Gıda Takviyesi Olarak Astaksantin ve Sağlık Üzerine Etkileri

Yıl 2024, Cilt: 7 Sayı: 1, 33 - 45, 15.01.2024

Funda Işık , Kadriye Elif İmre

https://doi.org/10.19127/bshealthscience.1297807

Öz

Bu çalışma son 25 yılda özellikle son 5 yılda PubMed ve Web of Science veri tabanlarında "astaksantin", "sağlık etkisi" ve "diyet takviyeleri" anahtar kelimeleriyle taranan makaleler aracılığıyla astaksantin kaynakları, üretimi, gıda endüstrisindeki kullanımı ve sağlık üzerindeki potansiyel etkilerini incelemeyi amaçlamaktadır. Astaksantin üzerine yapılan bu kapsamlı derleme, bu doğal antioksidanın biyolojik etkilerini ve insan sağlığına olan potansiyel faydalarını ele almaktadır. Çalışma, astaksantinin oksidatif stres, inflamasyon, bağırsak mikrobiyotası, nörolojik hastalıklar, terapötik kullanımları ve yaşlanma karşıtı stratejilerdeki rolünü çeşitli yönlerden değerlendirmektedir. Bu çalışma astaksantinin gelecekteki klinik araştırmalarda ve sağlık uygulamalarında nasıl değerlendirilebileceğine dair önemli bir temel sunar. Özellikle yaşlanan nüfusun arttığı bir dönemde, astaksantin gibi doğal bir antioksidanın hastalıkların önlenmesi ve tedavisindeki potansiyeli üzerinde durulmaktadır.

Anahtar Kelimeler

Astaksantin, Gıda takviyesi, Sağlık

Astaxanthin as a Food Supplement and Its Effects on Health

Öz

This study aims to examine astaxanthin sources, production, use in the food industry, and potential effects on health through articles scanned in the PubMed and Web of Science databases with the keywords "astaxanthin", "health effect" and "dietary supplements" in the last 25 years, especially in the previous five years. This comprehensive review on astaxanthin addresses the biological effects of this natural antioxidant and its potential benefits to human health. The study evaluates various aspects of astaxanthin's role in oxidative stress, inflammation, gut microbiota, neurological diseases, therapeutic uses, and anti-aging strategies. This study provides an essential basis for how astaxanthin can be evaluated in future clinical research and healthcare applications. Significantly, when the aging population is increasing, the potential of a natural antioxidant such as astaxanthin in preventing and treating diseases is emphasized.

