Araştırma Makalesi
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Evaluation of the Effects of Coronary Artery Surgery on Pulmonary Functions by Pulmonary Function Test

Yıl 2021, , 331 - 336, 30.06.2021
https://doi.org/10.34087/cbusbed.856434

Öz

Objective: Chronic obstructive pulmonary disease (COPD) is a frequent comorbid disease in patients undergoing coronary artery bypass grafting (CABG) surgery, with an incidence ranging from 4% to 20.5%. Conventionally, COPD was recognized as a surgical contraindication to CABG. Because of the recent improvements in surgical techniques, anesthesia, and postoperative management, CABG has been performed more commonly in patients with COPD. However, studies have shown the various effects of COPD on postoperative morbidity and mortality after CABG. In our study, we aimed to investigate the effect of CABG surgery on respiratory functions with the respiratory function test performed in the preoperative and postoperative periods.
Material and Methods: Fifty patients who underwent isolated CABG surgery in our clinic were included in the study. 24 Patients with preoperative FEV1 value <%70 were taken into COPD group (Group 1) and the remaining 26 patients were taken into control group (Group 2) according to the respiratory function tests.
Results: In COPD group mechanical ventilation time (Group 1: 16.5 ± 2.6 hours, Grup 2: 14.9 ± 2.7 hours; p=0.0001) and hospital stay (Group 1: 13.8 ± 5.4 days, Group 2: 10.1 ± 2.5 days; p=0.004) were significantly increased compared to the control group. Pulmonary function parameters were not significantly changed in COPD group but on the other hand significant decrease in postoperative values was seen in the control group.
Conclusion: The diagnosis, evaluation and start of appropriate treatment of COPD in preoperative period are significantly important factors in order to reduce of respiratory complications during postoperative period in CABG patients. For this reason preoperative respiratory function tests should be applied routinely in CABG patients.

