Interactions between Cytokines and Drugs in COVID-19 Potential Interactions between Increased Cytokines in COVID-19 and Drugs used to Treat COVID-19

Tülün Öztürk; Tuğba Çavuşoğlu; Canet İncir; Yeşim Tunçok

doi:10.34087/cbusbed.873082

Derleme

Interactions between Cytokines and Drugs in COVID-19 Potential Interactions between Increased Cytokines in COVID-19 and Drugs used to Treat COVID-19

Yıl 2021, , 174 - 185, 31.12.2020

Tülün Öztürk , Tuğba Çavuşoğlu , Canet İncir Yeşim Tunçok

https://doi.org/10.34087/cbusbed.873082

Cited By: 2

Öz

Abstract
During COVID-19 infection, virus and host cell interactions lead to the acute production of very strong immune mediators. The clinical status caused by damage throughout the body is mostly due to excessive pro-inflammatory cytokine production from virus-induced macrophages and granulocytes. Under infectious and inflammatory conditions, clinical and experimental studies have demonstrated that hepatic and extrahepatic cytochrome P450 (CYP) enzymes and carrier proteins responsible for drug metabolism are specifically regulated by many cytokines. Downregulation of these enzymes by cytokines can cause an elevation in plasma drug levels and/or lead to adverse drug reactions and/or toxicity. Based on the knowledge of cytokine-drug interactions occurring in the infection and inflammation stage, the aim of this review was to ascertain the influence of uncontrolled cytokine release on the metabolism of drugs used alone or in combination to treat COVID-19 patients and predict drug-drug interactions causing adverse effects.

Anahtar Kelimeler

cytokine,, drug interactions, COVİD-19, cytochrome P450

Kaynakça

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COVİD-19 da Sitokinler ve COVİD- 19 Tedavisinde Kullanılan İlaçlar Arasında Potansiyel İlaç Etkileşimleri.

Yıl 2021, , 174 - 185, 31.12.2020

Tülün Öztürk , Tuğba Çavuşoğlu , Canet İncir Yeşim Tunçok

https://doi.org/10.34087/cbusbed.873082

Cited By: 2

Öz

COVID-19 infeksiyonu sırasında virus ve konakçı hücrel etkileşimleri, çok güçlü immun mediyatörlerin akut üretilmesine yol açar. Klinik durumdaki bozulma, virüsün indüklediği makrofaj ve granülositlerin ürettiği aşırı proinflammatuar sitokinlere bağlanmaktadır. İndüksiyon ve inflammasyon koşulları altında, klinik ve deneysel çalışmalar, ilaç metabolizmsından sorımlu hepatik ve ekstrahepatik sitokrom P450 enzimleri ve taşıyıcı proteinlerin spesifik olarak pek çok sitokinler tarafından düzenlendiğini göstermektedir. Bu enzimlerin sitokinler tarafından down regülasyonu plazma ilaç düzeylerinde yükselmeye neden olabilir ve/veya istenmeyan ilaç reaksiyonlarına ve/veya toksisiteye yol açabilir. İnflamasyon ve infeksiyon durumunda oluşan sitokin-ilaç etkileşimleri temelinde, bu derlemenin amacı , COVİD 19 hastalarını tedavi etmek için tek başına veya kombinasyonda kullanılan ilaçların metabolizması üzerine, hastalığın seyrinde ortaya çıkan kontrolsüz sitokin salınımının etkisini anlamaktır.