Anahtar Kelimeler

Astaxanthin, Dietary supplements, Health

Kaynakça

• Ambati RR, Phang SM, Ravi S, Aswathanarayana RG. 2014. Astaxanthin: sources, extraction, stability, biological activities and its commercial applications--a review. Mar Drugs, 12(1): 128-152. https://doi.org/10.3390/md12010128.
• Anarjan N, Tan CP. 2013. Chemical stability of astaxanthin nanodispersions in orange juice and skimmed milk as model food systems. Food Chem, 139(1-4): 527-531. https://doi.org/10.1016/j.foodchem.2013.01.012.
• Andersen LP, Holck S, Kupcinskas L, Kiudelis G, Jonaitis L, Janciauskas D, Permin H, Wadström T. 2007. Gastric inflammatory markers and interleukins in patients with functional dyspepsia treated with astaxanthin. FEMS Immunol Med Microbiol, 50(2): 244-248. https://doi.org/10.1111/j.1574-695X.2007.00257.x
• Aneesh PA, Ajeeshkumar KK, Lekshmi RGK, Anandan R, Ravishankar CN, Mathew S. 2022. Bioactivities of astaxanthin from natural sources, augmenting its biomedical potential: A review. Trends Food Sci Technol, 125: 81-90. https://doi.org/10.1016/j.tifs.2022.05.004.
• Alzheimer's Association. 2018. 2018 Alzheimer's disease facts and figures. Alzheimers Dementia, 14(3): 367-425. https://doi.org/10.1016/j.jalz.2018.02.001.
• Atalay PB, Kuku G, Tuna BG. 2019. Effects of carbendazim and astaxanthin co-treatment on the proliferation of MCF-7 breast cancer cells. In Vitro Cell Devel Biol Anim, 55(2): 113-119. https://doi.org/10.1007/s11626-018-0312-0.
• Bennedsen M, Wang X, Willen R, Wadstrom T, Andersen LP. 1999. Treatment of H-pylori infected mice with antioxidant astaxanthin reduces gastric inflammation, bacterial load and modulates cytokine release by splenocytes. Immunol Lett, 70(3): 185-189. https://doi.org/10.1016/S0165-2478(99)00145-5.
• Bjorklund G, Gasmi A, Lenchyk L, Shanaida M, Zafar S, Mujawdiya PK, Lysiuk R, Antonyak H, Noor S, Akram M, Smetanina K, Piscopo S, Upyr T, Peana M. 2022. The role of astaxanthin as a nutraceutical in health and age-related conditions. Molecules, 27(21): 7167. https://doi.org/10.3390/molecules27217167.
• Bohn T, Desmarchelier C, Dragsted LO, Nielsen CS, Stahl W, Ruhl R, Keijer J, Borel P. 2017. Host-related factors explaining interindividual variability of carotenoid bioavailability and tissue concentrations in humans. Molec Nutrit Food Res, 61(6): 1600685. https://doi.org/ARTN 160068510.1002/mnfr.201600685.
• Brasil FB, Gobbo RCB, de Almeida FJS, Luckachaki MD, Dall'Oglio EL, de Oliveira MR. 2021. The signaling pathway PI3K/Akt/Nrf2/HO-1 plays a role in the mitochondrial protection promoted by astaxanthin in the SH-SY5Y cells exposed to hydrogen peroxide. Neurochem Int, 146. https://doi.org/ARTN 105024.
• Brendler T, Williamson EM. 2019. Astaxanthin: How much is too much? A safety review. Phytotherapy Res, 33(12): 3090-3111. https://doi.org/10.1002/ptr.6514.
• Cao YR, Yang L, Qiao X, Xue CH, Xu J. 2021. Dietary astaxanthin: an excellent carotenoid with multiple health benefits. Crit Rev Food Sci Nutrit, 2021: 1-27 https://doi.org/10.1080/10408398.2021.1983766.
• Capelli B, Talbott S, Ding, L. 2019. Astaxanthin sources: Suitability for human health and nutrition. Funct Foods Health Disease, 9(6): 430-445. https://doi.org/10.31989/ffhd.v9i6.584.
• Chalyk NE, Klochkov VA, Bandaletova TY, Kyle NH, Petyaev IM. 2017. Continuous astaxanthin intake reduces oxidative stress and reverses age-related morphological changes of residual skin surface components in middle-aged volunteers. Nutrit Res, 48: 40-48. https://doi.org/10.1016/j.nutres.2017.10.006.
