Sweeteners, Glucose Intolerance and Microbiota
Yıl 2017,
- Mikrobiyota, 34 - 38, 15.11.2017
Fatih Gültekin
,
Manolya Eser Öner
Hasan Basri Savaş
Bora Doğan
Öz
The use of food additives in food production are inevitable in this modern world. Although only safe amount of them are approved, their safety have always been questioned. The effects of food additives on microbiota have not been investigated in detailed manner up to know. In this review the effects of sweeteners, a part of food additives, were reviewed and showed that they affect microbiota. As a rusult, nonnutritive syntetic sweeteners can lead to glucose intolerance by affecting microbiota and a part of sugar alcohols show probiotic like effects.
Kaynakça
- 1. Jin Y, Wu S, Zeng Z, Fu Z. Effects of environmental pollutants on gut
microbiota. Environ Pollut. 2017; 222: 1-9.
- 2. Gültekin F. A'dan Z'ye Gıda Katkı Maddeleri. Server İletişim, 2014,
İstanbul.
- 3. Suez J, Korem T, Zeevi D, Zilberman-Schapira G, Thaiss C.A,
Maza O, Israeli D, Zmora N, Gilad S, Weinberger A, Kuperman Y,
Harmelin A, Kolodkin-Gal I, Shapiro H, Halpern Z, Segal E, Elinav E.
Artifi cial sweeteners induce glucose intolerance by altering the gut
microbiota. Nature. 2014; 514: 181-186.
- 4. Palmnäs MS, Cowan TE, Bomhof MR, Su J, Reimer RA, Vogel
HJ, Hittel DS, Shearer J. Low-dose aspartame consumption
differentially affects gut microbiota-host metabolic interactions in
the diet-induced obese rat. PLoS One. 2014; 14: 9(10)
- 5. Frankenfeld CL, Sikaroodi M, Lamb E, Shoemaker S, Gillevet
PM. High-intensity sweetener consumption and gut microbiome
content and predicted gene function in a cross-sectional study of
adults in the United States. Ann Epidemiol. 2015; 25(10): 736-42
- 6. Daly K, Darby AC, Hall N, Nau A, Bravo D, Shirazi-Beechey SP.
Dietary supplementation with lactose or artifi cial sweetener
enhances swine gut Lactobacillus population abundance. Br J Nutr.
2014; 111 Suppl 1: 30-5
- 7. Abou-Donia MB, El-Masry EM, Abdel-Rahman AA, McLendon RE,
Schiffman SS. Splenda alters gut microfl ora and increases intestinal
p-glycoprotein and cytochrome p-450 in male rats, J Toxicol
Environ Health A. 2008; 71(21): 1415–1429.
- 8. Beards E, Tuohy K, Gibson G. A human volunteer study to assess
the impact of confectionery sweeteners on the gut microbiota
composition. Br J Nutr. 2010 Sep;104(5):701-8. doi: 10.1017/
S0007114510001078. Epub 2010 Apr 7.
- 9. Thabuis C, Herbomez AC, Desailly F, Florence R, Wils D, GuérinDeremaux
L. Prebiotic like effects of Sweet Pearle maltitol through
changes in caecal and fecal parameters. Food Nutr Sci. 2012; 3:
1375-1381.
- 10. Oku T, Akiba M, Lee MH, Moon SJ, Hosoya N. Metabolic fate of
ingested [14C]-maltitol in man. J Nutr Sci Vitaminol. 1991; 37:
529–544.
- 11. Lynch H, Milgrom P, “Xylitol and dental caries: an overview for
clinicians”, J Calif Dent Assoc, 2003, 31(3), 205-209.
- 12. Campus G, Cagetti MG, Sacco G, Solinas G, Mastroberardino
S, Lingström P, “Six months of daily high-dose xylitol in highrisk
schoolchildren: a randomized clinical trial on plaque pH and
salivary mutans streptococci”, Caries Res, 2009, 43(6), 455-461.
- 13. Salminen S, Salminen E, Koivistoinen P, Bridges J, Marks V. Gut
microfl ora interactions with xylitol in the mouse, rat and man. Food
Chem Toxicol. 1985; 23: 985–990.
- 14. Tamura M, Hoshi C, Hori S. Xylitol affects the intestinal microbiota
and metabolism of daidzein in adult male mice. Int J Mol Sci.
2013;14: 23993-24007.
- 15. Yebra MJ, Perez-Martinez G. Cross-talk between the L-sorbose and
D-sorbitol (D-glucitol) metabolic pathways in Lactobacillus casei.