Kaynakça

  • Rabe, K.F, Watz H, Chronic obstructive pulmonary disease, Lancet, 2017, 389, 1931–1940.
  • Zhao, H, Li, L, Yang, G, et al., Postoperative outcomes of patients with chronic obstructive pulmonary disease undergoing coronary artery bypass grafting surgery A meta-analysis, Medicine, 2019, 98, 6.
  • O’Boyle, F, Mediratta, N, Chalmers, J, et al., Long-term survival of patients with pulmonary disease undergoing coronary artery bypass surgery, European Journal of Cardiothoracic Surgery, 2013, 43, 697–703.
  • Ho, C.H, Chen, Y.C, Chu, C.C, et al, Postoperative complications after coronary artery bypass grafting in patients with chronic obstructive pulmonary disease, Medicine, 2016, 95(8), e2926.
  • Samuels, L.E, Kaufman, M.S, Morris, R.J, et al., Coronary artery bypass grafting in patients with COPD, Chest, 1998, 113, 878–882.
  • U.S. Department of Health and Human Services. The Health Consequences of Smoking. A Report of the Surgeon General, 2004.
  • Türkoğlu, T. Kardiyopulmoner Bypassa Girilmeden (Off-Pump) Atan Kalpte Ve Kardiyopulmoner Bypass Kullanılarak Kardiyak Arrest İle Uygulanan Koroner Bypass Cerrahisi Sonrası Atrial Fibrilasyon Gelişiminin Karşılaştırılması [Tez]. İstanbul: Dr. Siyami Ersek Göğüs Kalp Ve Damar Cerrahisi Eğitim Ve Araştırma Hastanesi, 2004.
  • American Thoracic Society/European Respiratory Society statement: standards for the diagnosis and management of individuals with alpha-1 antitrypsin deficiency, American Journal of Respiratory and Critical Care Medicine, 2003, 168, 818-900.
  • Hnizdo, E, Sullivan, P.A, Bang, K.M, et al., Association between chronic obstructive pulmonary disease and employment by industry and occupation in the US population: a study of data from the Third National Health and Nutrition Examination Survey, American Journal of Epidemiology, 2002, 156 (8), 738-746.
  • Grover, F.L, Hammermeister, K.E, Burchfiel, C, Initial report of the veterans administration preoperative risk assesment study for cardiac surgery, The Annals of Thoracic Surgery, 1990, 50, 12-26.
  • King, R.C, Reece, T.B, Hurst, J.L, et al, Minimally invasive coronary artery grafting decreases hospital stay and cost, Annals of Surgery, 1997, 225, 805-809.
  • Matarese, A, Santulli, G, Angiogenesis in chronic obstructive pulmonary disease: a translational appraisal, Translational Medicine@UniSa, 2012, 3, 49–56.
  • Lymperopoulos, A, Rengo, G, Zincarelli, C, et al., An adrenal beta-arrestin 1-mediated signaling pathway underlies angiotensin II-induced aldosterone production in vitro and in vivo, Proceeding of the National Academy of Sciences USA, 2009, 106, 5825–5830.
  • Dabul, S, Bathgate-Siryk, A, Valero, T.R, et al., Suppression of adrenal barrestin1 - dependent aldosterone production by ARBs: head-to-head comparison, Scientific Reports, 2015, 5, 8116.
  • Kropski, J.A, Richmond, B.W, Gaskill, C.F, et al., Deregulated angiogenesis in chronic lung diseases: a possible role for lung mesenchymal progenitor cells (2017 Grover Conference Series), Pulmonary Circulation, 2018, 8, 2045893217739807.
  • Mascitelli, L, Pezzetta,, F, Goldstein M.R, Inhibition of the reninangiotensin system in severe COPD, European Respiratory Journal, 2008, 32, 1130, author reply 1131.
  • Efird, J.T, Griffin, W, O’Neal, W.T, et al., Long-term survival after cardiac surgery in patients with chronic obstructive pulmonary disease, American Journal of Critical Care, 2016, 25, 266–276.
  • Meszaros, K, Fuehrer, U, Grogg, S, et al, Risk factors for sternal wound infection after open heart operations vary according to type of operation, The Annals of Thoracic Surgery, 2016, 101, 1418–1425.
  • Morse, D.P, Indications for open-heart surgery: risks, and results, Springfield, III: Charles C Thomas, 1963.
  • Magovern, J.A, Sakert, T, Magovern, G.J, et al, A model that predicts morbidity and mortality after coronary artery bypass graft surgery, Journals of the American College of Cardiology, 1996, 28, 1147–1153.
  • Higgins, T.L, Estafanous, F.G, Loop, F.D, et al., Stratification of morbidity and mortality outcome by preoperative risk factors in coronary artery bypass patients. A clinical severity score, JAMA, 1992, 267, 2344–2348.
  • Gibbon, J.H, Application of a mechanical heart-lung apparatus to cardiac surgery, Minnesota Medicine, 1954, 37, 171.
  • Angouras, D.C, Anagnostopoulos, C.E, Chamogeorgakis, T.P, et al., Postoperative and long-term outcome of patients with chronic obstructive pulmonary disease undergoing coronary artery bypass grafting, The Annals of Thoracic Surgery, 2010, 89, 1112–1118.
  • Michalopoulos, A, Geroulanos, S, Papadimitriou, L, et al., Mild or moderate chronic obstructive pulmonary disease risk in elective coronary artery bypass grafting surgery, World Journal of Surgery, 2001, 25, 1507–1511.
  • Zheng, Z, Zhang, L, Hu, S, et al., Risk factors and in-hospital mortality in Chinese patients undergoing coronary artery bypass grafting: analysis of a large multi-institutional Chinese database, The Journal of Thoracic and Cardiovascular Surgery, 2012, 144, 355–359.
  • Kurulay, E, Cingoz, F, Kilic, S, et al., Supraventricular tachyarrythmia prophylaxis alter coronary artery surgery in chronic obstructive pulmonary disease patients (early amiodarone prophylaxis trial), European Journal of Cardiothoracic Surgery, 2004, 25, 224-230.
  • Warner, M.A, Divertie, M.B, Tinker, J.H, Preoperative cessation smoking and pulmonary complications in coronary artery bypass patients, Anesthesiology, 1984, 60, 380-383.
  • Güler, M, Kirali, K, Toker, M.E, et al. Different CABG methods in patients with chronic obstructive pulmonary disease, Annals of Thoracic Surgery, 2001, 71(1), 152-7.
  • Gass, G.D, Olsen, G.N, Preoperative pulmonary functional testing to predict postoperative morbidity and mortality, Chest, 1986, 89, 127-135.
  • Ried, M, Unger, P, Puehle, T, et al., Mild-to-moderate COPD as a risk factor for increased 30-day mortality in cardiac surgery, The Thoracic and Cardiovascular Surgeon, 2010, 58, 387–391.
  • Ozyaprak, B, Kahraman, N, The assessment of the effect of low tidal volume ventilation on postoperative respiratory functions during cardiopulmonary bypass in heart surgery, International Journal of Clinical and Experimental Medicine, 2019, 12(6), 7426-7433.
  • Türkay, C, Akbulut, E, Özbudak, Ö, Gölbaşı, İ, ve ark., Koroner bypass cerrahisi uygulanan hastalarda kronik obstrüktif akciğer hastalığının mortalite ve morbiditeye etkisi, Türk Göğüs Kalp Damar Cerrahisi Dergisi, 2000, 8(3), 678-681.
  • Rosen, A.B, Humphries, J.O, Muhlbaier, L.H, Kiefe, C.I, Kresowik, T, Peterson, E.D, Effect of clinical factors on length of stay after coronary artery bypass surgery: results of the cooperative cardiovascular Project, American Heart Journal, 1999, 138, 69-77.
  • Braun, S.R, Birnbaum, M.L, Chopra, P.S, Pre and postoperative pulmonary function abnormalities in coronary artery revascularization surgery, Chest, 1978, 73, 316-320.
  • Kandemir, Ö, Büyükateş, M, Turan, S.A, ve ark, Kronik obstrüktif akciğer hastalığının yaygın olduğu bir bölgede koroner bypass cerrahisi sonuçları, Türk Göğüs Kalp Damar Cerrahisi Dergisi, 2007, 15(2), 113-117.