• Chan KC, Chen SC, Chen PC. 2019. Astaxanthin attenuated thrombotic risk factors in type 2 diabetic patients. Journal of Funct Foods, 53: 22-27. https://doi.org/10.1016/j.jff.2018.12.012.
• Chang Y, Lu CW, Chen YJ, Lin TY, Huang SK, Wang SJ. 2018. Astaxanthin protects against kainic acid-induced seizures and pathological consequences. Neurochem Int, 116: 85-94. https://doi.org/10.1016/j.neuint.2018.02.008.
• Choi HD, Youn YK, Shin WG. 2011. Positive effects of astaxanthin on lipid profiles and oxidative stress in overweight subjects. Plant Foods Human Nutrit, 66(4): 363-369. https://doi.org/10.1007/s11130-011-0258-9.
• Cui GY, Li L, Xu WX, Wang MY, Jiao DY, Yao BB, Xu KT, Chen YL, Yang SH, Long M, Li P, Guo Y. 2020. Astaxanthin protects ochratoxin a-ınduced oxidative stress and apoptosis in the heart via the Nrf2 pathway. Oxidative Medic Cell Longevity. 2020: 7639109. https://doi.org/10.1155/2020/7639109.
• Davinelli S, Melvang HM, Andersen LP, Scapagnini G, Nielsen ME. 2019. Astaxanthin from shrimp cephalothorax stimulates the ımmune response by enhancing IFN-gamma, IL-10, and IL-2 secretion in splenocytes of helicobacter pylori-ınfected mice. Mar Drugs, 17(7): 382. https://doi.org/10.3390/md17070382.
• Diao WL, Chen WA, Cao WM, Yuan H, Ji H, Wang TW, Zhu XX, Zhou H, Guo HQ, Zhao XZ. 2019. Astaxanthin protects against renal fibrosis through inhibiting myofibroblast activation and promoting CD8(+) T cell recruitment. Biochimica Et Biophysica Acta-General Subjects, 1863(9): 1360-1370. https://doi.org/10.1016/j.bbagen.2019.05.020.
• Donoso A, Gonzalez-Duran J, Munoz AA, Gonzalez PA, Agurto-Munoz C. 2021. Therapeutic uses of natural astaxanthin: An evidence-based review focused on human clinical trials. Pharmacol Res, 166: 105479. https://doi.org/10.1016/j.phrs.2021.105479.
• Du X, Wang X, Yan X, Yang Y, Li Z, Jiang Z, Ni H. 2020. Hypoglycaemic effect of all-trans astaxanthin through inhibiting α-glucosidase. J Funct Foods, 74: 104168.
• EFSA Panel on Additives and Products or Substances used in Animal Feed (FEEDAP). 2014. Scientific opinion on the safety and efficacy of synthetic astaxanthin as feed additive for salmon and trout, other fish, ornamental fish, crustaceans and ornamental birds. EFSA J, 12(6): 3724. https://doi.org/10.2903/j.efsa.2014.3724.
• EFSA Panel on Nutrition, Novel Foods and Food Allergens (NDA), Turck D, Castenmiller J, de Henauw S, Hirsch‐Ernst KI, Kearney J, Knutsen HK. 2020. Safety of astaxanthin for its use as a novel food in food supplements. EFSA J, 18(2): e05993.
• Ekpe L, Inaku K, Ekpe V. 2018. Antioxidant effects of astaxanthin in various diseases—a review. J Molec Pathophysiol, 7(1): 1-6.
• El-Agamy SE, Abdel-Aziz AK, Wahdan S, Esmat A, Azab SS. 2018. Astaxanthin ameliorates doxorubicin-ınduced cognitive ımpairment (Chemobrain) in experimental rat model: Impact on oxidative, ınflammatory, and apoptotic machineries. Molec Neurobiol, 55(7): 5727-5740. https://doi.org/10.1007/s12035-017-0797-7.
• Esterbauer H, Gebicki J, Puhl H, Jurgens G. 1992. The role of lipid-peroxidation and antioxidants in oxidative modification of Ldl. Free Radical Biol Medic, 13(4): 341-390. https://doi.org/Doi 10.1016/0891-5849(92)90181-F.
• Fakhri S, Abbaszadeh F, Dargahi L, Jorjani M. 2018. Astaxanthin: A mechanistic review on its biological activities and health benefits. Pharmacol Res, 136: 1-20. https://doi.org/10.1016/j.phrs.2018.08.012.
• Fang N, Wang C, Liu X, Zhao X, Liu Y, Liu, X, Du Y, Zhang Z, Zhang H. 2019. De novo synthesis of astaxanthin: From organisms to genes. Trends Food Sci Technol, 92: 162-171. https://doi.org/10.1016/j.tifs.2019.08.016.
