ORAL RİSPERİDON KULLANIMINA BAĞLI ŞİDDETLİ HİPOGLİSEMİ: BİR OLGU SUNUMU Oral Risperidone-Induced Severe Hypoglycemia: A Case Report

Yıl 2019, Cilt: 9 Sayı: 1, 166 - 168, 26.03.2019

Mehmet Hamdi Örüm , Mahmut Zabit Kara

Öz

ÖZET

Risperidon, ikinci nesil atipik antipsikotiktir ve sıklıkla psikiyatrik bozuklukların tedavisinde kullanılır.

En sık görülen yan etkileri sedasyon, kilo alımı ve ortostatik hipotansiyondur. Literatürde

risperidon kullanımına bağlı reaktif hipoglisemi ile ilgili az sayıda vaka bulunmaktadır. Bu çalışmada,

risperidon kullanımına bağlı şiddetli hipoglisemi gelişen 22 yaşında bir erkek hastayı sunduk.

Anahtar Sözcükler: Antipsikotik; Hipoglisemi; Risperidon; Yan etki

ABSTRACT

Risperidone is a second generation atypical antipsychotic and it is often used for the management

of the psychiatric disorders. The most commonly seen adverse effects recorded are sedation,

weight gain and orthostatic hypotension. There are few cases in the literature related to reactive

hypoglycemia due to risperidone use. We present a 22-year-old male patient with severe

hypoglycemia due to risperidone use in this case report.

Keywords: Antipsychotic; Hypoglycemia; Risperidone; Side effect

Anahtar Kelimeler

ORAL RİSPERİDON KULLANIMINA BAĞLI ŞİDDETLİ HİPOGLİSEMİ: BİR OLGU SUNUMU Oral Risperidone-Induced Severe Hypoglycemia: A Case Report

Kaynakça

• 1. Fujita T, Mizoguchi Y, Kunitake Y, Tateishi H, Inaba T, Kato TA, et al. Second-generation antipsychotic-induced hypoglycemia. Prim Care Companion CNS Disord. 2018;20(1). Pii: 17br02186. 2. Murad MH, Coto-Yglesias F, Wang AT, Sheidaee N, Mullan RJ, Elamin MB, et al. Clinical review: druginduced hypoglycemia: a systematic review. J Clin Endocrinol Metab. 2009;94(3):741-5. 3. Orum MH, Han-Almis B, Karaca HT. Rapid onset of pedal edema associated with risperidone in two male patients: Simultaneous clinical cases. J Mood Disord. 2017;7(4):237-40. 5. Nagamine T. Hypoglycemia associated with insulin hypersecretion following the addition of olanzapine to conventional antipsychotics. Neuropsychiatr Dis Treat. 2006;2:583-5. 6. Sharma T, Sharma A, Sharma PK, Kansal D. An unusual case of trifluoperazine induced hypoglycemia. Int J Basic Clin Pharmacol 2015;4:1029-30 7. Ishiguro H, Hanyu O, Houya S, Morohashi K, Kuroiwa G, Kuwabara O, et al. A case of hypoglycemia attributable to atypical antipsychotic drugs. Diabetology international. 2015;6(4):341-6. 8. Fagerholm V, Haaparanta M, Scheinin M. α2-adrenoceptor regulation of blood glucose homeostasis. Basic Clin Pharmacol Toxicol. 2011;108(6):365-70. 9. Nagamine T. Severe hypoglycemia associated with risperidone. Psychiatry and Clinical Neurosciences 2016;70:421.