Anahtar Kelimeler

Sitpkin, İlaç etkileşimleri, sİtokrom P450

Kaynakça

1. World Health Organization (2020). Naming the coronavirus disease (COVID-19) and the virus that causes it. https://www.who.int/emergencies/diseases/novel-coronavirus-2019/technical-guidance/naming-the-coronavirus-disease-(covid-2019)-and-the-virus-that-causes-it (accessed 21 January 2021).
2. Prajapat, M, Sarma, P, Shekhar, N, et al. Drug targets for corona virus: A systematic review, Indian Journal of Pharmacology 2020; 52: 56–65.
3. Kazak, A, Hintistan, S, Önal, B. COVID-19 Vaccine Development Studies in the World and Turkey, Celal Bayar University-Health Sciences Institute Journal, 2020, 7, 571-575.
4. Wang, F, Nie, J, Wang, H, et al. Characteristics of peripheral lymphocyte subset alteration in COVID-19 pneumonia, The Journal of Infectious Diseases, 2020, 221; 1762-1769. https:// doi.org/ 10.1093/infdis/jiaa150.
5. Mehta, P, McAuley, D, F, Brown, M, Sanchez, E, Tattersall, R, S, Manson, J, J, H, L, H, Acros Speciality Collaboration, COVID-19: consider cytokine storm syndromes and İmmunosuppression, The Lancet 2020; 395: 1034-1035.
6. Li, G, Fan, Y, Lai, Y, et al. Coronavirus infections and immune responses, Journal of Medical Viroogy, 2020, 92, 424-432.
7. Mc Gonagle, D, Sharif, K, O’Regan, A, Brigewood, C, Interleukin-6 use in COVID-19 pneumonia related macrophage activation syndrome, Autoimmunity Reviews. 2020: 19; 102537.
8. Sen, E, S, Ramanan, A, V, Cytokine Storm Syndrome Associated with Hemorrhagic Fever and Other Viruses, in: R, O, Cron, E, M, Behrens, (Eds), Cytokine Storm Syndrome. Springer Nature Switzerland AG, 2019, pp 277-298.
9. Huang, C, Wang, Y, Li, X, et al. Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China. Lancet London England 2020, 395, 497-506.
10. Li, H, Xiang, X, Ren, H, et al. Serum Amyloid A is a biomarker to distinguish the severity and prognosis of Coronavirus Disease 2019 (COVID-19), The Journal of Infection, 2020, 80, 646-655.
11. Stavropoulou, E, Pircalabioru, G, G, Bezirtzoglou, E. The Role of Cytochromes P450 in infection. Frontiers in Immunology 2018, 31, 89.
12. Goralski, K, B, Ladda, A, M, O McNeil, J, Drug-Cytokine Interactions, in: Georgiev V, Pai MP, Kiser JJ, Gubbins PO and Rodvold KA (Eds), Drug Interactions in Infectious Diseases: Mechanisms and Models of Drug Interactions, Switzerland, Springer International Publishing, 2018, pp 163-204.
13. Morgan, E, T, Impact of infectious and inflammatory disease on cytochrome P450-mediated drug metabolism and pharmacokinetics. Clinical Pharmacology and Therapeutics, 2009, 85, 434 - 438.
14. Aitken, A, E, Morgan, E, T. Gene-Specific Effects of Inflammatory Cytokines on Cytochrome P4502C, 2B6 and 3A4 mRNA Levels in Human Hepatocytes, Drug Metabolism & Disposition, 2007, 35, 1687-1693.
15. Aitken, A, Richardson, T, A, Morgan, E, T, Regulatıon of drug-metabolızıng enzymes and transporters in inflammation, Annual Review of Pharmacology and Toxicology, 2006, 46, 123–149.
16. Bleau, A, M, Maurel, P, Pichette, V, Interleukin-1beta, interleukin-6, tumour necrosis factor-alpha and interferon-gamma released by a viral infection and an aseptic inflammation reduce YP1A1, 1A2 and 3A6 expression in rabbit hepatocytes. European Journal of Pharmacology, 2003, 473,197-206.
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41. Feldmann, M, Maini, R, N, Woody, J, N, et al. Trials of anti-tumour necrosis factor therapy for COVID-19 are urgently needed. The Lancet 2020, 395, 1407-1409.
42. Jamilloux, Y, Henry, T, Belot, A, et al. Should we stimulate or suppress immune responses in COVID-19? Cytokine and anti-cytokine interventions. Autoimmunity, Reviews 2020; 19: 102567.
43. Chorin, E, Dai, M, Shulman, E, et al. The QT interval in patients with COVID-19 treated with hydroxychloroquine and azithromycin. medRxiv 2020.04.02.20047050.