• Gammone MA, Riccioni G, D'Orazio N. 2015. Marine carotenoids against oxidative stress: Effects on human health. Mar Drugs, 13(10): 6226-6246. https://doi.org/10.3390/md13106226.
• Gao Y, Yang L, Chin YX, Liu F, Li RW, Yuan SH, Xue CH, Xu J, Tang QJ. 2020. Astaxanthin n-Octanoic acid diester ameliorates ınsulin resistance and modulates gut microbiota in high-fat and high-sucrose diet-fed mice. Int J Molec Sci, 21(6): 2149. https://doi.org/ARTN 214910.3390/ijms21062149.
• Gowda KMD, Kumari NS, Ullal H. 2020. Role of astaxanthin in the modulation of brain-derived neurotrophic factor and spatial learning behavior in perinatally undernourished Wistar rats. Nutrit Neurosc, 23(6): 422-431. https://doi.org/10.1080/1028415x.2018.1515301.
• Grimmig B, Daly L, Subbarayan M, Hudson C, Williamson R, Nash K, Bickford PC. 2018. Astaxanthin is neuroprotective in an aged mouse model of Parkinson's disease. Oncotarget, 9(12): 10388-10401. https://doi.org/10.18632/oncotarget.23737.
• Grunwald JE, Metelitsina TI, DuPont JC, Ying GS, Maguire MG. 2005. Reduced foveolar choroidal blood flow in eyes with increasing AMD severity. Invest Ophthalmol Visual Scie, 46(3): 1033-1038. https://doi.org/10.1167/iovs.04-1050.
• Hashimoto H, Arai K, Hayashi S, Okamoto H, Takahashi J, Chikuda M. 2016. The effect of astaxanthin on vascular endothelial growth factor (VEGF) levels and peroxidation reactions in the aqueous humor. J Clin Biochem Nutrit, 59(1): 10-15. https://doi.org/10.3164/jcbn.15-137.
• Higuera-Ciapara I, Felix-Valenzuela L, Goycoolea FM. 2006. Astaxanthin: A review of its chemistry and applications. Crit Rev Food Sci Nutrit, 46(2): 185-196. https://doi.org/10.1080/10408690590957188.
• Hossain AM, Brennan MA, Mason SL, Guo X, Zeng XA, Brennan CS. 2017. The effect of astaxanthin-rich microalgae “Haematococcus pluvialis” and wholemeal flours incorporation in improving the physical and functional properties of cookies. Foods, 6(8): 57. https://doi.org/10.3390/foods6080057.
• Hussein G, Sankawa U, Goto H, Matsumoto K, Watanabe H. 2006. Astaxanthin, a carotenoid with potential in human health and nutrition. J Natural Prod, 69(3): 443-449. https://doi.org/10.1021/np050354+.
• Hwang YH, Kim KJ, Kim SJ, Mun SK, Hong SG, Son YJ, Yee ST. 2018. Suppression effect of astaxanthin on osteoclast formation ın vitro and bone loss ın vivo. Int J Molec Sci, 19(3): 912. https://doi.org/10.3390/ijms19030912.
• Ishiwata S, Kato T, Kasai T, Sato A, Yatsu S, Matsumoto H, Shitara J, Murata A, Shimizu M, Suda S, Matsue Y, Naito R, Hiki M, Daida H. 2021. Changes in self-reported physical activity and health-related quality of life following 3-month astaxanthin supplementation in patients with heart failure: results from a pilot study. Annals Palliative Medic, 10(2): 1396-1403. https://doi.org/10.21037/apm-20-1378.
• Issa AR, Sun J, Petitgas C, Mesquita A, Dulac A, Robin M, Mollereau B, Jenny A, Cherif-Zahar B, Birman S. 2018. The lysosomal membrane protein LAMP2A promotes autophagic flux and prevents SNCA-induced Parkinson disease-like symptoms in the Drosophila brain. Autophagy, 14(11): 1898-1910. https://doi.org/10.1080/15548627.2018.1491489.
• Ito N, Saito H, Seki S, Ueda F, Asada T. 2019. Effects of composite supplement containing astaxanthin and sesamin on cognitive functions in people with mild cognitive ımpairment: A randomized, double-blind, placebo-controlled trial. J Alzheimer's Disease, 68(2): 839-839. https://doi.org/10.3233/Jad-189016.
• Ito N, Seki S, Ueda F. 2018. The protective role of astaxanthin for uv-ınduced skin deterioration in healthy people-A randomized, double-blind, placebo-controlled trial. Nutrients, 10(7): 817. https://doi.org/10.3390/nu10070817.