Koroner Arter Cerrahisinin Solunum Fonksiyonlarına Etkilerinin Solunum Fonksiyon Testi İle Değerlendirilmesi

Yıl 2021, , 331 - 336, 30.06.2021
https://doi.org/10.34087/cbusbed.856434

Öz

Giriş ve Amaç: Kronik Obstrüktif Akciğer Hastalığı (KOAH), koroner arter bypass greft operasyonu (CABG) yapılan hastalarda sık bir komorbid hastalıktır ve insidansı %4 ile %20,5 aralığındadır. KOAH geleneksel olarak CABG için cerrahi kontraendikasyon olarak bilinir. Cerrahi teknik, anestezi ve postoperatif hasta yönetimindeki son gelişmelerden dolayı CABG artık KOAH’lı hastalarda çok yaygın bir şekilde yapılmaktadır. Ancak son çalışmalar, CABG sonrası postoperatif mortalite ve morbidite üzerine KOAH’ın çeşitli etkilerini göstermiştir. Çalışmamızda CABG ameliyatının solunum fonksiyonlarına etkisini preoperatif ve postoperatif dönemde yapılan solunum fonksiyon testi ile araştırmayı amaçladık.
Gereç ve Yöntemler: Kliniğimizde izole CABG cerrahisi uygulanan 50 hasta çalışmaya dahil edildi. Preoperatif solunum fonksiyon testinde FEV1 değeri <%70 olan toplam 24 hasta KOAH grubunu (Grup 1), geri kalan 26 hasta ise kontrol grubunu (Grup 2) oluşturdu.
Bulgular: KOAH grubunda mekanik ventilasyonda kalış süresi (Grup 1’de 16.5 ± 2.6 saat, Grup 2’de 14.9 ± 2.7 saat; p=0.0001) ve hastanede yatış süreleri (Grup 1’de 13.8 ± 5.4 gün, Grup 2’de 10.1 ± 2.5 gün; p=0.004) bakımından kontrol grubuna göre anlamlı olarak uzamış idi. Solunum fonksiyon test parametrelerine bakıldığında KOAH grubunda zaten düşük olan değerlerde anlamlı bir düşme gözlenmezken, Kontrol grubunda postoperatif değerlerde preoperatif değerlere göre anlamlı bir düşme gözlenmiştir.
Sonuç: CABG ameliyatı geçirecek hastalara preoperatif dönemde KOAH tanısının konması ve şiddetinin belirlenmesi; preoperatif dönemde gerekli tedavinin başlanması, intraoperatif ve postoperatif dönemde gelişebilecek komplikasyonları azaltmak ve/veya önlemek, takip edilecek stratejiler ve alınacak önlemler açısından önemlidir. Bu nedenle CABG ameliyatı olacak her hastaya preoperatif dönemde solunum fonksiyon testi rutin olarak uygulanmalıdır