44. Borba, M, G, S, Val, F, F, A, Sampaio, V, S, et al. Effect of high vs low doses of chloroquine diphosphate as adjunctive therapy for patients hospitalized with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection: a randomized clinical trial, JAMA 2020; 3: e208857.
45. Magagnoli J, Narendran S, Pereira F, et al. Outcomes of hydroxychloroquine usage in United States veterans hospitalized with Covid-19. medRxiv. 2020.
46. Kany, S, Vollrath, J, T, Relja, B. Cytokines in Inflammatory Disease, The International Journal of Molecular Sciences, 2019, 20, 6008.
47. Cressman, AM, Petrovic, V, Piquette-Miller, M. Inflammation-mediated changes in drug transporter expression/activity: implications for therapeutic drug response, Expert Review of Clinical Pharmacology, 2012, 5, 69- 89.
48. Petrovic, V, Teng, S, Piquette-Miller, M. Regulation of drug transporters during infection and inflammation, Molecular Intervention 2007, 7, 99- 111.
49. Heemskerk, S, Peters, J,G,P, Louisse, J, Sagar, S, Russel, F,G,M, Masereeuw, R. Regulation of P-glycoprotein in renal proximal tubule epithelial cells by LPS and TNF-alpha, Journal of Biomedical and Biotechnology 2010; 525180.
50. Bezirtzoglou, E, Intestinal cytochromes P450 regulating the intestinal micro-biota and its probiotic profile, Microbial Ecology in Health Disease, 2012, 23, 1–10.
51. Clark, E, S, Jones, B, C. Human cytochromes P450 and their role in metabolism based drug-drug interaction, in: Rodrigues A, D (Ed), Drug–Drug Interactions: Drugs and the Pharmaceutical Sciences, Marcel Dekker, New York, USA, 2002, pp. 55–88. 5 2. Chang, KC, Bell, TD, Lauer, BA, Chai, H. Altered Theophylline Pharmacokinetics During Acute Respiratory Viral Illness, The Lancet 1978, 27, 1132-1133.
53. Renton, KW, Knickle, LC. Regulation of cytochrome P450 during infectious disease. Can Journal of Physiology and Pharmacology, 1990, 68, 777-781.
54. Overton, C, L, Hudder, A, Novak, R, F. The CYP2E Subfamily, in: Ioannides C (Ed), Cytochromes P450. Role in the Metabolism and Toxicity of Drugs and other Xenobiotics. RSC Publishing, Cambridge, UK, 2008, pp. 282.
55. Zhou, J, Li, F. Potential pharmacokinetic interactions of therapeutic cytokines or cytokine modulators on small-molecule drugs: mechanistic understanding via studies using in vitro systems. Drug Metabolism and Drug Interactions, 2014, 29, 17–28.
56. Tufan, A, Avanoğlu, Güler, A, Matuccı-Cerınıc, M. COVID-19, immune system response, hyper inflammation and repurposing antirheumatic drugs. Turkish Journal of Medical Science, 2020, 50, 620-632.
57. Sanaee, F, Clements, J, D, Waugh, A, W, G,. Fedorak, R, N, Lewanczuk, R, Jamali, F. Drug-disease interaction: Crohn’s disease elevates verapamil plasma concentrations but reduces response to the drug proportional to disease activity, British Journal of Clinical Pharmacology, 2011, 72, 787-797.
58. Tapner, M, Liddle, C, Goodwin, B, George, J, Farrell, G,C. Interferon gamma down-regulates cytochrome P450 3A genes in primary cultures of well-differentiated rat hepatocytes, Hepatology, 1996, 24, 367-373.
59. Ashino, T, Arima, Y, Shioda, S, Iwakura, Y, Numazawa, S, Yoshida, T. Effect of interleukin-6 neutralization on cyp3a11 and metallothionein-1/2 expressions in arthritic mouse liver, European Journal of Pharmacology, 2007, 558, 199-207.
60. Frye, R, F, Zgheib, N, K, Matzke, G, R, et al. Liver disease selectively modulates cytochrome P450--mediated metabolism, Clinical Pharmacology and Therapeutics, 2006, 80, 235-245.
61. Muntanı, J, Longo, V, Mitjavila, M, T, Gervası, P, G, Ingelman-Sundberg M. Effect of carrageenan-induced granuloma on hepatic cytochrome P-450 isozymes in rats. Inflammation 1995, 19, 143-156.
62. Getachew, Y, James, L, Lee, W, M, Thiele, D, L, Miller B, C, Susceptibility to acetamino-phen (APAP) toxicity unexpectedly is decreased during acute viral hepatitis in mice, Biochemical Pharmacology, 2010; 79: 1363-1371.
