Yeast prions

Yıl 2010, Cilt: 1 Sayı: 3, 45 - 51, 05.04.2013

Yusuf Tutar

https://doi.org/10.12808/bcs.v1i3.10

Öz

Abstract

Prions are responsible for neurodegenerative diseases. Altered protein conformation induces normally folded proteins to adopt infective prion form. The prion protein appears to be responsible for different diseases with different pathologies. Propagating prions are viable in S. cerevisiae cells; therefore, these eukaryotic cells provide a unique system to study prion propagation and protein disaggregation to investigate prion phenomena. Several research groups work on prions and related diseases and S. cerevisiae is a tractable model. This review focuses on [PSI+], [URE3] and [RNQ+] prions.

Keywords: Prion, PSI, URE3, PIN, Sup35, Ure2, Rqn1

Özet

Maya prionları

Prionlar nörodejeneretif hastalıklardan sorumludurlar. Değişmiş protein konformasyonu normal proteinlerin enfektif prion haline geçmesini indükler. Prion protein farklı patolojideki hastalıkların oluşumundan sorumludur. Biriken prionlar S. cerevisiae hücrelerinde görselleştirilebilirler, bunun için bu ökaryotik hücreler prion konusunu araştırmada prion birikimi ve protein ayrışması için önemli bir sistem oluşturur. Birçok araştırma grubu prion ve ilgili hastalıkları çalışmaktadırlar ve S. cerevisiae uygun bir modeldir. Bu derleme [PSI+], [URE3] ve [RNQ+] prionları üzerine yoğunlaşmıştır.

Anahtar sözcükler: Prion, PSI, URE3, PIN, Sup35, Ure2, Rqn1

Anahtar Kelimeler

Prion, PSI, URE3, PIN, Sup35, Ure2, Rqn1

Kaynakça

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