Kaynakça

  • Rabe, K.F, Watz H, Chronic obstructive pulmonary disease, Lancet, 2017, 389, 1931–1940.
  • Zhao, H, Li, L, Yang, G, et al., Postoperative outcomes of patients with chronic obstructive pulmonary disease undergoing coronary artery bypass grafting surgery A meta-analysis, Medicine, 2019, 98, 6.
  • O’Boyle, F, Mediratta, N, Chalmers, J, et al., Long-term survival of patients with pulmonary disease undergoing coronary artery bypass surgery, European Journal of Cardiothoracic Surgery, 2013, 43, 697–703.
  • Ho, C.H, Chen, Y.C, Chu, C.C, et al, Postoperative complications after coronary artery bypass grafting in patients with chronic obstructive pulmonary disease, Medicine, 2016, 95(8), e2926.
  • Samuels, L.E, Kaufman, M.S, Morris, R.J, et al., Coronary artery bypass grafting in patients with COPD, Chest, 1998, 113, 878–882.
  • U.S. Department of Health and Human Services. The Health Consequences of Smoking. A Report of the Surgeon General, 2004.
  • Türkoğlu, T. Kardiyopulmoner Bypassa Girilmeden (Off-Pump) Atan Kalpte Ve Kardiyopulmoner Bypass Kullanılarak Kardiyak Arrest İle Uygulanan Koroner Bypass Cerrahisi Sonrası Atrial Fibrilasyon Gelişiminin Karşılaştırılması [Tez]. İstanbul: Dr. Siyami Ersek Göğüs Kalp Ve Damar Cerrahisi Eğitim Ve Araştırma Hastanesi, 2004.
  • American Thoracic Society/European Respiratory Society statement: standards for the diagnosis and management of individuals with alpha-1 antitrypsin deficiency, American Journal of Respiratory and Critical Care Medicine, 2003, 168, 818-900.
  • Hnizdo, E, Sullivan, P.A, Bang, K.M, et al., Association between chronic obstructive pulmonary disease and employment by industry and occupation in the US population: a study of data from the Third National Health and Nutrition Examination Survey, American Journal of Epidemiology, 2002, 156 (8), 738-746.
  • Grover, F.L, Hammermeister, K.E, Burchfiel, C, Initial report of the veterans administration preoperative risk assesment study for cardiac surgery, The Annals of Thoracic Surgery, 1990, 50, 12-26.
  • King, R.C, Reece, T.B, Hurst, J.L, et al, Minimally invasive coronary artery grafting decreases hospital stay and cost, Annals of Surgery, 1997, 225, 805-809.
  • Matarese, A, Santulli, G, Angiogenesis in chronic obstructive pulmonary disease: a translational appraisal, Translational Medicine@UniSa, 2012, 3, 49–56.
  • Lymperopoulos, A, Rengo, G, Zincarelli, C, et al., An adrenal beta-arrestin 1-mediated signaling pathway underlies angiotensin II-induced aldosterone production in vitro and in vivo, Proceeding of the National Academy of Sciences USA, 2009, 106, 5825–5830.
  • Dabul, S, Bathgate-Siryk, A, Valero, T.R, et al., Suppression of adrenal barrestin1 - dependent aldosterone production by ARBs: head-to-head comparison, Scientific Reports, 2015, 5, 8116.
  • Kropski, J.A, Richmond, B.W, Gaskill, C.F, et al., Deregulated angiogenesis in chronic lung diseases: a possible role for lung mesenchymal progenitor cells (2017 Grover Conference Series), Pulmonary Circulation, 2018, 8, 2045893217739807.
  • Mascitelli, L, Pezzetta,, F, Goldstein M.R, Inhibition of the reninangiotensin system in severe COPD, European Respiratory Journal, 2008, 32, 1130, author reply 1131.
  • Efird, J.T, Griffin, W, O’Neal, W.T, et al., Long-term survival after cardiac surgery in patients with chronic obstructive pulmonary disease, American Journal of Critical Care, 2016, 25, 266–276.
  • Meszaros, K, Fuehrer, U, Grogg, S, et al, Risk factors for sternal wound infection after open heart operations vary according to type of operation, The Annals of Thoracic Surgery, 2016, 101, 1418–1425.
