The Relationship Between Platelet Activation and Recanalization Time in Cerebral Venous Thrombosis

Yıl 2019, , 100 - 105, 28.06.2019

Mustafa Ceylan , Fatma Şimşek

https://doi.org/10.34087/cbusbed.486839

Öz

Objective: Cerebral venous thrombosis is a rare cause of stroke. Treatment consists of anticoagulant agents. Aim of treatment is to remove the clot and maintain the recanalization. Duration of recanalization often lasts between 3 and 12 months. Thrombocytes have an important role in thrombosis. Mean thrombocyte volume (MTV) and thrombocyte distribution width (TDW) are the parameters associated with thrombocyte activation. In this study, we investigated the possible factors that affect the recanalization duration and assessed link between recanalization and the MTV and TDW.

Material and Method: Between January 2012 and June 2018 Our retrospective study includes 37 patients (6 male, 31 female) who had the diagnosis of cerebral venous thrombosis followed by recanalization. Control group consisted of age and gender matched healthy individuals.

Results: MTV and TDW were higher in thrombosis group. Mean recanalization duration was 7.7 months. Age, gender, etiology, presence of parenchymal injury, and number of affected sinus were not associated with recanalization duration. Superior sagittal sinus involvement was, statistically, found to be associated with recanalization duration.

Conclusions: Most of our findings differed from the literature. This suggests the methodological differences of our study. We also think that diverse results could be due to affected recanalization process by many factors at the same time and individual differences. We found that MTV and TDW cannot be used as biomarkers in the prediction of duration of recanalization.

Anahtar Kelimeler

Mean thrombocyte volume, Thrombocyte distribution width, Cerebral venous thrombosis, Recanalization duration

Serebral Venöz Trombozda Trombosit Aktivasyonu ile Rekanalizasyon Süresi İlişkisi

Öz

Amaç: Serebral venöz tromboz nadir görülen bir inme nedenidir. Tedavide antikoagülan ajanlar kullanılmaktadır. Tedavide amaç trombozu ortadan kaldırarak rekanalizasyonu sağlamaktır. Rekanalizasyon süresi sıklıkla 3-12 ay arasında değişmektedir. Trombositlerin tromboz oluşumunda önemli rolü vardır. Ortalama trombosit hacmi (OTH) ve trombosit dağılım genişliği (TDG) trombosit aktivasyonunu gösteren parametrelerdir. Biz çalışmamızda rekanalizasyon süresi üzerine etki eden faktörleri, OTH ve TDG ile rekanalizasyon süresi arasında bir ilişki olup olmadığını belirlemeyi amaçladık.

Gereç ve Yöntemler: Çalışmamız retrospektif olup serebral venöz tromboz tanısı ile takipli ve takipte rekanalizasyon izlenen 37 hastayı kapsamaktadır.

Bulgular: Çalışmaya Ocak 2012-Haziran 2018 tarihleri arasında serebral venöz tromboz tanısı ile takip edilip rekanalizasyon izlenen 6’sı erkek, 31’i kadın 37 hasta ve yaş, cinsiyet eşleşmeli sağlıklı bireyler alındı. OTH ve TDG değerleri SVT grubunda anlamlı olarak daha yüksekti, ortalama rekanalizasyon süresi 7.7 aydı. Yaş, cinsiyet, etyoloji, parankim hasarı, tutulan sinüs ve tutulan sinüs sayısı rekanalizasyon süresi üzerine etkili değildi. Süperior sagital sinüs tutulumu ile rekanalizasyon süresi arasında anlamlı istatistiksel ilişki tespit edildi.

Sonuç: Tespitlerimizin çoğu literatür ile farklıydı,  bu durum metodolojik farklılıktan kaynaklanabileceği gibi rekanalizasyonun birçok faktör tarafından aynı anda etkilenebileceğini ve olguya göre değişebileceğini akla getirmektedir. Ayrıca OTH ve TDG’ nin rekanalizasyon süresinin tahmininde biyobelirteç olarak kullanımı uygun değildir.

Anahtar Kelimeler

Ortalama trombosit hacmi, Trombosit dağılım genişliği, Serebral venöz tromboz, Reanalizasyon zamanı

Kaynakça

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