Microbiology. 2002; 148:2351-2359.
- 16. Rhodes MW, Kator, H. Sorbitol-fermenting bifi dobacteria as
indicators of diffuse human faecal pollution in estuarine watersheds.
J Appl Microbiol. 1999; 87: 528-535.
- 17. Farnworth ER. In:Wildman REC (Ed.), Handbook of Nutraceutilcals
and Functional Foods. 2001; 407 - 422. Boca Raton, FL: CRC
Press.
- 18. Salminen S, Salminen E, Bridges J, Marks V. The effects of sorbitol
on the gastrointestinal microfl ora in rats. Z Ernahrungswiss. 1986;
25: 91-95.
- 19. Sarmiento-Rubiano LA, Zúñiga M, Pérez-Martínez G, Yebra
MJ. Dietary supplementation with sorbitol results in selective
enrichment of lactobacilli in rat intestine. Res Microbiol. 2007;
158(8-9): 694-701.
- 20. Goossens J, Röper H. Erythritol: a new sweetener. Food Sci Technol
Today. 1994; 8: 144–149.
- 21. Bernt WO, Borzelleca JF, Flamm G, Munro IC. Erythritol: A review
of biological and toxicological studies. Regul Toxicol Pharmacol.
1996; 24: 191–197.
- 22. Bornet FRJ, Blayo A, Dauchy F, Slama G. Plasma and urine kinetics
of erythritol after oral ingestion by healthy humans. Regul Toxicol
Pharmacol. 1996; 24: 280–285.
- 23. Ishikawa M, Miyashita M, Kawashima Y, Nakamura T, Saitou N,
Modderman J. Effects of oral administration of erythritol on patients
with diabetes. Regul Toxicol Pharmacol. 1996; 24: 303–308.
- 24. Noda K, Oku T. Metabolism and deposition of erythritol after oral
administration to rats. J Nutr. 1992; 122: 1266–1272.
- 25. Arrigoni E, Brouns F, Amadò R. Human gut microbiota does not
ferment erythritol. Br J Nutr. 2005; 94: 643–646.
Tatlandırıcılar, Glikoz İntoleransı ve Mikrobiyota
Yıl 2017,
- Mikrobiyota, 34 - 38, 15.11.2017
Fatih Gültekin
,
Manolya Eser Öner
Hasan Basri Savaş
Bora Doğan
Öz
Gıda katkı maddelerinin günümüz dünyasında kullanılması kaçınılmaz hale gelmiştir. Her ne kadar sadece güvenli miktarların gıdalarda kullanılmasına izin verilse de katkı maddelerinin güvenilirliği sürekli sorgulanmaktadır. Katkı maddelerinin mikrobiyotaya etkileri ise oldukça az çalışılmış bir konudur. Katkı maddelerinin bir kısmını oluşturan tatlandırıcıların etkisini incelediğimiz bu derlemede, tatlandırıcıların mikrobiyotayı etkiledikleri, bu etki sonucu sentetik olanların glikoz intoleransına yol açtıkları, şeker alkollerinin ise bir kısmının prebiyotik benzeri olumlu bir etki gösterdiği anlaşılmaktadır.
Kaynakça
- 1. Jin Y, Wu S, Zeng Z, Fu Z. Effects of environmental pollutants on gut
microbiota. Environ Pollut. 2017; 222: 1-9.
- 2. Gültekin F. A'dan Z'ye Gıda Katkı Maddeleri. Server İletişim, 2014,
İstanbul.
- 3. Suez J, Korem T, Zeevi D, Zilberman-Schapira G, Thaiss C.A,
Maza O, Israeli D, Zmora N, Gilad S, Weinberger A, Kuperman Y,
Harmelin A, Kolodkin-Gal I, Shapiro H, Halpern Z, Segal E, Elinav E.
Artifi cial sweeteners induce glucose intolerance by altering the gut
microbiota. Nature. 2014; 514: 181-186.
- 4. Palmnäs MS, Cowan TE, Bomhof MR, Su J, Reimer RA, Vogel
HJ, Hittel DS, Shearer J. Low-dose aspartame consumption
differentially affects gut microbiota-host metabolic interactions in
the diet-induced obese rat. PLoS One. 2014; 14: 9(10)
- 5. Frankenfeld CL, Sikaroodi M, Lamb E, Shoemaker S, Gillevet
PM. High-intensity sweetener consumption and gut microbiome
content and predicted gene function in a cross-sectional study of
adults in the United States. Ann Epidemiol. 2015; 25(10): 736-42
- 6. Daly K, Darby AC, Hall N, Nau A, Bravo D, Shirazi-Beechey SP.