• Iwamoto T, Hosoda K, Hirano R, Kurata H, Matsumoto A, Miki W, Kamiyama M, Itakura H, Yamamoto S, Kondo K. 2000. Inhibition of low-density lipoprotein oxidation by astaxanthin. J Atheroscler Thromb, 7(4): 216-222. https://doi.org/10.5551/jat1994.7.216.
• Jiang TF, Sun Q, Chen SD. 2016. Oxidative stress: A major pathogenesis and potential therapeutic target of antioxidative agents in Parkinson's disease and Alzheimer's disease. Progress Neurobiol, 147: 1-19. https://doi.org/10.1016/j.pneurobio.2016.07.005.
• Kammeyer A, Luiten RM. 2015. Oxidation events and skin aging. Ageing Res. Rev, 21: 16–29. https://doi.org/10.1016/j.arr.2015.01.001.
• Kim SH, Lim JW, Kim H. 2018. Astaxanthin ınhibits mitochondrial dysfunction and ınterleukin-8 expression in helicobacter pylori-ınfected gastric epithelial cells. Nutrients, 10(9): 1320. https://doi.org/10.3390/nu10091320.
• Kizawa Y, Sekikawa T, Kageyama M, Tomobe H, Kobashi R, Yamada T. 2021. Effects of anthocyanin, astaxanthin, and lutein on eye functions: a randomized, double-blind, placebo-controlled study. J Clin Biochem Nutrit, 69(1): 77-90. https://doi.org/10.3164/jcbn.20-149.
• Kohandel Z, Farkhondeh T, Aschner M, Pourbagher-Shahri AM, Samarghandian S. 2022. Anti-inflammatory action of astaxanthin and its use in the treatment of various diseases. Biomed Pharmacother, 145: 112179. https://doi.org/10.1016/j.biopha.2021.112179.
• Landon R, Gueguen V, Petite H, Letourneur D, Pavon-Djavid G, Anagnostou F. 2020. Impact of astaxanthin on diabetes pathogenesis and chronic complications. Mar Drugs, 18(7): 357. https://doi.org/10.3390/md18070357.
• Lee J, Kim MH, Kim H. 2022. Anti-oxidant and anti-ınflammatory effects of astaxanthin on gastrointestinal diseases. Int J Mol Sci, 23(24): 15471. https://doi.org/10.3390/ijms232415471.
• Lee H, Lim JW, Kim H. 2020. Effect of astaxanthin on activation of autophagy and inhibition of apoptosis in helicobacter pylori-ınfected gastric epithelial cell line AGS. Nutrients, 12(6): 1750. https://doi.org/10.3390/nu12061750.
• Li J, Guo C, Wu J. 2020. Astaxanthin in liver health and disease: A potential therapeutic agent. Drug Des Devel Ther, 14: 2275-2285. https://doi.org/10.2147/DDDT.S230749.
• Li X, Matsumoto T, Takuwa M, Ali MSES, Hirabashi T, Kondo H, Fujino H. 2020. Protective effects of astaxanthin supplementation against ultraviolet-ınduced photoaging in hairless mice. Biomedicines, 8(2): 18. https://doi.org/10.3390/biomedicines8020018.
• Lin WN, Kapupara K, Wen YT, Chen YH, Pan IH, Tsai RK. 2020. Haematococcus pluvialis-Derived Astaxanthin Is a Potential Neuroprotective Agent against Optic Nerve Ischemia. Marine Drugs, 18(2): 85. https://doi.org/ARTN 8510.3390/md18020085.
• Liu HL, Liu MH, Fu XQ, Zhang ZQ, Zhu LY, Zheng X, Liu JS. 2018. Astaxanthin prevents alcoholic fatty liver disease by modulating mouse gut microbiota. Nutrients, 10(9): 1298. https://doi.org/ARTN 129810.3390/nu10091298.
• Liu YJ, Yang L, Guo YL, Zhang T, Qiao X, Wang JF, Xu J, Xue CH. 2020. Hydrophilic astaxanthin: pegylated astaxanthin fights diabetes by enhancing the solubility and oral absorbability. J Agri Food Chem, 68(11): 3649-3655. https://doi.org/10.1021/acs.jafc.0c00784.
• Liu F, Smith AD, Solano-Aguilar G, Wang TTY, Pham Q, Beshah E, Tang QJ, Urban JF, Xue CH, Li RW. 2020. Mechanistic insights into the attenuation of intestinal inflammation and modulation of the gut microbiome by krill oil using in vitro and in vivo models. Microbiome, 8(1): 83. https://doi.org/10.1186/s40168-020-00843-8.
• Manabe Y, Komatsu T, Seki S, Sugawara T. 2018. Dietary astaxanthin can accumulate in the brain of rats. Biosci Biotechnol Biochem, 82(8): 1433-1436. https://doi.org/10.1080/09168451.2018.1459467.