63. Kraemer, M, J, Furukawa C, T, Koup J, R, Shapiro, G, G, Pierson, W, E, Bierman, C, W. Altered Theophylline Clearance During an Influenza B Outbreak, Pediatrics. 1982, 69, 476-80.
64. Liu, J, Cao, R, Xu, M, et al. Hydroxychloroquine, a less toxic derivative of chloroquine, is effective in inhibiting SARS-CoV-2 infection in vitro. Cell Discovery 2020, 6, 16.
65. Keyaerts, E, Vijgen, L, Maes, P, Neyts, J, van Ranst, M, In vitro inhibition of severe acute respiratory syndrome coronavirus by chloroquine, Biochemical and Biophysical Research Communications, 2004, 323, 264-268.
66. Yavuz, S, Ş, Ünal, S, Antiviral treatment of COVID-19. Turkish Journal of Medical Science, 2020, 50, 611-619.
67. Albertson, T, E, Chloroquine and Other Aminoquinolines, in: Olson KR (Ed), Poisoning & Drug Overdose. McGraw-Hill Education, 2018, pp.194-196.
68. Lee, J,Y , Vinayagamoorthy, N, Han, K, et al. Association of polymorphisms of cytochrome P450 2D6 with blood hydroxychloroquine levels in patients with systemic lupus erythematosus. Arthritis and Rhematology; 2016, 68, 184-190.
69. Wisniowska, B, Tylutki, Z, Wyszogrodzka, G, Polak, S. Drug-drug interactions and QT prolongation as a commonly assessed cardiac effect- comprehensive overview of clinical trials. BMC Pharmacology and Toxicology, 2016, 17, 12.
70. Fohnera, A, E, Sparreboomb, A, Altmana, R, B, Klein, T, E. Pharm GKB summary: macrolide antibiotic pathway, pharmacokinetics/pharmacodynamics, Pharmacogenet Genomics. 2017, 27, 164-167.
71. Faragon, J, J Jehan Z. Budak, J, Z, Drug Interactions with Antiretroviral Medications. © National HIV in Curriculum Section 3: Antiretroviral Therapy, https://www.hiv.uw.edu/go/antiretroviral-therapy/drug-drug-interactions/core-concept/all. 72. Chinello, P, Petrosillo, N, Pittalis, S, Biava, G, Ippolito, G, Nicastri, E, on behalf of the INMI Ebola Team. QTc interval prolongation during favipiravir therapy in an Ebolavirus-infected patient PLOS Neglected Tropical Diseases. PLoS Negl Trop Dis. 2017 Dec; 11(12): e0006034.
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75. Yang, B, B, Baughman, S, Sullivan, J, T, Pharmacokinetics of anakinra in subjects with different levels of renal function, International Journal of Clinical Pharmacology and Therapeutics, 2003, 74, 85-94.
76. Pelkonen, O, Turpeinen, M, Hakkola, J, Honkakoski, P, Hukkanen, J, Raunio, H. Inhibition and induction of human cytochrome P450 enzymes: current status, Archives of Toxicology, 2008, 82, 667–715.
77. Zhang, X, Peck, R. Clinical pharmacology of tocilizumab for the treatment of patients with rheumatoid arthritis. Expert Review of Clinical Pharmacolology, 2011, 4, 539-558.
78. Clarivet, B, Robin, P, Pers, Y,M, et al. Tocilizumab and mesenteric arterial thrombosis: drug-drug interaction with anticoagulants metabolized by CYP 450 and/or by P-glycoprotein, European Journal of Clinical Pharmacology, 2016, 72, 1413-1414.
79. Kim, S, Östör, A, J, K, Nisar, M, K, Interleukin-6 and cytochrome-P450, reason for concern? Rheumatolology International, 2012, 32, 2601-2604.
80. Zhang, X, Schmitt, C, Grange, S, et al. Disease-drug interaction studies of tocilizumab with cytochrome P450 substrates in vitro and in vivo. Clinical Pharmacolology and Therapeutics, 2009, 85, S59.
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82. Danese, S, Sans, M, Scaldaferri, F, et al. TNF-alpha blockade down-regulates the CD40/CD40L pathway in the mucosal microcirculation: a novel anti-inflammatory mechanism of infliximab in Crohn's disease, The Journal of Immunology, 2006, 176, 2617-2624.
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92. Daveluy, A, Raignoux, C, Miremont-Salamé G, et al, Drug interactions between inhaled corticosteroids and enzymatic inhibitors. European Journal of Clinical Pharmacology, 2009, 65, 743-745.
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Toplam 89 adet kaynakça vardır.

