Investigation of possible protective effects of 4 hydroxy phenylboronic acid on lipopolysaccharide-induced liver injury

Yıl 2022, , 430 - 439, 29.03.2022

Zafer Bayraktutan

https://doi.org/10.30728/boron.1057322

Öz

Boron products have been used in the field of health for many years. Boron products have been used in the field of health for many years. Boron products, which were used in the treatment of cancer for the first time in the medical field, have taken their place in medical treatments over the years due to their positive effects on cardiovascular health, bone health, wound healing and immune system. Boronic acids are a group of boron compounds that have recently been studied very popularly in medical research. Boronic acids have been known for their anti-microbial effect for more than 100 years. However, recent studies have shown that boronic acids have not only an antimicrobial effect, but also a strong anti-inflammatory effect and with these effects, they can be used in many inflammatory diseases. Liver injury is one of the diseases in which inflammation is seen. In recent years, the incidence of liver injury have increased extremely due to cancer, chemotherapies, use of antiviral drugs, increased hepatic steatosis and the use of wrong herbal supplements. For this reason, the treatment of liver damage is of greater importance today. In our study, we examined the role of 4-hydroxyphenylboronic acid, a derivative of boronic acid, in LPS-induced liver injury. When we looked at our results, we observed that 4 hydroxy phenylboronic acid treatment decreased the increased cytokine levels. Based on these results, we hope that 4 hydroxyphenylboronic acid will be an agent with the potential to treat liver injury.

Anahtar Kelimeler

4 hydroxy phenylboronic acid, Boron, LPS, Liver injury, BRL-3a

4 hidroksi fenilboronik asidin lipopolisakkarit ile indüklenmiş karaciğer hasarı üzerine muhtemel koruyucu etkilerinin incelenmesi

Öz

Bor ürünleri sağlık alanında uzun yıllardır kullanılmaktadır. Medikal anlamda ilk kez kanser tedavisinde kullanılan bor ürünleri yıllar içinde kardiyovasküler sağlık, kemik sağlığı, yara iyileşmesi ve immün sistem üzerine olan olumlu etkileri sebebiyle medikal tedavilerde yerini almıştır. Boronik asitler ise son zamanlarda medikal araştırmalarda oldukça popüler olarak incelenen bir bor bileşeni grubudur. Boronik asitler 100 yıldan daha uzun bir süredir sahip oldukları anti mikrobiyal etki ile biliniyorlardı. Ancak son zamanlarda yapılan çalışmalar boronik asitlerin sadece antimikrobiyal etkiye değil aynı zamanda anti enflamatuvar etkiye sahip olduklarını göstermiştir. Bu etkileriyle birçok enflamatuvar hastalıkta kullanılabilirler. Karaciğer hasarı da enflamasyonun görüldüğü hastalıklardan biridir. Son yıllarda karaciğer hasarının gerek kanser gerek kemoterapiler ve gerekse de kullanılan antiviral ilaç kullanımına bağlı olarak artışının yanı sıra hepatik steatozis ve yanlış bitkisel destekleyici ürün kullanımıyla birlikte insidansı son derece artmıştır. Bu sebeple karaciğer hasarının tedavi edilmesi günümüzde artık daha büyük önem arz etmektedir. Yaptığımız çalışmada bir boronik asit türevi olan 4 hidroksi fenilboronik asidin LPS ile indüklenmiş karaciğer hasarındaki rolünü inceledik. Sonuçlarımıza baktığımızda 4 hidroksi fenilboronik asit tedavisinin artmış olan sitokin seviyelerini düşürdüğünü gözlemledik. Bu sonuçlarımıza binaen 4 hidroksi fenilboronik asidin karaciğer hasarını tedavi etme potansiyeline sahip bir ajan olacağını ümit etmekteyiz.

Anahtar Kelimeler

4 hidroksi fenilboronik asit, Bor, LPS, Karaciğer hasarı, BRL-3a

Kaynakça

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