• Martinez-Alvarez O, Calvo MM, Gomez-Estaca J. 2020. Recent Advances in Astaxanthin Micro/Nanoencapsulation to Improve Its Stability and Functionality as a Food Ingredient. Mar Drugs, 18(8): 406. https://doi.org/10.3390/md18080406.
• Monroy-Ruiz J, Sevilla MA, Carron R, Montero MJ. 2011. Astaxanthin-enriched-diet reduces blood pressure and improves cardiovascular parameters in spontaneously hypertensive rats. Pharmacol Res, 63(1): 44-50. https://doi.org/10.1016/j.phrs.2010.09.003.
• Park JS, Chyun JH, Kim YK, Line LL, Chew BP. 2010. Astaxanthin decreased oxidative stress and inflammation and enhanced immune response in humans. Nutrit Metabol, 7: 18. https://doi.org/10.1186/1743-7075-7-18.
• Petri D, Lundebye AK. 2007. Tissue distribution of astaxanthin in rats following exposure to graded levels in the feed. Comp Biochem Physiol C Toxicol Pharmacol, 145(2):202-209
• Radice RP, Limongi AR, Viviano E, Padula MC, Martelli G, Bermano G. 2021. Effects of astaxanthin in animal models of obesity-associated diseases: A systematic review and meta-analysis. Free Radic Biol Med, 171: 156-168. https://doi.org/10.1016/j.freeradbiomed.2021.05.008.
• Rahman SO, Panda BP, Parvez S, Kaundal M, Hussain S, Akhtar M, Najmi AK. 2019. Neuroprotective role of astaxanthin in hippocampal insulin resistance induced by Abeta peptides in animal model of Alzheimer's disease. Biomed Pharmac, 110: 47-58. https://doi.org/10.1016/j.biopha.2018.11.043.
• Seabra LMJ, Pedrosa LFC. 2010. Astaxanthin: structural and functional aspects. Revista De Nutricao-Brazilian J Nutrit, 23(6): 1041-1050. https://doi.org/Doi 10.1590/S1415-52732010000600010.
• Sekikawa T, Kizawa Y, Li YM, Takara T. 2020. Cognitive function improvement with astaxanthin and tocotrienol intake: a randomized, double-blind, placebo-controlled study. J Clin Biochem Nutrit, 67(3): 307-316. https://doi.org/10.3164/jcbn.19-116.
• Sila A, Ghlissi Z, Kamoun Z, Makni M, Nasri M, Bougatef A, Sahnoun Z. 2015. Astaxanthin from shrimp by-products ameliorates nephropathy in diabetic rats. European J Nutrit, 54(2): 301-307. https://doi.org/10.1007/s00394-014-0711-2.
• Singh KN, Patil S, Barkate H. 2020. Protective effects of astaxanthin on skin: Recent scientific evidence, possible mechanisms, and potential indications. J Cosmet Dermatol, 19(1): 22-27. https://doi.org/10.1111/jocd.13019.
• Stachowiak B, Szulc P. 2021. Astaxanthin for the food industry. Molecules, 26(9): 2666. https://doi.org/10.3390/molecules26092666.
• Talukdar J, Bhadra B, Dattaroy T, Nagle V, Dasgupta S. 2020. Potential of natural astaxanthin in alleviating the risk of cytokine storm in COVID-19. Biomed Pharmac, 132: 110886. https://doi.org/10.1016/j.biopha.2020.110886.
• Tominaga K, Hongo N, Karato M, Yamashita E. 2012. Cosmetic benefits of astaxanthin on humans subjects. Acta Biochimica Polonica, 59(1): 43-47. https://doi.org/10.18388/abp.2012_2168.
• Tso MOM, Lam TT. 1996. Method of retarding and ameliorating central nervous system and eye damage. United States Patent No. 5527533. http://www.freepatentsonline.com/5527533.html.
• Wang JH, Liu SW, Wang H, Xiao S, Li C, Li Y, Liu BN. 2019. Xanthophyllomyces dendrorhous-Derived astaxanthin regulates lipid metabolism and gut microbiota in obese mice ınduced by a high-fat diet. Marine Drugs, 17(6): 337. https://doi.org/10.3390/md17060337.
• Wang HQ, Sun XB, Xu YX, Zhao H, Zhu QY, Zhu CQ. 2010. Astaxanthin upregulates heme oxygenase-1 expression through ERK1/2 pathway and its protective effect against beta-amyloid-induced cytotoxicity in SH-SY5Y cells. Brain Res, 1360: 159-167. https://doi.org/10.1016/j.brainres.2010.08.100.