Ayrıntılar

Birincil Dil	İngilizce
Konular	Klinik Tıp Bilimleri
Bölüm	Derleme
Yazarlar	Tülün Öztürk 0000-0003-1693-6674 Tuğba Çavuşoğlu 0000-0002-4787-8561 Canet İncir Bu kişi benim 0000-0002-6298-8419 Yeşim Tunçok 0000-0002-4049-336X
Yayımlanma Tarihi	31 Aralık 2020
Yayımlandığı Sayı	Yıl 2021

Kaynak Göster

APA	Öztürk, T., Çavuşoğlu, T., İncir, C., Tunçok, Y. (2020). Interactions between Cytokines and Drugs in COVID-19 Potential Interactions between Increased Cytokines in COVID-19 and Drugs used to Treat COVID-19. Celal Bayar Üniversitesi Sağlık Bilimleri Enstitüsü Dergisi, 8(1), 174-185. https://doi.org/10.34087/cbusbed.873082
AMA	Öztürk T, Çavuşoğlu T, İncir C, Tunçok Y. Interactions between Cytokines and Drugs in COVID-19 Potential Interactions between Increased Cytokines in COVID-19 and Drugs used to Treat COVID-19. CBU-SBED. Aralık 2020;8(1):174-185. doi:10.34087/cbusbed.873082
Chicago	Öztürk, Tülün, Tuğba Çavuşoğlu, Canet İncir, ve Yeşim Tunçok. “Interactions Between Cytokines and Drugs in COVID-19 Potential Interactions Between Increased Cytokines in COVID-19 and Drugs Used to Treat COVID-19”. Celal Bayar Üniversitesi Sağlık Bilimleri Enstitüsü Dergisi 8, sy. 1 (Aralık 2020): 174-85. https://doi.org/10.34087/cbusbed.873082.
EndNote	Öztürk T, Çavuşoğlu T, İncir C, Tunçok Y (01 Aralık 2020) Interactions between Cytokines and Drugs in COVID-19 Potential Interactions between Increased Cytokines in COVID-19 and Drugs used to Treat COVID-19. Celal Bayar Üniversitesi Sağlık Bilimleri Enstitüsü Dergisi 8 1 174–185.
IEEE	T. Öztürk, T. Çavuşoğlu, C. İncir, ve Y. Tunçok, “Interactions between Cytokines and Drugs in COVID-19 Potential Interactions between Increased Cytokines in COVID-19 and Drugs used to Treat COVID-19”, CBU-SBED, c. 8, sy. 1, ss. 174–185, 2020, doi: 10.34087/cbusbed.873082.
ISNAD	Öztürk, Tülün vd. “Interactions Between Cytokines and Drugs in COVID-19 Potential Interactions Between Increased Cytokines in COVID-19 and Drugs Used to Treat COVID-19”. Celal Bayar Üniversitesi Sağlık Bilimleri Enstitüsü Dergisi 8/1 (Aralık 2020), 174-185. https://doi.org/10.34087/cbusbed.873082.
JAMA	Öztürk T, Çavuşoğlu T, İncir C, Tunçok Y. Interactions between Cytokines and Drugs in COVID-19 Potential Interactions between Increased Cytokines in COVID-19 and Drugs used to Treat COVID-19. CBU-SBED. 2020;8:174–185.
MLA	Öztürk, Tülün vd. “Interactions Between Cytokines and Drugs in COVID-19 Potential Interactions Between Increased Cytokines in COVID-19 and Drugs Used to Treat COVID-19”. Celal Bayar Üniversitesi Sağlık Bilimleri Enstitüsü Dergisi, c. 8, sy. 1, 2020, ss. 174-85, doi:10.34087/cbusbed.873082.
Vancouver	Öztürk T, Çavuşoğlu T, İncir C, Tunçok Y. Interactions between Cytokines and Drugs in COVID-19 Potential Interactions between Increased Cytokines in COVID-19 and Drugs used to Treat COVID-19. CBU-SBED. 2020;8(1):174-85.

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