Yeni PDI tabanlı antiproliteratif kromoforlar

Yıl 2023, Cilt: 25 Sayı: 2, 761 - 769, 07.07.2023

Furkan Ozcil , Hatice Yıldırım , Merve Karaman , Funda Yükrük

https://doi.org/10.25092/baunfbed.1277996

Öz

Çalışmanın birincil amacı, yeni sentezlenmiş ve tanımlanmış iki perilen diimidin antiproliferatif aktivitesini bulmaktır. MTT testi, PC3 prostat kanseri hücre dizisi, Panc1 pankreas kanseri hücre dizisi, Saos2 osteosarkoma hücre dizisi, Hep3B hepatoma hücre dizisi ve HUVEC kanserli olmayan insan göbek damarı endotel hücrelerine karşı antiproliteratif etkiyi araştırmak için uygulandı. PC3, Pancl ve Saos 2 hücrelerine göre, her iki bileşiğin de oldukça sitotoksik olduğu bulundu; ancak, Hep3B hücrelerinde karşılaştırılabilir bir etki görülmedi. İkinci molekül, 40,88 g/ml ile en düşük IC50 değerine sahip olarak bulundu ve diğer hücre hatlarına kıyasla PC3 hücre çoğalmasını önemli ölçüde inhibe etti.

Anahtar Kelimeler

Perilen diimid, Antiproliferatif aktivite, Sitotoksisite

Destekleyen Kurum

This work was supported by grants from Balikesir University (BAP2013/19), The Scientific and Technological Research Council of Turkey (TUBITAK-110T026) and Undersecretariat of State Planning Organization (DPT-2005-K-120-170).

Proje Numarası

BAP2013/19, TUBITAK-110T026, DPT-2005-K-120-170

Teşekkür

Bu çalışmamızda bize destek olan Balıkesir Üniversitesi, TÜBİTAK ve DPT'ye çok teşekkür ederiz.

Novel perylene diimide based antiproliferative chromophores

Öz

The primary objective of the work was to monitor the antiproliferative activity of two newly synthesized and described perylene diimides. The MTT test was used to investigate the antiproliferative effect against PC3 the prostat cancer cell line, Panc1 pancreatic cancer cell line, Saos2 osteosarcoma cell line, Hep3B hepatoma cell line and HUVEC non-cancerous human umbilical vein endothelial cells. To PC3, Panc1, and Saos 2 cells, both compounds were found to be considerably cytotoxic; however, a comparable impact was not seen in Hep3B cells. Compound 2 had the lowest IC50 value of 40,88 µg/ml and significantly inhibited PC3 cell proliferation when compared to other cell lines.

Anahtar Kelimeler

Perylene diimide, Antiproliferatif Activity, Cytotoxicity

Proje Numarası

BAP2013/19, TUBITAK-110T026, DPT-2005-K-120-170

Kaynakça

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