• Wang X, Willen R, Wadstrom T. 2000. Astaxanthin-rich algal meal and vitamin C inhibit Helicobacter pylori infection in BALB/cA mice. Antimicrobial Agents Chemotherapy, 44(9), 2452-2457. https://doi.org/Doi 10.1128/Aac.44.9.2452-2457.2000.
• Wang YL, Zhu XL, Sun MH, Dang YK. 2019. Effects of astaxanthin onaxonal regeneration via cAMP/PKA signaling pathway in mice with focal cerebral infarction. European Rev Medic Pharmacol Sci, 23: 135-143. https://doi.org/10.26355/eurrev_201908_18640.
• Yamashita E. 2006. The effects of a dietary supplement containing astaxanthin on skin condition. Carotenoid Sci, 10: 91-95.
• Yang L, Qiao X, Gu JY, Li XM, Cao YR, Xu J, Xue CH. 2021a. Influence of molecular structure of astaxanthin esters on their stability and bioavailability. Food Chem, 343: 128497.
• Yang L, Qiao X, Liu J, Wu LL, Cao YR, Xu J, Xue CH. 2021b. Preparation, characterization and antioxidant activity of astaxanthin esters with different molecular structures. J Sci Food Agri, 101(6): 2576-2583. https://doi.org/10.1002/jsfa.10887.
• Yang M, Chen Y, Zhao T, Wang ZJ. 2020. Effect of astaxanthin on metabolic cataract in rats with type 1 diabetes mellitus. Experim Molec Pathol, 113: 104372. https://doi.org/10.1016/j.yexmp.2020.104372.
• Yaqoob Z, Arshad MS, Imran M, Munir H, Qaisrani TB, Khalid W, Asghar Z, Suleria HAR. 2022. Mechanistic role of astaxanthin derived from shrimp against certain metabolic disorders. Food Sci Nutr, 10(1): 12-20. https://doi.org/10.1002/fsn3.2623.
• Yasui Y, Hosokawa M, Mikami N, Miyashita K, Tanaka T. 2011. Dietary astaxanthin inhibits colitis and colitis-associated colon carcinogenesis in mice via modulation of the inflammatory cytokines. Chemico-Biol Interact, 193(1): 79-87. https://doi.org/10.1016/j.cbi.2011.05.006.
• Ye QY, Zhang XD, Huang BX, Zhu YG, Chen XC. 2013. Astaxanthin Suppresses MPP+-Induced Oxidative Damage in PC12 Cells through a Sp1/NR1 Signaling Pathway. Marine Drugs, 11(4): 1019-1034. https://doi.org/10.3390/md11041019.
• Yoon HS, Cho HH, Cho S, Lee SR, Shin MH, Chung JH. 2014. Supplementing with dietary astaxanthin combined with collagen hydrolysate improves facial elasticity and decreases matrix metalloproteinase-1 and-12 expression: a comparative study with placebo. J Medic Food, 17(7): 810-816. https://doi.org/10.1089/jmf.2013.3060.
• Yu WJ, Liu JG. 2020. Astaxanthin isomers: Selective distribution and isomerization in aquatic animals. Aquaculture, 520: 734915.
• Zhang J, Wang QZ, Zhao SH, Ji X, Qiu J, Wang J, Zhou Y, Cai Q, Zhang J, Gao HQ. 2017. Astaxanthin attenuated pressure overload-induced cardiac dysfunction and myocardial fibrosis: Partially by activating SIRT1. Biochim Et Biophysica Acta-General Subj, 1861(7): 1715-1728. https://doi.org/10.1016/j.bbagen.2017.03.007.
• Zhang X, Hou Y, Li J, Wang J. 2021. The Role of Astaxanthin on Chronic Diseases. Crystals, 11(5): 505. https://doi.org/10.3390/cryst11050505.
• Zhang XS, Lu Y, Li W, Tao T, Peng L, Wang WH, Gao S, Liu C, Zhuang Z, Xia DY, Hang CH, Li W. 2021. Astaxanthin ameliorates oxidative stress and neuronal apoptosis via SIRT1/NRF2/Prx2/ASK1/p38 after traumatic brain injury in mice. British J Pharmacol, 178(5): 1114-1132. https://doi.org/10.1111/bph.15346.
• Zhang XS, Lu Y, Wu Q, Dai HB, Li W, Lv SY, Zhou XM, Zhang X, Hang CH, Wang J. 2019. Astaxanthin mitigates subarachnoid hemorrhage injury primarily by increasing sirtuin 1 and inhibiting the Toll-like receptor 4 signaling pathway. Faseb J, 33(1): 722-737. https://doi.org/10.1096/fj.201800642RR.