Alzheimer ve Parkinson hastalıklarında bor içeren bileşiklerin nörokoruyucu etkisi

Yıl 2024, Cilt: 9 Sayı: 1, 42 - 51, 29.03.2024

Barış Bitmez , Beste Balbal

https://doi.org/10.30728/boron.1408368

Öz

Bu derlemede bor içeren bileşiklerin nörodejenerasyon süreci üzerindeki etkileri anlatılmaktadır. Bor içeren bileşikler nöronlar üzerinde çeşitli koruyucu etkiler gösterirler. Son araştırmalar, bor takviyesinin nöronlarda antioksidan savunma mekanizmalarının artmasına yol açtığını, inflamasyonu baskıladığını ve oksidatif hasara karşı iyi bir koruma potansiyeli sergilediğini göstermiştir. Bu doğrultuda yazılan derleme makalesinde, bor içeren bileşiklerin nöro-koruyucu etkilerinin araştırıldığı çalışmalar incelendi ve bor içeren bileşiklerin nörodejeneratif hastalıkların tedavisinde spesifik hedeflere ilaç olarak uygulanmasına ilişkin daha ileri çalışmalara gerek olduğu tespit edildi.

Anahtar Kelimeler

Bor, nörodejenerasyon, Alzheimer Hastalığı, Parkinson Hastalığı, nöroinflamasyon

Neuroprotective Effect of Boron-Containing Compounds on Alzheimer's and Parkinson's Diseases

Öz

This review describes the effects of boron-containing compounds on the neurodegeneration process. Boron-containing compounds show various protective effects on neurons. Recent studies have shown that boron supplementation leads to increased antioxidant defense mechanisms in neurons, suppressing inflammation and exhibiting the potential to protect against oxidative damage. In this review article, studies investigating the neuroprotective effects of boron-containing compounds were examined and it was determined that further studies were needed on the application of boron-containing compounds as drugs to specific targets in the treatment of neurodegenerative diseases.

Anahtar Kelimeler

Boron, neurodegeneration, Alzheimer Disease, Parkinson Disease, neuroinflammation

Kaynakça

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