerici M. Neutrophil-lymphocyte ratio, monocyte-lymphocyte ratio and platelet-lymphocyte ratio in non-affective psychosis: a meta-analysis and systematic review. World J Biol Psychiatry 2020; 21(5): 326-338.
• Referans 30. Baykara S, Kaya Ş, Berk SS. Complete Blood Count Parameters and Lymphocyte-related Ratios in Patients with Alcohol Use Disorder. J Addict Depend 2019; 20(4): 206–213.
• Referans 31. Fecho K, Nelson CJ, Lysle DT. Phenotypic and functional assessments of immune status in the rat spleen following acute heroin treatment. Immunopharmacol 2000; 46:193-207. Referans32. Pérez-Castrillón JL, Pérez-Arellano JL, García-Palomo JD, Jiménez-López A, De Castro S. Opioids depress in vitro human monocyte chemotaxis. Immunopharmacol 1992; 23:57-61.