ANALYSIS OF NEW POTENTIAL HEMOGRAM BIOMARKERS IN PATIENTS PRESENTING TO THE EMERGENCY DEPARTMENT WITH EPILEPTIC SEIZURES Acil Servise Epileptik Nöbet ile Başvuran Hastalarda Yeni Potansiyel Hemogram Biyobelirteçlerinin Analizi

Yıl 2024, Cilt: 14 Sayı: 3, 144 - 151, 15.09.2024

İbrahim Çaltekin , Ali Aygün , Mesut Tomakin , Ramiz Yazıcı , Güneş Seda Albayrak

Öz

ABSTRACT
Objective: We aimed to analyze the diagnostic value of new potential hemogram biomarkers in patients
presenting to the emergency department with epileptic seizures.
Material and Methods: Patients presenting with epileptic seizures to a tertiary hospital's emergency department
between January 1, 2023, and January 1, 2024, were retrospectively reviewed. The patients were
categorized into Group A (seizure patients) and Group B (healthy volunteers). Hemogram and biochemistry
data from routine blood tests were examined. To predict seizure status, ROC analysis was performed to
evaluate NLR, PLR and PNR. The area under the curve and cutoff values were calculated for each marker.
Results: Our study examined two groups: seizure patients and the control group. The mean age of the seizure
group was 50.31±1.83 years, and the mean age of the control group was 49.58±1.96 years (p>0.05). In
the seizure group (n=116), 55.8% were male and 44.2% were female, whereas in the control group (n=104),
57.8% were male and 42.2% were female (p>0.05). WBC, neutrophil count, NLR, and PLR values were significantly
higher in seizure patients compared to the control group (p<0.001, p<0.001, p<0.001, and p=0.035,
respectively). PNR and lymphocyte values were significantly lower in seizure patients compared to the control
group (p<0.001 and p=0.01, respectively).
Conclusion: We found significant changes in NLR, PLR, and PNR values in patients with epileptic seizures.
We believe that these biomarkers can assist clinicians in diagnosing seizures and distinguishing between
seizures and pseudoseizures, especially in emergency departments.

Anahtar Kelimeler

ANALYSIS OF NEW POTENTIAL HEMOGRAM BIOMARKERS IN PATIENTS PRESENTING TO THE, EMERGENCY DEPARTMENT WITH EPILEPTIC SEIZURES, Acil Servise Epileptik Nöbet ile Başvuran Hastalarda Yeni Potansiyel Hemogram Biyobelirteçlerinin Analizi

Kaynakça

• 1. Fisher RS, Acevedo C, Arzimanoglou A, Bogacz A, Cross JH, Elger CE, Vd. ILAE Official Report: A Practical Clinical Definition of Epilepsy. Epilepsia. 2014;55(4):475-82.
• 2. Calisir N, Bora I, Irgil E, Boz M. Prevalence of Epilepsy in Bursa City Center, an Urban Area of Turkey. Epilepsia. 2006;47(10):1691-9.
• 3. Icagasıoglu Df. Etiology and Risk Factors of Epilepsy. Basic Pediatr Neurology Diagnosis and Treatment. 2022;2091-98.
• 4. Manford M. Recent Advances in Epilepsy. J Neurol. 2017;264(8):1811-24.
• 5. Akdag G, Algın D, Erdinç O. Epılepsy. Osmangazi Journal of Medicine 2016;38(1).
• 6. Banote RK, Akel S, Zelano J. Blood Biomarkers in Epilepsy. Acta Neurol Scand. 2022;146(4):362-8.
• 7. Sabers A, Kjær TW. Epilepsi. Ugeskr Læg Online. 2014;176(26):1232-5.
• 8. Hampel KG, Garces-Sanchez M, Gomez-Ibanez A, Palanca-Camara M, Villanueva V. Diagnostic Challenges in Epilepsy. Rev Neurol. 2019;68(6):255-63.
• 9. Cakıl D, Inanir S, Baykan H, Aygun H, Kozan R. Psychogenic Non-Epileptic Seizures in the Differential Diagnosis of Epilepsy. Goztepe Journal of Medicine. 2013;28(1):41-7.
• 10. Huang Y, Ying Z, Quan W, Xiang W, Xie D, Weng Y, et al. The Clinical Significance of Neutrophil-To-Lymphocyte Ratio and Monocyte-To-Lymphocyte Ratio in Guillain-Barré Syndrome. Int J Neurosci. 2018;128(8):729-35.