Dietary supplementation with lactose or artifi cial sweetener
enhances swine gut Lactobacillus population abundance. Br J Nutr.
2014; 111 Suppl 1: 30-5
- 7. Abou-Donia MB, El-Masry EM, Abdel-Rahman AA, McLendon RE,
Schiffman SS. Splenda alters gut microfl ora and increases intestinal
p-glycoprotein and cytochrome p-450 in male rats, J Toxicol
Environ Health A. 2008; 71(21): 1415–1429.
- 8. Beards E, Tuohy K, Gibson G. A human volunteer study to assess
the impact of confectionery sweeteners on the gut microbiota
composition. Br J Nutr. 2010 Sep;104(5):701-8. doi: 10.1017/
S0007114510001078. Epub 2010 Apr 7.
- 9. Thabuis C, Herbomez AC, Desailly F, Florence R, Wils D, GuérinDeremaux
L. Prebiotic like effects of Sweet Pearle maltitol through
changes in caecal and fecal parameters. Food Nutr Sci. 2012; 3:
1375-1381.
- 10. Oku T, Akiba M, Lee MH, Moon SJ, Hosoya N. Metabolic fate of
ingested [14C]-maltitol in man. J Nutr Sci Vitaminol. 1991; 37:
529–544.
- 11. Lynch H, Milgrom P, “Xylitol and dental caries: an overview for
clinicians”, J Calif Dent Assoc, 2003, 31(3), 205-209.
- 12. Campus G, Cagetti MG, Sacco G, Solinas G, Mastroberardino
S, Lingström P, “Six months of daily high-dose xylitol in highrisk
schoolchildren: a randomized clinical trial on plaque pH and
salivary mutans streptococci”, Caries Res, 2009, 43(6), 455-461.
- 13. Salminen S, Salminen E, Koivistoinen P, Bridges J, Marks V. Gut
microfl ora interactions with xylitol in the mouse, rat and man. Food
Chem Toxicol. 1985; 23: 985–990.
- 14. Tamura M, Hoshi C, Hori S. Xylitol affects the intestinal microbiota
and metabolism of daidzein in adult male mice. Int J Mol Sci.
2013;14: 23993-24007.
- 15. Yebra MJ, Perez-Martinez G. Cross-talk between the L-sorbose and
D-sorbitol (D-glucitol) metabolic pathways in Lactobacillus casei.
Microbiology. 2002; 148:2351-2359.
- 16. Rhodes MW, Kator, H. Sorbitol-fermenting bifi dobacteria as
indicators of diffuse human faecal pollution in estuarine watersheds.
J Appl Microbiol. 1999; 87: 528-535.
- 17. Farnworth ER. In:Wildman REC (Ed.), Handbook of Nutraceutilcals
and Functional Foods. 2001; 407 - 422. Boca Raton, FL: CRC
Press.
- 18. Salminen S, Salminen E, Bridges J, Marks V. The effects of sorbitol
on the gastrointestinal microfl ora in rats. Z Ernahrungswiss. 1986;
25: 91-95.
- 19. Sarmiento-Rubiano LA, Zúñiga M, Pérez-Martínez G, Yebra
MJ. Dietary supplementation with sorbitol results in selective
enrichment of lactobacilli in rat intestine. Res Microbiol. 2007;
158(8-9): 694-701.
- 20. Goossens J, Röper H. Erythritol: a new sweetener. Food Sci Technol
Today. 1994; 8: 144–149.
- 21. Bernt WO, Borzelleca JF, Flamm G, Munro IC. Erythritol: A review
of biological and toxicological studies. Regul Toxicol Pharmacol.
1996; 24: 191–197.
- 22. Bornet FRJ, Blayo A, Dauchy F, Slama G. Plasma and urine kinetics
of erythritol after oral ingestion by healthy humans. Regul Toxicol
Pharmacol. 1996; 24: 280–285.
- 23. Ishikawa M, Miyashita M, Kawashima Y, Nakamura T, Saitou N,
Modderman J. Effects of oral administration of erythritol on patients
with diabetes. Regul Toxicol Pharmacol. 1996; 24: 303–308.
- 24. Noda K, Oku T. Metabolism and deposition of erythritol after oral
administration to rats. J Nutr. 1992; 122: 1266–1272.
- 25. Arrigoni E, Brouns F, Amadò R. Human gut microbiota does not
ferment erythritol. Br J Nutr. 2005; 94: 643–646.