  • Morse, D.P, Indications for open-heart surgery: risks, and results, Springfield, III: Charles C Thomas, 1963.
  • Magovern, J.A, Sakert, T, Magovern, G.J, et al, A model that predicts morbidity and mortality after coronary artery bypass graft surgery, Journals of the American College of Cardiology, 1996, 28, 1147–1153.
  • Higgins, T.L, Estafanous, F.G, Loop, F.D, et al., Stratification of morbidity and mortality outcome by preoperative risk factors in coronary artery bypass patients. A clinical severity score, JAMA, 1992, 267, 2344–2348.
  • Gibbon, J.H, Application of a mechanical heart-lung apparatus to cardiac surgery, Minnesota Medicine, 1954, 37, 171.
  • Angouras, D.C, Anagnostopoulos, C.E, Chamogeorgakis, T.P, et al., Postoperative and long-term outcome of patients with chronic obstructive pulmonary disease undergoing coronary artery bypass grafting, The Annals of Thoracic Surgery, 2010, 89, 1112–1118.
  • Michalopoulos, A, Geroulanos, S, Papadimitriou, L, et al., Mild or moderate chronic obstructive pulmonary disease risk in elective coronary artery bypass grafting surgery, World Journal of Surgery, 2001, 25, 1507–1511.
  • Zheng, Z, Zhang, L, Hu, S, et al., Risk factors and in-hospital mortality in Chinese patients undergoing coronary artery bypass grafting: analysis of a large multi-institutional Chinese database, The Journal of Thoracic and Cardiovascular Surgery, 2012, 144, 355–359.
  • Kurulay, E, Cingoz, F, Kilic, S, et al., Supraventricular tachyarrythmia prophylaxis alter coronary artery surgery in chronic obstructive pulmonary disease patients (early amiodarone prophylaxis trial), European Journal of Cardiothoracic Surgery, 2004, 25, 224-230.
  • Warner, M.A, Divertie, M.B, Tinker, J.H, Preoperative cessation smoking and pulmonary complications in coronary artery bypass patients, Anesthesiology, 1984, 60, 380-383.
  • Güler, M, Kirali, K, Toker, M.E, et al. Different CABG methods in patients with chronic obstructive pulmonary disease, Annals of Thoracic Surgery, 2001, 71(1), 152-7.
  • Gass, G.D, Olsen, G.N, Preoperative pulmonary functional testing to predict postoperative morbidity and mortality, Chest, 1986, 89, 127-135.
  • Ried, M, Unger, P, Puehle, T, et al., Mild-to-moderate COPD as a risk factor for increased 30-day mortality in cardiac surgery, The Thoracic and Cardiovascular Surgeon, 2010, 58, 387–391.
  • Ozyaprak, B, Kahraman, N, The assessment of the effect of low tidal volume ventilation on postoperative respiratory functions during cardiopulmonary bypass in heart surgery, International Journal of Clinical and Experimental Medicine, 2019, 12(6), 7426-7433.
  • Türkay, C, Akbulut, E, Özbudak, Ö, Gölbaşı, İ, ve ark., Koroner bypass cerrahisi uygulanan hastalarda kronik obstrüktif akciğer hastalığının mortalite ve morbiditeye etkisi, Türk Göğüs Kalp Damar Cerrahisi Dergisi, 2000, 8(3), 678-681.
  • Rosen, A.B, Humphries, J.O, Muhlbaier, L.H, Kiefe, C.I, Kresowik, T, Peterson, E.D, Effect of clinical factors on length of stay after coronary artery bypass surgery: results of the cooperative cardiovascular Project, American Heart Journal, 1999, 138, 69-77.
  • Braun, S.R, Birnbaum, M.L, Chopra, P.S, Pre and postoperative pulmonary function abnormalities in coronary artery revascularization surgery, Chest, 1978, 73, 316-320.
  • Kandemir, Ö, Büyükateş, M, Turan, S.A, ve ark, Kronik obstrüktif akciğer hastalığının yaygın olduğu bir bölgede koroner bypass cerrahisi sonuçları, Türk Göğüs Kalp Damar Cerrahisi Dergisi, 2007, 15(2), 113-117.
Toplam 35 adet kaynakça vardır.

