DVD-REG® TAKVİYE EDİCİ GIDA ÜRÜNÜNÜN AKUT SUB-AKUT TOKSİSİTESİNİN SIÇANLAR ÜZERİNDE ARAŞTIRILMASI

Yıl 2020, Cilt: 2 Sayı: 1, 10 - 24, 31.12.2020

Mustafa Yaşar , Güliz Saraç , Nisa Sipahi , Pınar Ağyar Yoldaş , Kağan Ağan , Aydan Fülden Ağan , Neslihan Şirin , Ertuğrul Kaya

Öz

Geleneksel ve tamamlayıcı tıp alanında tıbbi olarak faydalı olduğu bilinen bitkilerin farklı oranlarda karışım olarak kullanılması oldukça yaygın bir kullanım alanı bulmuştur. İlaç üretimindeki maddi ve zamansal kısıtlamalar, tedavi yerine destekleyici bitkisel bileşenlerin kullanımı açısından önemli bir fayda sağlamaktadır. Bununla birlikte, bu bileşenleri oluştururken, bitkilerin kökeninden aktif maddeye ve kullanılabilecek doz aralığına kadar birçok alanda toksik olmayan dozu belirlemek gerekmektedir. Bu çalışmada Remember Regeneration Tedavide (RTM) kullanıldığı bilinen DVD-REG® bitkisel takviyelerinin akut ve subakut toksisite analizleri yapılmıştır. Klinik gözlem bulguları ISO 10993-11:2017 standartlarına göre değerlendirilmiş olup kontrol ve uygulama grupları arasında herhangi bir değişikliğe ratlanılmamıştır. Hematolojik ve biyokimyasal kan parametreleri 0., 1., 7. ve 14. günlerinde değerlendirilmiş kontrol ve uygulama grupları arasında herhangi bir değişiklik tespit edilmemiştir. Histolojik açıdan toksisitenin araştırıldığı karaciğer, kalp, böbrek ve dalak dokularında gruplar arasında patolojik bir bulguya rastlanılmamıştır. Bu çalışma ile Türkiye’de kullanımakta olan gıda takviyesi DVD-REG®’in akut ve subakut etkileri araştırılmış olup elde edilen veriler kronik toksisite testleri için fayda sağlayacaktır.

Anahtar Kelimeler

DVD-REG®,, Akut toksisite, Subakut toksisite, Geleneksel ve tamamlayıcı tıp, Gıda takviyesi

EFFECT OF DVD-REG® FOOD SUPPLEMENT ON ACUTE AND SUB-ACUTE TOXICITY ON RATS

Öz

The use of herbs that are known to be medically useful in the field of traditional and complementary medicine has been widely used as a mixture in different proportions. Material and temporal restrictions in drug production provide a significant benefit in terms of using supportive herbal ingredients instead of treatment. However, when creating these components, it is necessary to determine the nontoxic dose in many areas, from the origin of plants to the active substance and the dose range that can be used. In this study, acute and subacute toxicity analyzes of DVD-REG® herbal supplements known to be used in Remember Regeneration Therapy Method (RTM) were performed. Clinical observation findings were evaluated according to ISO 10993-11:2017 standards and no changes were made between the control and application groups. Hematological and biochemical blood parameters were evaluated on days 0, 1, 7, and 14, and no changes were found between the control and administration groups. There was no pathological finding among the groups in liver, heart, kidney and spleen tissues where histological toxicity was investigated. In this study, which are now used in Turkey food supplement data obtained from the DVD-REG® was researched it will benefit for chronic effects of acute and subacute toxicity tests.

Anahtar Kelimeler

DVD-REG®, Acute Toxicity, Subacute Toxicity, Traditional and Complementary Medicine, Herbal Supplements

Kaynakça

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