Ayrıntılar

Birincil Dil Türkçe
Konular Kalp ve Damar Cerrahisi
Bölüm Araştırma Makalesi
Yazarlar

Tolga Onur Badak 0000-0002-7195-1968

Ahmet İhsan İşkesen Bu kişi benim

Yayımlanma Tarihi 30 Haziran 2021
Yayımlandığı Sayı Yıl 2021

Kaynak Göster

APA Badak, T. O., & İşkesen, A. İ. (2021). Koroner Arter Cerrahisinin Solunum Fonksiyonlarına Etkilerinin Solunum Fonksiyon Testi İle Değerlendirilmesi. Celal Bayar Üniversitesi Sağlık Bilimleri Enstitüsü Dergisi, 8(2), 331-336. https://doi.org/10.34087/cbusbed.856434
AMA Badak TO, İşkesen Aİ. Koroner Arter Cerrahisinin Solunum Fonksiyonlarına Etkilerinin Solunum Fonksiyon Testi İle Değerlendirilmesi. CBU-SBED. Haziran 2021;8(2):331-336. doi:10.34087/cbusbed.856434
Chicago Badak, Tolga Onur, ve Ahmet İhsan İşkesen. “Koroner Arter Cerrahisinin Solunum Fonksiyonlarına Etkilerinin Solunum Fonksiyon Testi İle Değerlendirilmesi”. Celal Bayar Üniversitesi Sağlık Bilimleri Enstitüsü Dergisi 8, sy. 2 (Haziran 2021): 331-36. https://doi.org/10.34087/cbusbed.856434.
EndNote Badak TO, İşkesen Aİ (01 Haziran 2021) Koroner Arter Cerrahisinin Solunum Fonksiyonlarına Etkilerinin Solunum Fonksiyon Testi İle Değerlendirilmesi. Celal Bayar Üniversitesi Sağlık Bilimleri Enstitüsü Dergisi 8 2 331–336.
IEEE T. O. Badak ve A. İ. İşkesen, “Koroner Arter Cerrahisinin Solunum Fonksiyonlarına Etkilerinin Solunum Fonksiyon Testi İle Değerlendirilmesi”, CBU-SBED, c. 8, sy. 2, ss. 331–336, 2021, doi: 10.34087/cbusbed.856434.
ISNAD Badak, Tolga Onur - İşkesen, Ahmet İhsan. “Koroner Arter Cerrahisinin Solunum Fonksiyonlarına Etkilerinin Solunum Fonksiyon Testi İle Değerlendirilmesi”. Celal Bayar Üniversitesi Sağlık Bilimleri Enstitüsü Dergisi 8/2 (Haziran 2021), 331-336. https://doi.org/10.34087/cbusbed.856434.
JAMA Badak TO, İşkesen Aİ. Koroner Arter Cerrahisinin Solunum Fonksiyonlarına Etkilerinin Solunum Fonksiyon Testi İle Değerlendirilmesi. CBU-SBED. 2021;8:331–336.
MLA Badak, Tolga Onur ve Ahmet İhsan İşkesen. “Koroner Arter Cerrahisinin Solunum Fonksiyonlarına Etkilerinin Solunum Fonksiyon Testi İle Değerlendirilmesi”. Celal Bayar Üniversitesi Sağlık Bilimleri Enstitüsü Dergisi, c. 8, sy. 2, 2021, ss. 331-6, doi:10.34087/cbusbed.856434.
Vancouver Badak TO, İşkesen Aİ. Koroner Arter Cerrahisinin Solunum Fonksiyonlarına Etkilerinin Solunum Fonksiyon Testi İle Değerlendirilmesi. CBU-SBED. 2021;8(2):331-6.